Menée en Suède par questionnaires auprès de 57 654 femmes dont 957 patientes atteintes d'un cancer du sein (âge médian : 54 ans), cette étude analyse l'effet de facteurs liés au mode de vie (consommation d'alcool et activité physique) sur le risque à 10 ans de développer la maladie

The impact of alcohol consumption and physical activity on breast cancer: the role of breast cancer risk

Rainey, Linda ; Eriksson, Mikael ; Trinh, Thang ; Czene, Kamila ; Broeders, Mireille J.M. ; van der Waal, Daniëlle ; Hall, Per

High alcohol consumption and physical inactivity are known breast cancer risk factors. However, whether the association between these lifestyle factors and breast cancer is modified by a woman's additional breast cancer risk factors has never been studied. Therefore, a population-based prospective cohort study of 57,654 Swedish women aged 40-74 years, including 957 breast cancer cases, was performed. Alcohol consumption and physical activity were measured with validated web-based self-report [...]

Menée à l'aide de données portant sur 9 886 femmes afro-américaines ménopausées (âge : 50-79 ans ; durée de suivi : 13 ans), cette étude analyse l'association entre des facteurs liés au mode vie modifiables (qualité de l'alimentation, activité physique), le risque de cancer et de décès attribuables à l'obésité

Association of Diet Quality and Physical Activity on Obesity-Related Cancer Risk and Mortality in Black Women: Results from the Women's Health Initiative

Chebet, Joy J ; Thomson, Cynthia A. ; Kohler, Lindsay N. ; Ehiri, John E ; Luo, Juhua ; Cheng, Ting-Yuan David ; Pan, Kathy ; Chlebowski, Rowan T. ; Nassir, Rami ; Sealy-Jefferson, Shawnita ; Manson, JoAnn E. ; Saquib, Nazmus ; Bell, Melanie L

Background : Obesity-related cancers disproportionately affect the Black community. We assessed the relationship between diet quality, physical activity and their combined effect on obesity-related cancer risk and mortality in Black women enrolled in the Women's Health Initiative (WHI). Methods : Data from postmenopausal (50-79 years), Black women enrolled in WHI clinical trials or observational studies were analyzed. Exposure variables included baseline physical activity (MET-hours/week of [...]

Menée aux Etats-Unis auprès de 1 170 patients atteints d'un cancer de la tête et du cou et de 1 303 témoins, cette étude analyse l'association entre la qualité de l'alimentation, évaluée à l'aide de 3 indicateurs, et le risque de développer la maladie

The association between diet quality and cancer incidence of the head and neck

Saraiya, Veeral ; Bradshaw, Patrick ; Meyer, Katie ; Gammon, Marilie ; Slade, Gary ; Brennan, Paul ; Abedi-Ardekani, Behnoush ; Olshan, Andrew

The association between diet quality and head and neck cancer (HNC) was explored using a population-based case–control study of 1170 HNC cases and 1303 age-, race-, and sex-matched controls from the United States. Diet quality was assessed with three diet quality scores (DQS): (a) Healthy Eating Index 2005 (HEI-2005), (b) Mediterranean Diet Score (MDS), and (c) HNC-specific Mediterranean Diet Score (MDS-HNC), a modified MDS that we developed to be more applicable to HNC. Logistic regression [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2018 (12 études), cette méta-analyse évalue l'association entre une exposition professionnelle au formaldéhyde et le risque de lymphome non hodgkinien

Occupational exposure to formaldehyde and risk of non hodgkin lymphoma: a meta-analysis

Catalani, Simona ; Donato, Francesca ; Madeo, Egidio ; Apostoli, Pietro ; De Palma, Giuseppe ; Pira, Enrico ; Mundt, Kenneth A. ; Boffetta, Paolo

Background : Formaldehyde, a widely used chemical, is considered a human carcinogen. We report the results of a meta-analyses of studies on the relationship between occupational exposure to formaldehyde and risk of non-Hodgkin lymphoma (NHL). Methods : We performed a systematic review and meta-analysis according to international guidelines and we identified 12 reports of occupational populations exposed to formaldehyde. We evaluated inter-study heterogeneity and we applied a random effects [...]

