Cette étude analyse les données récentes sur le traitement des nausées et vomissements chez les patients atteints de cancer, et présente des recommandations pour leur prise en charge lorsque les patients reçoivent des anticoagulants oraux directs pour prévenir et traiter la survenue d'accident thromboembolique veineux

Use of Direct Oral Anticoagulants in Patients with Cancer: Practical Considerations for the Management of Patients with Nausea or Vomiting

Riess, Hanno ; Ay, Cihan ; Bauersachs, Rupert ; Becattini, Cecilia ; Beyer‐Westendorf, Jan ; Cajfinger, Francis ; Chau, Ian ; Cohen, Alexander T. ; Khorana, Alok A. ; Maraveyas, Anthony ; Renni, Marcos ; Young, Annie M.

Direct oral anticoagulants (DOACs) have proven efficacy and safety and are approved for use in the prevention and treatment of thromboembolic events in patients with venous thromboembolism (VTE) and those with atrial fibrillation (AF). There is no clear guidance on the use of DOACs in the significant proportion of these patients who have or will develop concomitant cancer. The occurrence of nausea and vomiting in these patients, despite implementation of guideline‐recommended antiemetic [...]

Menée au Canada auprès de 50 patients atteints d'un cancer de la prostate (âge : 42-86 ans), cette étude analyse l'association entre le degré de pratique d'une activité physique, leur image corporelle, leur perception sur la masculinité et leur qualité de vie

Perceptions of masculinity and body image in men with prostate cancer: the role of exercise

Langelier, David Michael ; Cormie, Prue ; Bridel, William ; Grant, Christopher ; Albinati, Natalia ; Shank, Jena ; Daun, Julia Teresa ; Fung, Tak S. ; Davey, Colin ; Culos-Reed, S. Nicole

Purpose : The goal of this study was to explore the association between levels of exercise and patterns of masculinity, body image, and quality of life in men undergoing diverse treatment protocols for prostate cancer. Methods : Fifty men with prostate cancer (aged 42–86) completed self-report measures. Self-reported measures included the following: the Godin Leisure Time Exercise Questionnaire (GLTEQ), Masculine Self-esteem Scale (MSES), Personal Attributes Questionnaire (PAQ), Body Image [...]

A partir des données des registres américains des cancers portant sur 56 347 patients atteints d'un carcinome hépatocellulaire diagnostiqué entre 2000 et 2014, cette étude évalue l'association entre un désalignement circadien et le risque de développer la maladie

Circadian misalignment and hepatocellular carcinoma incidence in the United States

VoPham, Trang ; Weaver, Matthew D. ; Vetter, Céline ; Hart, Jaime E ; Tamimi, Rulla M. ; Laden, Francine ; Bertrand, Kimberly A.

Background: Circadian misalignment may increase the risk of developing hepatocellular carcinoma (HCC). The aim of this study was to examine the association between distance from time zone meridian, a proxy for circadian misalignment, and HCC risk in the U.S. adjusting for known HCC risk factors. Methods: Surveillance, Epidemiology, and End Results (SEER) provided information on 56,347 HCC cases diagnosed between 2000 and 2014 from 16 population-based cancer registries in the U.S. Distance from [...]

Menée aux Etats-Unis à partir des données portant sur 5 085 patients ayant survécu plus de 2 ans à un lymphome hodgkinien diagnostiqué entre l'âge de 15 et 39 ans sur la période 1996-2012, cette étude analyse les disparités socioéconomiques dans la survenue de divers types de maladies (maladies endocriniennes, maladies de l'appareil circulatoire, maladies de l'appareil respiratoire, maladie rénale chronique, maladies hépatiques, ...) et dans la survenue d'un second cancer

Sociodemographic disparities in the occurrence of medical conditions among adolescent and young adult Hodgkin lymphoma survivors

Keegan, Theresa H. M. ; Li, Qian ; Steele, Amy ; Alvarez, Elysia M. ; Brunson, Ann ; Flowers, Christopher R. ; Glaser, Sally L. ; Wun, Ted

Purpose : Hodgkin lymphoma (HL) survivors experience high risks of second cancers and cardiovascular disease, but no studies have considered whether the occurrence of these and other medical conditions differ by sociodemographic factors in adolescent and young adult (AYA) survivors. Methods : Data for 5,085 patients aged 15–39 when diagnosed with HL during 1996–2012 and surviving ≥ 2 years were obtained from the California Cancer Registry and linked to hospitalization data. We examined the [...]

