Menée aux Etats-Unis à partir de données portant sur 190 698 participants sur la période 1993-2013, cette étude de cohorte évalue les disparités ethniques dans l'association entre une consommation d'alcool et le risque de cancer colorectal (durée de suivi : 16,7 ans ; 4 923 cas)

Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study

Park, Song-Yi ; Wilkens, Lynne R. ; Setiawan, Veronica Wendy ; Monroe, Kristine R. ; Haiman, Christopher A. ; Le Marchand, Loic

To investigate the association of alcohol intake with colorectal cancer risk by race/ethnicity as well as sex, lifestyle-related factors, alcoholic beverage type, and anatomical subsite, we analyzed data from 190,698 African Americans, Native Hawaiians, Japanese Americans, Latinos and whites in the Multiethnic Cohort Study, with 4,923 incident cases during a 16.7-year follow-up period (1993-2013). In multivariate Cox regression models, the hazard ratio (HR) was 1.16 (95% confidence interval [...]

A partir des données de la cohorte européenne EPIC incluant 471 495 participants, cette étude prospective évalue l'association entre la qualité nutritionnelle des aliments et des boissons, mesurée grâce au score FSAm-NPS, et le risque de cancer (période de suivi de la cohorte : 1992-2014, durée médiane de suivi : 15,3 ans ; 49 794 cas)

Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study

Deschasaux, Mélanie ; Huybrechts, Inge ; Murphy, Neil ; Julia, Chantal ; Hercberg, Serge ; Srour, Bernard ; Kesse-Guyot, Emmanuelle ; Latino-Martel, Paule ; Biessy, Carine ; Casagrande, Corinne ; Jenab, Mazda ; Ward, Heather ; Weiderpass, Elisabete ; Dahm, Christina C. ; Overvad, Kim ; Kyrø, Cecilie ; Olsen, Anja ; Affret, Aurélie ; Boutron-Ruault, Marie-Christine ; Mahamat-Saleh, Yahya ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Schwingshackl, Lukas ; Bamia, Christina ; Peppa, Eleni ; Trichopoulou, Antonia ; Masala, Giovanna ; Krogh, Vittorio ; Panico, Salvatore ; Tumino, Rosario ; Sacerdote, Carlotta ; Bueno-de-Mesquita, Bas ; Peeters, Petra H. ; Hjartåker, Anette ; Rylander, Charlotta ; Skeie, Guri ; Ramón Quirós, J. ; Jakszyn, Paula ; Salamanca-Fernández, Elena ; Huerta, José María ; Ardanaz, Eva ; Amiano, Pilar ; Ericson, Ulrika ; Sonestedt, Emily ; Huseinovic, Ena ; Johansson, Ingegerd ; Khaw, Kay-Tee ; Wareham, Nick ; Bradbury, Kathryn E. ; Perez-Cornago, Aurora ; Tsilidis, Konstantinos K. ; Ferrari, Pietro ; Riboli, Elio ; Gunter, Marc J. ; Touvier, Mathilde

Background : Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of a simplified labelling system to reflect the nutritional quality of food products. The Nutri-Score, a five-colour nutrition label, is derived from the Nutrient Profiling System of the British Food Standards Agency (modified version) (FSAm-NPS). How the consumption of foods with high/low FSAm-NPS [...]

A partir d'une revue de la littérature, cette étude évalue l'association entre l'alimentation et le risque de mélanome cutané, en fonction des types d'aliments, de nutriments et de boissons consommés

An Epidemiological Review of Diet and Cutaneous Malignant Melanoma

Yang, Keming ; Fung, Teresa T. ; Nan, Hongmei

Incidence of cutaneous malignant melanoma has continued to rise despite public efforts to promote sun protection behaviors among populations at risk. However, dietary factors may also affect the development of melanoma. In the past few decades, findings from epidemiologic and experimental research have linked consumption of several foods and other nutrients to the risk of melanoma. Caffeine has been associated with a lower risk of melanoma, and citrus fruits and alcohol with increased risk. [...]

A partir des données de deux cohortes néerlandaises incluant respectivement 120 852 et 40 011 participants, cette étude évalue l'association entre l'adhésion à un régime alimentaire de type méditerranéen et le risque de cancer du pancréas (durées médianes de suivi : 20,3 et 19,2 ans ; 449 cas)

Mediterranean diet adherence and risk of pancreatic cancer: A pooled analysis of two Dutch cohorts

Schulpen, Maya ; Peeters, Petra H. ; Brandt, Piet A.

