A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2018, cette méta-analyse évalue l'efficacité des cannabinoïdes oraux pour prévenir et soulager les nausées et vomissements induits par la chimiothérapie chez les patients atteints d'un cancer

Oral cannabinoid for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis

Chow, Ronald ; Valdez, Crystal ; Chow, Natalie ; Zhang, Daniel ; Im, James ; Sodhi, Emily ; Lock, Michael

Introduction : Chemotherapy-induced nausea and vomiting (CINV) is a burdensome adverse event frequently associated with chemotherapy treatment of cancer. Evidence suggests that cannabinoid CB2 receptors are present in brainstem neurons, and thus, there may exist a role for cannabinoids to counter CINV. The aim of this paper is to conduct a systematic review and meta-analysis of the efficacy and safety of oral cannabinoids compared with other treatments as documented in randomized controlled [...]

A partir d'une revue systématique de la littérature, cette méta-analyse (23 articles) évalue l'efficacité, pour améliorer la sexualité et la qualité de vie, des interventions destinées aux couples dont l'un des membres est atteint d'un cancer

A systematic review and meta-analysis of couple-based intervention on sexuality and the quality of life of cancer patients and their partners

Li, Minjie ; Chan, Carmen W. H. ; Chow, Ka Ming ; Xiao, Jinnan ; Choi, Kai Chow

Purpose : To synthesize the characteristics and effects of couple-based intervention on sexuality and the quality of life (QOL) of cancer patients and their intimate partners and its implications for future research and practice. Methods : A systematic review and meta-analysis of randomized and non-randomized controlled studies of interventions was conducted in nine English databases and two Chinese databases, with identification of related studies published in English and Chinese. The quality [...]

Menée aux Etats-Unis à partir de données 2005-2012 portant sur 1 833 patients ayant survécu à un lymphome non hodgkinien, cette étude de cohorte prospective analyse les facteurs associés à leur adhésion au dépistage des cancers et aux recommandations concernant la vaccination contre la grippe

Compliance with cancer screening and influenza vaccination guidelines in non-Hodgkin lymphoma survivors

Pophali, Priyanka A. ; Larson, Melissa C. ; Allmer, Cristine ; Farooq, Umar ; Link, Brian K. ; Maurer, Matthew J. ; Cerhan, James R. ; Thompson, Carrie A.

Purpose : Compliance with US Preventive Services Task Force (USPSTF) age-appropriate cancer screening and immunization guidelines in lymphoma survivors is not known. We sought to measure compliance in non-Hodgkin lymphoma (NHL) survivors and identify any differences based on patient, disease, and treatment characteristics. Methods : Eligible NHL survivors were identified from the Molecular Epidemiology Resource (MER) prospective cohort study. Survivors self-reported colorectal, breast, and [...]

Menée à partir de données portant sur des patients atteints d'un cancer du poumon non à petites cellules inclus dans des essais de phase II ou III, cette étude présente un outil permettant d'évaluer le risque de neutropénie sévère induite par la chimiothérapie

Predicting Risk of Chemotherapy-induced Severe Neutropenia: A Pooled Analysis in Individual Patients Data with Advanced Lung Cancer

Cao, Xiaowen ; Ganti, Apar Kishor ; Stinchcombe, Thomas ; Wong, Melisa L. ; Ho, James C. ; Shen, Chen ; Liu, Yingzhou ; Crawford, Jeffery ; Pang, Herbert ; Wang, Xiaofei

Objectives : Neutropenia is associated with the risk of life-threatening infections, chemotherapy dose reductions and delays that may compromise outcomes. This analysis was conducted to develop a prediction model for chemotherapy-induced severe neutropenia in lung cancer. Materials and Methods : Individual patient data from existing cooperative group phase II/III trials of stages III/IV non-small cell lung cancer or extensive small-cell lung cancer were included. The data were split into [...]

Menée au Royaume-Uni auprès de 24 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cette étude analyse la présence et la sévérité d'une cachéxie liée à la maladie, puis évalue l'association entre cette cachéxie et la réponse à la chimiothérapie

Determining the prevalence and severity of cancer cachexia in advanced non-small cell lung cancer and its relationship with chemotherapy outcomes

White, Rhys ; Weekes, C. Elizabeth ; Grant, Robert ; Baldwin, Christine ; Ahmed, Hafez

Purpose : Cancer cachexia (CC) is a syndrome characterised by an ongoing loss of skeletal muscle mass associated with reduced tolerance to treatment. This study explored the prevalence and severity of CC in advanced non-small cell lung cancer (NSCLC) patients and determined its relationship with chemotherapy outcomes. Methods : CC was classified into a four-stage model: no cachexia, pre-cachexia (PC), cachexia and refractory cachexia (RC) with categorisation determined from biochemical and body [...]

