Cette étude passe en revue les recommandations relatives à la prise en charge de la santé osseuse des patients atteints d'un cancer de stade avancé et à la détection précoce de métastases osseuses

Early identification and intervention matters: A comprehensive review of current evidence and recommendations for the monitoring of bone health in patients with cancer

Brodowicz, Thomas ; Hadji, Peyman ; Niepel, Daniela ; Diel, Ingo

Bone metastases are common in patients with advanced solid tumors, and many individuals experience debilitating skeletal-related events (SREs; e.g. pathologic fracture, hypercalcemia, radiotherapy or surgery to bone, and spinal cord compression). These events substantially affect disease outcomes, including survival and quality of life, and healthcare systems. Plain radiography is the most widely used imaging modality for the detection of bone metastases; skeletal scintigraphy, computed [...]

Mené sur 115 patients atteints d'une tumeur neuro-endocrine, cet essai randomisé évalue l'efficacité du lanréotide pour réduire les symptômes de diarrhée et de bouffées de chaleur (durée de suivi : 48 semaines)

Patient-Reported Symptom Control of Diarrhea and Flushing in Patients with Neuroendocrine Tumors Treated with Lanreotide Depot/Autogel: Results from a Randomized, Placebo-Controlled, Double-Blind and 32-Week Open-Label Study

Fisher, George A. ; Wolin, Edward M. ; Liyanage, Nilani ; Pitman Lowenthal, Susan ; Mirakhur, Beloo ; Pommier, Rodney F. ; Shaheen, Montaser ; Vinik, Aaron ; on behalf of the ELECT Study Group

In the double‐blind (DB) ELECT study, lanreotide depot/autogel significantly reduced versus placebo the need for short‐acting octreotide for symptomatic carcinoid syndrome (CS) control in neuroendocrine tumor (NET) patients. Here we present patient‐reported symptom data during DB and initial open‐label (IOL) treatment.Adults with NETs and CS history, with/without prior somatostatin analog use, were randomized to 16 weeks’ DB lanreotide 120 mg subcutaneous or placebo every 4 weeks, followed by [...]

Menée aux Etats-Unis à partir de données portant sur 68 463 patients atteints de cancer, cette étude analyse les facteurs associés au risque d'utilisation prolongée d'opioïdes après un traitement chirurgical à visée curative, et évalue les doses quotidiennes utilisées

New Persistent Opioid Use Among Patients With Cancer After Curative-Intent Surgery

Jay Soong-Jin Lee ; Hsou Mei Hu ; Anthony L. Edelman ; Chad M. Brummett ; Michael J. Englesbe ; Jennifer F. Waljee ; Jeffrey B. Smerage ; Jennifer J. Griggs ; Hari Nathan ; Jacqueline S. Jeruss ; Lesly A. Dossett

Purpose : The current epidemic of prescription opioid misuse has increased scrutiny of postoperative opioid prescribing. Some 6% to 8% of opioid-naïve patients undergoing noncancer procedures develop new persistent opioid use; however, it is unknown if a similar risk applies to patients with cancer. We sought to define the risk of new persistent opioid use after curative-intent surgery, identify risk factors, and describe changes in daily opioid dose over time after surgery. Methods : Using a [...]

Mené sur 120 patients atteints de cancer, cet essai randomisé évalue l'efficacité et les effets indésirables de la prochlorpérazine pour prévenir les nausées et vomissements induits par les opioïdes

Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial

Tsukuura, Hiroaki ; Miyazaki, Masayuki ; Morita, Tatsuya ; Sugishita, Mihoko ; Kato, Hiroshi ; Murasaki, Yuka ; Gyawali, Bishal ; Kubo, Yoko ; Ando, Masahiko ; Kondo, Masashi ; Yamada, Kiyofumi ; Hasegawa, Yoshinori ; Ando, Yuichi

Although opioid‐induced nausea and vomiting (OINV) often result in analgesic undertreatment in patients with cancer, no randomized controlled trials have evaluated the efficacy of prophylactic antiemetics for preventing OINV. We conducted this randomized, placebo‐controlled, double‐blind trial to evaluate the efficacy and safety of prophylactic treatment with prochlorperazine for preventing OINV.Cancer patients who started to receive oral oxycodone were randomly assigned in a 1:1 ratio to [...]

