Menée au Japon à partir des données de 10 études de cohorte incluant 354 154 participants, cette étude analyse l'association entre une pratique tabagique et le risque de cancer du pancréas, en fonction du sexe (durée de suivi : 4 695 593 personnes-années ; 1 779 cas)

Smoking and pancreatic cancer incidence: a pooled analysis of ten population-based cohort studies in Japan

Koyanagi, Yuriko N. ; Ito, Hidemi ; Matsuo, Keitaro ; Sugawara, Yumi ; Hidaka, Akihisa ; Sawada, Norie ; Wada, Keiko ; Nagata, Chisato ; Tamakoshi, Akiko ; Lin, Yingsong ; Takeuchi, Taro ; Kitamura, Yuri ; Utada, Mai ; Sadakane, Atsuko ; Mizoue, Tetsuya ; Naito, Mariko ; Tanaka, Keitaro ; Shimazu, Taichi ; Tsugane, Shoichiro ; Inoue, Manami

Background: Detailed prospective evaluation of cigarette smoking associated with pancreatic cancer risk in large Asian populations is limited. The aim of this study was to examine this association in a Japanese population, with a particular focus on evaluating sex differences. Methods: We performed a pooled analysis of ten population-based cohort studies. We calculated study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression, and then [...]

Menée aux Etats-Unis à partir de données portant sur 51 418 hommes et sur 93 427 femmes, cette étude de cohorte prospective analyse l'association entre une consommation de produits laitiers et le risque de carcinome hépatocellulaire (durée de suivi : 32 ans ; 164 cas)

A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women

Yang, Wanshui ; Sui, Jing ; Ma, Yanan ; Simon, Tracey G. ; Chong, Dawn ; Meyerhardt, Jeffrey A. ; Willett, Walter C. ; Giovannucci, Edward L. ; Chan, Andrew T. ; Zhang, Xuehong

Although increasing dairy product intake has been associated with risk of several cancers, epidemiological studies on hepatocellular carcinoma are sparse and have yielded inconsistent results. We prospectively assessed the associations of dairy products (total, milk, butter, cheese, and yogurt) and their major components (calcium, vitamin D, fats, and protein) with the risk of hepatocellular carcinoma development among 51,418 men and 93,427 women in the Health Professionals Follow-up Study and [...]

Menée en Chine à partir de données portant sur 500 000 participants sur la période 2004-2008, cette étude de cohorte prospective analayse l'association entre l'indice de masse corporelle et le risque de cancer (durée de suivi : 8,9 ans ; 21 474 cas)

Cancer incidence in relation to body fatness among 0.5 million men and women: findings from the China Kadoorie Biobank

Wang, Lu ; Jin, Guangfu ; Yu, Canqing ; Lv, Jun ; Guo, Yu ; Bian, Zheng ; Yang, Ling ; Chen, Yiping ; Hu, Zhibin ; Chen, Feng ; Chen, Zhengming ; Li, Liming ; Shen, Hongbing ; on behalf of the China Kadoorie Biobank Collaborative Group

High body-mass index (BMI) has been associated with an increased risk of several cancers. Evidence relating body fatness, especially based on different anthropometric measures, to risk of major cancers in China from prospective cohort studies is lacking. The prospective China Kadoorie Biobank (CKB) study recruited 0.5 million adults aged 30-79 years from 10 diverse areas across China during 2004-2008, recording 21,474 incident cancers during 8.95 years of follow-up. BMI, body fat percentage [...]

A partir des données de la cohorte européenne EPIC portant sur 476 160 participants, cette étude analyse l'association entre une consommation de noix et de graines et le risque d'adénocarcinome canalaire du pancréas (durée moyenne de suivi : 14 ans ; 1 283 cas)

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into cancer and Nutrition

Obón-Santacana, Mireia ; Luján-Barroso, Leila ; Freisling, Heinz ; Naudin, Sabine ; Boutron-Ruault, Marie-Christine ; Mancini, Francesca Romana ; Rebours, Vinciane ; Kühn, Tilman ; Katzke, Verena ; Boeing, Heiner ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Lasheras, Cristina ; Rodriguez-Barranco, Miguel ; Amiano, Pilar ; Santiuste, Carmen ; Ardanaz, Eva ; Khaw, Kay-Thee ; Wareham, Nicholas J. ; Schmidt, Julie A ; Aune, Dagfinn ; Trichopoulou, Antonia ; Thriskos, Paschalis ; Peppa, Eleni ; Masala, Giovanna ; Grioni, Sara ; Tumino, Rosario ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; Sciannameo, Veronica ; Vermeulen, Roel ; Sonestedt, Emily ; Sund, Malin ; Weiderpass, Elisabete ; Skeie, Guri ; Gonzalez, Carlos A ; Riboli, Elio ; Duell, Eric J

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95%CI) for nut intake and PDAC risk. [...]