Studies investigating the association of Mediterranean diet (MD) adherence with pancreatic cancer risk are limited and had inconsistent results. We examined the association between MD adherence and pancreatic cancer incidence by pooling data from the Netherlands Cohort Study (NLCS, 120852 subjects) and the Dutch cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-NL, 40011 subjects). MD adherence was assessed using alternate and modified Mediterranean diet scores [...]

Menée aux Etats-Unis à partir de données portant sur 1 968 patientes atteintes d'un cancer du sein après la ménopause, cette étude de cohorte évalue l'association entre un régime alimentaire riche en œstrogènes et le risque de développer la maladie (période de suivi : 261 959 personnes-années)

An Estrogen-Related Dietary Pattern and Postmenopausal Breast Cancer Risk in a Cohort of Women with a Family History of Breast Cancer

Guinter, Mark A. ; Sandler, Dale P. ; McLain, Alexander C. ; Merchant, Anwar T. ; Steck, Susan E.

Background: The results of previous studies on diet and postmenopausal breast cancer risk have been inconclusive, but there is some evidence that dietary patterns developed to correlate with estrogen levels are associated with breast cancer. We aimed to examine the association of a previously developed estrogen-related dietary pattern (ERDP) with postmenopausal breast cancer in the Sister Study. Methods: The ERDP was calculated from food frequency questionnaire responses among Sister Study [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'association entre une exposition environnementale ou d'origine professionnelle à des biphényles polychlorés et le risque de développer un lymphome non hodgkinien

Occupational and environmental exposure to polychlorinated biphenyls and risk of non-Hodgkin lymphoma: a systematic review and meta-analysis of epidemiology studies

Catalani, Simona ; Donato, Francesca ; Tomasi, Cesare ; Pira, Enrico ; Apostoli, Pietro ; Boffetta, Paolo

We carryied out a meta-analysis of studies on exposure to polychlorinated biphenyls (PCBs) and risk of non-Hodgkin lymphoma (NHL). Through a systematic search of the literature, we identified relative risks (RRs) for PCB exposure and NHL risk in 30 populations (10 occupational exposure, seven high environmental exposure, 13 without special exposure). We performed random effects meta-analyses for exposure to all PCBs, specific PCB congeners and risk of all NHL and NHL subtypes. The meta-RR for [...]

Menée à Taïwan à partir de données portant sur plus de 350 000 cuisiniers, cette étude évalue les disparités, selon le sexe, dans l'association entre une exposition professionnelle aux fumées des huiles de cuisson et le risque de cancer du poumon, sur la période 1984-2011

Gender differences and lung cancer risk in occupational chefs: analyzing more than 350,000 chefs in Taiwan, 1984–2011

Lin, Pei-Chen ; Peng, Chiung-Yu ; Pan, Chih-Hong ; Lin, Pi-I Debby ; Wu, Ming-Tsang

Objectives : Cooking oil fumes (COFs) contain many carcinogens. We investigated the association between COFs and incidence risk of any cancer and lung cancer in chefs. Methods : We identified Chinese food chefs and non-Chinese food chefs from Taiwan’s national database of certified chefs in 1984–2007. Of them, 379,275 had not been diagnosed as having any cancer before chef certification. We followed them in Taiwan’s Cancer Registry Database (1979–2010) and Taiwan’s National Death Statistics [...]

Menée en France à partir de données portant sur 79 365 femmes âgées entre 40 et 65 ans, cette étude de cohorte prospective évalue l'association entre l'utilisation d'une contraception orale et le risque de mélanome cutané (période de suivi : 1992-2008 ; 539 cas)

Oral contraceptive use and cutaneous melanoma risk: a French prospective cohort study

Cervenka, I. ; Mahamat-Saleh, Y. ; Savoye, I. ; Dartois, L. ; Boutron-Ruault, M.C. ; Fournier, A. ; Kvaskoff, M.

Cutaneous melanoma has been suspected to be influenced by female hormones. Several studies reported a positive association between oral contraceptive (OC) use and melanoma risk. However, findings were conflicting and data from large prospective studies are lacking. E3N is a prospective cohort of 98,995 French women aged 40–65 years at inclusion in 1990. Exposure to lifetime OC use was assessed in 1992 and through biennial questionnaire updates. To assess the association between OC use and [...]