Mené sur 66 patientes ayant survécu à un cancer du sein de stade 0 à III (âge : de 32 à 72 ans) après un traitement chirurgical, une radiothérapie et/ou une chimiothérapie, cet essai randomisé évalue l'efficacité d'un massage suédois thérapeutique hebdomadaire pour réduire les symptômes de fatigue liée à la maladie

Massage therapy decreases cancer-related fatigue: Results from a randomized early phase trial

Kinkead, Becky ; Schettler, Pamela J. ; Larson, Erika R. ; Carroll, Dedric ; Sharenko, Margaret ; Nettles, James ; Edwards, Sherry A. ; Miller, Andrew H. ; Torres, Mylin A. ; Dunlop, Boadie W. ; Rakofsky, Jeffrey J. ; Rapaport, Mark Hyman

BACKGROUND: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, yet treatment options for CRF are limited. In this study, we evaluated the efficacy of weekly Swedish massage therapy (SMT) versus an active control condition (light touch [LT]) and waitlist control (WLC) on persistent CRF in breast cancer survivors. METHODS: This early phase, randomized, single-masked, 6-week investigation of SMT, LT, and WLC enrolled 66 female stage 0-III breast [...]

A partir d'une revue systématique de la littérature, cette étude analyse les recommandations de l'"American Society of Clinical Oncology" relatives à l'utilisation d'agents thérapeutiques dans la prise en charge des métastases osseuses et des douleurs associées chez les patientes atteintes d'un cancer du sein de stade métastatique

Role of Bone-Modifying Agents in Metastatic Breast Cancer: An American Society of Clinical Oncology–Cancer Care Ontario Focused Guideline Update

Catherine Van Poznak ; Mark R. Somerfield ; William E. Barlow ; J. Sybil Biermann ; Linda D. Bosserman ; Mark J. Clemons ; Sukhbinder K. Dhesy-Thind ; Melissa S. Dillmon ; Andrea Eisen ; Elizabeth S. Frank ; Reshma Jagsi ; Rachel Jimenez ; Richard L. Theriault ; Theodore A. Vandenberg ; Gary C. Yee ; Beverly Moy

Purpose : To update, in collaboration with Cancer Care Ontario (CCO), key recommendations of the American Society of Clinical Oncology (ASCO) guideline on the role of bone-modifying agents (BMAs) in metastatic breast cancer. This focused update addressed the new data on intervals between dosing and the role of BMAs in control of bone pain. Methods : A joint ASCO-CCO Update Committee conducted targeted systematic literature reviews to identify relevant studies. Results : The Update Committee [...]

Menée aux Etats-Unis par enquête auprès de 255 patientes atteintes d'un cancer du sein et ayant reçu un traitement chirurgical (174 tumorectomies, 22 mastectomies, 59 mastectomies avec reconstruction mammaire ; âge médian : 57 ans), cette étude analyse l'association entre l'indice de masse corporelle, leur satisfaction vis-à-vis de leur apparence et de leur image corporelle après les traitements reçus et leur sexualité

Body mass index (BMI), postoperative appearance satisfaction, and sexual function in breast cancer survivorship

Rojas, K. E. ; Matthews, N. ; Raker, C. ; Clark, M. A. ; Onstad, M. ; Stuckey, A. ; Gass, J.

Purpose : We sought to explore the correlation between BMI and postoperative sexual function, body image, and breast-specific sensuality before and after breast cancer surgery. Methods : A cross-sectional survey of patients at least 1 year from surgery employed the Female Sexual Function Index (FSFI) and investigator-generated questions. Patients who underwent lumpectomy (L), mastectomy (M), and mastectomy with reconstruction (MR) were compared across three BMI groups: normal weight, [...]

A partir des données du registre californien des cancers portant sur la période 2000-2013 et incluant des patients atteints d'un cancer du sein, de la prostate, du poumon ou du côlon-rectum, cette étude analyse les facteurs cliniques, médicaux, sociodémographiques, économiques et géographiques associés aux disparités ethniques dans la survie

Racial and Ethnic Disparities in Cancer Survival: The Contribution of Tumor, Sociodemographic, Institutional, and Neighborhood Characteristics

Libby Ellis ; Alison J. Canchola ; David Spiegel ; Uri Ladabaum ; Robert Haile ; Scarlett Lin Gomez

Purpose : Racial/ethnic disparities in cancer survival in the United States are well documented, but the underlying causes are not well understood. We quantified the contribution of tumor, treatment, hospital, sociodemographic, and neighborhood factors to racial/ethnic survival disparities in California. Materials and Methods : California Cancer Registry data were used to estimate population-based cancer-specific survival for patients diagnosed with breast, prostate, colorectal, or lung cancer [...]