Menée aux Etats-Unis à partir de données portant sur 85 000 participants, cette étude analyse les disparités ethniques et sociodémographiques dans l'association entre le dépistage du cancer colorectal, l'incidence de la maladie et la mortalité

Association of Race and Socioeconomic Status With Colorectal Cancer Screening, Colorectal Cancer Risk, and Mortality in Southern US Adults

Warren Andersen, Shaneda ; Blot, William J. ; Lipworth, Loren ; Steinwandel, Mark ; Murff, Harvey J. ; Zheng, Wei

Importance : Colorectal cancer (CRC) screening is rarely studied in populations who may face additional barriers to participate in cancer screening, such as African American individuals and individuals with low socioeconomic status (SES). Objective : To examine the associations of CRC screening and modalities with CRC incidence and mortality by race and SES. Design, Setting, and Participants : This cohort study used data from the Southern Community Cohort Study, which enrolled more than 85 000 [...]

A partir des données des registres américains des cancers portant sur des patientes âgées de plus de 66 ans et atteintes d'un cancer du sein diagnostiqué entre 2007 et 2011, cette étude analyse l'association entre une utilisation d'hydrochlorothiazide (un diurétique thiazidique) et la survenue d'effets indésirables induits par une chimiothérapie adjuvante à base de cyclophosphamide (hospitalisation pour une neutropénie et arrêt du traitement anticancéreux)

Association Between Concomitant Use of Hydrochlorothiazide and Adverse Chemotherapy-Related Events among Older Women with Breast Cancer Treated with Cyclophosphamide

Hsu, Christine D. ; Hinton, Sharon Peacock ; Reeder-Hayes, Katherine E. ; Sanoff, Hanna K. ; Lund, Jennifer L.

Background: The pharmacy reference database, Micromedex, lists concomitant hydrochlorothiazide and cyclophosphamide use as a potential, major drug–drug interaction (DDI), although only one small, single-center study supports this claim. Our objective was to estimate associations between this potential DDI and two adverse chemotherapy-related events, neutropenia-related hospitalizations and treatment regimen discontinuation, among a cohort of women with breast cancer initiating adjuvant [...]

Menée aux Etats-Unis à partir de données portant sur des patients atteints d'un cancer de la tête et du cou, cette étude évalue leur état de santé buccale (salive, mucite, gingivite, etc.), leur acuité gustative et olfactive pendant et après les traitements anticancéreux (radiothérapie, avec ou sans chimiothérapie)

Oral examination findings, taste and smell testing during and following head and neck cancer therapy

Epstein, Joel B. ; Villines, Dana ; Epstein, Geena L. ; Smutzer, Gregory

Purpose : Diet and nutrition are critical in health and disease and are highly impacted by the presence and treatment for head and neck cancer (HNC). The purpose of this paper is to present oral examination findings and taste and smell test results in patients during and following HNC. Methods : Patients with HNC were evaluated during and following radiation therapy with/without chemotherapy. Oral examination findings including mucositis, saliva, oral hygiene (plaque levels, gingivitis), and [...]

Menée aux Etats-Unis à partir de données portant sur 6 458 patients atteints d'un carcinome épidermoïde nasosinusien diagnostiqué entre 2010 et 2016 (âge médian : 64 ans), cette étude analyse les modalités de dépistage du papillomavirus humain (HPV), l'association entre une infection par le HPV et la survie

Human papillomavirus and survival of patients with sinonasal squamous cell carcinoma

Oliver, Jamie R. ; Lieberman, Seth M. ; Tam, Moses M. ; Liu, Cheng Z. ; Li, Zujun ; Hu, Kenneth S. ; Morris, Luc G. T. ; Givi, Babak

BACKGROUND : To the authors' knowledge, the question of whether human papillomavirus (HPV) infection is associated with outcomes in patients with sinonasal squamous cell carcinoma (SNSCC) is not well studied at this time. In the current study, the authors investigated patterns of HPV testing and its association with survival in patients with SNSCC using the National Cancer Data Base. METHODS : The authors selected all SNSCC cases diagnosed between 2010 and 2016. HPV testing practices, [...]