Menée aux Etats-Unis à partir de données portant sur 1 661 patientes atteintes d'un cancer de l'ovaire diagnostiqué entre 1997 et 2012, cette étude analyse les disparités géographiques dans la survie, en fonction du lieu de résidence (zone rurale ou urbaine)

Rural-metropolitan disparities in ovarian cancer survival: A statewide population-based study

Park, Jihye ; Blackburn, Brenna E. ; Rowe, Kerry ; Snyder, John ; Wan, Yuan ; Deshmukh, Vikrant ; Newman, Michael ; Fraser, Alison ; Smith, Ken ; Herget, Kim ; Burt, Lindsay ; Werner, Theresa ; Gaffney, David K. ; Lopez, Ana Maria ; Mooney, Kathi ; Hashibe, Mia

Purpose : To investigate rural-metropolitan disparities in ovarian cancer survival, we assessed ovarian cancer mortality, and differences in prognostic factors by rural-metropolitan residence. Methods : The Utah Population Database was used to identify ovarian cancer cases diagnosed between 1997-2012. Residential location information at the time of cancer diagnosis was used to stratify rural-metropolitan residence. All-cause death and ovarian cancer death risks were estimated using Cox [...]

Menée en Suède à partir de données portant sur 4 262 paires de frères atteints d'un cancer de la prostate, cette étude analyse les similitudes de leur maladie, du point de vue du niveau du risque de récidive (score de Gleason, stade clinique, taux de PSA), selon les spécificités de leur fraternité (jumeaux monozygotes, jumeaux dizygotes, frères, demi-frères)

Concordance of Non–Low-Risk Disease Among Pairs of Brothers With Prostate Cancer

Fredrik Jansson ; Linda Drevin ; Thomas Frisell ; Pär Stattin ; Ola Bratt ; Olof Akre

Purpose : Prostate cancer among first-degree relatives is a strong risk factor for diagnosis of prostate cancer, and the contribution of heritable factors in prostate cancer etiology is high. We investigated how the concordance of non–low-risk prostate cancer among brothers is affected by their genetic relation. Methods : We identified 4,262 pairs of brothers with prostate cancer in the Prostate Cancer Database Sweden. Their cancers were categorized as low risk (Gleason score ≤ 6; clinical [...]

Menée aux Etats-Unis par enquête auprès de 698 patients ayant survécu à un cancer pédiatrique (âge médian : 39, 4 ans) et auprès de 210 témoins, cette étude analyse les facteurs associés à leur recours et à leur accès aux soins de santé psychique

Mental health insurance access and utilization among childhood cancer survivors: a report from the childhood cancer survivor study

Perez, Giselle K. ; Kirchhoff, Anne C. ; Recklitis, Christopher ; Krull, Kevin R. ; Kuhlthau, Karen A. ; Nathan, Paul C. ; Rabin, Julia ; Armstrong, Gregory T. ; Leisenring, Wendy ; Robison, Leslie L. ; Park, Elyse R.

Purpose : To describe and compare the prevalence of mental health access, preference, and use among pediatric cancer survivors and their siblings. To identify factors associated with mental health access and use among survivors. Methods : Six hundred ninety-eight survivors in the Childhood Cancer Survivor Study (median age = 39.4; median years from diagnosis = 30.8) and 210 siblings (median age = 40.4) were surveyed. Outcomes included having mental health insurance coverage, delaying care due [...]

Menée aux Pays-Bas auprès de 81 patients ayant survécu à un cancer, cette étude évalue l'efficacité d'une psychothérapie comportementale pour soulager une fatigue sévère après les traitements anticancéreux (durée moyenne de suivi : 10 ans)

Are the effects of cognitive behavior therapy for severe fatigue in cancer survivors sustained up to 14 years after therapy?

