A partir d'une revue de la littérature, cette étude présente des préconisations pour une bonne utilisation des opioïdes dans la prise en charge de la douleur chez les patients atteints d'un cancer

Opioids in cancer-related pain: current situation and outlook

George, Brigitte ; Minello, Christian ; Allano, Gilles ; Maindet, Caroline ; Burnod, Alexis ; Lemaire, Antoine

Purpose : Despite progress in treatments, cancer pain remains underestimated, poorly assessed and under-treated. Prescribing strong opioids, because of their specificities, requires precision in management considering their pharmacology but also a clear understanding of recommendations. Some clinicians highlight the risk of addiction, excessive sedation and respiratory depression and their need for information. Our objective in this review is to suggest some clinical guidance for the [...]

A partir d'une revue de la littérature, cette étude analyse les recommandations pour la prise en charge de la santé osseuse chez des patients ayant survécu à un cancer pédiatrique

Bone health in childhood cancer: review of the literature and recommendations for the management of bone health in childhood cancer survivors

Marcucci, G ; On behalf of the International Osteoporosis Foundation Cancer ; Bone working group ; Beltrami, G ; Tamburini, A ; Body, J J ; Confavreux, C B ; Hadji, P ; Holzer, G ; Kendler, D ; Napoli, N ; Pierroz, D D ; Rizzoli, R ; Brandi, M L

In the past decades, new cancer treatment approaches for children and adolescents have led to a decrease in recurrence rates and an increase in long-term survival.Recent studies have focused on the evaluation of the late effects on bone of pediatric cancer-related treatments, such as chemotherapy, radiation and surgery. Treatment of childhood cancer can impair the attainment of peak bone mass, predisposing to premature onset of low bone mineral density, or causing other bone side effects, such [...]

Mené sur 249 patients atteints d'un cancer traité par chimiothérapie adjuvante ou palliative, cet essai randomisé évalue l'efficacité d'un outil pédagogique permettant de prendre en charge leurs symptômes

Development and evaluation of the Cancer Symptom Management System: Symptom Management Improves your LifE (SMILE)—a randomized controlled trial

Rha, Sun Young ; Nam, Jung Mo ; Lee, Jiyeon

Purpose : To develop a Cancer Symptom Management System: Symptom Management Improves your LifE (SMILE) and evaluate the effect and feasibility of the system in cancer symptom management. Methods : The Cancer Symptom Management System: SMILE was developed, and a nonblinded, randomized controlled trial was conducted. Cancer patients starting adjuvant or palliative chemotherapy (CTx) were enrolled and randomized to control (symptom monitoring), experimental 1 (Exp 1; symptom monitoring + report), [...]

Menée aux Etats-Unis par enquête auprès de patients atteints d'un cancer du côlon ou du sein (2 487 répondants), cette étude analyse la présence de symptomes de fatigue, de détresse psychologique et de douleur, puis évalue leurs perceptions des soins reçus

Perceptions of Patients With Breast and Colon Cancer of the Management of Cancer-Related Pain, Fatigue, and Emotional Distress in Community Oncology

Tenbroeck G. Smith ; Alyssa N. Troeschel ; Kathleen M. Castro ; Neeraj K. Arora ; Kevin Stein ; Joseph Lipscomb ; Otis W. Brawley ; Ryan M. McCabe ; Steven B. Clauser ; Elizabeth Ward

PURPOSE : Pain, fatigue, and distress are common among patients with cancer but are often underassessed and undertreated. We examine the prevalence of pain, fatigue, and emotional distress among patients with cancer, as well as patient perceptions of the symptom care they received. PATIENTS AND METHODS : Seventeen Commission on Cancer–accredited cancer centers across the United States sampled patients with local/regional breast (82%) or colon (18%) cancer. We received 2,487 completed surveys [...]

