Menée au Japon à partir de données portant sur 81 patients atteints d'un cancer des glandes salivaires et sur 810 témoins, cette étude évalue l'association entre le tabagisme et le risque de développer la maladie, par sous-type histologique

Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case-control study

Sawabe, Michi ; Ito, Hidemi ; Takahara, Taishi ; Oze, Isao ; Kawakita, Daisuke ; Yatabe, Yasushi ; Hasegawa, Yasuhisa ; Murakami, Shingo ; Matsuo, Keitaro

BACKGROUND: Major salivary gland cancers (M-SGCs) are rare, and have distinct heterogeneous histopathological subtypes. To the authors' knowledge, no consistent evidence of an association between cigarette smoking and the risk of M-SGCs has appeared to date. Furthermore, evidence of potential heterogeneity in the impact of smoking on histopathological subtypes is scarce, despite the fact that the histopathological subtypes of M-SGC exhibit different genetic features. METHODS: The authors [...]

Menée en Norvège à partir de données sur la période 2006-2014 portant sur 4 402 patientes atteintes d'un cancer du sein et sur 22 025 témoins, cette étude évalue l'association entre une consommation d'alcool, une pratique tabagique, une activité physique et le risque de développer la maladie, par sous-type histologique

Alcohol, physical activity, smoking and breast cancer subtypes in a large nested case-control study from the Norwegian Breast Cancer Screening Program

Ellingjord-Dale, Merete ; Vos, Linda ; Hjerkind, Kirsti Vik ; Hjartåker, Anette ; Russnes, Hege G. ; Tretli, Steinar ; Hofvind, Solveig ; dos-Santos-Silva, Isabel ; Ursin, Giske

Background:To what extent alcohol, smoking and physical activity are associated with the various subtypes of breast cancer is not clear. We took advantage of a large population-based screening cohort to determine whether these risk factors also increase the risk of the poor prognosis subtypes. Methods:We conducted a matched case-control study nested within the Norwegian Breast Cancer Screening Program during 2006-2014. A total of 4 402 breast cancer cases with risk factor and receptor data were [...]

Menée en Chine à partir de données portant sur 109 169 hommes inclus depuis 2006, cette étude de cohorte prospective évalue l'association entre le niveau de glycémie à jeun et le risque de cancer primitif du foie

The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study

Feng, Xiaoshuang ; Wang, Gang ; Li, Ni ; Lyu, Zhangyan ; Chen, Shuohua ; Wei, Luopei ; Chen, Yuheng ; Xie, Shuanghua ; Yang, Wenjing ; Yin, Jian ; Cui, Hong ; Chen, Hongda ; Ren, Jiansong ; Shi, Jufang ; Wu, Shouling ; Dai, Min ; He, Jie

Background: To investigate the association between fasting blood glucose (FBG) levels and the risk of incident primary liver cancer (PLC) in Chinese males, a large prospective cohort was performed in the current study. Methods: A total of 109 169 males participating in the routine checkups every two years were recruited in the Kailuan male cohort study since May 2006. Cox proportional hazards regression models and restricted cubic spline (RCS) were used to evaluate the association between [...]

Menée en Finlande, en Suède, en Norvège et en Islande entre 1961 et 2005, cette étude évalue l'association entre une exposition professionnelle à des poussières de bois et le risque de développer, chez les hommes, un cancer du nez ou un cancer du rhinopharynx (393 cas d'adénocarcinome nasal, 2 446 autres types de cancer nasal, 1 747 cas de cancer du rhinopharynx)

Occupational exposure to wood dust and risk of nasal and nasopharyngeal cancer: A case-control study among men in four nordic countries—With an emphasis on nasal adenocarcinoma

Siew, Sie Sie ; Martinsen, Jan Ivar ; Kjaerheim, Kristina ; Sparén, Pär ; Tryggvadottir, Laufey ; Weiderpass, Elisabete ; Pukkala, Eero

The current study aims to provide stronger evidence to aid in our understanding of the role of cumulative occupational exposure to (softwood-dominated) mixed wood dust in aetiology of nasal cancer. We included broad exposure occurred in a range of wood-processing occupation across varied industries in four Nordic countries. A population-based case-control study was conducted on all male cases with nasal adenocarcinoma (393 cases), other types of nasal cancer (2,446) and nasopharyngeal cancer [...]