A partir d'une cartographie du réseau d'interactions entre protéines du papillomavirus humain (HPV) et protéines de l'hôte, cette étude identifie un ensemble de mécanismes cellulaires par lesquels un virus tel que le HPV induit une oncogenèse

Multiple Routes to Oncogenesis are Promoted by the Human Papillomavirus-Host Protein Network

Eckhardt, Manon ; Zhang, Wei ; Gross, Andrew M ; Von Dollen, John ; Johnson, Jeffrey R ; Franks-Skiba, Kathleen E ; Swaney, Danielle L ; Johnson, Tasha L ; Jang, Gwendolyn M ; Shah, Priya S ; Brand, Toni M ; Archambault, Jacques ; Kreisberg, Jason F. ; Grandis, Jennifer R. ; Ideker, Trey ; Krogan, Nevan J

We have mapped a global network of virus-host protein interactions by purification of the complete set of Human Papillomavirus (HPV) proteins in multiple cell lines followed by mass spectrometry analysis. Integration of this map with tumor genome atlases shows that the virus targets human proteins frequently mutated in HPV(-) but not HPV(+) cancers, providing a unique opportunity to identify novel oncogenic events phenocopied by HPV infection. For example, we find that the Nrf2 transcriptional [...]

Menée aux Etats-Unis à partir de données portant sur 96 650 participants, dont 125 patients atteints d'un cancer de l'œsophage et 372 témoins, cette étude évalue l'association entre la présence, dans la cavité buccale, de papillomavirus humains de type alpha, bêta et gamma, et le risque de développer la maladie

Oral Alpha, Beta, and Gamma HPV Types and Risk of Incident Esophageal Cancer

Agalliu, Ilir ; Chen, Zigui ; Wang, Tao ; Hayes, Richard B. ; Freedman, Neal D. ; Gapstur, Susan M. ; Burk, Robert D.

Background: Several studies have examined association between human papillomaviruses (HPV) and esophageal cancer, but results have been inconsistent. This is the first prospective study to investigate associations between α, β and γ HPV detection in the oral cavity and risk of esophageal cancer. Methods: We conducted a nested case–control study among 96,650 cancer-free participants in the American Cancer Society Cancer Prevention Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer [...]

Menée en Corée à partir de données portant sur 23 530 patients diabétiques atteints d'un cancer métastatique diagnostiqué entre 2009 et 2011, cette étude évalue l'association entre divers traitements hypoglycémiants (inhibiteurs anti-DPP-4, metformine, insuline) et le risque de développer des métastases

Association between glucose-lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy

Noh, Yoojin ; Jeon, Sang-Min ; Shin, Sooyoung

Preclinical data suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors may promote metastatic progression of preexisting cancer via nuclear factor erythroid 2 related factor 2 (NRF2) activation. We aimed to investigate the association between different glucose-lowering treatments, including DPP-4 inhibitors and metformin, both with potential NRF2 modulating effects, and new-onset metastatic cancer among type 2 diabetes patients with comorbid incident cancer. This population-based cohort [...]

Menée en Europe à partir de données portant sur 1 705 patients atteints d'un cancer du pancréas et sur 1 084 témoins, cette étude évalue l'association entre des maladies auto-immunes et le risque de développer la maladie

Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches

Gomez-Rubio, Paulina ; Piñero, Janet ; Molina-Montes, Esther ; Gutiérrez-Sacristán, Alba ; Marquez, Mirari ; Rava, Marta ; Michalski, Christoph W. ; Farré, Antoni ; Molero, Xavier ; Löhr, Matthias ; Perea, José ; Greenhalf, William ; O'Rorke, Michael ; Tardon, Adonina ; Gress, Thomas ; Barberà, Victor M. ; Crnogorac-Jurcevic, Tatjana ; Muñoz-Bellvís, Luís ; Domínguez-Muñoz, Enrique ; Balsells, Joaquim ; Costello, Eithne ; Yu, Jingru ; Iglesias, Mar ; Ilzarbe, Lucas ; Kleeff, Jorg ; Kong, Bo ; Mora, Josefina ; Murray, Liam ; O'Driscoll, Damian ; Poves, Ignasi ; Lawlor, Rita T. ; Ye, Weimin ; Hidalgo, Manuel ; Scarpa, Aldo ; Sharp, Linda ; Carrato, Alfredo ; Real, Francisco X. ; Furlong, Laura I. ; Malats, Nuria

Deciphering the underlying genetic basis behind pancreatic cancer PC and its associated multimorbidities will enhance our knowledge towards PC control. The study investigated the common genetic background of PC and different morbidities through a computational approach and further evaluated the less explored association between PC and autoimmune diseases AIDs through an epidemiological analysis. Gene-disease associations GDAs of 26 morbidities of interest and PC were obtained using the DisGeNET [...]