Menée en Chine à partir de données portant sur 535 patients atteints d'un cancer colorectal et sur 552 témoins, cette étude évalue l'association entre le niveau sérique de vitamine A et de vitamine E d'origine alimentaire et le risque de cancer colorectal

Dietary and serum vitamins A and E and colorectal cancer risk in Chinese population: a case–control study

Luo, Hong ; Fang, Yu-Jing ; Lu, Min-Shan ; Pan, Zhi-Zhong ; Huang, Jing ; Chen, Yu-ming ; Zhang, Cai-xia

The effect of vitamin A (VA) and vitamin E (VE) on colorectal cancer (CRC) risk is controversial. The aim of this study is to examine the association between serum concentrations and dietary intakes of VA and VE and the risk of CRC in Guangdong, China. A total of 535 cases and 552 sex and age-matched (5-year interval) controls were recruited during July 2010 to September 2014. Dietary information was assessed by face-to-face interviews using a validated food frequency questionnaire. [...]

Menée en population américaine, cette étude cas-témoins évalue l'association entre une consommation d'aliments riches en graisses et le risque de néoplasie précoce du côlon proximal, détectée par coloscopie haute-définition

Associations of dietary fat with risk of early neoplasia in the proximal colon in a population-based case–control study

Mo, Allen ; Wu, Rong ; Grady, James P. ; Hanley, Matthew P. ; Toro, Margaret ; Swede, Helen ; Devers, Thomas J. ; Hartman, Terryl J. ; Rosenberg, Daniel W.

Purpose : Excess dietary fat consumption is strongly associated with the risk of colorectal cancer, but less is known about its role in the earliest stages of carcinogenesis, particularly within the proximal colon. In the following case–control study, we evaluated the relationship between the intake of dietary fats and the frequency of early proximal neoplasia [aberrant crypt foci (ACF) or polyps], detectable by high-definition colonoscopy with contrast dye-spray. Methods : Average-risk [...]

A partir d'une revue systématique de la littérature (98 études), cette étude analyse la prévalence d'une infection par Helicobacter pylori dans certains secteurs et groupes professionnels (professionnels de la santé, professionnels du secteur agricole et forestier, mineurs, etc.) et fait l'hypothèse d'un mode de transmission spécifique à ces activités

The occupational risk of Helicobacter pylori infection: a systematic review

Kheyre, Hassan ; Morais, Samantha ; Ferro, Ana ; Costa, Ana Rute ; Norton, Pedro ; Lunet, Nuno ; Peleteiro, Bárbara

Purpose : The aim of this systematic review was to describe the prevalence of Helicobacter pylori infection in specific occupational groups and to compare them with the general population. Methods : We searched PubMed® to identify original studies reporting the prevalence of H. pylori infection in occupational groups. The differences between occupational groups and the general population were analyzed taking into account the direction and statistical significance of the differences observed [...]

A partir des données de 11 études portant sur 29 049 patients atteints d'une leucémie diagnostiquée avant l'âge de 5 ans et sur 68 231 témoins, cette étude évalue l'effet, sur le risque de développer la maladie, de la distance entre le lieu de résidence et des lignes électriques aériennes

Proximity to overhead power lines and childhood leukaemia: an international pooled analysis

Amoon, Aryana T. ; Crespi, Catherine M. ; Ahlbom, Anders ; Bhatnagar, Megha ; Bray, Isabelle ; Bunch, Kathryn J. ; Clavel, Jacqueline ; Feychting, Maria ; Hémon, Denis ; Johansen, Christoffer ; Kreis, Christian ; Malagoli, Carlotta ; Marquant, Fabienne ; Pedersen, Camilla ; Raaschou-Nielsen, Ole ; Röösli, Martin ; Spycher, Ben D. ; Sudan, Madhuri ; Swanson, John ; Tittarelli, Andrea ; Tuck, Deirdre M. ; Tynes, Tore ; Vergara, Ximena ; Vinceti, Marco ; Wünsch-Filho, Victor ; Kheifets, Leeka

Background : Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines. Methods : We present a pooled analysis combining individual-level data (29,049 cases and [...]

