Menée aux Etats-Unis par enquête, cette étude analyse la prévalence d'une douleur chronique chez les patients ayant survécu à un cancer et analyse l'impact de cette douleur sur leur qualité de vie

Prevalence of Chronic Pain and High-Impact Chronic Pain in Cancer Survivors in the United States

Jiang, Changchuan ; Wang, Haowei ; Wang, Qian ; Luo, Yiming ; Sidlow, Robert ; Han, Xuesong

The population of cancer survivors in the United States is growing rapidly. In 2016, the number of survivors was 15.5 million; with the aging of the population and advances in early detection and treatment methods, this number is expected to reach 26.1 million by 2040. Chronic pain is one of the most common long-term effects of cancer treatment and has been linked with an impaired quality of life, lower adherence to treatment, and higher health care costs. Nevertheless, there is a paucity of [...]

Mené sur 50 patients atteints d'un cancer, cet essai de phase II évalue l'intérêt, du point de vue des symptômes déclarés par les patients, d'une thérapie "Scrambler" à base de neurostimulation électrique transcutanée pour traiter et diminuer la sévérité d'une neuropathie périphérique induite par la chimiothérapie

Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial

Loprinzi, Charles ; Le-Rademacher, Jennifer G. ; Majithia, Neil ; McMurray, Ryan P. ; O’Neill, Carrie R. ; Bendel, Markus A. ; Beutler, Andreas ; Lachance, Daniel H. ; Cheville, Andrea ; Strick, David M. ; Black, David F. ; Tilburt, Jon C. ; Smith, Thomas J.

Introduction : Chemotherapy-induced peripheral neuropathy (CIPN) is a prominent clinical problem, with limited effective therapies. Preliminary non-randomized clinical trial data support that Scrambler Therapy is helpful in this situation. Methods : Patients were eligible if they had CIPN symptoms for at least 3 months and CIPN-related tingling or pain at least 4/10 in severity during the week prior to registration. They were randomized to receive Scrambler Therapy versus transcutaneous [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2018 (22 essais randomisés), cette méta-analyse évalue l'efficacité de la pratique du Tai Chi pour améliorer la qualité de vie physique et psychique de patients ayant survécu à un cancer

The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis

Ni, Xiaosha ; Chan, Raymond Javan ; Yates, Patsy ; Hu, Wenyi ; Huang, Xianhong ; Lou, Yan

Purposes : To assess the effects of Tai Chi on quality of life (QOL) of cancer survivors. Methods : The following databases were searched: PubMed, Cochrane CENTRAL, EBSCO (including MEDLINE, CINAHL, and other databases), ScienceDirect, CNKI, Wangfang Data, and CQVIP until April 25, 2018. Randomized controlled trials (RCTs) published in English or Chinese examining the effects of Tai Chi intervention for cancer survivors were included. The primary outcome was QOL; the secondary outcomes were [...]

Menée aux Etats-Unis à partir de données portant sur 1 604 patients atteints d'un cancer de la prostate, cette étude de cohorte analyse l'efficacité d'un outil permettant de mesurer la qualité de leur vie sexuelle après une prostatectomie radicale

Validity of the Patient-Reported Outcome Measurement Information System (PROMIS) Sexual Interest and Satisfaction Measures in Men Following Radical Prostatectomy

Nnenaya Q. Agochukwu ; Daniela Wittmann ; Nicholas R. Boileau ; Rodney L. Dunn ; James E. Montie ; Tae Kim ; David C. Miller ; James Peabody ; Noelle E. Carlozzi ; for the Michigan Urological Surgery Improvement Collaborative

PURPOSE : Patient-reported outcomes after radical prostatectomy have focused on erectile function. To date, no studies have validated the Patient-Reported Outcome Measurement Information System (PROMIS) Sexual Interest and Satisfaction single item measures in patients with prostate cancer, nor have studies examined how these measures relate to erectile function. In addition, data are lacking with regard to the clinical responsiveness of these measures to treatment. We sought to validate and [...]

Menée en France à partir des données portant sur 459 patientes atteintes d'un cancer du sein, cette étude de cohorte identifie les facteurs associés à l'évolution de leur fatigue pendant les 2 années suivant un traitement chirurgical

Factors of the evolution of fatigue dimensions in patients with breast cancer during the 2 years after surgery

Person, Hélène ; Guillemin, Francis ; Conroy, Thierry ; Velten, Michel ; Rotonda, Christine

Women with breast cancer are increasingly being cured of the disease but fatigue remains the most frequently reported symptom. The aims of this study were to identify distinct trajectories in 4 fatigue dimensions during 2 years after breast cancer surgery and to explore the demographic, clinical and personality characteristics associated with these profiles. We included women from the prospective longitudinal multicenter FATSEIN cohort in France. They completed the Multidimensional Fatigue [...]