Menée à partir de données portant sur 5 033 enfants atteints d'un lymphome et sur 4 990 témoins, cette étude britannique analyse l'association entre une exposition d'origine professionnelle du père à divers produits (céramiques, verres, fumées de métal, pesticides, solvants, etc) et le risque de développer la maladie chez l'enfant

Case–control study of paternal occupational exposures and childhood lymphoma in Great Britain, 1962–2010

Bunch, Kathryn J. ; Kendall, Gerald M. ; Stiller, Charles A. ; Vincent, Timothy J. ; Murphy, Michael F. G.

Background : This nationwide study investigates associations between paternal occupational exposure and childhood lymphoma. Methods : The UK National Registry of Childhood Tumours provided cases of childhood lymphoma born and diagnosed in Great Britain 1962–2010. Control births, unaffected by childhood cancer, were matched on sex, birth period and birth registration sub-district. Fathers’ occupations were assigned to one or more of 33 exposure groups and also coded for occupational social [...]

A partir d'une revue systématique de la littérature (30 études), cette méta-analyse évalue l'association entre une exposition professionnelle à de l'oxyde d'éthylène et le risque de cancer hématopoïétique et de cancer du sein

Ethylene oxide and risk of lympho-hematopoietic cancer and breast cancer: a systematic literature review and meta-analysis

Marsh, Gary M. ; Keeton, Kara A. ; Riordan, Alexander S. ; Best, Elizabeth A. ; Benson, Stacey M.

Purpose : To conduct a systematic literature review and meta-analysis of studies of lympho-hematopoietic cancers (LHC) and breast cancer risk among persons occupationally exposed to ethylene oxide (EO). Methods : We performed a literature search for articles available in PubMed and Web of Science databases to identify literature and subsequently systematically searched the reference lists of identified studies, published review papers and meta-analyses, as well as relevant government or [...]

A partir de données d'études récentes, cette étude analyse l'association entre des infections (bactériémie, cellulite), le microbiote intestinal et le risque de cancer colorectal

The close interrelation between colorectal cancer, infection and microbiota

Massaut, Edouard ; Hendlisz, Barbara ; Klastersky, Jean

Purpose of review : Evaluate the recent literature about the relation of clinical infection and colorectal cancer in terms of diagnosis of an occult infection and possible impact on oncological outcome and review the possible role of the gut microbiota in the role of colorectal cancer oncogenesis. Recent : findings Data published within the 2 last years have been reviewed and the conclusions, mostly supporting previously published information, have been critically discussed. Summary : Infection [...]

Menée aux Etats-Unis à partir de données portant sur 1 827 875 enfants sur la période 2003-2016, cette étude de cohorte analyse l'association entre une obésité maternelle, le poids de l'enfant à la naissance et le risque de cancer pédiatrique (2 352 cas de cancer, 747 cas de leucémie avant l'âge de 14 ans)

Maternal Obesity, Birth Size, and Risk of Childhood Cancer Development

Stacy, Shaina L ; Buchanich, Jeanine M ; Ma, Zhen-qiang ; Mair, Christina ; Robertson, Linda ; Sharma, Ravi K ; Talbott, Evelyn O ; Yuan, Jian-Min

Infants and children are particularly vulnerable to in utero and early life exposures. Thus, a mother's exposures before and during pregnancy may have important consequences for her child's health, including cancer development. We examined whether birth certificate-derived maternal anthropometric characteristics are associated with increased risk of subsequent childhood cancer development, accounting for established maternal and infant risk factors. Pennsylvania birth and cancer registry files [...]

A partir de données portant sur 2 724 982 participants (durée de suivi : 38 369 156 personnes-années), cette étude évalue l'association entre le tabagisme ou la consommation d'alcool et le risque de cancers des voies biliaires

Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies

McGee, Emma E ; Jackson, Sarah S ; Petrick, Jessica L ; Van Dyke, Alison L ; Adami, Hans-Olov ; Albanes, Demetrius ; Andreotti, Gabriella ; Beane-Freeman, Laura E ; de González, Amy Berrington ; Buring, Julie E ; Chan, Andrew T ; Chen, Yu ; Fraser, Gary E ; Freedman, Neal D ; Gao, Yu-Tang ; Gapstur, Susan M ; Gaziano, J Michael ; Giles, Graham G ; Grant, Eric J ; Grodstein, Francine ; Hartge, Patricia ; Jenab, Mazda ; Kitahara, Cari M ; Knutsen, Synnove F ; Koh, Woon-Puay ; Larsson, Susanna C ; Lee, I-Min ; Liao, Linda M ; Luo, Juhua ; Milne, Roger L ; Monroe, Kristine R ; Neuhouser, Marian L ; O’Brien, Katie M ; Peters, Ulrike ; Poynter, Jenny N ; Purdue, Mark P ; Robien, Kim ; Sandler, Dale P ; Sawada, Norie ; Schairer, Catherine ; Sesso, Howard D ; Simon, Tracey G ; Sinha, Rashmi ; Stolzenberg-Solomon, Rachael ; Tsugane, Shochiro ; Wang, Renwei ; Weiderpass, Elisabete ; Weinstein, Stephanie J ; White, Emily ; Wolk, Alicja ; Yuan, Jian-Min ; Zeleniuch-Jacquotte, Anne ; Zhang, Xuehong  ; Zhu, Bin ; McGlynn, Katherine A ; Campbell, Peter T ; Koshiol, Jill

Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear.We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random effects meta-analysis produced summary estimates. All statistical [...]

Menée aux Etats-Unis à partir de données portant sur 57 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë avec une hyperdiploïdie élevée, cette étude analyse la fréquence de mutations constitutionnelles de gènes prédisposant à la maladie (SH2B3, CREBBP, PMS2, MLL, ABL1 et MYH9GAB2) et identifie un nouveau gène de susceptiblité (GAB2)

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children

De Smith, Adam J. ; Lavoie, Geneviève ; Walsh, Kyle M. ; Aujla, Sumeet ; Evans, Erica ; Hansen, Helen M. ; Smirnov, Ivan ; Kang, Alice Y. ; Zenker, Martin ; Ceremsak, John J. ; Stieglitz, Elliot ; Muskens, Ivo S. ; Roberts, William ; McKean-Cowdin, Roberta ; Metayer, Catherine ; Roux, Philippe P. ; Wiemels, Joseph L.

High hyperdiploidy (HD) is the most common cytogenetic subtype of childhood acute lymphoblastic leukemia (ALL), and a higher incidence of HD has been reported in ALL patients with congenital cancer syndromes. We assessed the frequency of predisposing germline mutations in 57 HD-ALL patients from the California Childhood Leukemia Study (CCLS) via targeted sequencing of cancer-relevant genes. Three out of 57 patients (5.3%) harbored confirmed germline mutations that were likely causal, in NBN, [...]

Menée à partir de données portant sur 79 194 patients atteints d'un cancer de la prostate et sur 61 112 témoins de type européen, cette étude d'association sur le transcriptome entier identifie de nouveaux loci de susceptibilité à la maladie

Identification of novel susceptibility loci and genes for prostate cancer risk: A transcriptome-wide association study in over 140,000 European descendants

Wu, Lang ; Wang, Jifeng ; Cai, Qiuyin ; Cavazos, Taylor B ; Emami, Nima C ; Long, Jirong ; Shu, Xiao-Ou ; Lu, Yingchang ; Guo, Xingyi ; Bauer, Joshua A. ; Pasaniuc, Bogdan ; Penney, Kathryn L. ; Freedman, Matthew L ; Kote-Jarai, Zsofia ; Witte, John S. ; Haiman, Christopher A. ; Eeles, Rosalind A. ; Zheng, Wei

Genome-wide association studies have identified genetic variants associated with prostate cancer risk. However, these variants explain only a small fraction of the heritable component of prostate cancer risk, and the genes responsible for many of the identified associations remain unknown. To discover novel prostate cancer genetic loci and possible causal genes at previously identified risk loci, we performed a transcriptome-wide association study in 79,194 cases and 61,112 controls of European [...]

Menée à Taïwan à partir de données portant sur 139 426 participants entre 2008 et 2013, cette étude analyse l'association entre une hyperthyroïdie ou une hypothyroïdie et le risque de cancer colorectal

Association Between Thyroid Disorders and Colorectal Cancer Risk in Adult Patients in Taiwan

L’Heureux, Abby ; Wieland, Daniel R. ; Weng, Chien-Huan ; Chen, Yi-Huei ; Lin, Ching-Heng ; Lin, Tseng-Hsi ; Weng, Chien-Hsiang

Importance : Thyroid hormones have been shown to affect several important pathways in cancer development, including colorectal cancer (CRC). Clinical studies examining the association between thyroid disorders and colorectal cancer have conflicting results and have predominantly involved white populations. Objective : To determine if a diagnosis of hyperthyroidism or hypothyroidism is associated with the risk of developing colorectal cancer in an East Asian population. Design, Setting, and [...]