A partir d'une revue systématique de la littérature (33 essais, 3 257 patients), cette étude évalue l'intérêt, du point de vue de la qualité de vie des patients atteints de cancer, d'une activité physique aérobique (marche, course à pied, vélo) pendant une chimiothérapie

A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment

Cave, J. ; Paschalis, A. ; Huang, C. Y. ; West, M. ; Copson, E. ; Jack, S. ; Grocott, M. P. W.

Purpose : Aerobic exercise improves prognosis and quality of life (QoL) following completion of chemotherapy. However, the safety and efficacy of aerobic exercise during chemotherapy is less certain. A systematic review was performed of randomised trials of adult patients undergoing chemotherapy, comparing an exercise intervention with standard care. Method : From 253 abstracts screened, 33 unique trials were appraised in accordance with PRISMA guidance, including 3257 patients. Interventions [...]

Menée au Canada auprès de 268 patients atteints de cancer et traités en milieu ambulatoire, cette étude analyse la pertinence d'un outil permettant de détecter et de prendre en charge leurs symptômes, et évalue son effet sur la qualité de vie et sur leurs besoins en soins de support

The impact of automated screening with Edmonton Symptom Assessment System (ESAS) on health-related quality of life, supportive care needs, and patient satisfaction with care in 268 ambulatory cancer patients

Diplock, Benjamin D. ; McGarragle, Kaitlin M. C. ; Mueller, Willem A. ; Haddad, Sana ; Ehrlich, Rachel ; Yoon, Dong-Hyun A. ; Cao, Xingshan ; Al-Allaq, Yaseen ; Karanicolas, Paul ; Fitch, Margaret I. ; Myers, Jeff ; Mitchell, Alex J. ; Ellis, Janet W. M.

Purpose : We aimed to assess the impact of implementing Edmonton Symptom Assessment System (ESAS) screening on health-related quality of life (HRQoL) and patient satisfaction with care (PSC) in ambulatory oncology patients. ESAS is now a standard of care in Ontario cancer centers, with the goal of improving symptom management in cancer patients, yet few studies examine impact of ESAS on patient outcomes. Methods : We compared ambulatory oncology patients who were not screened prior to ESAS site [...]

Menée en Italie à partir de données portant sur 246 patientes atteintes d'un cancer du sein traité par des chimiothérapies à base d'anthracycline et de cyclophosphamide, cette étude prospective analyse le risque de nausées et vomissements induits par la chimiothérapie, et évalue l'adhésion aux recommandations relatives à l'utilisation de médicaments antiémétiques

Incidence of nausea and vomiting in breast cancer patients treated with anthracycline plus cyclophosphamide-based chemotherapy regimens in Italy: NAVY observational study

De Laurentiis, Michelino ; Bonfadini, Chiara ; Lorusso, Vito ; Cilenti, Giuseppina ; Di Rella, Francesca ; Altavilla, Giuseppe ; Otero, Manuela ; Ardizzoia, Antonio ; Marchetti, Paolo ; Peverelli, Giorgia ; Amoroso, Domenico ; Vecchio, Stefania ; Fiorio, Elena ; Orecchia, Simona

Purpose : Chemotherapy-induced nausea and vomiting (CINV) is a common adverse event with cancer chemotherapy, despite the availability of effective antiemetic agents. This is a prospective observational study of Italian breast cancer patients treated with anthracycline plus cyclophosphamide (AC), assessed CINV incidence, adherence to national antiemetic guidelines (AIOM 2012), and the relationship with CINV outcomes. Methods : Patients with breast cancer scheduled to receive their first cycle [...]

Menée aux Pays-Bas à partir de données portant sur 99 enfants atteints d'une leucémie lymphoblastique aiguë, cette étude évalue l'association entre les niveaux sériques de vitamine D et le risque de mucite buccale induite par le méthotrexate

A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

Oosterom, N. ; Dirks, N. F. ; Heil, S. G. ; de Jonge, R. ; Tissing, W. J. E. ; Pieters, R. ; van den Heuvel-Eibrink, M. M. ; Heijboer, A. C. ; Pluijm, S. M. F.

Purpose : Children with acute lymphoblastic leukemia (ALL) are at increased risk of vitamin D deficiency, which might make them more susceptible to developing adverse events. Previous studies showed that low vitamin D levels were associated with an increased inflammatory mucosal state and impaired mucosal tissue barriers. We examined the prevalence of vitamin D deficiency and studied the association between vitamin D levels and methotrexate (MTX)-induced oral mucositis in pediatric ALL. Methods [...]