Menée à partir des données des registres américains des cancers portant sur 242 940 femmes et 158 347 hommes ayant survécu à un cancer diagnostiqué entre l'âge de 15 ans et de 39 ans sur la période 1985-2015, cette étude analyse les disparités dans le risque de décès lié à une autre cause que le cancer

Disparities in mortality from noncancer causes among adolescents and young adults with cancer

Anderson, Chelsea ; Lund, Jennifer L. ; Weaver, Mark A. ; Wood, William A ; Olshan, Andrew F. ; Nichols, Hazel B.

Background: Few studies have examined noncancer outcomes among patients diagnosed with cancer as adolescents and young adults (AYAs). We examined risk of mortality from noncancer causes after an AYA cancer diagnosis, and investigated disparities according to race/ethnicity and other characteristics. Methods: Patients with a first primary cancer at ages 15-39 years diagnosed during 1985-2015 were identified in the Surveillance, Epidemiology and End Results database (N=242,940 women, 158,347 [...]

Menée aux Etats-Unis à partir de données portant sur 212 patients ayant survécu à une leucémie lymphoblastique aiguë pendant l'enfance, cette étude analyse l'association entre une exposition à une anesthésie et des déficiences neurocognitives, en fonction des doses et du type d'anesthésiant reçus, ainsi que de la durée d'exposition

Association Between Anesthesia Exposure and Neurocognitive and Neuroimaging Outcomes in Long-term Survivors of Childhood Acute Lymphoblastic Leukemia

Banerjee, Pia ; Rossi, Michael G. ; Anghelescu, Doralina L. ; Liu, Wei ; Breazeale, Ashley M. ; Reddick, Wilburn E. ; Glass, John O. ; Phillips, Nicholas S. ; Jacola, Lisa M. ; Sabin, Noah D. ; Inaba, Hiroto ; Srivastava, Deokumar ; Robison, Leslie L. ; Pui, Ching-Hon ; Hudson, Melissa M. ; Krull, Kevin R.

Importance : Limited studies have reported associations between anesthesia and neurocognitive and neuroimaging outcomes, particularly in pediatric patients who undergo multiple exposures to anesthesia as part of chronic disease management. Objective : To investigate whether general anesthesia is associated with neurocognitive impairment and neuroimaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia. Design, Setting, and Participants : A cohort study of 212 [...]

Menée aux Etats-Unis à partir de données portant sur 232 patients atteints d'une tumeur des cellules germinales de stade avancé (dont 193 cas de tumeur non séminomateuse), cette étude analyse l'effet à long terme de la présence d'un tératome sur la survie et sur le risque de décès liés à la maladie (durée médiane de suivi : 17 ans)

Impact of Teratoma on the Cumulative Incidence of Disease-Related Death in Patients With Advanced Germ Cell Tumors

Samuel A. Funt ; Sujata Patil ; Darren R. Feldman ; Robert J. Motzer ; Dean F. Bajorin ; Joel Sheinfeld ; Satish K. Tickoo ; Victor E. Reuter ; George J. Bosl

PURPOSE : In men with metastatic germ cell tumors (GCTs), risk-directed treatment is determined, in part, by a distinction between seminoma and nonseminomatous GCT (NSGCT). The importance of NSGCT cell type is uncertain. We evaluated the long-term impact of teratoma on survival in patients with NSGCT. METHODS : Prechemotherapy, primary tumors from patients who received platinum-based chemotherapy were studied, and the histology was confirmed by a genitourinary pathologist. The cumulative [...]

Menée à partir de données portant sur 650 patients atteints d'un cancer du poumon non à petites cellules traité par inhibiteurs de points de contôle immunitaire, cette étude analyse l'association entre une utilisation de corticoïdes au début de l'immunothérapie et la survie, selon que les corticoïdes sont administrés pour des raisons palliatives liées au cancer ou administrés pour d'autres raisons médicales

Immune Checkpoint Inhibitor Outcomes for Patients With Non–Small-Cell Lung Cancer Receiving Baseline Corticosteroids for Palliative Versus Nonpalliative Indications

Biagio Ricciuti ; Suzanne E. Dahlberg ; Anika Adeni ; Lynette M. Sholl ; Mizuki Nishino ; Mark M. Awad

PURPOSE : Baseline use of corticosteroids is associated with poor outcomes in patients with non–small-cell lung cancer (NSCLC) treated with programmed cell death-1 axis inhibition. To approach the question of causation versus correlation for this association, we examined outcomes in patients treated with immunotherapy depending on whether corticosteroids were administered for cancer-related palliative reasons or cancer-unrelated indications. PATIENTS AND METHODS : Clinical outcomes in patients [...]