A partir d'une revue systématique de la littérature (24 études cas-témoins incluant un total de 13 421 cas, 3 études de cohorte incluant un total de 890 cas), cette méta-analyse évalue l'association entre une utilisation de talc sur la zone génitale et le risque de développer un cancer de l'ovaire

Perineal Talc Use and Ovarian Cancer: A Systematic Review and Meta-Analysis

Penninkilampi, Ross ; Eslick, Guy D.

Background: It has been posited that there is an association between perineal talc use and the incidence of ovarian cancer. To date, this has only been explored in observational studies. Objectives: To perform a meta-analysis to evaluate the association between perineal talc use and risk of ovarian cancer. Methods: Studies were identified using six electronic databases. Observational studies involving at least 50 cases of ovarian cancer were eligible for inclusion. We analyzed the association [...]

Menée en Finlande à partir de données portant sur 13 100 femmes atteintes d'un Lichen plan sur la période 1969-2012, cette étude évalue l'association entre la présence de cette maladie inflammatoire, touchant la peau ou la muqueuse de la bouche, et le risque de développer un cancer (1 520 cas de cancer)

Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland

Halonen, Pia ; Jakobsson, Maija ; Heikinheimo, Oskari ; Riska, Annika ; Gissler, Mika ; Pukkala, Eero

The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969–2012. These patients were linked with subsequent cancer diagnoses from the Finnish Cancer Registry until 2014. Standardized incidence ratios (SIRs) were counted for different cancers by dividing the observed numbers of [...]

A partir d'une revue systématique des méta-analyses et des études d'association sur le génome entier (198 études), cette étude évalue l'association entre 63 polymorphismes de gènes et le risque de développer un cancer du poumon

Genetic Polymorphisms and Lung Cancer Risk: Evidence from Meta-analyses and Genome-wide Association Studies

Liu, Caiyang ; Cui, Huijie ; Gu, Dongqing ; Zhang, Min ; Fang, Yanfei ; Chen, Siyu ; Tang, Mingshuang ; Zhang, Ben ; Chen, Huanwen

A growing number of studies investigating the association between Single Nucleotide Polymorphisms (SNPs) and lung cancer risk have been published since over a decade ago. An updated integrative assessment on the credibility and strength of the associations is required. We searched PubMed, Medline, and Web of Science on or before August 29th, 2016. A total of 198 were deemed eligible for inclusion, which addressed the associations between 108 variants and lung cancer. Among the 108 variants, 63 [...]

A partir des données de 8 études de cohorte menées aux Etats-Unis, en Europe et en Chine, cette étude évalue l'association entre le niveau sanguin d'hormone anti-Müllérienne et le risque de cancer de l'endomètre chez des femmes avant la ménopause (329 cas et 339 témoins)

Anti-Mullerian hormone and endometrial cancer: a multi-cohort study

Fortner, Renée T. ; Schock, Helena ; Jung, Seungyoun ; Allen, Naomi E. ; Arslan, Alan A. ; Brinton, Louise A. ; Egleston, Brian L. ; Falk, Roni T. ; Gunter, Marc J. ; Helzlsouer, Kathy J. ; Idahl, Annika ; Johnson, Theron S. ; Kaaks, Rudolf ; Krogh, Vittorio ; Lundin, Eva ; Merritt, Melissa A. ; Navarro, Carmen ; Onland-Moret, N. Charlotte ; Palli, Domenico ; Shu, Xiao-Ou ; Sluss, Patrick M. ; Staats, Paul N. ; Trichopoulou, Antonia ; Weiderpass, Elisabete ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Dorgan, Joanne F.

Background: The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. Methods: We investigated this association among [...]