Menée auprès de 71 patients atteints de cancer, cette étude prospective analyse les facteurs prédictifs associés à l'efficacité de la morphine dispensée par voie orale pour traiter une dyspnée liée à la maladie

Effects of Oral Morphine on Dyspnea in Patients with Cancer: Response Rate, Predictive Factors, and Clinically Meaningful Change (CJLSG1101)

Takahashi, Kosuke ; Kondo, Masashi ; Ando, Masahiko ; Shiraki, Akira ; Nakashima, Harunori ; Wakayama, Hisashi ; Kataoka, Kensuke ; Yamamoto, Masashi ; Sugino, Yasuteru ; Nishikawa, Mitsunori ; Imaizumi, Kazuyoshi ; Kojima, Eiji ; Sumida, Atsushi ; Takeyama, Yoshihiro ; Saito, Hiroshi ; Hasegawa, Yoshinori

Although the efficacy of parenteral morphine for alleviating dyspnea has been previously demonstrated in several studies, little is known regarding the efficacy of oral morphine for dyspnea among patients with cancer, including its response rate and predictive factors of effectiveness. Therefore, the aim of this study was to clarify the effectiveness of oral morphine on dyspnea in patients with cancer and elucidate the predictive factors of its effectiveness.In this multicenter prospective [...]

Menée aux Etats-Unis à partir de données portant sur 3 051 patients atteints d'un cancer diagnostiqué entre 2013 et 2017 (âge médian : 60, 6 ans), cette étude de cohorte prospective analyse les facteurs cliniques, démographiques, ethniques associés à la présence d'une infection par le virus de l'hépatite B ou C, ou par le virus HIV au moment du diagnostic de cancer

Prevalence of hepatitis B virus, hepatitis C virus, and HIV infection among patients with newly diagnosed cancer from academic and community oncology practices

Ramsey, S. D. ; Unger, J. M. ; Baker, L. H. ; et al.,

Importance:  Universal screening of patients with newly diagnosed cancer for hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV is not routine in oncology practice, and experts disagree about whether universal screening should be performed. Objective : To estimate the prevalence of HBV, HCV, and HIV infection among persons with newly diagnosed cancer. Design, Setting, and Participants  Multicenter prospective cohort study of patients with newly diagnosed cancer (ie, identified within 120 [...]

Menée à partir de données portant sur 306 enfants atteints d'une leucémie lymphoblastique aiguë hypodiploïde, cette étude internationale rétrospective analyse, sur la période 1997-2013 (durée médiane de suivi : 6,6 ans), l'évolution des traitements et la survie associée

Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study

Ching-Hon Pui ; Paola Rebora ; Martin Schrappe ; Andishe Attarbaschi ; Andre Baruchel ; Giuseppe Basso ; Hélène Cavé ; Sarah Elitzur ; Katsuyoshi Koh ; Hsi-Che Liu ; Kajsa Paulsson ; Rob Pieters ; Lewis B. Silverman ; Jan Stary ; Ajay Vora ; Allen Yeoh ; Christine J. Harrison ; Maria Grazia Valsecchi ; on behalf of the Ponte di Legno Childhood ALL Working Group

PURPOSE : We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials. PATIENTS AND METHODS : This retrospective study collected data on 306 patients with hypodiploid ALL who were enrolled in the protocols of 16 cooperative study groups or institutions between 1997 and 2013. The clinical and biologic characteristics, early therapeutic [...]

Menée en Allemagne à partir de données portant sur 2 223 patientes atteintes d'un cancer du sein après la ménopause, cette étude évalue l'effet d'une supplémentation en antioxydants, avant le diagnositic et pendant la chimiothérapie ou la radiothérapie, sur la survie sans récidive et sur la mortalité spécifique et toutes causes confondues

Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy

Jung, Audrey Y. ; Cai, Xinting ; Thoene, Kathrin ; Obi, Nadia ; Jaskulski, Stefanie ; Behrens, Sabine ; Flesch-Janys, Dieter ; Chang-Claude, Jenny

Background : There is a paucity of information on the prevalence of dietary supplement use in breast cancer survivors. Only a few studies have examined the impact of dietary supplements, particularly antioxidants, on breast cancer prognosis and the results are inconclusive. Objective : We examined pre- and postdiagnosis use of supplements in postmenopausal breast cancer survivors in Germany and investigated associations between postdiagnosis use of antioxidants and other supplements, and [...]

A partir des données des registres américains des cancers portant sur la période 1999-2013, cette étude évalue les disparités ethniques et démographiques dans l'évolution de l'incidence du cancer des voies biliaires, en fonction de la localisation anatomique

Biliary tract cancer incidence and trends in the United States by demographic group, 1999-2013

Van Dyke, Alison L. ; Shiels, Meredith S. ; Jones, Gieira S. ; Pfeiffer, Ruth M. ; Petrick, Jessica L. ; Beebe-Dimmer, Jennifer L. ; Koshiol, Jill

Background : Biliary tract cancers (BTCs) are rare but deadly cancers (gallbladder cancer [GBC], intrahepatic cholangiocarcinoma [ICC], extrahepatic cholangiocarcinoma [ECC], and ampulla of Vater cancer [AVC]). A recent US study reported increasing GBC incidence among people younger than 45 years and blacks; however, it did not examine trends for other biliary tract sites. Methods : This study characterized demographic differences in BTC incidence rates and time trends by anatomic site. [...]