Menée aux Etats-Unis à partir des données des cohortes "the Nurses’ Health Study" et "the Nurses’ Health Study II" portant au total sur 189 933 femmes, cette étude analyse l'association entre le travail de nuit en horaires rotatifs et le risque de cancer hématopoïétique (1 910 cas), par sous-types

Rotating nightshift work and hematopoietic cancer risk in U.S. female nurses

Zhang, Yin ; Birmann, Brenda M ; Papantoniou, Kyriaki ; Zhou, Eric S ; Erber, Astrid Christine ; Schernhammer, Eva S

Nightshift work is a plausible risk factor for hematologic cancer, but epidemiological evidence remains sparse, especially for individual subtypes. We prospectively examined the association of rotating nightshift work with hematopoietic cancer risk.This cohort study included US females from the Nurses’ Health Study (NHS: n = 76,846, 1988-2012) and Nurses' Health Study II (NHSII: n = 113,087, 1989-2013). Rotating nightshift work duration was assessed at baseline (both cohorts) and cumulatively [...]

Menée aux Etats-Unis à partir de données de la cohorte "Sister study" portant sur 48 451 femmes (durée moyenne de suivi : 9,1 ans), cette étude analyse l'association entre les horaires de travail posté et le risque de cancer du sein (3 191 cas)

Shift work and working at night in relation to breast cancer incidence

Sweeney, Marina R ; Sandler, Dale P. ; Niehoff, Nicole M ; White, Alexandra J

Background: Night shift work has been classified by the International Agency for Research on Cancer (IARC) as a probable carcinogen in humans. Several studies have assessed night shift work in relation to breast cancer risk, with inconsistent results. Methods: In the prospective Sister Study cohort, current and past occupational history was collected for 48,451 participants. We used Cox proportional hazards models to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2019 (14 études), cette méta-analyse évalue l'association entre le temps passé au soleil et le risque de cancer du sein

Solar Ultraviolet Radiation and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Troy W. R. Hiller ; Dylan E. O’Sullivan ; Darren R. Brenner ; Cheryl E. Peters ; Will D. King

Background: A protective relationship has been hypothesized between exposure to solar ultraviolet radiation (UVR) and the development of breast cancer. Objective: The objective of this study was to conduct a systematic literature review and meta-analysis of studies examining the association of exposure to solar UVR and breast cancer risk. Methods: We searched Medline, EMBASE, and Web of Science for all studies investigating exposure to solar UVR and breast cancer risk. Separate analyses were [...]

Menée aux Etats-Unis sur la période 1993-2013 auprès de 118 441 femmes et de 96 810 hommes (âge moyen : 60,5-61,3 ans), cette étude analyse l'association entre une exposition aux polluants de l'air ambiant et le risque de cancer du cerveau (94 hommes, 116 femmes) et de méningiome (130 hommes, 425 femmes), en fonction du sexe et de l'origine ethnique

Association between outdoor air pollution and risk of malignant and benign brain tumors: The Multiethnic Cohort Study

Wu, Anna H ; Wu, Jun ; Tseng, Chiuchen ; Yang, Juan ; Shariff-Marco, Salma ; Fruin, Scott ; Larson, Timothy ; Setiawan, Veronica W ; Masri, Shahir ; Porcel, Jacqueline ; Jain, Jennifer ; Chen, Thomas C ; Stram, Daniel O ; Marchand, Loïc Le ; Ritz, Beate ; Cheng, Iona

There are increasing concerns about the potential impact of air pollution on chronic brain inflammation and microglia cell activation but evidence of its carcinogenic effects is limited.We used kriging interpolation and land use regression models to estimate long-term air pollutant exposures of oxides of nitrogen (NOx, NO2), kriging interpolation for ozone (O3), carbon monoxide (CO), and particulate matter (PM2.5, PM10), and nearest monitoring station measurements for benzene for 103,308 men [...]

