Menée en Grande-Bretagne auprès de 166 patientes atteintes d'un cancer gynécologique entre 2014 et 2016 (endomètre, col utérin, ovaire, vulve), cette étude de cohorte prospective évalue l'association entre l'indice de masse corporelle et la qualité de leur vie sexuelle, avant et après les traitements (3 mois et 1 an après)

Body mass index and sexual function in women with gynaecological cancer

Donkers, Hannah ; Smits, Anke ; Eleuteri, Antonio ; Bekkers, Ruud ; Massuger, Leon ; Galaal, Khadra

Objectives : To investigate the association between body mass index (BMI) and sexual functioning in gynaecologic cancer patients. To determine the association between socio-economic deprivation and sexual functioning. Methods : This is a prospective cohort study on women undergoing surgery for suspected or proven gynaecological cancer between September 2014 and February 2016 in the Royal Cornwall Hospital Trust. Patients were invited to participate by completing the Female Sexual Function Index [...]

Menée en Italie auprès de 246 patients atteints d'un cancer de stade avancé et traités dans une unité de soins palliatifs ou de soins de support intensifs, cette étude évalue l'association entre un délire et l'intensité de leurs symptômes (douleur, dépression, faiblesse, nausées, perte d'appétit, etc)

Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium

Mercadante, Sebastiano ; Adile, Claudio ; Ferrera, Patrizia ; Cortegiani, Andrea ; Casuccio, Alessandra

Aim : The aim of this study was to investigate the relationship between delirium and symptom expression in patients with advanced cancer admitted to an acute supportive/palliative care unit (ASPCU). Methods : A consecutive sample of patients with advanced cancer who were admitted to an ASPCU was prospectively assessed for a period of 10 months. The Edmonton Symptom Assessment Scale (ESAS) and the MDAS (Memorial Delirium Assessment Scale) were measured at admission (T0) and after 7 days of [...]

Mené sur des patients atteints d'une leucémie myéloïde aiguë, cet essai de phase II à bras unique évalue l'efficacité de l'aprépitant pour réduire les nausées et vomissements induits par une chimiothérapie d'induction à base de daunorubicine et de cytarabine

A phase II open-label study of aprepitant as anti-emetic prophylaxis in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy

Brandwein, Joseph M. ; Seki, Jack T. ; Atenafu, Eshetu G. ; Rostom, Amr ; Lutynski, Andrzej ; Rydlewski, Anna ; Schimmer, Aaron D. ; Schuh, Andre C. ; Gupta, Vikas ; Yee, Karen W. L.

Despite the widespread use of 5-HT3 antagonists as anti-emetic prophylaxis in patients with acute myeloid leukemia (AML) receiving induction chemotherapy, nausea and vomiting persist in many cases. We performed a Phase II single-arm study evaluating the use of aprepitant on days 1–5, in combination with a 5-HT antagonist on days 1–3, in AML patients undergoing induction chemotherapy with daunorubicin on days 1–3 plus cytarabine, given as a continuous infusion, on days 1–7. This was compared to [...]

Mené en Italie sur 50 patientes atteintes d'un lymphœdème associé à un cancer du sein, cet essai randomisé évalue l'efficacité, du point de vue de la réduction du volume excessif du membre supérieur et de la réduction des déficiences du bras, de l'épaule et de la main, de l'ajout d'un produit à base de diosmine, coumarine et arbutine à un drainage lymphatique manuel

Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema

Cacchio, Angelo ; Prencipe, Rosa ; Bertone, Marina ; De Benedictis, Luciana ; Taglieri, Luciano ; D’Elia, Erika ; Centoletti, Cesidia ; Di Carlo, Giancarlo

Purpose : To assess the effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy (CDT) on the management of patients with a breast cancer-related lymphedema (BCRL). Methods : Fifty outpatients (average age of 56.2 ± 2.7 years, range 28–71) with a BCRL were enrolled for this study. Patients were randomly assigned (1:1 ratio) to receive either CDT consisting of skin care, manual lymphatic drainage, remedial exercises, [...]

