Mené sur 90 patients atteints d'un cancer gastrointestinal, cet essai randomisé évalue l'efficacité de l'ajout du célécoxib à l'acétate de mégestrol pour traiter une cachexie/anorexie induite par la maladie

Randomized double-blind clinical trial of combined treatment with megestrol acetate plus celecoxib versus megestrol acetate alone in cachexia-anorexia syndrome induced by GI cancers

Kouchaki, Bizhan ; Janbabai, Ghasem ; Alipour, Abbas ; Ala, Shahram ; Borhani, Samaneh ; Salehifar, Ebrahim

Purpose : Previous studies reported promising efficacy for celecoxib in the treatment of cancer cachexia. We designed this study to test the hypothesis that combination therapy with megestrol acetate (MA) plus celecoxib is superior to MA alone. Methods : Ninety eligible gastrointestinal cancer patients randomly received either MA 320 mg/day plus placebo (arm1) or MA 320 mg/day plus celecoxib 200 mg/day (arm2). Patients were evaluated at baseline, then 1 and 2 months after starting [...]

Menée aux Etats-Unis auprès de 334 patients ayant survécu à un cancer entre 2007 et 2015, cette étude analyse les facteurs associés à leur capacité d'endurance et à leur fatigabilité

Fatigability and endurance performance in cancer survivors: Analyses from the Baltimore Longitudinal Study of Aging

Gresham, Gillian ; Dy, Sydney M. ; Zipunnikov, Vadim ; Browner, Ilene S. ; Studenski, Stephanie A. ; Simonsick, Eleanor M. ; Ferrucci, Luigi ; Schrack, Jennifer A.

BACKGROUND: Fatigue is prevalent and distressing among cancer survivors, but its subjective nature makes it difficult to identify. Fatigability, defined as task-specific fatigue, and endurance performance may be useful supplemental measures of functional status in cancer survivors. METHODS: Fatigability, endurance performance, and cancer history were assessed every 2 years in Baltimore Longitudinal Study of Aging participants between 2007 and 2015. Fatigability was defined according to the Borg [...]

Menée auprès de patients atteints d'un mélanome de stade avancé ou métastatique présentant la mutation BRAFV600, cette étude évalue l'impact, sur la qualité de vie des patients, de l'ajout du cobimétinib à un traitement à base de vémurafénib

Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma

Dréno, Brigitte ; Ascierto, Paolo A. ; Atkinson, Victoria ; Liszkay, Gabriella ; Maio, Michele ; Mandalà, Mario ; Demidov, Lev ; Stroyakovskiy, Daniil ; Thomas, Luc ; de la Cruz-Merino, Luis ; Dutriaux, Caroline ; Garbe, Claus ; Bartley, Karen ; Karagiannis, Thomas ; Chang, Ilsung ; Rooney, Isabelle ; Koralek, Daniel O. ; Larkin, James ; McArthur, Grant A. ; Ribas, Antoni

Background: In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. Methods: Patients completing the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) at baseline and ⩾1 time point thereafter constituted the analysis [...]

Mené sur 95 patientes ayant survécu à un cancer de l'ovaire, cet essai randomisé compare l'efficacité de 3 méthodes de diagnostic d'un lymphœdème des membres inférieurs et évalue les effets, sur la réduction du risque de lymphœdème, d'un programme d'activité physique à base de marche rapide pendant 6 mois

Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity

Iyer, Neel S. ; Cartmel, Brenda ; Friedman, Louis ; Li, Fangyong ; Zhou, Yang ; Ercolano, Elizabeth ; Harrigan, Maura ; Gottlieb, Linda ; McCorkle, Ruth ; Schwartz, Peter E. ; Irwin, Melinda L.

BACKGROUND: Lymphedema is a poorly understood side effect of gynecologic cancer treatment. This study was designed to determine the prevalence of lower limb lymphedema (LLL) in a sample of ovarian cancer survivors via 3 different diagnostic methods and to assess the effect of a randomized exercise intervention. METHODS: Physically inactive ovarian cancer survivors (n = 95) were enrolled in a 6-month randomized trial of exercise (primarily brisk walking) versus attention control. LLL was [...]