Menée en Finlande à partir de données incluant 75 336 patients atteints d'un cancer de la prostate sur la période 1995-2015, cette étude analyse l'association entre une utilisation d'anticoagulants et la mortalité par cancer (durée médiane de suivi : 172 ans ; 32 628 utilisateurs d'anticoagulants ; 27 233 décès dont 8 033 décès par cancer)

Anticoagulants and cancer mortality in the Finnish randomized study of screening for prostate cancer

Kinnunen, P. T. T. ; Murtola, T. J. ; Talala, K. ; Taari, K. ; Tammela, T. L. J. ; Auvinen, A.

Purpose : Anticoagulants may reduce mortality of cancer patients, though the evidence remains controversial. We studied the association between different anticoagulants and cancer death. Methods : All anticoagulant use during 1995–2015 was analyzed among 75,336 men in the Finnish Randomized Study of Screening for Prostate Cancer. Men with prevalent cancer were excluded. Multivariable Cox regression was performed to compare risk of death from any cancer and disease-specific death from 9 specific [...]

Menée en France à partir des données du PMSI, cette étude analyse la prévalence d'hommes hospitalisés pour un cancer du sein entre 2009 et 2013

Prevalence of patients hospitalised for male breast cancer in France using the French nationwide hospital administrative database

Cottenet, Jonathan ; Dabakuyo-Yonli, Tienhan Sandrine ; Mariet, Anne-Sophie ; Roussot, Adrien ; Arveux, Patrick ; Quantin, Catherine

Background : Breast cancer (BC) in men is a rare and neglected disease representing <1% of all cancers in men and only 1% of all incident BC in western countries. Objective : This study aimed to describe trends in the prevalence of patients hospitalised for male BC in France from 2009 to 2013, using the national administrative database (PMSI). Methods : We included all men aged ≥18 admitted to hospital for BC during this period and estimated the prevalence of male breast cancer hospitalised in [...]

Menée aux Etats-Unis, cette étude analyse les disparités dans l'incidence du gliome et dans la survie associée, en fonction du niveau socioéconomique du comté, du lieu d'habitation (zone rurale ou urbaine) et de l'appartenance ethnique du patient

Glioma incidence and survival variations by county-level socioeconomic measures

Cote, David J. ; Ostrom, Quinn T. ; Gittleman, Haley ; Duncan, Kelsey R. ; CreveCoeur, Travis S. ; Kruchko, Carol ; Smith, Timothy R. ; Stampfer, Meir J. ; Barnholtz-Sloan, Jill S.

Background : Multiple studies have reported higher rates of glioma in areas with higher socioeconomic status (SES) but to the authors' knowledge have not stratified by other factors, including race/ethnicity or urban versus rural location. Methods : The authors identified the average annual age-adjusted incidence rates and calculated hazard ratios for death for gliomas of various subtypes, stratified by a county-level index for SES, race/ethnicity, US region, and rural versus urban status. [...]

A partir d'une revue systématique de la littérature (79 essais randomisés, 8 678 participants), cette méta-analyse évalue l'efficacité d'interventions psychologiques destinées à développer, chez des patients atteints d'un cancer, la confiance en leurs capacités pour améliorer leurs comportements de santé

Interventions to Enhance Self-Efficacy in Cancer Patients: A Meta-Analysis of Randomized Controlled Trials

Merluzzi, T.V. ; Pustejovsky, J.E. ; Philip, E.J. ; Sohl, S.J. ; Berendsen, M. ; Salsman, J.M.

Objective : Self‐efficacy expectations are associated with improvements in problematic outcomes widely considered clinically significant (i.e., emotional distress, fatigue, pain), related to positive health behaviors, and, as a type of personal agency, inherently valuable. Self‐efficacy expectancies, estimates of confidence to execute behaviors, are important in that changes in self‐efficacy expectations are positively related to future behaviors that promote health and well‐being. The current [...]