Menée sur un modèle murin, cette étude met en évidence le rôle du triclosan, un agent antibactérien et antifongique, dans l'augmentation de l'inflammation du côlon et dans la cancérogenèse colique

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Yang, Haixia ; Wang, Weicang ; Romano, Kymberleigh A. ; Gu, Min ; Sanidad, Katherine Z. ; Kim, Daeyoung ; Yang, Jun ; Schmidt, Birgitta ; Panigrahy, Dipak ; Pei, Ruisong ; Martin, Derek A. ; Ozay, E. Ilker ; Wang, Yuxin ; Song, Mingyue ; Bolling, Bradley W. ; Xiao, Hang ; Minter, Lisa M. ; Yang, Guang-Yu ; Liu, Zhenhua ; Rey, Federico E. ; Zhang, Guodong

Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. In addition, TCS treatment increases [...]

Menée au Danemark à partir de données portant sur 19 273 patients atteints d'un mélanome malin et sur 192 730 témoins, cette étude évalue l'association entre une utilisation d'hydrochlorothiazide, une molécule utilisée comme médicament diurétique de la classe des thiazidiques, et le risque de développer la maladie

Association of hydrochlorothiazide use and risk of malignant melanoma

Pottegard, A. ; Pedersen, S. ; Schmidt, S. ; Hölmich, L. ; Friis, S. ; Gaist, D.

We have recently shown that hydrochlorothiazide use increases the risk of lip and nonmelanoma skin cancer, notably squamous cell carcinoma.1,2 It would have substantial implications if the carcinogenic effect of hydrochlorothiazide also extended to malignant melanoma. Methods : Similarly to our recent studies of hydrochlorothiazide,1,2 we identified histologically verified melanoma cases (January 2004 to December 2015), each matched 1:10 (risk-set sampling; age, sex, and date) to cancer-free [...]

Menée auprès de 3 006 patients ayant survécu à un cancer pédiatrique (âge médian : 35,8 ans), cette étude analyse l'association entre la présence de mutations dans des gènes de prédisposition au cancer et le risque de développer un second cancer

Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer

Wang, Zhaoming ; Wilson, Carmen L. ; Easton, John ; Thrasher, Andrew ; Mulder, Heather ; Liu, Qi ; Hedges, Dale J. ; Wang, Shuoguo ; Rusch, Michael C. ; Edmonson, Michael N. ; Levy, Shawn ; Lanctot, Jennifer Q. ; Caron, Eric ; Shelton, Kyla ; Currie, Kelsey ; Lear, Matthew ; Patel, Aman ; Rosencrance, Celeste ; Shao, Ying ; Vadodaria, Bhavin ; Yergeau, Donald ; Sapkota, Yadav ; Brooke, Russell J. ; Moon, WonJong ; Rampersaud, Evadnie ; Ma, Xiaotu ; Chang, Ti-Cheng ; Rice, Stephen V. ; Pepper, Cynthia ; Zhou, Xin ; Chen, Xiang ; Chen, Wenan ; Jones, Angela ; Boone, Braden ; Ehrhardt, Matthew J. ; Krasin, Matthew J. ; Howell, Rebecca M. ; Phillips, Nicholas S. ; Lewis, Courtney ; Srivastava, Deokumar ; Pui, Ching-Hon ; Kesserwan, Chimene A. ; Wu, Gang ; Nichols, Kim E. ; Downing, James R. ; Hudson, Melissa M. ; Yasui, Yutaka ; Robison, Leslie L. ; Zhang, Jinghui

Purpose : Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed the contribution of pathogenic/likely pathogenic (P/LP) mutations in cancer predisposition genes to their SN risk. Patients and Methods : Whole-genome sequencing (30-fold) was performed on samples from childhood cancer survivors who were ≥ 5 years since initial cancer diagnosis and participants in the St Jude Lifetime Cohort Study, a [...]

A partir d'échantillons tumoraux prélevés sur 21 patientes atteintes d'un adénocarcinome pulmonaire diagnostiqué avant l'âge de 45 ans et n'ayant jamais fumé, cette étude identifie des mutations constitutionnelles de 8 gènes de prédisposition à la maladie

Germline mutations in young non-smoking women with lung adenocarcinoma

Donner, Iikki ; Katainen, Riku ; Sipilä, Lauri J. ; Aavikko, Mervi ; Pukkala, Eero ; Aaltonen, Lauri A.

Objectives : Although the primary cause of lung cancer is smoking, a considerable proportion of all lung cancers occur in never smokers. Gender influences the risk and characteristics of lung cancer and women are overrepresented among never smokers with the disease. Young age at onset and lack of established environmental risk factors suggest genetic predisposition. In this study, we used population-based sampling of young patients to discover candidate predisposition variants for lung [...]