A partir des données du projet "The Cancer Genome Atlas" portant sur 287 patients atteints d'un carcinome épidermoïde de la tête et du cou et sur 130 patients atteints d'un carcinome épidermoïde du poumon, cette étude évalue l'association entre des altérations de gènes liées à une pratique tabagique et le risque de développer la maladie

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas

Desrichard, Alexis ; Kuo, Fengshen ; Chowell, Diego ; Lee, Ken-Wing ; Riaz, Nadeem ; Wong, Richard J. ; Chan, Timothy A. ; Morris, Luc G. T.

Background : Tobacco smoking creates DNA damage, inducing mutations and potentially altering the tumor immune microenvironment. These types of genetic and immune microenvironment alterations are critical factors known to affect tumor response to immunotherapy. Here we analyze the association between the mutational signature of tobacco smoking, tumor mutational load, and metrics of immune activity in squamous cell carcinomas arising in the head and neck and lung. Methods : Using RNA and DNA [...]

A partir des données de deux études prospectives américaines portant sur 1 530 patients atteints de mélanome cutané, sur 3 979 patients atteints d'un carcinome basocellulaire et sur 30 648 patients atteints d'un carcinome épidermoïde, cette étude évalue l'association entre une consommation d'aliments riches en graisses et le risque de développer un cancer de la peau

Fat intake and risk of skin cancer in US adults

Park, Min Kyung ; Li, Wen-Qing ; Qureshi, Abrar A. ; Cho, Eunyoung

Background: Fat intake has been associated with certain cancers, including colorectal, breast, and prostate cancers. However, literature on dietary fat and skin cancer has been limited. Methods: We examined the association between fat intake and risk of skin cancer including cutaneous malignant melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) within two prospective studies; the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Dietary [...]

A partir de données britanniques portant sur 2 636 patientes atteintes d'un cancer du sein après la ménopause et sur 123 546 témoins, cette étude évalue l'association entre une consommation de café et le risque de développer la maladie, en prenant en compte une utilisation d'un traitement hormonal substitutif de la ménopause

Interactions of coffee consumption and postmenopausal hormone use in relation to breast cancer risk in UK Biobank

Yaghjyan, Lusine ; Rich, Shannan ; Mao, Liang ; Mai, Volker ; Egan, Kathleen M.

Purpose : We investigated the association of coffee consumption with postmenopausal breast cancer risk, overall and by the status of postmenopausal hormone therapy (PMH). Methods : This study included 126,182 postmenopausal women (2,636 with breast cancer and 123,546 without) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Information on breast cancer risk factors and coffee consumption was collected at baseline and [...]

Menée en France auprès de 383 hommes atteints d'un cancer de l'hypopharynx, de 454 hommes atteints d'un cancer du larynx et de 2 780 témoins, cette étude évalue l'association entre une exposition professionnelle à 5 types de solvants à base de pétrole (benzène, gasoline, white spirit, ...) et à 5 types de solvants oxygénés (alcools, ester, cétone, ...) et le risque de développer la maladie

Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

Barul, Christine ; Carton, Matthieu ; Radoi, Loredana ; Menvielle, Gwenn ; Pilorget, Corinne ; Bara, Simona ; Stücker, Isabelle ; Luce, Danièle

Background : To examine associations between occupational exposure to petroleum-based and oxygenated solvents and the risk of hypopharyngeal and laryngeal cancer. Methods : ICARE is a large, frequency-matched population-based case-control study conducted in France. Lifetime occupational history, tobacco smoking and alcohol consumption were collected. Analyses were restricted to men and included 383 cases of hypopharyngeal cancer, 454 cases of laryngeal cancer, and 2780 controls. Job–exposure [...]

A partir d'une revue systématique de la littérature (34 études, 12 043 patients, 15 209 témoins), cette méta-analyse évalue l'association entre le polymorphisme C609T du gène NQO1 et le risque de cancer des voies digestives

NQO1 Gene C609T Polymorphism (dbSNP: rs1800566) and Digestive Tract Cancer Risk: A Meta-Analysis

Yadav, Upendra ; Kumar, Pradeep ; Rai, Vandana

Several studies reported that polymorphism C609T (rs1800566) in (NAD(P)H): quinoneoxidoreductase 1 (NQO1) gene is associated with risk to digestive tract (DT) cancers, like esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC). Authors conducted a meta-analysis to investigate association between C609T polymorphism and DT cancer risk. Eligible studies were extracted from the databases of PubMed, Google Scholar, Science Direct, and Springer Link. All retrieved articles were [...]

A partir de données portant sur 1 988 patients atteints d'un mélanome cutané et sur 1 542 témoins, cette étude de séquençage sur l'exome entier identifie le gène GOLM1 comme étant un gène de prédisposition à la maladie

A Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma

Teerlink, Craig C. ; Huff, Chad ; Stevens, Jeff ; Yu, Yao ; Holmen, Sheri L. ; Silvis, Mark R. ; Trombetti, Kirby ; Zhao, Hua ; Grossman, Douglas ; Farnham, James M. ; Wen, Jingran ; Facelli, Julio C. ; Thomas, Alun ; Babst, Markus ; Florell, Scott R. ; Meyer, Laurence ; Zone, John J. ; Leachman, Sancy ; Cannon-Albright, Lisa A.

Background : Statistically significant linkage of melanoma to chromosome 9q21 was previously reported in a Danish pedigree resource and independently confirmed in Utah high-risk pedigrees, indicating strong evidence that this region contains a melanoma predisposition gene. Methods : Whole-exome sequencing of pairs of related melanoma case subjects from two pedigrees with evidence of 9q21 linkage was performed to identify the responsible predisposition gene. Candidate variants were tested for [...]