Cette étude analyse les recommandations de l'"American Society of Clinical Oncology" concernant la prise en charge de l'ostéoporose chez des patients adultes ayant survécu à un cancer non métastatique

Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline

Charles L. Shapiro ; Catherine Van Poznak ; Christina Lacchetti ; Jeffrey Kirshner ; Richard Eastell ; Robert Gagel ; Sean Smith ; Beatrice J. Edwards ; Elizabeth Frank ; Gary H. Lyman ; Matthew R. Smith ; Rahul Mhaskar ; Tara Henderson ; Joan Neuner

PURPOSE : The aim of this work is to provide evidence-based guidance on the management of osteoporosis in survivors of adult cancer. METHODS : ASCO convened a multidisciplinary Expert Panel to develop guideline recommendations based on a systematic review of the literature. RESULTS : The literature search of the 2018 systematic review by the US Preventive Services Task Force in the noncancer population was used as the evidentiary base upon which the Expert Panel based many of its [...]

Menée aux Etats-Unis par enquête auprès de 13 750 028 patients ayant survécu à un cancer, cette étude analyse les facteurs associés à des troubles du sommeil et l'utilisation de pratiques médicales corps-esprit (médecine traditionnelle chinoise, méditation, yoga...)

Cancer, sleep problems, and mind-body medicine use: Results of the 2017 National Health Interview Survey

Voiss, Petra ; Höxtermann, Melanie Désirée ; Dobos, Gustav ; Cramer, Holger

Background : Sleep problems affect physical and emotional well‐being as well as immune system function. Evidence has demonstrated an improvement in sleep problems in patients with cancer through the use of mind‐body medicine (MBM). In the current study, the authors sought to elucidate the prevalence of sleep problems and the use of MBM in adult cancer survivors. Methods : The authors analyzed data from the 2017 US National Health Interview Survey (NHIS) to estimate the prevalence of sleep [...]

A partir des données de 8 essais internationaux de phase III menés dans 46 pays et incluant 9 670 patients atteints d'un cancer de la prostate (âge moyen : 69,2 ans), cette étude analyse les disparités géographiques dans l'utilisation des opioïdes et évalue les facteurs associés à cette utilisation

Global Variation in Opioid Use in Prostate Cancer Trials

Roydhouse, Jessica K. ; Suzman, Daniel L. ; Menapace, Laurel A. ; Mishra-Kalyani, Pallavi S. ; Sridhara, Rajeshwari ; Blumenthal, Gideon M. ; Beaver, Julia A. ; Pazdur, Richard ; Kluetz, Paul G.

Importance : Regional variation in opioid use may be attenuated when pharmaceutical-sponsored trials include care that is often standardized by protocols. Understanding such variation is important for global trials that sometimes include time to opioid use as an end point. Objective : To identify whether regional and country-level variation in opioid use exists among prostate cancer clinical trials across the world. Design, Setting, and Participants : International phase 3 randomized clinical [...]

Menée au Royaume-Uni par enquête auprès de 526 puis 510 patients ayant survécu à un cancer colorectal, cette étude analyse l'évolution de leurs besoins en soins après la fin des traitements anticancéreux (15 puis 24 mois après un traitement chirurgical) et leur qualité de vie

Supportive care needs of patients following treatment for colorectal cancer: risk factors for unmet needs and the association between unmet needs and health-related quality of life—results from the ColoREctal Wellbeing (CREW) study

Sodergren, S. C. ; Wheelwright, S. J. ; Permyakova, N. V. ; Patel, M. ; Calman, L. ; Smith, P. W. F. ; Din, A. ; Richardson, A. ; Fenlon, D. ; Winter, J. ; Corner, J. ; Foster, C. ; Armes, Jo ; Baird, Janis ; Bateman, Andrew ; Beck, Nick ; Moon, Graham ; Hall, Peter ; Poole, Karen ; Restorick-Banks, Susan ; Roderick, Paul ; Smith, Lesley ; Taylor, Claire ; Walters, Jocelyn ; Williams, Fran ; Members of Study Advisory Committee

Purpose : To investigate unmet needs of patients with colorectal cancer (CRC) at the end of treatment and whether unmet needs improve over time. Identify predictors of need following treatment and whether unmet need is associated with worse health-related quality of life (HRQoL). Methods : As part of the UK ColoREctal Wellbeing (CREW) cohort study, patients treated for CRC completed the Supportive Care Needs Survey Short Form-34 (SCNS SF-34) 15 and 24 months following surgery, along with [...]

