Menée à partir de données portant sur 106 126 femmes (durée moyenne de suivi : 12,5 ans), cette étude évalue l'association entre l'adhésion aux recommandations de "l'American Cancer Society" en matière de comportements de santé (alimentation, activité physique, ...) et le risque de cancer du sein (7 088 cas), la mortalité globale (1 162 décès) ou la mortalité spécifique (462 décès)

Adherence to lifestyle-related cancer prevention guidelines and breast cancer incidence and mortality

Cifu, Gabriella ; Arem, Hannah

Background : Breast cancer is the most common cancer in women. Many lifestyle factors have been associated with an increased risk of breast cancer incidence and mortality. An index-based approach to analyzing adherence to American Cancer Society (ACS) guidelines as a whole may better explain associations between lifestyle variables and breast cancer incidence and mortality. Methods : We created an index based on ACS-specific guidelines, including body mass index (BMI), physical activity, [...]

Mené auprès de 19 114 personnes âgées en bonne santé (âge 65 ans ou plus ; durée médiane de suivi : 4,7 ans), cet essai évalue l'effet de la consommation quotidienne d'une faible dose d'aspirine sur la mortalité toutes causes confondues et évalue la proportion de décès liés aux cancers

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

McNeil, John J. ; Nelson, Mark R. ; Woods, Robyn L. ; Lockery, Jessica E. ; Wolfe, Rory ; Reid, Christopher M. ; Kirpach, Brenda ; Shah, Raj C. ; Ives, Diane G. ; Storey, Elsdon ; Ryan, Joanne ; Tonkin, Andrew M. ; Newman, Anne B. ; Williamson, Jeff D. ; Margolis, Karen L. ; Ernst, Michael E. ; Abhayaratna, Walter P. ; Stocks, Nigel ; Fitzgerald, Sharyn M. ; Orchard, Suzanne G. ; Trevaks, Ruth E. ; Beilin, Lawrence J. ; Donnan, Geoffrey A. ; Gibbs, Peter ; Johnston, Colin I. ; Radziszewska, Barbara ; Grimm, Richard ; Murray, Anne M.

Background : In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo. Methods : From 2010 through 2014, we enrolled community-dwelling persons in Australia and the [...]

Menée aux Etats-Unis à partir de l'analyse des rapports du "Vaccine Adverse Event Reporting System" concernant 241 personnes vaccinées sur la période 2009-2017, cette étude identifie les événements indésirables associés à un vaccin (Cervarix) contre les papillomavirus humains de type 16 et 18

Safety of bivalent human papillomavirus vaccine in the U.S. Vaccine Adverse Event Reporting System (VAERS), 2009-2017

Suragh, Tiffany A. ; Lewis, Paige ; Arana, Jorge ; Mba-Jonas, Adamma ; Li, Rongxia ; Stewart, Brock ; Shimabukuro, Tom T. ; Cano, Maria

Background : Human papillomavirus (HPV) vaccines prevent infection with oncogenic virus types. We analyzed reports to the U.S. Vaccine Adverse Event Reporting System (VAERS) of adverse events (AE) following bivalent HPV vaccine (2vHPV). Methods : We conducted descriptive analysis of 2vHPV reports, reviewed individual reports, calculated crude AE reporting rates, and conducted empirical Bayesian data mining. Results : Of 241 2vHPV reports, 158 were in females, 64 in males (2vHPV is approved for [...]

Menée au Royaume-Uni auprès de 23 768 participants de la cohorte EPIC-Norfolk, cette étude évalue la performance d'un modèle, basé sur des facteurs de risque liés au mode de vie et stipulés dans le code européen contre le cancer, pour prédire l'incidence des principaux cancers évitables (poumon, colorectal, vessie, rein, œsophage, sein et endomètre)

Development and validation of lifestyle-based models to predict incidence of the most common potentially preventable cancers

Usher-Smith, Juliet A. ; Sharp, Stephen J. ; Luben, Robert ; Griffin, Simon J.

Background: Most risk models for cancer are either specific to individual cancers or include complex or predominantly non-modifiable risk factors. Methods: We developed lifestyle-based models for the five cancers for which the most cases are potentially preventable through lifestyle change in the UK (lung, colorectal, bladder, kidney and oesophageal for men and breast, lung, colorectal, endometrial and kidney for women). We selected lifestyle risk factors from the European Code against Cancer [...]