A partir des données de plusieurs registres européens et des registres américains des cancers sur la période 2003-2014, cette étude analyse les disparités dans l'utilisation de la chimiothérapie et de la radiothérapie chez des patients atteints d'un cancer du pancréas, ayant subi ou non une résection

Non-surgical therapies for resected and unresected pancreatic cancer in Europe and USA in 2003-2014: A large international population-based study

Huang Lei ; Jansen Lina ; Balavarca Yesilda ; van der Geest Lydia ; Lemmens Valery ; Van Eycken Liesbet ; De Schutter Harlinde ; Johannesen Tom B. ; Primic‐Žakelj Maja ; Zadnik Vesna ; Mägi Margit ; Pulte Dianne ; Schrotz‐King Petra ; Brenner Hermann

The role of chemotherapy in the treatment of pancreatic cancer (PaC) has been well‐established, while radiation plays ambiguous roles. This international large‐scale population‐based study aimed to investigate the real‐world application of chemotherapy and radiotherapy for resected and unresected PaC in Europe and USA. Population‐based data from multiple European national cancer registries and the US Surveillance, Epidemiology, and End Results (SEER)‐18 database during 2003‐2014 were analyzed. [...]

Menée aux Etats-Unis à partir de données portant sur 338 445 patients atteints d'un cancer du poumon non à petites cellules de stade métastatique (stade IV) diagnostiqué entre 2004 et 2014, cette étude rétrospective analyse l'association entre le volume d'activité du centre hospitalier, la survie des patients et la mortalité

Association between hospital volume and mortality of patients with metastatic non-small cell lung cancer

Goyal, Gaurav ; Kommalapati, Anuhya ; Bartley, Adam C. ; Gunderson, Tina M. ; Adjei, Alex A. ; Go, Ronald S.

Background : Prior studies have shown superior surgical outcomes of stage I-III non-small cell lung cancer (NSCLC) in centers with higher patient volumes. However, there is a lack of such information in stage IV NSCLC. Patients and Methods : This is a retrospective study of stage IV NSCLC patients diagnosed between 2004 and 2014 using the National Cancer Data Base (NCDB). We classified the total number of patients treated at facilities into quartiles: quartile 1 (Q1): < 23; quartile 2 (Q2): 24 [...]

A partir des données de registres de pays scandinaves portant sur 721 patients ayant survécu au moins 5 ans à un neuroblastome pédiatrique, cette étude analyse le risque à long terme d'hospitalisation et de maladies somatiques (maladies du sang, maladies endocriniennes, maladies du système circulatoire, maladies du système nerveux)

Somatic late effects in 5-year survivors of neuroblastoma: A population- based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

Norsker Filippa Nyboe ; Rechnitzer Catherine ; Cederkvist Luise ; Tryggvadottir Laufey ; Madanat‐Harjuoja Laura‐Maria ; Øra Ingrid ; Thorarinsdottir Halldora K. ; Vettenranta Kim ; Bautz Andrea ; Schrøder Henrik ; Hasle Henrik ; Winther Jeanette Falck

Because of the rarity of neuroblastoma and poor survival until the 1990s, information on late effects in neuroblastoma survivors is sparse. We comprehensively reviewed the long‐term risk for somatic disease in neuroblastoma survivors. We identified 721 5‐year survivors of neuroblastoma in Nordic population‐based cancer registries and identified late effects in national hospital registries covering the period 1977–2012. Detailed treatment information was available for 46% of the survivors. The [...]

A partir des données des registres américains des cancers sur la période 2000-2014, cette étude analyse les disparités ethniques dans l'évolution du risque de gliome chez l'adulte, et dans la survie à 1 et 5 ans (244 808 cas)

Adult glioma incidence and survival by race or ethnicity in the United States from 2000 to 2014

Ostrom, Q. T. ; Cote, D. J. ; Ascha, M. ; Kruchko, C. ; Barnholtz-Sloan, J. S.

Importance : Glioma is the most commonly occurring malignant brain tumor in the United States, and its incidence varies by age, sex, and race or ethnicity. Survival after brain tumor diagnosis has been shown to vary by these factors. Objective : To quantify the differences in incidence and survival rates of glioma in adults by race or ethnicity. Design, Setting, and Participants : This population-based study obtained incidence data from the Central Brain Tumor Registry of the United States and [...]

A partir des données du registre danois des cancers portant sur 6 694 patientes âgées de 30 à 84 ans et atteintes d'un cancer de l'endomètre diagnostiqué entre 2000 et 2012, cette étude évalue l'association entre une utilisation de statines et la mortalité spécifique ou la mortalité par autre cause (durée médiane de suivi : 4,5 ans ; 753 décès par cancer de l'endomètre, 765 décès par autre cause)

Statin use and mortality among endometrial cancer patients: a Danish nationwide cohort study

Dyg Sperling Cecilie ; Verdoodt Freija ; Kjær Hansen Merete ; Dehlendorff Christian ; Friis Søren ; Kjaer Susanne K.