Menée aux Etats-Unis à partir des données portant sur 1 708 patients ayant survécu à un cancer pédiatrique dont 167 atteints d'une neurofibromatose de type 1 (NF1), cette étude analyse les facteurs associés au risque de développer d'autres tumeurs

Subsequent Neoplasms After a Primary Tumor in Individuals With Neurofibromatosis Type 1

Smita Bhatia ; Yanjun Chen ; F. Lennie Wong ; Lindsey Hageman ; Kandice Smith ; Bruce Korf ; Ashley Cannon ; Daniel J. Leidy ; Alejandro Paz ; Joseph E. Andress ; Gregory K. Friedman ; Katie Metrock ; Joseph P. Neglia ; Michael Arnold ; Lucie M. Turcotte ; Peter de Blank ; Wendy Leisenring ; Gregory T. Armstrong ; Leslie L. Robison ; D. Wade Clapp ; Kevin Shannon ; Jean L. Nakamura ; Michael J. Fisher

PURPOSE : Fundamental gaps in knowledge regarding the risk of subsequent neoplasms (SNs) in children with pathogenic neurofibromatosis type 1 (NF1) variants exposed to radiation and/or alkylator chemotherapy have limited the use of these agents. METHODS : We addressed these gaps by determining the SN risk in 167 NF1-affected versus 1,541 non–NF1-affected 5-year childhood cancer survivors from the Childhood Cancer Survivor Study and 176 nonoverlapping NF1-affected individuals with primary tumors [...]

Menée à partir des données du registre finlandais des cancers portant sur 13 860 patients ayant survécu 5 ans à un cancer diagnostiqué avant l'âge de 35 ans, cette étude cas-témoins analyse les facteurs associés au risque de développer une maladie de la fonction rénale ou une maladie osseuse métabolique

Diseases of renal function and bone metabolism following treatment for early-onset cancer: A registry-based study

Liuhto, Niilo ; Grönroos, Marika H. ; Malila, Nea ; Madanat-Harjuoja, Laura ; Matomäki, Jaakko ; Lähteenmäki, Päivi

Modern cancer therapy has led to a growing number of pediatric and young adult cancer survivors, who are prone to increased morbidities caused by the late‐effects of therapy. The aim of this study was to investigate pediatric and young adult cancer survivors' morbidity due to renal and bone metabolism diseases and especially to study bone metabolism in cancer survivors with renal disease. Patients were identified from the Finnish Cancer Registry, and the cohort consisted of 13,860, 5‐year [...]

Menée au Royaume-Uni à partir de données portant sur 196 patients atteints d'un cancer traité entre 2015 et 2018, cette étude analyse l'association entre un traitement antibiotique dispensé avant ou pendant un traitement anticancéreux par inhibiteurs de points de contrôle immunitaire, la réponse à l'immunothérapie, et la survie globale

Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer

Pinato, David J. ; Howlett, Sarah ; Ottaviani, Diego ; Urus, Heather ; Patel, Aisha ; Mineo, Takashi ; Brock, Cathryn ; Power, Danielle ; Hatcher, Olivia ; Falconer, Alison ; Ingle, Manasi ; Brown, Anna ; Gujral, Dorothy ; Partridge, Sarah ; Sarwar, Naveed ; Gonzalez, Michael ; Bendle, Maggie ; Lewanski, Conrad ; Newsom-Davis, Thomas ; Allara, Elias ; Bower, Mark

Importance : Gut dysbiosis impairs response to immune checkpoint inhibitors (ICIs) and can be caused by broad-spectrum antibiotic (ATB) therapy. Objective : To evaluate whether there is an association between ATB therapy administered concurrently (cATB) or prior (pATB) to ICI therapy and overall survival (OS) and treatment response to ICI therapy in patients with cancer treated with ICIs in routine clinical practice. Design, Setting, and Participants :This prospective, multicenter, cohort study [...]

