A partir d'une revue systématique de la littérature (13 études), cette étude évalue l'association entre la durée et l'intensité d'une activité physique et le risque de cancer du testicule

Physical activity and risk of testicular cancer: a systematic review

Huang, Stephanie ; Signal, Virginia ; Sarfati, Diana ; Shaw, Caroline ; Stanley, James ; McGlynn, Katherine ; Gurney, Jason

Background : Physical activity has been implicated as a risk factor in the development of testicular cancer (TC), but the relationship remains controversial. This systematic review pooled available evidence regarding this association. Methods : Using Boolean search terms and following PRISMA guidelines, we examined the risk of TC across three categories of exposure: intensity (i.e. comparison of risk between those previously exposed to high, moderate and low levels of physical activity); [...]

A partir des données mondiales GLOBOCAN pour l'année 2012, cette étude analyse la part de cancers du foie attribuable, par zone géographique, à une infection par le virus de l'hépatite B ou de l'hépatite C (770 000 cas en 2012)

Fraction and incidence of liver cancer attributable to hepatitis B and C viruses worldwide

Maucort-Boulch, Delphine ; de Martel, Catherine ; Franceschi, Silvia ; Plummer, Martyn

High-quality data on liver cancers by probable cause are scarce in many regions of the world. The United Nations recently set a goal of eliminating viral hepatitis as a major public health threat by 2030. We aimed to estimate the number of new cases of cancers attributable to hepatitis B virus (HBV) and hepatitis C virus (HCV) at a global, regional and country level, and by development status. We used data on the prevalence of HBV and HCV in hepatocellular carcinoma from a systematic review [...]

Couplée aux données de la cohorte européenne EPIC et portant sur 485 patients atteints d'un cancer colorectal et sur 485 témoins, cette étude prospective évalue l'association entre le niveau sérique d'anticorps anti-Streptococcus gallolyticus et le risque de développer la maladie

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

Butt, Julia ; Jenab, Mazda ; Willhauck-Fleckenstein, Martina ; Michel, Angelika ; Pawlita, Michael ; Kyrø, Cecilie ; Tjønneland, Anne ; Boutron-Ruault, Marie-Christine ; Carbonnel, Franck ; Severi, Gianluca ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Karakatsani, Anna ; Panico, Salvatore ; Tumino, Rosario ; Agnoli, Claudia ; Palli, Domenico ; Sacerdote, Carlotta ; Bueno-de-Mesquita, Bas ; Weiderpass, Elisabete ; Sánchez, María-José ; Bonet Bonet, Catalina ; Huerta, José María ; Ardanaz, Eva ; Bradbury, Kathryn ; Gunter, Marc ; Murphy, Neil ; Freisling, Heinz ; Riboli, Elio ; Tsilidis, Kostas ; Aune, Dagfinn ; Waterboer, Tim ; Hughes, David J.

The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre-diagnostic serum [...]

A partir des données de la cohorte "Women’s Health Initiative" portant sur 21 103 femmes après la ménopause, cette étude évalue l'association entre le niveau sérique de glucose et d'insuline, et le risque de développer un cancer du sein, de l'endomètre ou de l'ovaire (durée moyenne de suivi : 14,7 ans ; 1 185 cas de cancer du sein, 156 cas de cancer de l'endomètre, 130 cas de cancer de l'ovaire)

Serum glucose and insulin and risk of cancers of the breast, endometrium, and ovary in postmenopausal women

Kabat, Geoffrey C. ; Kim, Mimi Y. ; Lane, Dorothy S. ; Zaslavsky, Oleg ; Ho, Gloria Y.F. ; Luo, Juhua ; Nicholson, Wanda K. ; Chlebowski, Rowan T. ; Barrington, Wendy E. ; Vitolins, Mara Z. ; Lin, Xiaochen ; Liu, Simin ; Rohan, Thomas E.

Limited evidence suggests that hyperinsulinemia may contribute to the risk of breast, endometrial, and, possibly, ovarian cancer. The aim of this study was to assess the association of serum glucose and insulin with risk of these cancers in postmenopausal women, while taking into account potential confounding and modifying factors. We studied 21 103 women with fasting baseline insulin and glucose measurements in a subsample of the Women’s Health Initiative. The subsample was composed of four [...]

A partir de données portant sur 137 patients atteints d'un mélanome cutané et sur 99 témoins, cette étude italienne évalue l'association entre le niveau sérique de 25-hydroxyvitamine D mesuré au moment du diagnostic et le risque de développer la maladie

25-Hydroxyvitamin D serum levels and melanoma risk: a case–control study and evidence synthesis of clinical epidemiological studies

Cattaruzza, Maria Sofia ; Pisani, Daniela ; Fidanza, Laura ; Gandini, Sara ; Marmo, Giovanna ; Narcisi, Alessandra ; Bartolazzi, Armando ; Carlesimo, Marta

There is accumulating evidence that the vitamin D pathway may play a role in melanoma. The aim of this study was to investigate the association between 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of cutaneous melanoma. A case–control study with 137 incident cases of melanoma (serum samples collected at the time of diagnosis) and 99 healthy controls (serum samples collected between October and April) was carried out and evaluated in the framework of an evidence synthesis of clinical [...]

Menée aux Etats-Unis à partir de données portant sur 403 268 femmes âgées de plus de 65 ans et à partir de 472 220 examens mammographiques entre 1996 et 2012, cette étude de cohorte prospective évalue l'association entre des antécédents familiaux au premier degré de cancer du sein et le risque de développer la maladie, en fonction de la densité mammaire (durée moyenne de suivi : 6,3 ans ; 10 929 cas de cancer invasif)

Family history and breast cancer risk among older women in the breast cancer surveillance consortium cohort

Braithwaite, D. ; Miglioretti, D. L. ; Zhu, W. ; et al.,

Importance  : First-degree family history is a strong risk factor for breast cancer, but controversy exists about the magnitude of the association among older women. Objective:  To determine whether first-degree family history is associated with increased risk of breast cancer among older women, and identify whether the association varies by breast density. Design, Setting, and Participants : Prospective cohort study between 1996 and 2012 from 7 Breast Cancer Surveillance Consortium (BCSC) [...]