Menée à l'aide des données des registres américains des cancers et auprès de 1 267 femmes sous traitement androgène (âge moyen : 61 ans), cette étude analyse l'effet à long terme de ce traitement sur le risque de cancer du sein invasif (11 cas)

Incidence of invasive breast cancer in women treated with testosterone implants: a prospective 10-year cohort study

Glaser, Rebecca L. ; York, Anne E. ; Dimitrakakis, Constantine

Background : Testosterone implants have been used for over eighty years to treat symptoms of hormone deficiency in pre and postmenopausal women. Evidence supports that androgens are breast protective. However, there is a lack of data on the long-term effect of testosterone therapy on the incidence of invasive breast cancer (IBC). This study was specifically designed to investigate the incidence of IBC in pre and postmenopausal women (presenting with symptoms of androgen deficiency) treated with [...]

Menée au Danemark sur la période 2000-2015 auprès de 12 271 patients atteints d'un cancer de la vessie (âge médian : 72 ans ; 75% d'hommes), cette étude analyse l'association entre une utilisation d'antibiotiques spécifiques aux infections urinaires et le risque de développer la maladie, en fonction du type de tumeur et de la dose utilisée

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case-control study

Pottegård, Anton ; Kristensen, Kasper Bruun ; Friis, Søren ; Hallas, Jesper ; Jensen, Jørgen Bjerggaard ; Nørgaard, Mette

Schistosoma haematobium infection can lead to squamous cell carcinomas (SCC) of the bladder. Whether this also applies to more common urinary tract infections (UTIs) is unclear. We therefore aimed to investigate the association between UTIs, reflected by use of specific antibiotics, and risk of SCC of the bladder. We conducted a Danish nationwide case-control study and identified histologically verified bladder cancer cases (2000-2015; n=12,271) and age- and sex-matched cancer-free controls. We [...]

Menée aux Etats-Unis auprès d'une cohorte incluant 463 049 personnes (âge : 50-71 ans ; durée médiane de suivi : 15,5 ans), cette étude analyse l'association entre des facteurs liés au mode de vie et le risque de néoplasme myéloprolifératif (490 cas), en fonction du sexe

Lifestyle Factors and Risk of Myeloproliferative Neoplasms in the NIH-AARP Diet and Health Study

Podoltsev, Nikolai A. ; Wang, Xiaoyi ; Wang, Rong ; Hofmann, Jonathan N. ; Liao, Linda M. ; Zeidan, Amer M. ; Mesa, Ruben ; Ma, Xiaomei

The etiology of Philadelphia chromosome negative myeloproliferative neoplasms (MPN) is largely unknown. We assessed potential associations between lifestyle factors and MPN risk in the NIH-AARP Diet and Health Study. In this prospective cohort with 463,049 participants aged 50-71 years at baseline (1995-1996) and a median follow-up of 15.5 years, we identified 490 MPN cases, including 190 with polycythemia vera (PV) and 146 with essential thrombocythemia (ET). Multivariable Cox proportional [...]

Menée en Chine sur la période 2010-2015 auprès de 69 742 personnes exemptes de diabète (âge moyen : 50 ans ; durée médiane de suivi : 5 ans), cette étude analyse l'association entre l'évolution de la glycémie à jeûn et le risque de cancer (1 364 cas dont 472 cancers gastro-intestinaux), puis examine l'influence de l'indice de masse corporelle sur cette association

The Association between Fasting Blood Glucose Trajectory and Cancer Risk in Chinese Population Without Diabetes

Feng, Xiaoshuang ; Wang, Gang ; Lyu, Zhangyan ; Chen, Shuohua ; Wei, Luopei ; Li, Xin ; Wen, Yan ; Chen, Yuheng ; Xie, Shuanghua ; Cui, Hong ; Chen, Hongda ; Li, Jiang ; Lin, Chunqing ; Ren, Jiansong ; Shi, Jufang ; Wu, Shouling ; Dai, Min ; Li, Ni ; He, Jie

To examine the associations between fasting blood glucose (FBG) trajectories, the changes in FBG over time, and the risk of cancer, particularly for gastrointestinal cancer, we enrolled 69 742 participants without diabetes from the Kailuan cohort. FBG trajectories (2006-2010) were modeled by group-based trajectory modeling, and five trajectories were identified: low-increasing (n=6275), moderate-stable (n=44 120), moderate-increasing (n=10 149), elevated-decreasing (n=5244), and elevated-stable [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2019 (45 études), cette méta-analyse évalue la prévalence de Fusobacterium nucleatum dans les tumeurs colorectales puis analyse l'association entre cette bactérie, le risque de cancer colorectal et la survie associée

