Menée au Danemark auprès de 40 patients atteints d'un cancer de stade avancé et ne recevant ni chimiothérapie ni radiothérapie, cette étude multicentrique évalue l'efficacité de l'olanzapine pour prévenir et traiter leurs nausées et vomissements

Antiemetic use of olanzapine in patients with advanced cancer: results from an open-label multicenter study

Harder, Signe ; Groenvold, Mogens ; Isaksen, Jesper ; Sigaard, Jarl ; Frandsen, Karin Bruun ; Neergaard, Mette Asbjoern ; Mondrup, Lise ; Herrstedt, Jørn

Introduction : The antipsychotic drug olanzapine is effective against chemotherapy-induced nausea and targets multiple receptors known to be involved in the emetic reflex arch. The drug has a mean half-life of 30 h, which allows for a single daily administration and is therefore of interest in patients with advanced cancer suffering from nausea. Objectives : To investigate the antiemetic effect and tolerability of olanzapine in patients with advanced cancer not receiving chemotherapy or [...]

Menée en Espagne à partir de données portant sur 1 588 patients atteints d'un carcinome hépatocellulaire, cette étude de cohorte évalue l'association entre une infection par le VIH (132 cas) et la survie globale

Influence of HIV Infection on the Natural History of Hepatocellular Carcinoma: Results From a Global Multicohort Study

David J. Pinato ; Elias Allara ; Ting-Yi Chen ; Franco Trevisani ; Beatriz Minguez ; Marco Zoli ; Marianne Harris ; Alessia Dalla Pria ; Nicolás Merchante ; Heather Platt ; Mamta Jain ; Eugenio Caturelli ; Luciana Kikuchi ; Juan Pineda ; Mark Nelson ; Fabio Farinati ; Gian Ludovico Rapaccini ; Ayse Aytaman ; Michael Yin ; Chee-Kiat Tan ; Mark Bower ; Edoardo G. Giannini ; Norbert Bräu ; the Liver Cancer in HIV ; ITA.LI.CA Study Groups

PURPOSE : Conflicting evidence indicates that HIV seropositivity may influence the outcome of patients with hepatocellular carcinoma (HCC), a leading cause of mortality in people with HIV. We aimed to verify whether HIV affected the overall survival (OS) of patients with HCC, independent of treatment and geographic origin. PATIENTS AND METHODS : We designed an international multicohort study of patients with HCC accrued from four continents who did not receive any anticancer treatment. We [...]

Menée au Royaume-Uni à partir de données portant sur 4 235 patients ayant survécu à un cancer diagnostiqué entre 1990 et 2011 avant l'âge de 29 ans, cette étude analyse l'association entre des admissions hospitalières pour des morbidités respiratoires, les risques respiratoires liés aux traitements anticancéreux et le risque de décès

Respiratory morbidity in young people surviving cancer: Population-based study of hospital admissions, treatment-related risk factors and subsequent mortality

Smith, Lesley ; Glaser, Adam W ; Peckham, Daniel ; Greenwood, Darren C ; Feltbower, Richard G

Respiratory diseases are a major cause of late morbidity and mortality amongst childhood cancer survivors. This population-based study investigates respiratory hospital admissions in long-term survivors of cancers diagnosed in young people to identify specific respiratory morbidities, treatment-related risks and their relationship to subsequent morbidity and mortality. Population-based cancer registrations in Yorkshire, England, diagnosed between 1990 and 2011 aged 0-29 years, were linked to [...]

A partir des données des registres américains des cancers portant sur 1 136 patients ayant survécu à un lymphome hodgkinien diagnostiqué entre 1955 et 1986 avant l'âge de 17 ans, cette étude analyse les facteurs associés au risque de développer une tumeur solide (durée médiane de suivi : 26,6 ans)

Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma–identification of high-risk populations to guide surveillance: A report from the Late Effects Study Group

Holmqvist, Anna S. ; Chen, Yanjun ; Berano Teh, Jennifer ; Sun, Canlan ; Birch, Jillian M. ; van den Bos, Cor ; Diller, Lisa R. ; Dilley, Kimberley ; Ginsberg, Jill ; Martin, Laura T. ; Nagarajan, Rajaram ; Nathan, Paul C. ; Neglia, Joseph P. ; Terenziani, Monica ; Tishler, David ; Meadows, Anna T. ; Robison, Leslie L. ; Oberlin, Odile ; Bhatia, Smita

Background : Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations. Methods : The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. The risk of SMN [...]