Mené sur 160 patientes atteintes d'un lymphœdème du membre supérieur associé à un cancer du sein, cet essai randomisé évalue l'efficacité, du point de vue de la réduction du volume du lymphœdème à 7 mois, de l'ajout d'un drainage lymphatique manuel à une thérapie décongestive

Manual lymphatic drainage adds no further volume reduction to Complete Decongestive Therapy on breast cancer-related lymphoedema: a multicentre, randomised, single-blind trial

Tambour, Mette ; Holt, Marianne ; Speyer, Anette ; Christensen, Robin ; Gram, Bibi

Background : We investigated the comparability of Complete Decongestive Therapy (CDT) including manual lymphatic drainage (MLD) vs. without MLD in the management of arm lymphoedema in patients with breast cancer. Methods : Patients randomised into either treatment including MLD (T+MLD) or treatment without MLD (T−MLD) received treatment 2×weekly for 4 weeks. The primary outcome was the volume reduction (%) of arm lymphoedema at 7-month follow-up. The secondary outcomes were volume reduction [...]

Cet article présente des axes de recherche sur les problématiques liées à l'emploi pour les patients ayant survécu à un cancer

Cancer Survivorship and Employment: Intersection of Oral Agents, Changing Workforce Dynamics, and Employers’ Perspectives

Bradley, Cathy J. ; Brown, Kelsey L. ; Haan, Michelle ; Glasgow, Russell E. ; Newman, Lee S. ; Rabin, Borsika ; Ritzwoller, Debra P. ; Tenney, Liliana

The ability to continue employment during and following cancer diagnosis and treatment is critical to working-age cancer survivors. Prolonged survival combined with concerns of the financial burden associated with high-cost therapies makes the mitigation of work-related consequences all the more relevant, particularly in light of recent workforce trends and evolving employment dynamics. Research that integrates the needs of survivors, employers, and the workforce is required so that [...]

Menée aux Etats-Unis à partir de données portant sur 9 646 498 patients décédès d'un cancer sur la période 1999-2015, cette étude analyse les facteurs ethniques, sociodémographiques et géographiques associés au lieu du décès (domicile, hôpital)

Place of death for patients with cancer in the United States, 1999 through 2015: racial, age, and geographic disparities

Chino, Fumiko ; Kamal, Arif H. ; LeBlanc, Thomas W. ; Zafar, S. Yousuf ; Suneja, Gita ; Chino, Junzo P.

BACKGROUND Place of death is an essential component of high quality cancer care and comprehensive national trends and disparities in place of death are unknown. METHODS Deidentified death certificate data were obtained via the National Center for Health Statistics. All cancer deaths from 1999 through 2015 were included. Multivariate logistic regression was used to test for disparities in place of death associated with sociodemographic variables. RESULTS From 1999 through 2015, a total of [...]

A partir des données de la base GLOBOCAN, cette étude présente une estimation de l'incidence de 36 types de cancers et de la mortalité dans 185 pays, pour l'année 2018

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

Ferlay, J. ; Colombet, M. ; Soerjomataram, I. ; Mathers, C. ; Parkin, D.M. ; Piñeros, M. ; Znaor, A. ; Bray, F.

Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of [...]

Menée en Finlande à partir de données portant sur 1 753 premiers enfants de patientes ayant survécu à un cancer de stade précoce et sur 5 123 premiers enfants de femmes sans antécédent de cancer, cette étude évalue les facteurs associés au risque d'accouchement prématuré en lien avec les traitements anticancéreux

Risk factors for preterm delivery among early onset cancer survivors: A Finnish register-based study

Melin, Johanna ; Heinävaara, Sirpa ; Malila, Nea ; Tiitinen, Aila ; Gissler, Mika ; Madanat-Harjuoja, Laura

Previous studies have shown an elevated risk for preterm delivery among early onset cancer survivors. Whether the preterm delivery starts spontaneously, due to possible uterine damage because of cancer treatment, or is induced due to maternal conditions is unclear. Our aim was to assess pregnancy related conditions in female cancer survivors possibly underlying the elevated risk for preterm labor. Nationwide cancer and birth registries were merged to identify 1,753 first deliveries of cancer [...]

A partir des données des registres américains des cancers portant sur 370 994 patients adultes atteints d'un lymphome diagnostiqué sur la période 1995-2009, cette étude analyse l'évolution de la survie par sous-type histologique

Adult leukemia survival trends in the United States by subtype: A population-based registry study of 370,994 patients diagnosed during 1995-2009

Bailey, Chris ; Richardson, Lisa C. ; Allemani, Claudia ; Bonaventure, Audrey ; Harewood, Rhea ; Moore, Angela R. ; Stewart, Sherri L. ; Weir, Hannah K. ; Coleman, Michel P.