Van Gessel, Lidewij D. ; Abrahams, Harriët J. G. ; Prinsen, Hetty ; Bleijenberg, Gijs ; Heins, Marianne ; Twisk, Jos ; van Laarhoven, Hanneke W. M. ; Verhagen, Stans C. A. H. H. V. M. ; Gielissen, Marieke F. M. ; Knoop, Hans

Purpose : Cognitive behavior therapy (CBT) reduces cancer-related fatigue (CRF) in cancer survivors in the short term. We examined fatigue levels up to 14 years after CBT. Methods : Eligible participants of two randomized controlled trials who had completed CBT for CRF and a post-treatment assessment were contacted (n = 81). Fatigue was assessed with the subscale “fatigue severity” of the Checklist Individual Strength (CIS-fatigue). The course of fatigue over time was examined with linear mixed [...]

A partir d'une revue systématique de la littérature (27 articles), cette étude analyse le rapport coût-efficacité du test multigénique "Oncotype DX" pour aider à la décision thérapeutique chez des patientes atteintes d'un cancer du sein

Cost-Effectiveness Analyses of the 21-Gene Assay in Breast Cancer: Systematic Review and Critical Appraisal

Shi-Yi Wang ; Weixiong Dang ; Ilana Richman ; Sarah S. Mougalian ; Suzanne B. Evans ; Cary P. Gross

Purpose : Prior studies examining cost effectiveness of the 21-gene assay (Oncotype DX [ODX]) for women with hormone receptor–positive, early-stage breast cancer have yielded disparate results. We aimed to explore why these analyses may have yielded different conclusions. Methods : We conducted a systematic literature review of cost-effectiveness analyses (CEAs) of ODX. We examined the extent to which the structure of CEA modeling, the assumptions of the models, and the selection of input [...]

Menée à partir d'un modèle mathématique simulant le parcours clinique de patients âgés de 65 ans et atteints d'un carcinome épidermoïde de l'oropharynx de stade IVA , cette étude compare les rapports coût-efficacité d'une protonthérapie et d'une radiothérapie avec modulation d'intensité

Cost-effectiveness analysis of IMRT versus proton therapy for oropharyngeal squamous cell carcinoma

Sher, David J. ; Tishler, Roy B. ; Pham, Nhat-Long ; Punglia, Rinaa S.

Purpose : There has been a strong interest in using intensity-modulated proton beam therapy (PBT) instead of intensity-modulated radiation therapy (IMRT) in the management of stage III-IVB oropharynx cancer (OPC). In this study, we compared the cost-effectiveness of these two modalities. Methods : A Markov model was constructed to compare IMRT with PBT for a 65 year-old patient with stage IVA OPSCC. We assumed PBT led to a 25% reduction in: long-term xerostomia, short-term dysgeusia, and the [...]

Menée aux Etats-Unis à partir des données des services Medicaid et Medicare, cette étude analyse l'association entre les rémunérations, les défraiements ou les avantages perçus des laboratoires pharmaceutiques par les cancérologues (cadeaux, repas, voyages, rémunération des interventions et des activités liées à la recherche) et les décisions thérapeutiques pour deux pathologies bénéficiant de plusieurs options médicamenteuses (cancer métastatique à cellules rénales et leucémie myéloïde chronique)

Pharmaceutical industry payments and oncologists’ selection of targeted cancer therapies in medicare beneficiaries

Mitchell, A. P. ; Winn, A. N. ; Dusetzina, S. B.

Physicians and teaching hospitals in the United States receive approximately $7 billion from the pharmaceutical industry annually.1 These payments have been associated with higher-cost, brand-name pharmaceutical prescribing.2-4 Whether industry payments are associated with physician treatment choice in oncology is uncertain. We examined the association between oncologists’ receipt of payments from pharmaceutical manufacturers and drug selection in 2 situations where there are multiple treatment [...]