Menée au Canada auprès de patients atteints d'une tumeur hématologique, cette étude de cohorte analyse l'évolution de leur qualité de vie dans l'année suivant une greffe de cellules souches hématopoïétiques, en prenant notamment en compte les symptômes et les effets indésirables liés à la maladie et aux traitements, la présence de symptômes dépressifs et l'estime de soi

Quality of life trajectories during the first year following hematopoietic cell transplantation: an inception cohort study

Devins, Gerald M. ; Mah, Kenneth ; Messner, Hans A. ; Xenocostas, Anargyros ; Gauvin, Lise ; Lipton, Jeffrey H.

Background : Allogeneic hematopoietic cell transplantation (HCT) affects quality of life (QOL). Patient-reported outcomes examine symptoms, side effects, distress, and physical and social problems, but positive outcomes have been ignored. This inception cohort study followed people over the first year following HCT to document positive and negative outcomes. Methods : People with hematologic cancers treated by HCT completed complementary self-report instruments at four milestones: (a) [...]

Menée aux Etats-Unis auprès de 3 595 patientes ayant survécu à un cancer du sein, cette étude de cohorte évalue les facteurs associés au risque de troubles vasomoteurs, en lien avec les traitements anticancéreux reçus

Predictors of vasomotor symptoms among breast cancer survivors

Reeves, Katherine W. ; Pennell, Michael ; Foraker, Randi E. ; Crandall, Carolyn J. ; Stefanick, Marcia ; Paskett, Electra D.

Purpose : Vasomotor symptoms (VMS) are a common side effect of breast cancer treatment, yet modifiable factors that may predict VMS among breast cancer survivors are unknown. Methods : We estimated multivariable-adjusted odds ratios and 95% confidence intervals (aOR, 95% CI) for predictors of VMS among 3595 breast cancer survivors enrolled in the Life and Longevity after Cancer (LILAC) study, an ancillary study of the Women’s Health Initiative (WHI). Results : VMS post-diagnosis were reported [...]

Menée aux Pays-Bas à partir de données portant sur 384 patients atteints d'un cancer, cette étude analyse l'association entre la présence d'une fatigue, de symptômes de dépression et leur capacité de travail, durant les 18 mois suivant leur retour à l'emploi

Fatigue and depressive symptoms improve but remain negatively related to work functioning over 18 months after return to work in cancer patients

Dorland, H. F. ; Abma, F. I. ; Van Zon, S. K. R. ; Stewart, R. E. ; Amick, B. C. ; Ranchor, A. V. ; Roelen, C. A. M. ; Bültmann, U.

Purpose : The aims of this study are to investigate the course of work functioning, health status, and work-related factors among cancer patients during 18 months after return to work (RTW) and to examine the associations between these variables and work functioning over time. Methods : Data were used from the 18-month longitudinal “Work Life after Cancer” (WOLICA) cohort, among 384 cancer patients who resumed work. Linear mixed models were performed to examine the different courses during [...]

Menée aux Etats-Unis à partir de données portant sur 79 176 patients ayant survécu plus de 2 ans à un cancer diagnostiqué entre 15 et 39 ans sur la période 1996-2012, cette étude de cohorte rétrospective évalue les facteurs associés au risque de maladie cardiovasculaire (2 249 cas de maladie cardiovasculaire jusqu'en 2014) et analyse l'impact de ces maladies sur la mortalité

Cardiovascular disease incidence in adolescent and young adult cancer survivors: a retrospective cohort study

Keegan, Theresa H. M. ; Kushi, Lawrence H. ; Li, Qian ; Brunson, Ann ; Chawla, X. ; Chew, Helen K. ; Malogolowkin, Marcio ; Wun, Ted

Purpose : Few population-based studies have focused on cardiovascular disease (CVD) risk in adolescent and young adult (AYA; 15–39 years) cancer survivors and none have considered whether CVD risk differs by sociodemographic factors. Methods : Analyses focused on 79,176 AYA patients diagnosed with 14 first primary cancers in 1996–2012 and surviving > 2 years after diagnosis with follow-up through 2014. Data were obtained from the California Cancer Registry and State hospital discharge data. CVD [...]

A partir des données du registre suisse des cancers pédiatriques portant sur 6 034 patients atteints d'un cancer diagnostiqué entre 1985 et 2015 avant l'âge de 15 ans et sur 60 034 témoins, cette étude analyse la distribution géographique des cas, en fonction du lieu de résidence à la naissance et au diagnostic

Spatial clustering of childhood cancers in Switzerland: a nationwide study

Konstantinoudis, Garyfallos ; Kreis, Christian ; Ammann, Roland A. ; Niggli, Felix ; Kuehni, Claudia E. ; Spycher, Ben D.

