Menée aux Etats-Unis, cette étude estime les marges d'exposition à un composé cancérogène appelé pulégone présent dans plusieurs produits tabagiques et cigarettes électroniques aromatisés à la menthe ou au menthol

Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products

Jabba, Sairam V. ; Jordt, Sven-Eric

Pulegone, a constituent of oil extracts prepared from mint plants, including peppermint, spearmint and pennyroyal, is a carcinogen that causes hepatic carcinomas, pulmonary metaplasia, and other neoplasms on oral administration in rodents. In 2018, the US Food and Drug Administration (FDA) banned synthetic pulegone as a food additive. Studies by the Centers for Disease Control and Prevention (CDC) detected substantial amounts of pulegone in mint- and menthol-flavored e-cigarette liquids and [...]

Menée aux Etats-Unis auprès de 101 721 participants de l'essai "Prostate, Lung Colorectal and Ovarian Cancer Screening Trial" (durée médiane de suivi : 12,5 ans), cette étude analyse l'association entre une consommation de viande transformée et le risque de cancer de la vessie (776 cas)

Processed meat intake and bladder cancer risk in the prostate, lung, colorectal and ovarian (PLCO) cohort

Xu, Xin

Background : The association between processed meat intake and bladder cancer risk has been evaluated by several observational studies with inconsistent results. Methods : In a cohort of 101,721 subjects in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we analyzed the association of processed meat intake with bladder cancer risk. Results : After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Intake of processed red meat was [...]

Menée en France à partir des données 2005-2013 des registres des cancers portant sur 155 192 agriculteurs, cette étude analyse l'association entre une exposition professionnelle aux pesticides et aux désinfectants (cultures, animaux) et le risque de myélome multiple (269 cas)

Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort

Tual, Séverine ; Busson, Amandine ; Boulanger, Mathilde ; Renier, Marine ; Piel, Clément ; Pouchieu, Camille ; Pons, Romain ; Perrier, Stéphanie ; Levêque-Morlais, Noémie ; Karuranga, Patrick ; Lemarchand, Clémentine ; Arveux, P. ; Bara, S. ; Bouvier, A. M. ; Busquet, T. ; Colonna, M. ; Coureau, G. ; Delanoé, M. ; Grosclaude, P. ; Guizard, A. V. ; Herbrecht, P. ; Laplante, J. J. ; Lapôtre-Ledoux, B. ; Launoy, G. ; Lenoir, D. ; Marrer, E. ; Marcotullio, E. ; Maynadié, M. ; Molinié, F. ; Monnereau, A. ; Paumier, A. ; Jarriges, J. ; Thibaudier, J. M. ; Troussard, X. ; Velten, M. ; Wavelet, E. ; Woronoff, A. S. ; Marcotullio, Elisabeth ; Guizard, Anne-Valérie ; Monnereau, Alain ; Baldi, Isabelle ; Lebailly, Pierre ; AGRICAN-Group

Purpose : Epidemiological studies have found an increased risk of multiple myeloma (MM) in farmers. Few studies have investigated the detailed circumstances of occupational pesticide exposure which could explain these increased risks (pesticide use on crops, seeds or on animals, contact with treated crops) and the role of other exposures. In the Agriculture and Cancer cohort (AGRICAN), we assessed the associations between MM and crop- or animal-related activities, with specific attention to [...]

Menée au Canada par questionnaire auprès de 26 607 participants (âge : 35 à 69 ans), cette étude analyse, en fonction du sexe, l'association entre une consommation d'alcool et/ou de cigarettes et le risque de cancer par localisation (2 370 cas)

The individual and combined effects of alcohol consumption and cigarette smoking on site-specific cancer risk in a prospective cohort of 26,607 adults: results from Alberta’s Tomorrow Project

Viner, Benjamin ; Barberio, Amanda M. ; Haig, Tiffany R. ; Friedenreich, Christine M. ; Brenner, Darren R.

Purpose : Alcohol consumption and cigarette smoking increase the risk of developing several cancers. We examined the individual and synergistic effects of these modifiable lifestyle factors on overall and site-specific cancer risk. Methods : Baseline participant data were acquired from Alberta’s Tomorrow Project (ATP). Adults 35–69 years old who consented to data linkage and completed relevant questionnaires were included (n = 26,607). Incident cases of cancer up to December 2017 were [...]

Menée au Danemark sur la période 1995-2011 auprès de 1 330 852 femmes âgées de 20 à 44 ans (durée médiane de suivi : 20,9 ans), cette étude analyse l'association entre un traitement pour la fertilité et le risque de cancer du sein (20 567 cas)

A cohort study of breast cancer risk after 20 years of follow-up of women treated with fertility drugs

Guleria, Sonia ; Kjaer, Susanne K. ; Albieri, Vanna ; Frederiksen, Kirsten ; Jensen, Allan

Background : Using a nationwide cohort of Danish women, we investigated the association between use of fertility drugs and risk of breast cancer. Methods : The study cohort included women aged 20-44 years and living in Denmark between 1 January 1995 and 31 December 2011. Information on fertility status, use of fertility drugs, breast cancer, covariates and vital status was obtained from the Danish Infertility Cohort and various Danish national registers. Cox proportional hazard regression [...]