Statin use has been linked to improved prognosis of some cancer types, however, for endometrial cancer, the results are equivocal. We therefore examined the effect of statin use on endometrial cancer mortality. From the Danish Cancer Registry, we identified all women in Denmark aged 30‐84 years with primary endometrial cancer during 2000‐2012. Data on drug use, mortality outcomes and potential confounders were retrieved from nationwide registries. We used Cox proportional hazards regression [...]

A partir de données portant sur 201 patients atteints d'un carcinome épidermoïde de l'oropharynx, cette étude évalue l'association entre un marqueur de la présence d'un tréponème (Treponema denticola), le statut du papillomavirus humain, l'expression des récepteurs TLR 5, TLR 7 et TLR 9 et la survie

Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma

Kylmä, Anna Kaisa ; Jouhi, Lauri ; Listyarifah, Dyah ; Mohamed, Hesham ; Mäkitie, Antti ; Remes, Satu Maria ; Haglund, Caj ; Atula, Timo ; Nieminen, Mikko T. ; Sorsa, Timo ; Hagström, Jaana

Background : An opportunistic oral pathogen, Treponema denticola (Td), has been linked to orodigestive carcinogenesis, but its role in oropharyngeal squamous cell carcinoma (OPSCC) has remained open. We evaluated the presence of Td chymotrypsin-like protease (Td-CTLP) in a series of 201 unselected consecutive OPSCC patients, and the relation of the Td-CTLP to human papillomavirus (HPV) status, to expression of toll-like receptors (TLR) 5, 7, and 9, and to clinical parameters and patient [...]

Menée au Royaume-Uni à partir de données portant sur 220 patients atteints d'un carcinome épidermoïde de la tête et du cou de stade métastatique, cette étude analyse les diverses lignes de traitements reçus, l'utilisation des soins et des ressources de santé

Treatment patterns and health care resource use in patients receiving multiple lines of therapy for metastatic squamous cell carcinoma of the head and neck in the United Kingdom

La Elizabeth M. ; Smyth Emily Nash ; Talbird Sandra E. ; Li Li ; Kaye James A. ; Lin Aimee Bence ; Bowman Lee

This study evaluated the patterns of care and health care resource use (HCRU) in patients with metastatic squamous cell carcinoma of the head and neck (SCCHN) who received ≥3 lines of systemic therapy in the United Kingdom (UK). Oncologists (n = 40) abstracted medical records for patients with metastatic SCCHN who initiated third‐line systemic therapy during 1 January 2011–30 August 2014 (n = 220). Patient characteristics, treatment patterns and SCCHN‐related HCRU were summarised descriptively [...]

Menée au Portugal et en Italie à partir de données portant sur 195 patients atteints de cancer et traités à l'extérieur de l'hôpital, cette étude évalue l'association entre un syndrome de démoralisation, une anxiété, une dépression, la qualité de vie et des idées suicidaires

Relationship of demoralization with anxiety, depression and quality of life: A Southern European study of Italian and Portuguese cancer patients

Nanni Maria Giulia ; Caruso Rosangela ; Travado Luzia ; Ventura Cidalia ; Palma Alessandra ; Berardi Alejandra M. ; Meggiolaro Elena ; Ruffilli Federica ; Martins Cristina ; Kissane David ; Grassi Luigi

Background : Demoralization syndrome is a significant condition that has not been greatly studied in Southern European countries. Aims To extend the knowledge of demoralization in Southern Europe by examining its prevalence according to different methods of assessment, its relationship with anxiety and depression, and its impact on quality of life among cancer patients. Methods : A convenience sample of 195 cancer outpatients from two oncology centers (102 from Lisbon, Portugal and 93 from [...]

Menée aux Pays-Bas auprès de 378 patients atteints de divers types de cancers, cette étude analyse l'évolution, pendant les 18 mois suivant le retour au travail, de leurs symptômes cognitifs, de leur fatigue et de leurs symptômes dépressifs en lien avec le contexte professionnel

Work-specific cognitive symptoms and the role of work characteristics, fatigue and depressive symptoms in cancer patients during 18 months post return to work

Dorland H.F. ; Abma F.I. ; Roelen C.A.M. ; Stewart R. ; Amick B.C. ; Bültmann U. ; Ranchor A.V.

Objective : Cancer patients can experience work‐specific cognitive symptoms post return to work (RTW). The study aims to: 1) describe the course of work‐specific cognitive symptoms in the first 18 months post RTW, and 2) examine the associations of work characteristics, fatigue and depressive symptoms with work‐specific cognitive symptoms over time. Methods : This study used data from the 18‐months longitudinal “Work Life after Cancer” cohort. The Cognitive Symptom Checklist‐Work, Dutch Version [...]