Menée au Japon par questionnaire auprès de 151 patients atteints d'un cancer traité par chimiothérapie ambulatoire (âge médian : 66,5 ans), cette étude transversale analyse les facteurs psychologiques associés à leurs demandes en matière de conseils nutritionnels

Need and demand for nutritional counselling and their association with quality of life, nutritional status and eating-related distress among patients with cancer receiving outpatient chemotherapy: a cross-sectional study

Koshimoto, Saori ; Arimoto, Masako ; Saitou, Keiko ; Uchibori, Mayumi ; Hashizume, Akiko ; Honda, Akiko ; Amano, Koji ; Nakajima, Yasuaki ; Uetake, Hiroyuki ; Matsushima, Eisuke

Purpose : Patients with cancer often experience general nutritional problems as the disease progresses. We aimed to examine if there is a need and demand for nutritional counselling among cancer outpatients, and explore relevant psychological factors pertaining to eating and nutrition. Methods : A survey was conducted among adult patients receiving outpatient chemotherapy at the Tokyo Medical and Dental University Hospital. The participants completed self-report questionnaires, which included [...]

Menée en Suède à partir de données portant sur 9 318 hommes nés entre 1952 et 1956 et atteints de cancer, cette étude évalue l'association entre leur capacité de résilience au stress à la fin de leur adolescence et la survie (durée médiane de suivi : 3 ans ; 2 541 décès dont 2 322 décès par cancer)

Stress Resilience in Late Adolescence and Survival among Cancer Patients: A Swedish Register-Based Cohort Study

Udumyan, Ruzan ; Montgomery, Scott ; Fang, Fang ; Valdimarsdóttir, Unnur ; Fall, Katja

Background: Chronic stress has been suggested to play a role in cancer progression, but few studies have so far examined the potential influence of stress susceptibility. This national register-based cohort study utilizes a unique data source to investigate whether a stress resilience measure is associated with survival in cancer patients. Methods: The cohort includes 9,318 Swedish male cancer patients born during 1952 to 1956 who had their stress resilience evaluated at a semistructured [...]

Menée aux Etats-Unis par enquête auprès de 693 femmes et 185 hommes ayant survécu à un cancer, cette étude analyse les facteurs associés à une détresse psychologique liée à l'infertilité et évalue son impact sur la qualité de vie

Infertility-Related Distress Following Cancer for Women and Men: A Mixed Method Study

Ussher, Jane M. ; Perz, Janette

Objective : Infertility-related distress is recognised to be a long-term effect of cancer. There have been attempts to examine predictors of such distress, but there is inconsistency in the findings. This study examined the psychological impact of infertility-related distress in women and men cancer survivors, across age group, parity, cancer type, time since diagnosis, and relationship context; and the association of distress with acceptance of illness and relationship satisfaction. Methods : [...]

Menée aux Etats-Unis auprès de 150 patients atteints d'un cancer épidermoïde de la tête et du cou, cette étude analyse 11 grands types de préoccupations (guérison, survie, capacité à avaler, etc.) et le sentiment de regret liés à la décision thérapeutique

Priorities, concerns, and regret among patients with head and neck cancer

Windon, Melina J. ; D’Souza, Gypsyamber ; Faraji, Farhoud ; Troy, Tanya ; Koch, Wayne M. ; Gourin, Christine G. ; Kiess, Ana P. ; Pitman, Karen T. ; Eisele, David W. ; Fakhry, Carole

Background : In the era of deintensification, little data are available regarding patients’ treatment preferences. The current study evaluated treatment-related priorities, concerns, and regret among patients with head and neck squamous cell cancer (HNSCC). Methods : A total of 150 patients with HNSCC ranked the importance of 10 nononcologic treatment goals relative to the oncologic goals of cure and survival. The level of concern regarding 11 issues and decision regret was recorded. Median [...]

A partir des données des registres suédois des cancers portant sur 478 patients atteints d'une tumeur neuroendocrine gastro-entéro-pancréatique de stade métastatique diagnostiquée entre 2005 et 2013 (âge moyen : 64 ans), cette étude analyse les coûts directs et indirects (perte de productivité, journées d'absence pour maladie) associés à la maladie et à ses traitements

Cost-of-illness of metastatic gastroenteropancreatic neuroendocrine tumours in Sweden—A population-based register-linkage study

Lesén, Eva ; Granfeldt, Daniel ; Houchard, Aude ; Berthon, Anthony ; Dinet, Jérôme ; Gabriel, Sylvie ; Björstad, Åse ; Björholt, Ingela ; Elf, Anna-Karin ; Johanson, Viktor

The objective was to estimate the cost-of-illness of grades 1 and 2 metastatic gastroenteropancreatic neuroendocrine tumours (GEP-NETs) in Sweden in 2013 in a population-based study including all patients diagnosed between 2005 and 2013. Data were obtained from national registers, and patients who utilised healthcare resources due to metastatic GEP-NETs in 2013 were included. The study included 478 patients (mean age 64 [SD=11] years, 51% men). The majority (80%) had small intestinal NET, 10% [...]

Menée aux Etats-Unis par enquête auprès de 450 oncologues (149 répondants), cette étude analyse leurs connaissances et leurs comportements vis-à-vis de patients LGBTQ (lesbiennes, gay, bisexuels, transgenres, queer) atteints d'un cancer

National Survey of Oncologists at National Cancer Institute–Designated Comprehensive Cancer Centers: Attitudes, Knowledge, and Practice Behaviors About LGBTQ Patients With Cancer

Matthew B. Schabath ; Catherine A. Blackburn ; Megan E. Sutter ; Peter A. Kanetsky ; Susan T. Vadaparampil ; Vani N. Simmons ; Julian A. Sanchez ; Steven K. Sutton ; Gwendolyn P. Quinn

PURPOSET : to identify potential gaps in attitudes, knowledge, and institutional practices toward lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) patients, a national survey of oncologists at National Cancer Institute–Designated Comprehensive Cancer Centers was conducted to measure these attributes related to LGBTQ patients and desire for future training and education. METHODS : A random sample of 450 oncologists from 45 cancer centers was selected from the American Medical [...]