Menée aux Etats-Unis auprès de 162 679 participants, cette étude de cohorte prospective évalue l'association entre une activité physique, l'obésité et le risque de cancer du poumon, en fonction du statut tabagique

The relationship between physical activity, obesity, and lung cancer risk by smoking status in a large prospective cohort of US adults

Patel, Alpa V. ; Carter, Brian D. ; Stevens, Victoria L. ; Gaudet, Mia M. ; Campbell, Peter T. ; Gapstur, Susan M.

Physical activity has been associated with lower lung cancer risk in numerous studies with estimates ranging from 20 to 50% lower risk in the most versus the least active study participants. Underweight and obesity have also been associated with lower lung cancer risk, with a nonlinear, inverted U-shaped relationship. However, associations of physical activity and obesity with lung cancer are likely significantly confounded by smoking since individuals who smoke are generally less active and [...]

Menée auprès de 457 patients atteints du syndrome de Lynch, cette étude de cohorte prospective évalue l'association entre le caractère pro-inflammatoire de l'alimentation et le risque de cancer colorectal (durée médiane de suivi : 59 mois ; 200 cas de cancer)

Inflammatory potential of the diet and colorectal tumor risk in persons with Lynch syndrome

Brouwer, Jesca GM ; Makama, Maureen ; van Woudenbergh, Geertruida J ; Vasen, Hans FA ; Nagengast, Fokko M ; Kleibeuker, Jan H ; Kampman, Ellen ; van Duijnhoven, Fränzel JB

Background: Persons with Lynch syndrome (LS) have high lifetime risk of developing colorectal tumors (CRTs) because of a germline mutation in one of their mismatch repair (MMR) genes. An important process in the development of CRTs is inflammation, which has been shown to be modulated by diet.Objective: We aimed to investigate the association between the inflammatory potential of the diet and the risk of CRTs in persons with LS. Design: We used the dietary intake of 457 persons with LS from a [...]

Menée dans 7 pays à partir de données portant sur 1 906 patients atteints d'un méningiome et sur 5 565 témoins, cette étude évalue l'association entre une exposition professionnelle à divers produits chimiques, des poussières combustibles ou des vapeurs d'huiles et le risque de développer la maladie

The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents

McElvenny, Damien M ; van Tongeren, Martie ; Turner, Michelle C ; Benke, Geza ; Figuerola, Jordi ; Fleming, Sarah ; Hours, Martine ; Kincl, Laurel ; Krewski, Daniel ; McLean, Dave ; Parent, Marie-Élise ; Richardson, Lesley ; Schlehofer, Brigitte ; Schlaefer, Klaus ; Sadetzki, Siegal ; Schüz, Joachim ; Siemiatycki, Jack ; Cardis, Elisabeth

Background : Little is known about occupational risk factors for meningioma. Objectives :To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents. Methods: The INTEROCC study was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure [...]

Menée au Royaume-Uni à partir de données portant sur 22 395 femmes atteintes d'un diabète de type 2, cette étude évalue l'association entre une utilisation d'analogues de l'insuline à action prolongée et le risque de cancer du sein (durée de suivi : 12 ans ; 321 cas de cancer)

Long-Term Use of Long-Acting Insulin Analogs and Breast Cancer Incidence in Women With Type 2 Diabetes

Jennifer W. Wu ; Laurent Azoulay ; Agnieszka Majdan ; Jean-François Boivin ; Michael Pollak ; Samy Suissa

Purpose : The association between long-acting insulin analogs and increased breast cancer risk is uncertain, particularly with the short follow-up in previous studies. We assessed this risk long term in women with type 2 diabetes. Methods : A population-based cohort of women 40 years or older, all of whom were treated with long-acting (glargine, detemir) or neutral protamine Hagedorn (NPH) insulin between 2002 and 2012, was formed using the United Kingdom’s Clinical Practice Research Datalink. [...]

A partir de données internationales de diverses études cas-témoins, cette étude évalue l'association entre des douleurs liées au cycle menstruel et le risque de cancer épithélial de l'ovaire

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium

Babic, Ana ; Harris, Holly R. ; Vitonis, Allison F. ; Titus, Linda J. ; Jordan, Susan J. ; Webb, Penelope M. ; Australian Ovarian Cancer Study, Group ; Risch, Harvey A. ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Wicklund, Kristine ; Goodman, Marc T. ; Modugno, Francesmary ; Moysich, Kirsten B. ; Ness, Roberta B. ; Kjaer, Susanne K. ; Schildkraut, Joellen ; Berchuck, Andrew ; Pearce, Celeste L. ; Wu, Anna H. ; Cramer, Daniel W. ; Terry, Kathryn L.

Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype have not been adequately evaluated due to lack of power. We assessed menstrual pain using either direct questions about having experienced menstrual pain, or indirect questions about menstrual pain as indication for use of hormones or [...]

Menée aux Etats-Unis à partir de données portant sur environ 21 000 femmes, cette étude de cohorte prospective évalue l'association entre divers phénotypes d'obésité, la présence d'un syndrome métabolique et le risque de développer un cancer du sein après la ménopause (durée de suivi : 15 ans ; 1 176 cas)

Metabolic obesity phenotypes and risk of breast cancer in postmenopausal women

Kabat, Geoffrey C. ; Kim, Mimi Y. ; Lee, Jennifer S. ; Ho, Gloria Y. ; Going, Scott B. ; Beebe-Dimmer, Jennifer ; Manson, JoAnn E. ; Chlebowski, Rowan T. ; Rohan, Thomas E.

Background: Obesity and the metabolic syndrome (MetS) have both been linked to increased risk of postmenopausal breast cancer; however, their relative contributions are poorly understood. Methods: We examined the association of metabolic phenotypes of obesity defined by presence of the MetS (yes, no) and body mass index (normal, overweight, obese) with risk of postmenopausal breast cancer in a prospective analysis of a cohort of postmenopausal women (n ~ 21,000) with baseline measurements of [...]