Menée auprès de 64 personnes ayant participé aux efforts de sauvetage après l'attaque du World Trade Center et atteintes d'un cancer de la tête et du cou diagnostiqué entre 2002 et 2016, cette étude cas-témoins identifie les facteurs de risque de la maladie

Risk factors for head and neck cancer in the World Trade Center Health Program General Responder Cohort: results from a nested case–control study

Bover Manderski, Michelle T ; Black, Kathleen ; Udasin, Iris G ; Giuliano, Anna R ; Steinberg, Michael B ; Ohman Strickland, Pamela ; Black, Taylor M ; Dasaro, Christopher R ; Crane, Michael ; Harrison, Denise ; Moline, Jacqueline ; Luft, Benjamin J ; Passannante, Marian R ; Lucchini, Roberto G ; Todd, Andrew C ; Graber, Judith M

Objectives : Head and neck cancers (HNCs) may be among the health consequences of involvement in the World Trade Center (WTC) response on and after 11 September 2001. We conducted a nested case–control study of WTC Health Program (WTCHP) general responders to examine the effects of WTC exposures and behavioural risk factors on HNC. Methods : We enrolled 64 cases and 136 controls, matched on age, sex and race/ethnicity within risk sets. We assessed tobacco and alcohol use, sexual activity, and [...]

Menée en Bosnie auprès de 116 patients atteints d'un cancer gastrique et de 203 témoins (âge : 33-90 ans ; 69% d'hommes), cette étude identifie 5 polymorphismes de gènes codant pour les kinases mitotiques Aurora associés au risque de développer la maladie

Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Mesic, Aner ; Rogar, Marija ; Hudler, Petra ; Bilalovic, Nurija ; Eminovic, Izet ; Komel, Radovan

Background : Single nucleotide polymorphisms (SNPs) in genes encoding mitotic kinases could influence development and progression of gastric cancer (GC). Methods : Case-control study of nine SNPs in mitotic genes was conducted using qPCR. The study included 116 GC patients and 203 controls. In silico analysis was performed to evaluate the effects of polymorphisms on transcription factors binding sites. Results : The AURKA rs1047972 genotypes (CT vs. CC: OR, 1.96; 95% CI, 1.05–3.65; p = 0.033; [...]

Menée en Chine auprès de 6 564 personnes (67,9 % d'hommes ; durée de suivi : 45 668 personnes-années), cette étude analyse l'association entre la présence d'un syndrome métabolique et le risque de carcinome hépatocellulaire (89 cas) chez des patients atteints d'une hépatite B

The influence of metabolic syndrome on the risk of hepatocellular carcinoma in patients with chronic hepatitis B infection in mainland China

Tan, Yifei ; Zhang, Xiaoyun ; Zhang, Wei ; Tang, Li ; Yang, Hanwei ; Yan, Ke ; Jiang, Li ; Yang, Jian ; Li, Chuan ; Yang, Jiayin ; Wen, Tianfu ; tang, huairong ; Yan, Lunan

Background : The association between metabolic syndrome (MS), both in terms of its components and as a whole, and the risk of hepatocellular carcinoma (HCC) in subjects with hepatitis B virus (HBV) infection remains unclear, especially in mainland China. Methods : We prospectively included 6,564 individuals with HBV infection from an initial cohort of 105,397 civil servants. The multivariate-adjusted hazard ratio (HR) and 95% confidence interval (95%CI) were evaluated using Cox proportional [...]

Menée aux Etats-Unis auprès de 1 508 femmes atteintes d'un cancer du sein diagnostiqué en 1996-1997 (âge au diagnostic : 20 à 98 ans), cette étude analyse l'association entre des sites de méthylation de l'ADN tumoral, des facteurs reproductifs et le risque de développer la maladie

Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer

McCullough, Lauren E. ; Collin, Lindsay J. ; Conway, Kathleen ; White, Alexandra J. ; Cho, Yoon Hee ; Shantakumar, Sumitra ; Terry, Mary Beth ; Teitelbaum, Susan L. ; Neugut, Alfred I. ; Santella, Regina M. ; Chen, Jia ; Gammon, Marilie D.

Background : Reproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We hypothesized that altered DNA methylation, measured in tumor tissue, could act in concert with reproductive factors to impact breast carcinogenesis. Methods : Among a population-based sample of women newly diagnosed with first primary breast cancer, reproductive history was assessed using a life-course calendar approach in an [...]