Menée aux Etats-Unis à partir de données portant sur 184 patientes atteintes d'un cancer du sein de stade précoce, cette étude analyse les facteurs associés au risque de neuropathie périphérique induite par la chimiothérapie, et compare la sévérité des symptômes déclarés par les patientes et par le médecin

Patient-reported and clinician-reported chemotherapy-induced peripheral neuropathy in patients with early breast cancer: Current clinical practice

Nyrop, Kirsten A. ; Deal, Allison M. ; Reeder-Hayes, Kathryn E. ; Shachar, Shlomit S. ; Reeve, Bryce B. ; Basch, Ethan ; Choi, Seul Ki ; Lee, Jordan T. ; Wood, William A. ; Anders, Carey K. ; Carey, Lisa A. ; Dees, Elizabeth C. ; Jolly, Trevor A. ; Kimmick, Gretchen G. ; Karuturi, Meghan S. ; Reinbolt, Raquel E. ; Speca, JoEllen C. ; Muss, Hyman B.

Background : In the current study, the authors investigated the incidence of moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) for chemotherapy regimens commonly used in current clinical practice for the treatment of patients with early breast cancer. Patient-reported and clinician-assessed CIPN severity scores were compared, and risk factors for CIPN severity were identified. Methods : Patients completed a Patient-Reported Symptom Monitoring form and oncologists completed a [...]

Menée en Chine à partir de données portant sur 263 patients atteints d'un carcinome hépatocellulaire binodulaire et ayant subi une résection hépatique entre 2003 et 2015, cette étude de cohorte rétrospective identifie les facteurs associés à l'évolution de la survie globale et de la survie sans récidive

Long-Term Survival Outcomes After Liver Resection for Binodular Hepatocellular Carcinoma: A Multicenter Cohort Study

Wang, Ming‐Da ; Li, Chao ; Li, Jun ; Zhang, Wan‐Guang ; Jiang, Wei‐Qin ; Yu, Jiong‐Jie ; Xing, Hao ; Wu, Han ; Han, Jun ; Li, Zhen‐Li ; Xu, Xin‐Fei ; Chen, Ting‐Hao ; Zhou, Ya‐Hao ; Gu, Wei‐Min ; Wang, Hong ; Zeng, Yong‐Yi ; Zhang, Yao‐Ming ; Pawlik, Timothy M. ; Lau, Wan Yee ; Wu, Meng‐Chao ; Yang, Jia‐Mei ; Shen, Feng ; Yang, Tian

The long‐term prognosis after liver resection for multinodular (≥3 nodules) hepatocellular carcinoma (HCC) is generally considered to be unfavorable. However, the role of liver resection for binodular HCC is less investigated.From a multicenter database, consecutive patients who underwent curative‐intent liver resection for binodular HCC and without macrovascular invasion between 2003 and 2015 were retrospectively reviewed. Patients’ clinical variables as well as perioperative and long‐term [...]

Menée à partir de données portant sur 695 patients atteints d'un cancer (âge moyen : 66 ans), cette étude prospective internationale analyse les diverses stratégies thérapeutiques d'une embolie pulmonaire détectée de façon accidentelle et évalue son impact à long terme sur la santé des patients (risque de récidive de la maladie thromboembolique veineuse, saignement important, mortalité toutes causes confondues au cours des 12 mois suivant l'embolie)

Treatment and Long-Term Clinical Outcomes of Incidental Pulmonary Embolism in Patients With Cancer: An International Prospective Cohort Study

Noémie Kraaijpoel ; Suzanne M. Bleker ; Guy Meyer ; Isabelle Mahé ; Andrés Muñoz ; Laurent Bertoletti ; Annemarieke Bartels-Rutten ; Jan Beyer-Westendorf ; Ettore Porreca ; Carine Boulon ; Nick van Es ; Diana I. Iosub ; Francis Couturaud ; Mercedes Biosca ; Teresa Lerede ; Philippe Lacroix ; Anthony Maraveyas ; Anita Aggarwal ; Philippe Girard ; Harry R. Büller ; Marcello Di Nisio ; on behalf of the UPE investigators

PURPOSE : Pulmonary embolism is incidentally diagnosed in up to 5% of patients with cancer on routine imaging scans. The clinical relevance and optimal therapy for incidental pulmonary embolism, particularly distal clots, is unclear. The aim of the current study was to assess current treatment strategies and the long-term clinical outcomes of incidentally detected pulmonary embolism in patients with cancer. PATIENTS AND METHODS : We conducted an international, prospective, observational cohort [...]