Background : The lifetime risk of developing leukemia in the United States is 1.5%. There are challenges in the estimation of population-based survival using registry data because treatments and prognosis vary greatly by subtype. The objective of the current study was to determine leukemia survival estimates in the United States from 1995 to 2009 according to subtype, sex, geographical area, and race. Methods : Five-year net survival was estimated using data for 370,994 patients from 43 [...]

A partir des données des registres américains des cancers portant sur 1 008 patients atteints d'une leucémie lymphocytaire chronique diagnostiquée en 2008 et sur 1 367 patients atteints de la même maladie en 2014, cette étude analyse, dans un contexte de vie réelle, l'évolution des traitements entre ces deux périodes

Real-world testing and treatment patterns in chronic lymphocytic leukemia: A SEER patterns of care analysis

Seymour, Erlene K. ; Ruterbusch, Julie J. ; Beebe-Dimmer, Jennifer L. ; Schiffer, Charles A.

Background : Laboratory testing and treatments for chronic lymphocytic leukemia (CLL) have changed dramatically within the last decade. The authors evaluated changes in patterns of real-world testing and treatment over time by comparing 2 population-based cohorts. Methods : The National Cancer Institute–sponsored Patterns of Care study was conducted among patients with CLL who were sampled from 14 Surveillance, Epidemiology, and End Results (SEER) program registries. Demographics, testing, and [...]

Menée aux Etats-Unis à partir de données portant sur 2 801 patients atteints d'un cancer colorectal de stade invasif et non métastatique entre 1993 et 2013, cette étude évalue l'association entre la qualité de l'alimentation, mesurée par l'indice développé par l'"American Cancer Society", avant et après le diagnostic, et la mortalité

Associations of Pre- and Postdiagnosis Diet Quality With Risk of Mortality Among Men and Women With Colorectal Cancer

Mark A. Guinter ; Marjorie L. McCullough ; Susan M. Gapstur ; Peter T. Campbell

Purpose : Dietary patterns, indicators of overall diet quality, are associated with colorectal cancer (CRC) incidence but less consistently with mortality among CRC survivors. We prospectively evaluated associations of diet quality pre- and postdiagnosis with risk of mortality among men and women with CRC. Patients and Methods : In the Cancer Prevention Study-II Nutrition Cohort, 2,801 participants were cancer free at baseline in 1992/1993 and subsequently diagnosed with invasive, nonmetastatic [...]

Menée à partir des données des registres américains des cancers portant sur 1 112 patientes atteintes d'un cancer métaplasique du sein et sur 21 321 patientes atteintes d'un cancer du sein triplement négatif, cette étude analyse la survie globale des patientes en fonction des types et sous-types tumoraux

Prognosis in different subtypes of metaplastic breast cancer: a population-based analysis

He, Xuexin ; Ji, Jiali ; Dong, Rongrong ; Liu, Hong ; Dai, Xiaolan ; Wang, Chongjian ; Esteva, Francisco J. ; Yeung, Sai-Ching Jim

Background : Metaplastic breast cancer (MpBC) is a rare histological subtype of breast cancer recognized as a unique pathologic entity in 2000. However, the pathogenesis, optimal therapy, and prognosis of MpBC and the potential effect of systemic treatments on different subtypes of MpBC are not well defined. Methods : A retrospective population-based study was performed to identify breast cancer patients with MpBC and other triple-negative breast cancers (TNBC) between 2010 and 2014 using the [...]

A partir des données de deux essais de phase III incluant des patientes atteintes d'un cancer du sein de stade précoce HER2+, cette étude analyse l'effet des traitements anticancéreux (lapatinib, trastuzumab) sur la survenue d'une grossesse, ses complications et son issue, que ces traitements aient été dispensés avant la grossesse ou en début de grossesse (non connue)

Pregnancies during and after trastuzumab and/or lapatinib in patients with human epidermal growth factor receptor 2–positive early breast cancer: analysis from the NeoALTTO (BIG 1-06) and ALTTO (BIG 2-06) trials

Lambertini, Matteo ; Martel, Samuel ; Campbell, Christine ; Guillaume, Sébastien ; Hilbers, Florentine S. ; Schuehly, Uwe ; Korde, Larissa ; Azim, Hatem A. ; Di Cosimo, Serena ; Tenglin, Richard C. ; Huober, Jens ; Baselga, Jose ; Moreno-Aspitia, Alvaro ; Piccart-Gebhart, Martine ; Gelber, Richard D. ; de Azambuja, Evandro ; Ignatiadis, Michail

Background : Limited data exist on the safety of using anti–human epidermal growth factor receptor 2 (HER2) targeted agents during pregnancy. To date, only retrospective studies have assessed the prognosis of patients with a pregnancy after prior early breast cancer, with no data in HER2-positive patients. Methods The Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization (NeoALTTO) trial and the Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO) trial were randomized [...]