Menée aux Etats-Unis à partir de données portant sur 3 579 patients atteints d'un cancer de la prostate de stade précoce (stade I à II) traité par prostatectomie radicale entre 1994 et 2004, cette étude de cohorte rétrospective analyse l'association entre le statut marital au moment du traitement chirurgical et la mortalité spécifique

The association of marital status and mortality among men with early-stage prostate cancer treated with radical prostatectomy: insight into post-prostatectomy survival strategies

Khan, Saira ; Nepple, Kenneth G. ; Kibel, Adam S. ; Sandhu, Gurdarshan ; Kallogjeri, Dorina ; Strope, Seth ; Grubb, Robert ; Wolin, Kathleen Y. ; Sutcliffe, Siobhan

Purpose : The purpose of this study was to determine the association of marital status, a marker of social support, with all-cause and prostate cancer-specific mortality in a cohort of men with early-stage prostate cancer treated with radical prostatectomy. Methods : We conducted a retrospective cohort study of 3,579 men treated for localized (stage 1–2) prostate cancer with radical prostatectomy at a single institution between 1994 and 2004. Marital status (not married vs. married) and marital [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2018 (10 articles), cette étude analyse les caractéristiques d'interventions d'e-santé destinées à réduire et à prendre en charge les symptômes d'anxiété et de dépression et à améliorer la qualité de vie chez des patients atteints d'un cancer de la prostate

Systematic Review of Technology-Based Interventions to Improve Anxiety, Depression, and Health Related Quality of Life Among Patients with Prostate Cancer

Qan'ir, Yousef ; Song, Lixin

Objectives : This review aimed to systematically evaluate the characteristics of Technology‐Based Interventions (TBIs) and their effectiveness on anxiety, depression, and HRQoL among patients with prostate cancer. Methods : We identified eligible research reports published in English language between January 1, 2000 and September 15, 2018 from CINAHL, EMBASE, “Library & Information Science Abstracts,” “Library, Information Science & Technology Abstracts,” “Library & Information Science Source,” [...]

Menée au Portugal à partir de données portant sur 94 patientes atteintes d'un cancer du sein, cette étude identifie les facteurs associés à une anxiété avant le début de la radiothérapie

First day of radiotherapy for women with breast cancer: predictors of anxiety

Grilo, Ana M. ; Gomes, Ana I. ; Monsanto, Fátima ; Albino, Daniel ; Augusto, Cláudio ; Pragana, Catarina

Purpose : Radiotherapy treatment may generate anxiety, especially on the first day of treatment. This study aimed to identify potential predictors of radiotherapy-related anxiety in women with breast cancer before treatment initiation, in terms of treatment concerns and trait anxiety. Methods : This transversal study included 94 patients from one Radiation Oncology Department, who had been diagnosed with primary breast cancer and who had been prescribed external radiotherapy for the first time. [...]

Menée aux Etats-Unis auprès de 782 participantes, cette étude identifie les facteurs associés à une utilisation optimale des médias sociaux pour promouvoir la prévention du cancer du col de l'utérus

Facts or stories? How to use social media for cervical cancer prevention: A multi-method study of the effects of sender type and content type on increased message sharing

Zhang, Jingwen ; Le, Gem ; Larochelle, David ; Pasick, Rena ; Sawaya, George F. ; Sarkar, Urmimala ; Centola, Damon

Social media has become a valuable tool for disseminating cancer prevention information. However, the design of messages for achieving wide dissemination remains poorly understood. We conducted a multi-method study to identify the effects of sender type (individuals or organizations) and content type (personal experiences or factual information) on promoting the spread of cervical cancer prevention messages over social media. First, we used observational Twitter data to examine correlations [...]

Menée en Australie par enquête auprès de 103 patients atteints d'un cancer (96 répondants), cette étude prospective analyse leurs connaissances et leurs perceptions vis-à-vis des soins palliatifs

Cancer patients’ perceptions of palliative care

Chosich, Benjamin ; Burgess, Marjorie ; Earnest, Arul ; Franco, Michael ; Runacres, Fiona ; William, Leeroy ; Poon, Peter ; Yoong, Jaclyn

Purpose : Despite clear benefits of early integration of palliative care (PC) and oncology, concerns remain about negative perceptions of PC. Our aim was to explore current knowledge and perceptions of PC in cancer patients. Methods : We conducted a prospective, cross-sectional survey. A 16-item questionnaire was distributed to all cancer patients (N = 103) upon admission to the oncology ward of an Australian tertiary academic hospital. Chi-squared test was used to examine for significant [...]