Purpose : Childhood cancers are rare and little is known about their etiology. Potential risk factors include environmental exposures that might implicate spatial variation of cancer risk. Previous studies of spatial clustering have mainly focused on childhood leukemia. We investigated spatial clustering of different childhood cancers in Switzerland using exact geocodes of place of residence. Methods : We included 6,034 cancer cases diagnosed at age 0–15 years during 1985–2015 from the Swiss [...]

A partir des données des registres américains des cancers sur la période 1998-2009 et portant sur 5 975 patients âgés, cette étude évalue l'association entre les traitements reçus et la survie, selon deux catégories d'âge (66-74 ans, et plus de 75 ans)

Evaluation of Treatment Patterns and Survival Outcomes in Elderly Pancreatic Cancer Patients: A Surveillance, Epidemiology, and End Results-Medicare Analysis

Shaib, Walid L. ; Jones, Jeb S. ; Goodman, Michael ; Sarmiento, Juan M. ; Maithel, Shishir K. ; Cardona, Kenneth ; Kane, Sujata ; Wu, Christina ; Alese, Olatunji B. ; El‐Rayes, Bassel F.

Management of pancreatic cancer (PC) in elderly patients is unknown; clinical trials exclude patients with comorbidities and those of extreme age. This study evaluated treatment patterns and survival outcomes in elderly PC patients using linked Surveillance, Epidemiology, and End Results (SEER) and Medicare data.Histology codes 8140, 8500, 8010, 8560, 8490, 8000, 8260, 8255, 8261, 8263, 8020, 8050, 8141, 8144, 8210, 8211, or 8262 in Medicare Parts A and B were identified. Data regarding [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2017 (37 études), cette méta-analyse évalue l'association entre des comorbidités, une fragilité, la mortalité, globale et spécifique, et la survie, sans maladie ou sans récidive, chez des patients atteints d'un cancer colorectal

Impact of comorbidity and frailty on prognosis in colorectal cancer patients: a systematic review and meta-analysis

Boakye, Daniel ; Rillmann, Bettina ; Walter, Viola ; Jansen, Lina ; Hoffmeister, Michael ; Brenner, Hermann

Introduction : Colorectal cancer (CRC) is largely diagnosed at old age, when comorbidities and frailty are common and might be important prognostic factors of CRC. We aimed to systematically review epidemiological evidence on the prognostic role of comorbidity and frailty in CRC patients. Methods : We systematically searched the PubMed and Web of Science databases up to August 08, 2017 for observational studies that used a standardized index to assess comorbidity or frailty, investigated and [...]

Menée en Grande-Bretagne à partir de données portant sur 2 432 patients atteints d'un ostéosarcome et sur 1 619 patients atteints d'un sarcome d'Ewing diagnostiqué entre 1985 et 2008 avant l'âge de 50 ans, cette étude analyse l'association entre des indicateurs socioéconomiques (lieu de résidence, zone rurale/urbaine, foyer possédant une voiture, taux de chômage dans la zone géographique du lieu de résidence, etc.) et la mortalité prématurée (3, 6, 12 mois et 3 et 5 ans après le diagnostic)

Socio-economic patterning in early mortality of patients aged 0–49 years diagnosed with primary bone cancer in Great Britain, 1985–2008

Blakey, Karen ; Feltbower, Richard G. ; James, Peter W. ; Libby, Gillian ; Stiller, Charles ; Norman, Paul ; Gerrand, Craig ; McNally, Richard J. Q.

Background : Studies have shown marked improvements in survival between 1981 and 2000 for Ewing sarcoma patients but not for osteosarcoma. This study aimed to explore socio-economic patterning in early mortality rates for both tumours. Procedure : The study analysed all 2432 osteosarcoma and 1619 Ewing sarcoma cases, aged 0–49 years, diagnosed in Great Britain 1985–2008 and followed to 31/12/2009. Logistic regression models were used to calculate risk of dying within three months, six months, [...]

Menée aux Etats-Unis à partir de données portant sur 723 femmes âgées entre 40 et 64 ans (347 patientes atteintes d'un cancer du sein de stade précoce et 376 témoins), cette étude analyse l'évolution de leur situation professionnelle et de leur implication dans leur emploi, pendant les deux années suivant le diagnostic

Early-stage breast cancer and employment participation after 2 years of follow-up: A comparison with age-matched controls

Ekenga, Christine C. ; Pérez, Maria ; Margenthaler, Julie A. ; Jeffe, Donna B.