Menée en Allemagne à partir de données portant sur 21 680 patients atteints d'un cancer, cette étude identifie les facteurs associés à la présence et à la sévérité de divers symptômes de détresse psychologique

Distress in cancer patients: who are the main groups at risk?

Herschbach, Peter ; Britzelmeir, Ingrid ; Dinkel, Andreas ; Giesler, Jürgen M. ; Herkommer, Kathleen ; Nest, Alexandra ; Pichler, Theresia ; Reichelt, Ralf ; Tanzer-Küntzer, Sylvia ; Weis, Joachim ; Marten-Mittag, Birgitt

Objectives : Psychosocial distress is common in cancer patients and survivors and encompasses a broad range of concerns and psychological symptoms. The aim of the current study was to identify subgroups of respondents who experience a specific constellation of distress symptoms. Methods : This study uses data from a large data base (n = 21 680) of cancer patients from diverse settings who provided data in the Questionnaire on Distress in Cancer Patients ‐ Short Form (QSC‐R10). Cluster analysis [...]

Menée en Corée à partir de données portant sur 6 292 hommes et 4 455 femmes atteints d'un cancer, cette étude analyse l'association entre des troubles psychiques, des traitements psychiatriques et la mortalité

Impact of Onset of Psychiatric Disorders and Psychiatric Treatment on Mortality Among Patients with Cancer

Lee, Sang Ah ; Nam, Chung Mo ; Kim, Young Hoon ; Kim, Tae Hyun ; Jang, Sung-In ; Park, Eun-Cheol

Background : Psychiatric disorders are common in patients with cancer. The impact of both psychiatric disorders and psychiatric treatment on mortality in patients with cancer needs to be established. Materials and Methods : Nationwide claims data were analyzed. To investigate the association between psychiatric disorders and mortality, 6,292 male and 4,455 female patients with cancer who did not have a record of psychiatric disorders before cancer onset were included. To examine the association [...]

A partir d'une revue de la littérature publiée jusqu'en février 2018 (13 études), cette étude analyse les outils de détection d'une détresse psychologique et les services de soins de support par téléphone dédiés aux patients atteints d'un cancer

Distress screening and supportive care referrals used by telephone-based health services: a systematic review

Taylor, Jo ; Fradgley, Elizabeth A. ; Clinton-McHarg, Tara ; Roach, Della ; Paul, Chris L.

Purpose : People affected by chronic diseases such as cancer report high levels of distress and a need for psychosocial support. It is unclear whether telephone-based services for people affected by chronic disease are a practical setting for implementing distress screening, referral protocols and rescreening to direct supportive care where it is needed. This systematic review aimed to describe the published literature regarding distress screening and supportive care referral practices in [...]

Menée aux Etats-Unis par questionnaire auprès de 572 patientes ayant survécu à un cancer du sein HR+, cette étude analyse les facteurs cliniques, sociodémographiques, médicaux et psychosociaux associés à leurs opinions concernant une thérapie endocrinienne adjuvante

Sociodemographic, clinical, psychosocial, and healthcare-related factors associated with beliefs about adjuvant endocrine therapy among breast cancer survivors

Sutton, Arnethea L. ; Salgado, Teresa M. ; He, Jun ; Hurtado-de-Mendoza, Alejandra ; Sheppard, Vanessa B.

Objective : Adjuvant endocrine therapy (AET) reduces the risk of recurrence and mortality in women with hormone receptor–positive breast cancer. However, adherence to AET remains suboptimal. Women’s beliefs about medication have been associated with medication adherence. The purpose of this study was to identify multilevel factors associated with women’s beliefs about AET. Methods : Beliefs about AET, measured using the Belief about Medicines Questionnaire (BMQ), sociodemographic (e.g., age), [...]

Menée en France par enquête auprès de 138 patients atteints d'un cancer (100 répondants) et recevant des soins palliatifs, cette étude analyse leur utilisation de médecines complémentaires (aromathérapie, naturopathie, vitamines, etc.)

The use of complementary medicine in palliative care in France: an observational cross-sectional study

Filbet, Marilene ; Schloss, Janet ; Maret, Jean-Baptiste ; Diezel, Helene ; Palmgren, Per J. ; Steel, Amie

Purpose : Palliative care for cancer deals with physical, psychosocial, and spiritual issues faced by cancer patients, their families, communities, and healthcare providers. Research on complementary medicine (CM) use in France is limited despite high rates of reported CM use in other countries including by palliative patients. This study describes the use of CM by individuals receiving palliative care in Lyon, France. Design : This study employed an observational cross-sectional survey design. [...]