A partir d'une revue systématique de la littérature (27 études), cette méta-analyse évalue les disparités ethniques dans la survie chez des patients atteints d'un cancer du poumon aux Etats-Unis, en prenant en compte le statut tabagique

Race/ethnicity and lung cancer survival in the United States: a meta-analysis

Klugman, Madelyn ; Xue, Xiaonan ; Hosgood, H. Dean

Purpose : Lung cancer mortality has been shown to vary by race and ethnicity in cancer registries; however, studies often do not account for smoking status. We sought to summarize the independent contribution of race and ethnicity to survival in US lung cancer patients, accounting for important variables including smoking status. Methods : PubMed was used to identify 1,877 potentially eligible studies of which 27 were included. Studies were excluded if they did not account for age, race and/or [...]

Menée à partir des données des registres néerlandais des cancers portant sur 18 419 patientes âgées ayant survécu à un cancer du sein non métastatique traité par chirurgie entre 2003 et 2009, cette étude analyse l'association entre l'âge (70-74 ans, 75-79 ans et plus de 80 ans), la présence de comorbidités et le risque de récidive locale ou distante

Impact of Older Age and Comorbidity on Locoregional and Distant Breast Cancer Recurrence: A Large Population-Based Study

de Boer, Anna Z. ; van der Hulst, Heleen C. ; de Glas, Nienke A. ; Marang‐van de Mheen, Perla J. ; Siesling, Sabine ; de Munck, Linda ; de Ligt, Kelly M. ; Portielje, Johanneke E. A. ; Bastiaannet, Esther ; Liefers, Gerrit Jan

Background : Studies have demonstrated worse breast cancer‐specific mortality with older age, despite an increasing risk of dying from other causes due to comorbidity (competing mortality). However, findings on the association between older age and recurrence risk are inconsistent. The aim of this study was to assess incidences of locoregional and distant recurrence by age, taking competing mortality into account. Materials and Methods : Patients surgically treated for nonmetastasized breast [...]

A partir d'une revue systématique de la littérature (23 essais contrôlés et 9 essais ouverts), cette méta-analyse évalue l'efficacité des interventions de nature psychologique pour réduire la peur de la récidive chez des patients atteints d'un cancer ou ayant survécu à la maladie

Effect of Psychological Intervention on Fear of Cancer Recurrence: A Systematic Review and Meta-Analysis

Nina M. Tauber ; Mia S. O’Toole ; Andreas Dinkel ; Jacqueline Galica ; Gerry Humphris ; Sophie Lebel ; Christine Maheu ; Gozde Ozakinci ; Judith Prins ; Louise Sharpe ; Allan “Ben” Smith ; Belinda Thewes ; Sébastien Simard ; Robert Zachariae

PURPOSE : Fear of cancer recurrence (FCR) is a significantly distressing problem that affects a substantial number of patients with and survivors of cancer; however, the overall efficacy of available psychological interventions on FCR remains unknown. We therefore evaluated this in the present systematic review and meta-analysis. METHODS : We searched key electronic databases to identify trials that evaluated the effect of psychological interventions on FCR among patients with and survivors of [...]

Menée au Canada, aux Etats-Unis, en Australie et au Royaume-Uni par enquêtes auprès de 23 831 adultes fumeurs réguliers, cette étude longitudinale analyse l'évolution, entre 2002 et 2015, des opinions et des normes sociales concernant le tabagisme

Trends in social norms towards smoking between 2002 and 2015 among daily smokers: Findings from the International Tobacco Control Four Country Survey (ITC 4C)

East, Katherine A ; Hitchman, Sara C ; McNeill, Ann ; Ferguson, Stuart G ; Yong, Hua-Hie ; Cummings, K Michael ; Fong, Geoffrey T ; Borland, Ron

Objective : To assess trends in daily smokers’ social norms and opinions of smoking between 2002 and 2015 in Canada, US, UK and Australia. Method : Data were from Waves-1 (2002) to -9 (2013-2015) of the longitudinal International Tobacco Control Four Country Survey (Canada, US, UK, Australia), involving 23,831 adult daily smokers. Generalised estimating equation logistic regression models, adjusted for demographics and survey design effects, assessed associations of Wave and country with [...]