Menée en Italie par entretiens auprès de 266 patients ayant survécu à un cancer de stade I à III diagnostiqué en 2012 (âge : 20-59 ans), cette étude identifie les facteurs associés au processus de retour au travail

Factors influencing return to work of cancer survivors: a population-based study in Italy

Paltrinieri, Sara ; Vicentini, Massimo ; Mazzini, Elisa ; Ricchi, Elena ; Fugazzaro, Stefania ; Mancuso, Pamela ; Giorgi Rossi, Paolo ; Costi, Stefania

Purpose : Little is known about return to work (RTW) of cancer survivors (CSs) in Central and Southern Europe. This study investigates the RTW rate of Italian CSs, describes their sick leave (SL) pattern, and explores factors affecting their RTW process. Methods : A population-based cross-sectional survey involving CSs registered at the Cancer Registry of Reggio Emilia Province (Italy) was launched in July 2016. Eligibility was restricted to individuals with first diagnosis of cancer in 2012 [...]

Menée à partir des données du registre national américain des cancers portant sur 515 patients atteints d'un carcinome épidermoïde du pancréas, cette étude analyse les traitements reçus en fonction du stade de la maladie puis identifie les facteurs pronostiques associés à la survie globale

Survival and prognostic factors in patients with pancreatic squamous cell carcinoma

Tella, Sri Harsha ; Kommalapati, Anuhya ; Yadav, Siddhartha ; Bergquist, John R. ; Truty, Mark J. ; Durgin, Lori ; Ma, Wen Wee ; Cleary, Sean P. ; McWilliams, Robert R. ; Mahipal, Amit

Objectives : Squamous cell carcinoma (SCC) of pancreas is rare entity with poorly defined prognostic factors and therapeutic outcomes. We sought to determine the overall survival (OS) and prognostic factors of patients with pancreatic SCC using National Cancer Database (NCDB) (2004–15). Methods : Kaplan-Meier method and log-rank test were used to perform OS analysis. Propensity-matched analysis was used to compare the OS of pancreatic SCC and adenocarcinoma. Results : Of the 515 cases included [...]

Cette étude analyse, au niveau mondial sur la période 1988-2007, l'évolution de l'incidence du cancer colorectal chez les personnes âgées de moins de 50 ans

Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases

Lui, Rashid N ; Tsoi, Kelvin KF ; Ho, Jason MW ; Lo, CM ; Chan, Felix CH ; KYAW, Moe Htet ; Sung, Joseph JY

Background: Colorectal cancer (CRC) incidence among young adults in the United States (US) is on the rise, but whether this phenomenon is present in other parts of the world is not well documented. This study aims to explore the temporal change of incidence rates for CRC in various countries across the globe. Methods: We extracted CRC incidence and population data from 1988-2007 based on data from the International Agency for Research on Cancer and compared incidence between age groups. Twelve [...]

A partir des données des registres américains des cancers portant sur 163 892 patientes atteintes d'un carcinome canalaire in situ diagnostiqué entre 1990 et 2015, cette étude analyse les disparités ethniques dans le risque de développer un cancer invasif du sein en fonction du statut des récepteurs hormonaux (ER et PR) et selon les résultats d'un test analysant l'expression intratumorale de 21 gènes (durée médiane de suivi : 90 mois ; 8 333 cas de cancer invasif du sein)

Race and risk of subsequent aggressive breast cancer following ductal carcinoma in situ

Liu, Ying ; West, Robert ; Weber, Jason D. ; Colditz, Graham A.