A partir des données des registres américains des cancers portant sur 80 403 patients ayant survécu à un carcinome à cellules rénales, cette étude analyse les facteurs clinicopathologiques associés au risque de développer une tumeur rénale bilatérale (durée médiane de suivi : 8,3 ans)

Risk factors for metachronous bilateral renal cell carcinoma: A Surveillance, Epidemiology, and End Results analysis

Syed, Jamil S. ; Nguyen, Kevin A. ; Holford, Theodore R. ; Hofmann, Jonathan N. ; Shuch, Brian

Background : Patients treated for renal cell carcinoma (RCC) may be diagnosed with a metachronous, contralateral tumor. We evaluated the risks of contralateral tumor development using the Surveillance, Epidemiology, and End Results database. Methods : Among RCC patients, we identified those with a metachronous, contralateral RCC diagnosed ≥1 year after primary diagnosis. We performed a competing risks analysis to evaluate associations between clinicopathologic factors and metachronous, [...]

Menée au Japon auprès de 147 patients atteints d'un cancer de stade avancé recevant des soins palliatifs et des soins de support, cette étude analyse la sévérité de leurs symptômes ayant un impact sur la nutrition et évalue la détresse psychologique liée à l'alimentation, selon que le patient souffre ou non d'une cachexie

Eating-related distress in advanced cancer patients with cachexia and family members: a survey in palliative and supportive care settings

Amano, Koji ; Morita, Tatsuya ; Koshimoto, Saori ; Uno, Teruaki ; Katayama, Hirofumi ; Tatara, Ryohei

Purpose : Few studies have investigated nutrition impact symptoms and eating-related distress among advanced cancer patients and their families. This is a questionnaire survey to examine the severity of nutrition impact symptoms and the prevalence of eating-related distress among them in palliative and supportive care settings. Methods : Questionnaires for patients and their families were preliminarily developed. We selected 16 common symptoms of advanced cancer, i.e., 9 symptoms of the ESAS-r [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité des immunothérapies à base de lymphocytes CAR-T pour traiter les patients pédiatriques atteints d'une leucémie lymphoblastique aiguë à cellules B réfractaire ou récidivante

Cost-Effectiveness of Chimeric Antigen Receptor T-Cell Therapy in Pediatric Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Sarkar, Reith R. ; Gloude, Nicholas J. ; Schiff, Deborah ; Murphy, James D.

Background : Chimeric antigen receptor T-cell (CAR-T) therapy is a promising new class of cancer therapy but has a high up-front cost. We evaluated the cost-effectiveness of CAR-T therapy among pediatric patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). Methods : We built a microsimulation model for pediatric patients with relapsed/refractory B-ALL receiving either CAR-T therapy or standard of care. Outcomes included costs, quality of life (health utility), [...]

Cet article décrit le processus par lequel l'"International Cancer Control Partnership" a élaboré un outil destiné à aider les pays et les partenaires internationaux à développer et mettre en œuvre un plan national de lutte contre le cancer

Cancer control planning: self-assessment for pre-planning, development, implementation and evaluation of national cancer control plans

Given, Leslie S. ; Hohman, Karin ; Kostelecky, Brenda ; Vinson, Cynthia

The development of cancer control plans as a clearly defined concept began in the U.S. in the early 1990s. On an international level, the same concept has been described as “national cancer control planning” or national cancer control plan (NCCP) development and implementation. Recent efforts by the National Cancer Institute’s Center for Global Health and its partners have increased international and country-level interest in NCCPs. Central to the development of these plans has been a need for [...]

Menée au Danemark par questionnaire auprès de 7 295 patients atteints d'un cancer du poumon, cette étude analyse la faisabilité d'une méthodologie pour collecter les données relatives aux symptômes auto-déclarés par les patients

Patient-reported outcomes (PROs) in lung cancer: Experiences from a nationwide feasibility study

Brønserud, Majken M. ; Iachina, Maria ; Green, Anders ; Groenvold, Mogens ; Dørflinger, Liv ; Jakobsen, Erik

Objectives : Our objectives were to examine the feasibility of a nationwide collection of patient-reported outcomes (PROs) in a lung cancer population as well as in various sub-populations, and to describe the characteristics of responders compared to non-responders. Materials and methods : All patients diagnosed with lung cancer in Denmark are registered in the Danish Lung Cancer Registry (DLCR). The 7,295 patients registered in DLCR from 1 October 2013 until 30 September 2015 who had received [...]