Menée aux Etats-Unis à partir de données portant sur 15 620 patients adultes ayant survécu à un cancer pédiatrique (âge médian : 26 ans ; durée médiane depuis le diagnostic : 17 ans) et sur 3 991 témoins, cette étude analyse leurs perceptions relatives aux risques concernant leur santé et notamment le risque de cancer ultérieur en lien avec les traitements reçus

Perceptions of future health and cancer risk in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Gibson Todd M. ; Li Chenghong ; Armstrong Gregory T. ; Srivastava Deo Kumar ; Leisenring Wendy M. ; Mertens Ann ; Brinkman Tara M. ; Diller Lisa ; Nathan Paul C. ; Hudson Melissa M. ; Robison Leslie L.

BACKGROUND Survivors of childhood cancer are at significant risk for serious chronic health conditions and subsequent cancers because of their prior treatment exposures. However, little is known about survivors' perceptions of their future health risks. METHODS This study examined self‐reported levels of concern about future health and subsequent cancer in 15,620 adult survivors of childhood cancer (median age, 26 years; median time since diagnosis, 17 years) and 3991 siblings in the Childhood [...]

Menée aux Pays-bas auprès de 2 144 patients atteints d'un cancer de la tête et du cou, cette étude de cohorte évalue l'association entre des symptômes dépressifs, avant et pendant la première année suivant le diagnostic de la maladie, et la survie globale

Depressive symptoms in relation to overall survival in people with head and neck cancer: a longitudinal cohort study

Jansen Femke ; Verdonck‐de Leeuw Irma M. ; Cuijpers Pim ; Leemans C. René ; Waterboer Tim ; Pawlita Michael ; Penfold Chris ; Thomas Steven J. ; Waylen Andrea ; Ness Andrew R.

Objective: To investigated the relation between pre‐treatment depressive symptoms (DS) and the course of DS during the first year after cancer diagnosis, and overall survival among people with head and neck cancer (HNC). Methods : Data from the Head and Neck 5000 prospective clinical cohort study were used. DS were measured using the Hospital Anxiety and Depression Scale (HADS) pre‐treatment, at 4 and 12 months follow‐up. Also socio‐demographic, clinical, lifestyle and mortality data were [...]

Menée aux Etats-Unis par enquête auprès de 698 patients ayant survécu à un cancer pédiatrique (âge médian : 36, 3 ; durée médiane depuis le diagnostic : 28,8 ans), cette étude analyse les facteurs (état de santé, assurance maladie, ...) associés à l'utilisation de soins de santé de ville, notamment les consultations médicales auprès d'infirmiers, de médecins généralistes ou spécialistes

Insurance, chronic health conditions, and utilization of primary and specialty outpatient services: a Childhood Cancer Survivor Study report

Mueller, Emily L. ; Park, Elyse R. ; Kirchhoff, Anne C. ; Kuhlthau, Karen ; Nathan, Paul C. ; Perez, Giselle K. ; Rabin, Julia ; Hutchinson, Raymond ; Oeffinger, Kevin C. ; Robison, Leslie L. ; Armstrong, Gregory T. ; Leisenring, Wendy M. ; Donelan, Karen

Purpose : Survivors of childhood cancer require life-long outpatient healthcare, which may be impacted by health insurance. This study sought to understand survivors’ utilization of outpatient healthcare provider services. Methods : The study examined cross-sectional survey data using an age-stratified sample from the Childhood Cancer Survivor Study of self-reported annual use of outpatient services. Multivariable logistic regression analyses were used to identify risk factors associated with [...]

Cet article plaide pour la prise en compte des coûts restant à charge des patients atteints de cancer dans l'analyse des coûts de santé en oncologie et dans la réforme du système de santé américain

The urgent need in oncology for a comprehensive cost of care task force

Palmer, J. D. ; Patel, T. T. ; Fisher, S. A.

Unsustainable health care costs have long been recognized and are fueling ongoing debate on health care reform. Health care reform grossly addresses societal financial burden but often undermines the significant financial hardship experienced by patients with chronic illnesses. Patients with cancer are especially vulnerable and bear higher out-of-pocket costs than do patients with other chronic illnesses.

A partir d'une revue systématique de la littérature publiée entre 1990 et 2016, cette étude évalue, du point de vue d'indicateurs bibliométriques (nombre d'articles publiés, indice de citation, facteur d'impact, ...), l'intérêt des registres cliniques des cancers colorectaux dans la recherche sur le cancer colorectal

The value of clinical colorectal cancer registries in colorectal cancer research: A systematic review

MacCallum, C. ; Skandarajah, A. ; Gibbs, P. ; Hayes, I.

Importance : Clinical colorectal cancer registries (CCCRs) are potentially powerful tools in colorectal cancer research. They are resource intensive, but to our knowledge, no formal review of their value exists. While quality control, clinical audit, and benchmarking are important factors in assessing the value of maintaining CCCRs, they are difficult to quantify. This study focuses on registry research output as a measure of value; the study hypothesizes that CCCRs do not produce sufficient [...]