Menée en Corée à partir de données portant sur 6 027 patients atteints d'une tumeur cérébrale diagnostiquée avant l'âge de 19 ans sur la période 2005-2014, cette étude analyse les facteurs associés au risque de développer la maladie, évalue la survie relative à 5 ans, puis compare ces données avec les données américaines

A nationwide, population-based epidemiologic study of childhood brain tumors in Korea, 2005-2014: A comparison with United States data

Kang, Ji-Man ; Ha, Johyun ; Hong, Eung Kyung ; Ju, Hee young ; Park, Byung Kiu ; Shin, Sang-Hoon ; Won, Young-Joo ; Jung, Kyu-Won ; Park, Hyeon Jin

Background: We investigated the epidemiologic characteristics of childhood brain tumors (CBTs) in Korea, and compared our findings to those from the US. Methods: We searched the Korea National Cancer Incidence Database of the Korea Central Cancer Registry (KCCR) from 2005 to 2014, which included all Korean patients with CBT aged 0-19 years at diagnosis. The age-standardized incidence rates (ASRs) and the 5-year relative survival rate (RSRs) were determined. The Central Brain Tumor Registry of [...]

A partir des données des registres américains des cancers portant sur 4 219 097 patients ayant survécu à un cancer, cette étude évalue les facteurs associés au risque de suicide en fonction de la localisation de la maladie, et met en avant le risque de suicide important chez les patients ayant survécu à un cancer de la tête et du cou (4 493 suicides ; dont 404 suicides parmi 151 167 cas de cancer de la tête et du cou) sur la période 2000-2014

Suicide risk among cancer survivors: Head and neck versus other cancers

Osazuwa-Peters, Nosayaba ; Simpson, Matthew C. ; Zhao, Longwen ; Adjei Boakye, Eric ; Olomukoro, Stephanie I. ; Deshields, Teresa ; Loux, Travis M. ; Varvares, Mark A. ; Schootman, Mario

Background : Cancer survivors face psychosocial issues that increase their risk of suicide. This study examined the risk of suicide across cancer sites, with a focus on survivors of head and neck cancer (HNC). Methods : The Surveillance, Epidemiology, and End Results 18-registry database (from 2000 to 2014) was queried for the top 20 cancer sites in the database, including HNC. The outcome of interest was suicide as a cause of death. The mortality rate from suicide was estimated for HNC sites [...]

Menée aux Etats-Unis auprès de 300 patientes ayant survécu à un cancer du sein de stade précoce, cette étude analyse le lien entre la peur de la récidive et l'utilisation de services de santé (recours téléphonique à des professionnels de l'oncologie, à des médecins généralistes, à des professionnels de la santé psychique, utilisation de médicaments psychotropes, etc.) et les coûts financiers associés

Assessing the relationship between fear of cancer recurrence and health care utilization in early-stage breast cancer survivors

Otto, Amy K. ; Soriano, Emily C. ; Siegel, Scott D. ; LoSavio, Stefanie T. ; Laurenceau, Jean-Philippe

Purpose : The purpose of this study was to determine whether fear of cancer recurrence (FCR) is associated with greater health care utilization (HCU) in early-stage breast cancer survivors. Methods : Three hundred early-stage breast cancer survivors diagnosed within the past 7 years reported on FCR as well as calls and visits to oncology providers and primary care providers during the preceding 3 months. Participants also reported on use of mental health services and psychotropic medications [...]

A partir d'une revue systématique de la littérature (26 études), cette étude identifie 54 polymorphismes à simple nucélotide de gènes associés à des symptômes psycho-neurologiques (anxiété, déficiences cognitives, dépression, fatigue, troubles du sommeil, douleur) chez des patientes atteintes d'un cancer du sein de stade précoce, pendant et après les traitements anticancéreux

Systematic review of genetic polymorphisms associated with psychoneurological symptoms in breast cancer survivors

Yang, Gee Su ; Kumar, Sreelakshmy ; Dorsey, Susan G. ; Starkweather, Angela R. ; Kelly, Debra Lynch ; Lyon, Debra E.