Fusobacterium nucleatum in the colorectum, and its association with cancer risk and survival: a systematic review and meta-analysis

Gethings-Behncke, Christian ; Coleman, Helen G. ; Jordao, Haydee WT ; Longley, Daniel B. ; Crawford, Nyree ; Murray, Liam J. ; Kunzmann, Andrew T

Background: The gut microbiome, in particular Fusobacterium nucleatum, has been reported to play a role in colorectal cancer development and in patient prognosis. We aimed to perform a systematic review and meta-analysis of published studies to assess the prevalence of F. nucleatum in colorectal tumours, and evaluate the association between F. nucleatum and colorectal cancer development and prognosis. Methods: MEDLINE, EMBASE and Web of Science databases were systematically searched for studies [...]

Menée en Allemagne auprès de 2 407 patients atteints d'un cancer colorectal et de 2 454 témoins (âge médian : 69 ans ; 59 % d'hommes), cette étude analyse l'association entre l'indice de masse corporelle et le risque de développer la maladie, par sous-types moléculaires et en fonction du sexe

Association of BMI and major molecular pathological markers of colorectal cancer in men and women

Carr, Prudence R ; Amitay, Efrat L ; Jansen, Lina ; Alwers, Elizabeth ; Roth, Wilfried ; Herpel, Esther ; Kloor, Matthias ; Schneider, Martin ; Blaker, Hendrik ; Chang-Claude, Jenny ; Brenner, Hermann ; Hoffmeister, Michael

Observational studies have consistently shown that a high BMI is associated with increased risk of colorectal cancer (CRC). However, the underlying mechanisms linking obesity to CRC remain unclear.To investigate the associations of BMI and CRC by major molecular pathological subtypes of CRC.This analysis included 2407 cases and 2454 controls from a large German population–based case–control study. Information on recent weight and height as well as other demographic and lifestyle data were [...]

Menée en Chine auprès de 248 patients atteints d'un cancer colorectal et de 463 témoins, cette étude analyse l'association entre 6 polymorphismes à simple nucléotide du gène de l'interleukine-4 (IL-4) et le risque de développer la maladie

The correlation between IL-4 polymorphisms and colorectal cancer risk in a population in Northwest China

Wen, Xiulin ; Xin, Xia ; Li, Jieqiong ; Qiao, Lina ; Liu, Fang ; Guo, Yuan ; Qu, Zhan ; Wang, Rui ; Li, Xiaomei

Our aim was to investigate whether polymorphisms in the interleukin-4 (IL-4) gene are associated with the risk of colorectal cancer (CRC) in a Chinese Han population. Six single-nucleotide polymorphisms (SNPs) in the IL-4 were genotyped by Agena MassARRAY in 248 CRC patients and 463 healthy controls. The association of IL-4 polymorphisms with CRC risk was assessed by genetic models, linkage disequilibrium, and haplotype analyses. The results suggested that the CC genotype of rs2243250 confers a [...]

Menée au Canada sur la période 2002-2006 à l'aide d'échantillons sanguins prélevés sur 522 patientes atteintes d'un cancer de l'endomètre et sur 976 témoins, cette étude analyse l'association entre les niveaux circulants d'hormones sexuelles endogènes (œstrone, œstradiol, globuline de liaison aux hormones sexuelles, testostérone et androstènedione) et le risque de développer la maladie

Case–control study of endogenous sex steroid hormones and risk of endometrial cancer

Friedenreich, Christine M. ; Derksen, Jeroen W. G. ; Speidel, Thomas ; Brenner, Darren R. ; Heer, Emily ; Courneya, Kerry S. ; Cook, Linda S.

Background : Epidemiologic evidence regarding the role of endogenous sex hormones in endometrial cancer etiology remains inconsistent. The objective of this study was to investigate if circulating levels of endogenous estrone, estradiol, sex hormone binding globulin (SHBG), testosterone, and androstenedione are associated with endometrial cancer risk. Methods : We conducted a population-based case–control study of 522 incident endometrial cancer cases and 976 population controls, in Alberta, [...]