Menée aux Etats-Unis à partir de données portant sur 114 414 participantes, cette étude de cohorte prospective évalue l'association entre une consommation de folates et de nutriments impliqués dans le métabolisme du carbone, et le risque de cancer de l'endomètre (durée moyenne de suivi : 16 ans ; 2 329 cas)

Dietary intake of nutrients involved in folate-mediated one-carbon metabolism and risk for endometrial cancer

Lu, Jana ; Trabert, Britton ; Liao, Linda M. ; Pfeiffer, Ruth M. ; Michels, Kara A.

Background : Studies disagree as to whether intakes of folate-mediated one-carbon metabolism nutrients are associated with endometrial cancer. Methods : Using data from the large, prospective NIH-AARP Diet and Health Study, we used Cox proportional hazards models to evaluate endometrial cancer risk associated with calorie-adjusted dietary intake of several B vitamins and methionine. All models accounted for age, race, body mass index (BMI), smoking, oral-contraceptive use, menopausal hormone [...]

Menée aux Pays-Bas à partir de données portant sur 120 852 participants âgés entre 55 et 69 ans, cette étude de cohorte évalue l'association entre la présence d'un calcul rénal et le risque de carcinome à cellules rénales ou de carcinome urothélial de la voie excrétrice urinaire supérieure (durée de suivi : 20,3 ans ; 4 352 participants dans la sous-cohorte, 544 cas de carcinome rénal, 140 cas de carcinome urothélial)

Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study

Jeroen A. A. van de Pol, ; Piet A. van den Brand, ; Leo J. Schouten

Background : We examined the association between kidney stones and renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC) risk in the Netherlands Cohort Study on diet and cancer. Methods : In total, 120,852 participants aged 55–69 completed a self-administered questionnaire on diet, medical conditions and other risk factors for cancer at baseline (1986). After 20.3 years of cancer follow-up 4352 subcohort members, 544 RCC cases and 140 UTUC cases were eligible for case-cohort [...]

Menée en Espagne à partir de données portant sur 848 patients atteints d'une maladie pulmonaire obstructive chronique, cette étude évalue l'association entre une distension pulmonaire statique et le risque de cancer du poumon (période de suivi : 2 858 personnes-années)

Static lung hyperinflation is an independent risk factor for lung cancer in patients with chronic obstructive pulmonary disease

Zamarrón, Ester ; Prats, Eva ; Tejero, Elena ; Pardo, Paloma ; Galera, Raúl ; Casitas, Raquel ; Martínez-Cerón, Elisabet ; Romera, Delia ; Jaureguizar, Ana ; García-Río, Francisco

Introduction : Static hyperinflation, a hallmark characteristic of some patients with chronic obstructive pulmonary disease, is related to higher mortality and cardiovascular morbidity. However, information about its association with lung cancer is scarce. Our aim was to evaluate whether static hyperinflation is associated with future risk of lung cancer in COPD patients. Methods : A cohort of 848 COPD patients recruited outside the hospital setting was monitored for an average period of 4.3 [...]

A partir de données produites à l'aide de technologies de séquençage à haut débit, cette étude passe en revue l'ensemble des anomalies génomiques, qu'il s'agisse des mutations constitutionnelles ou somatiques, impliquées dans l'étiologie de la leucémie lymphoblastique aiguë chez l'enfant

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia

Pui, Ching-Hon ; Nichols, Kim E. ; Yang, Jun J.

Advances in genomic research and risk-directed therapy have led to improvements in the long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic leukaemia (ALL). The application of next-generation sequencing technologies, especially transcriptome sequencing, has resulted in the identification of novel molecular subtypes of ALL with prognostic and therapeutic implications, as well as cooperative mutations that account for much of the heterogeneity in clinical [...]

Menée en Suède à partir de données portant sur 421 patients atteints d'un gliome et sur 671 témoins, cette étude évalue l'association entre la longueur relative des télomères des leucocytes et le risque de développer la maladie, indépendamment d'autres facteurs de risque (allergies, asthme, indice de masse corporelle, tabagisme)

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking

Andersson, Ulrika ; Degerman, Sofie ; Dahlin, Anna M. ; Wibom, Carl ; Johansson, Gunnar ; Bondy, Melissa L. ; Melin, Beatrice S.

Purpose : Previous studies have suggested an association between relative leukocyte telomere length (rLTL) and glioma risk. This association may be influenced by several factors, including allergies, BMI, and smoking. Previous studies have shown that individuals with asthma and allergy have shortened relative telomere length, and decreased risk of glioma. Though, the details and the interplay between rLTL, asthma and allergies, and glioma molecular phenotype is largely unknown. Methods : rLTL [...]