Purpose : Psychoneurological (PN) symptoms, such as anxiety, cognitive impairment, depression, fatigue, sleep disturbances, and pain, are highly prevalent in breast cancer patients undergoing cancer treatment. Emerging evidence suggests that genetic polymorphisms may contribute to differential symptom susceptibility. We aimed to systematically review associations between genetic polymorphisms and PN symptoms during or after cancer treatment for early-stage breast cancer. Methods : Twenty-six [...]

Mené aux Etats-Unis sur 60 patients âgés de plus de 65 ans et atteints d'une tumeur pulmonaire, mammaire ou gastro-intestinale traitée par une chimiothérapie de première ligne, cet essai randomisé évalue l'intérêt d'intégrer les pharmaciens dans le parcours de soins pour éviter la prise de médicaments inappropriés et augmenter le taux de vaccination contre la grippe et les infections à pneumocoques

Pilot Randomized Trial of a Pharmacy Intervention for Older Adults with Cancer

Nipp, Ryan D. ; Ruddy, Margaret ; Fuh, Charn‐Xin ; Zangardi, Mark L. ; Chio, Christine ; Kim, E. Bridget ; Li, Barbara Kong Mui ; Long, Ying ; Blouin, Gayle C. ; Lage, Daniel ; Ryan, David P. ; Greer, Joseph A. ; El‐Jawahri, Areej ; Temel, Jennifer S.

Background : Oncology clinicians often struggle with managing medications and vaccinations in older adults with cancer. We sought to demonstrate the feasibility and preliminary efficacy of integrating pharmacists into the care of older adults with cancer to enhance medication management and vaccination administration. Methods : We randomly assigned patients aged ≥65 years with breast, gastrointestinal, or lung cancer receiving first‐line chemotherapy to the pharmacy intervention or usual care. [...]

Menée en Espagne par enquête auprès de 650 patients atteints de cancer (âge moyen : 57,8 ans), cette étude transversale analyse les facteurs associés à leur utilisation des technologies de l'information et de la communication pour prendre en charge leur maladie

Oncology Patient Interest in the Use of New Technologies to Manage Their Disease: Cross-Sectional Survey

Collado-Borrell, Roberto ; Escudero-Vilaplana, Vicente ; Calles, Antonio ; Garcia-Martin, Estela ; Marzal-Alfaro, Belen ; Gonzalez-Haba, Eva ; Herranz-Alonso, Ana ; Sanjurjo-Saez, Maria

Background: Information and communication technologies (ICTs) in oncology can revolutionize the medical care of cancer patients. ICTs can promote patients’ empowerment and real-time disease monitoring. There is limited information about the impact of ICTs in cancer patients or their level of interest in using these tools for greater management of their condition. Objective: This study aimed to understand the ICT usage profile in hematology-oncology patients to identify their needs and determine [...]

Cette étude passe en revue les options palliatives pour prendre en charge les patients atteints d'une tumeur germinale maligne n'étant plus curable

Palliative Treatment of Germ Cell Cancer

Oing, Christoph ; Giannatempo, Patrizia ; Honecker, Friedemann ; Oechsle, Karin ; Bokemeyer, Carsten ; Beyer, Jörg

Most patients with metastatic germ-cell cancer (GCC) can be cured by cisplatin-based combination chemotherapy. Yet, about 10-15% of metastatic GCC patients will eventually die of their disease. This narrative review focuses on treatment options when cure is no longer realistic. Most patients with metastatic germ-cell cancer (GCC) can be cured by cisplatin-based combination chemotherapy. Yet, about 10-15% of metastatic GCC patients will eventually die of their disease. This narrative review [...]

Cette étude présente les recommandations américaines pour la prise en charge des patients âgés atteints de cancer, qu'il s'agisse notamment de leur inclusion dans des essais cliniques et du développement de l'information et de la communication au sujet de ces essais

Expanding the Evidence Base in Geriatric Oncology: Action Items From an FDA-ASCO Workshop

Levit, Laura A. ; Singh, Harpreet ; Klepin, Heidi D. ; Hurria, Arti

As part of the ongoing efforts to address the lack of clinical research on older adults with cancer, the American Society of Clinical Oncology (ASCO) and the US Food and Drug Administration cosponsored a public workshop on geriatric oncology in November 2017. The goals were to review progress, build collaborations across stakeholders, and generate new action items for increasing the evidence base for treating older adults with cancer. It built on previous work of the Institute of Medicine, [...]