Background : General populations of black women have a higher risk of developing breast cancer negative for both estrogen receptor (ER) and progesterone receptor (PR) in comparison with white counterparts. Racial differences remain unknown in the risk of developing aggressive invasive breast cancer (IBC) that is characterized by negativity for both ER and PR (ER–PR–) or higher 21-gene recurrence scores after ductal carcinoma in situ (DCIS). Methods : This study identified 163,892 women (10.5% [...]

Menée aux Etats-Unis à partir de données sur la période 2000-2015, cette étude analyse l'évolution de la prévalence d'hystérectomies et l'évolution de l'incidence du cancer de l'endomètre corrigée en fonction de ces hystérectomies, selon l'origine ethnique, géographique et selon le sous-type histologique et le stade de la maladie, puis estime la survie relative à 5 ans selon ces mêmes critères

Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers

Megan A. Clarke ; Susan S. Devesa ; Summer V. Harvey ; Nicolas Wentzensen

PURPOSE : Uterine corpus cancer incidence rates have been projected to increase, a prediction often attributed to the obesity epidemic. However, correct estimation of these rates requires accounting for hysterectomy prevalence, which varies by race, ethnicity, and region. Here, we evaluated recent trends in hysterectomy-corrected rates by race and ethnicity and histologic subtype and estimated differences in relative survival by race and ethnicity, subtype, and stage. METHODS : We estimated [...]

Menée à partir des données des registres américains des cancers, cette étude analyse, sur la période 1997-2009, les facteurs associés à l'évolution des traitements chez des patients atteints d'un cancer de la tête et du cou

Treatment trends in head and neck cancer: Surveillance, Epidemiology, and End Results (SEER) Patterns of Care analysis

Schlichting, Jennifer A. ; Pagedar, Nitin A. ; Chioreso, Catherine ; Lynch, Charles F. ; Charlton, Mary E.

Purpose : Recent advances in head and neck cancer (HNC) treatment, such as increased use of organ-preserving advanced radiation treatments, the approval of cetuximab for HNC treatment, and the increase in human papillomavirus (HPV)-related HNC, have changed clinical approaches to HNC management. We sought to identify treatment trends in a population-based cohort of HNC patients. Methods : The Surveillance, Epidemiology, and End Results Patterns of Care program collected additional treatment and [...]

A partir d'une revue de la littérature (7 méta-analyses), cette étude évalue l'intérêt des tests neuropsychologiques utilisés pour analyser les déficiences cognitives chez des patients atteints d'un cancer

Understanding the Profile of Cancer-Related Cognitive Impairments: A Critique of the Meta-Analyses

Horowitz, Todd S ; Trevino, Melissa ; Gooch, Ingrid M ; Duffy, Korrina A

A large body of evidence indicates that cancer survivors who have undergone chemotherapy have cognitive impairments. Substantial disagreement exists regarding which cognitive domains are impaired in this population. We suggest that is in part due to inconsistency in how neuropsychological tests are assigned to cognitive domains. The purpose of this paper is to critically analyze the meta-analytic literature on cancer-related cognitive impairments (CRCI) in order to quantify this inconsistency. [...]

Menée aux Etats-Unis par enquête auprès de patients ayant survécu à un cancer (1 656 répondants), cette étude analyse leurs difficultés sociales et économiques en lien avec la maladie

The social and economic toll of cancer survivorship: a complex web of financial sacrifice

Banegas, Matthew P. ; Schneider, Jennifer L. ; Firemark, Alison J. ; Dickerson, John F. ; Kent, Erin E. ; de Moor, Janet S. ; Virgo, Katherine S. ; Guy, Gery P. ; Ekwueme, Donatus U. ; Zheng, Zhiyuan ; Varga, Alexandra M. ; Waiwaiole, Lisa A. ; Nutt, Stephanie M. ; Narayan, Aditi ; Yabroff, K. Robin

Purpose : To assess the financial outcomes and associated social and economic effects on cancer survivors and their families. Methods : We assessed the responses of 1656 cancer survivors to a survey with both closed- and open-ended questions about cancer-related financial sacrifices they and their family experienced and evaluated differences in financial sacrifice by reported levels of cancer-related debt. Results : The most commonly reported financial sacrifices included cutbacks on household [...]