BACKGROUND: Although cancer survivors are more likely to be unemployed than individuals without a cancer history, employment participation after treatment of early-stage breast cancer has not been widely studied to date. The objectives of the current study were to evaluate employment trajectories in a cohort of patients with early-stage breast cancer and age-matched controls from the time of diagnosis to the 2-year follow-up, and identify factors associated with diminished and emerging [...]

Menée en Suède à partir de données portant sur 5 385 186 femmes entre 1973 et 2010, cette étude de cohorte évalue l'association entre une ligature des trompes et le risque de cancer du corps de l'utérus (35 711 cas de cancer)

Association between tubal ligation and endometrial cancer risk: A Swedish population-based cohort study

Falconer, Henrik ; Yin, Li ; Altman, Daniel

Tubal ligation results in less advanced stages and lower risk of metastatic spread at diagnosis of endometrial cancer (EC) but the primary preventive effect of the procedure is unclear. In a Swedish nationwide population-based cohort study, we crosslinked registry data for tubal ligation, EC, and death for Swedish women between 1973 and 2010. All women were followed until EC, emigration, hysterectomy for non-cancerous reasons, death, or end of follow-up. Primary outcome was incidence of EC and [...]

A partir des données GLOBOCAN 2012, cette étude estime, dans 5 pays en développement (Brésil, Russie, Inde, Chine et Afrique du Sud), la perte de la productivité en lien avec la mortalité prématurée par cancer

Productivity losses due to premature mortality from cancer in Brazil, Russia, India, China, and South Africa (BRICS): A population-based comparison

Pearce, Alison ; Sharp, Linda ; Hanly, Paul ; Barchuk, Anton ; Bray, Freddie ; de Camargo Cancela, Marianna ; Gupta, Prakash ; Meheus, Filip ; Qiao, You-Lin ; Sitas, Freddy ; Wang, Shao-Ming ; Soerjomataram, Isabelle

Background : Over two-thirds of the world’s cancer deaths occur in economically developing countries; however, the societal costs of cancer have rarely been assessed in these settings. Our aim was to estimate the value of productivity lost in 2012 due to cancer-related premature mortality in the major developing economies of Brazil, the Russian Federation, India, China and South Africa (BRICS). Methods : We applied an incidence-based method using the human capital approach. We used annual adult [...]

Menée aux Etats-Unis auprès de 26 patientes ayant survécu à un cancer (âge moyen : 16 ans) et auprès de 23 parents, cette étude analyse leurs connaissances et leurs perceptions des problématiques liées à la santé reproductive et à l'infertilité après un traitement anticancéreux

Knowledge and perceptions of infertility in female cancer survivors and their parents

Sandheinrich, Taryn ; Wondmeneh, Sarah B. ; Mohrmann, Caroline ; Gettinger, Katie ; Henry, Jennifer ; Hayashi, Robert J.

Purpose : The purpose of this study was to assess knowledge and perceptions of infertility, reproductive concerns, quality of life, and emotional burden of fertility concerns in adolescent female cancer survivors and their parents. Methods : A cross-sectional design was used to investigate reproductive knowledge and concerns among female childhood cancer survivors and their parents. The instruments administered at a single, routine visit were the 13-item knowledge instrument, Adolescent [...]

A partir d'une revue systématique de la littérature, cette étude fait le point sur l'utilisation d'antimicrobiens chez des patients atteints d'un cancer de stade avancé et recevant des soins palliatifs

Antimicrobial therapy in palliative care: an overview

Macedo, Filipa ; Nunes, Catarina ; Ladeira, Katia ; Pinho, Filipa ; Saraiva, Nadine ; Bonito, Nuno ; Pinto, Luísa ; Gonçalves, Francisco

In the advanced stages of illness, patients often face challenging decisions regarding their treatment and overall medical care. Terminal ill patients are commonly affected by infections. However, in palliative care, the use of antimicrobials can be an ethical dilemma. Deciding whether to treat, withhold, or withdraw the antimicrobial treatment for an infection can be difficult. Antimicrobial administration can lead to adverse outcomes but the two main benefits, longer survival and symptom [...]