Menée dans une région du Nord du Chili dont le sol est riche en arsenic, cette étude évalue, à partir de données portant sur 442 570 personnes et par rapport à la population générale du reste du pays, l'évolution de la mortalité par cancer du poumon, du rein ou de la vessie après la mise en place en 1970 d'une usine d'élimination de l'arsenic de l'eau

Lung, Bladder, and Kidney Cancer Mortality 40 Years After Arsenic Exposure Reduction

Smith, Allan H. ; Marshall, Guillermo ; Roh, Taehyun ; Ferreccio, Catterina ; Liaw, Jane ; Steinmaus, Craig

Background : Region II in northern Chile (population 442 570) experienced a sudden major increase in arsenic water concentrations in 1958 in the main city of Antofagasta, followed by a major reduction in exposure when an arsenic removal plant was installed in 1970. It provides a unique opportunity to study latency effects of exposure to arsenic, and this is the first study with mortality data up to 40 years after exposure reduction. Methods : We previously identified high mortality rates in [...]

Menée aux Pays-Bas sur la période 2008-2012, cette étude de cohorte rétrospective analyse l'évolution des prescriptions de thérapies systémiques pour les patients atteints d'un cancer du poumon non à petites cellules de stade IIIB/V, puis évalue la survie globale

Trends in prescribing systemic treatment and overall survival for non-small cell lung cancer stage IIIB/IV in the Netherlands: 2008–2012

Peters, Bas J. M. ; Cramer-vd Welle, Christine M. ; Smit, Arthur A. J. ; Schramel, Franz M. N. H. ; van de Garde, Ewoudt M. W.

The present study aims to give a detailed overview of day-to-day practice in the systemic treatment of NSCLC stage IIIB/IV and its clinical outcomes in six large teaching hospitals in the Netherlands in the period 2008–2012. A retrospective observational cohort study was conducted in the Care for Outcome registry. Patients diagnosed with stage IIIB/IV NSCLC were included and drug data were collected. Outcomes included percentage of patients treated with systemic treatment, percentage of [...]

A partir de données portant sur 1 789 patientes atteintes d'un cancer inflammatoire du sein, cette étude analyse la prévalence de mutations BRCA et les caractéristiques clinicopathologiques associées à la maladie

BRCA mutations in women with inflammatory breast cancer

Gutierrez Barrera, Angelica M. ; Fouad, Tamer M. ; Song, Juhee ; Webster, Rachel ; Elsayegh, Nisreen ; Wood, Anita L. ; Demir, Atakan ; Litton, Jennifer K. ; Ueno, Naoto T. ; Arun, Banu K.

BACKGROUND: Inflammatory breast cancer (IBC) often affects women at a relatively young age. To the authors' knowledge, the rate of BRCA variants among patients with IBC is not known. To determine the association between BRCA status and IBC, the authors evaluated its rate and compared the clinicopathologic characteristics of patients with IBC with those of patients with other breast cancers (non-IBC). METHODS: Patients who presented at the study institution's cancer genetics program and who [...]

A partir des données des registres danois des cancers portant sur 1 261 enfants nés entre 1973 et 2006 et atteints d'une tumeur du système nerveux central avant l'âge de 20 ans, cette étude analyse les caractéristiques familiales associées à la survie (âge des parents, nombre de frères et soeurs, vie citadine,...; durée de suivi : 10 ans)

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Erdmann, Friederike ; Winther, Jeanette Falck ; Dalton, Susanne Oksbjerg ; Zeeb, Hajo ; Krøyer, Anja ; Bautz, Andrea ; Schmiegelow, Kjeld ; Schüz, Joachim

Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N = 1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall [...]

Menée en Australie par entretiens auprès de 26 femmes devant subir une mastectomie bilatérale prophylactique, cette étude qualitative analyse les effets d'une consultation psychologique se déroulant avant l'intervention chirurgicale pour améliorer leur santé psychique et leur capacité à s'adapter à leur image corporelle après l'opération

Perceived influence of psychological consultation on psychological well-being, body image, and intimacy following bilateral prophylactic mastectomy: A qualitative analysis

Glassey, Rachael ; Hardcastle, Sarah J. ; O'Connor, Moira ; Ives, Angela ; kConFab, Investigators ; Saunders, Christobel

Objective: This study explored whether psychological consultation offered to women prior to bilateral prophylactic mastectomy (BPM) appeared to provide psychosocial benefit to younger women (<35 years) at high risk of developing breast cancer due to a mutation or family history. Methods: Qualitative interviews guided by interpretative phenomenological analysis were conducted retrospectively with 26 women who had undergone BPM. Participants were recruited from New Zealand and Australia, via a [...]