A partir d'une revue systématique de la littérature (14 études qualitatives), cette étude analyse, chez des patients adolescents et jeunes adultes atteints d'un cancer et chez leur famille, leurs capacités à comprendre l'information en santé, puis analyse le processus de prise de décision thérapeutique partagée par le médecin, le patient et sa famille

Clinician-patient-family decision-making and health literacy in adolescents and young adults with cancer and their families: A systematic review of qualitative studies

Gessler, Danielle ; Juraskova, Ilona ; Sansom-Daly, Ursula M. ; Shepherd, Heather L. ; Patterson, Pandora ; Muscat, Danielle Marie

Objective : Engaging in shared decision-making may be particularly difficult for adolescents and young adults with cancer (AYAs), possibly due to lower levels of health literacy. Family members of AYAs are likely to support decision-making about their healthcare by contributing to health literacy skills/practices, however the nature of this process is unclear. This systematic review synthesised qualitative studies that explored the process of decision-making and characterised how AYA healthcare [...]

A partir d'une revue de la littérature, cette étude analyse les enjeux éthiques liés à la détection de la détresse psychologique chez des patients atteints d'un cancer de la tête et du cou

Ethical considerations in screening head and neck cancer patients for psychosocial distress

Deleemans, Julie M. ; Mothersill, Kerry ; Bultz, Barry D. ; Schulte, Fiona

Rationale : Head and neck cancer (HNC) patients and survivors are a particularly vulnerable group with disproportionately high levels of psychosocial distress. Untreated psychosocial distress among HNC patients has consistently been associated with poorer health and psychosocial outcomes. Screening for distress (SFD) allows health care providers to identify and monitor patient’s distress, and when needed, to subsequently provide appropriate psychosocial supports that aim to reduce suffering and [...]

Menée aux Etats-Unis auprès de 61 médecins et 529 patients atteints d'un cancer, cette étude analyse leurs discussions concernant les médecines complémentaires et alternatives

A Multicenter Comparison of Complementary and Alternative Medicine (CAM) Discussions in Oncology Care: The Role of Time, Patient-Centeredness, and Practice Context

Tilburt, Jon ; Yost, Kathleen J. ; Lenz, Heinz‐Josef ; Zúñiga, María Luisa ; O'Byrne, Thomas ; Branda, Megan E. ; Leppin, Aaron L. ; Kimball, Brittany ; Fernandez, Cara ; Jatoi, Aminah ; Barwise, Amelia ; Kumbamu, Ashok ; Montori, Victor ; Koenig, Barbara A. ; Geller, Gail ; Larson, Susan ; Roter, Debra L.

Background : Little is known about how complementary and alternative medicine (CAM) is discussed in cancer care across varied settings in the U.S. Methods : In two practices affiliated with one academic medical center in southern California (SoCal), and one in the upper Midwest (UM), we audio‐recorded patient‐clinician interactions in medical oncology outpatient practices. We counted the frequency and duration of CAM‐related conversations. We coded recordings using the Roter Interaction [...]

Cet article présente une méthodologie pour élaborer un cadre global permettant de fournir des soins coordonnés de qualité aux patients ayant survécu à un cancer, et propose les étapes pour appliquer ce cadre

Developing a Quality of Cancer Survivorship Care Framework: Implications for Clinical Care, Research and Policy

Nekhlyudov, Larissa ; Mollica, Michelle A ; Jacobsen, Paul B ; Mayer, Deborah K ; Shulman, Lawrence N ; Geiger, Ann M

There are now close to 17 million cancer survivors in the U.S and this number is expected to continue to grow. One decade ago the Institute of Medicine report, From Cancer Patient to Cancer Survivor: Lost in Transition outlined 10 recommendations aiming to provide coordinated, comprehensive care for cancer survivors. Although there has been noteworthy progress made since the release of the report, gaps remain in research, clinical practice and policy.  Specifically, the recommendation calling [...]