A partir des données de la cohorte "Health Professionals Follow-up Study" incluant 5 158 patients atteints d'un cancer localisé de la prostate entre 1986 et 2012, cette étude évalue l'association entre une obésité, des variations de poids entre l'âge de 21 ans et l'âge au diagnostic, et le risque de cancer létal de la prostate

Weight change, obesity and risk of prostate cancer progression among men with clinically localized prostate cancer

Dickerman, Barbra A. ; Ahearn, Thomas U. ; Giovannucci, Edward ; Stampfer, Meir J. ; Nguyen, Paul L. ; Mucci, Lorelei A. ; Wilson, Kathryn M.

Obesity is associated with an increased risk of fatal prostate cancer. We aimed to elucidate the importance and relevant timing of obesity and weight change for prostate cancer progression. We identified 5,158 men diagnosed with localized prostate cancer (clinical stage T1/T2) from 1986 to 2012 in the Health Professionals Follow-up Study. Men were followed for biochemical recurrence and lethal prostate cancer (development of distant metastasis or prostate cancer-specific mortality) until 2012. [...]

Menée en Suède à partir de données portant sur 2 245 femmes travaillant dans un laboratoire entre 1950 et 1989, cette étude évalue le risque de cancer en association avec une exposition à des produits chimiques (383 cas de cancer diagnostiqués entre 1958 et 2012)

Cancer incidence in female laboratory employees: extended follow-up of a Swedish cohort study

Gustavsson, Per ; Andersson, Tomas ; Gustavsson, Annika ; Reuterwall, Christina

Objectives : Work in chemical laboratories is associated with exposure to chemicals, of which some are known or suspected carcinogens. A cohort study of laboratory workers in Stockholm followed until 1992 showed an excess of hematolymphatic malignancies in chemical laboratories and an excess of breast cancer among women working for more than 10 years in such laboratories. The follow-up of this cohort has now been extended by 20 years. Methods :The cohort comprised 2245 female laboratory workers [...]

Menée en Suède à partir de données portant sur 993 patients masculins atteints d'un cancer du poumon et sur 2 359 témoins, cette étude évalue l'association entre une exposition d'origine professionnelle à des fumées de moteurs diesel et le risque de développer la maladie, par sous-type histologique

Occupational exposure to diesel motor exhaust and risk of lung cancer by histological subtype: a population-based case–control study in Swedish men

Ilar, Anna ; Plato, Nils ; Lewné, Marie ; Pershagen, Göran ; Gustavsson, Per

We investigated occupational exposure to diesel motor exhaust (DME) and the risk of lung cancer by histological subtype among men, using elemental carbon (EC) as a marker of DME exposure. 993 cases and 2359 controls frequency-matched on age and year of study inclusion were analyzed by unconditional logistic regression in this Swedish case–control study. Work and smoking histories were collected by a questionnaire and telephone interviews. DME was assessed by a job-exposure matrix. We adjusted [...]

Menée en Australie, au Canada, en France, en Allemagne, en Israël, en Nouvelle-Zélande et au Royaume-Uni à partir de données portant sur 1 939 patients atteints d'un gliome, sur 1 822 patients atteints d'un méningiome et sur 5 404 témoins entre 2000 et 2004, cette étude évalue l'association entre une exposition professionnelle à des champs magnétiques d'extrêmement basse fréquence et le risque de développer une tumeur cérébrale

Interactions between occupational exposure to extremely low frequency magnetic fields and chemicals for brain tumour risk in the INTEROCC study

Turner, Michelle C ; Benke, Geza ; Bowman, Joseph D ; Figuerola, Jordi ; Fleming, Sarah ; Hours, Martine ; Kincl, Laurel ; Krewski, Daniel ; McLean, Dave ; Parent, Marie-Élise ; Richardson, Lesley ; Sadetzki, Siegal ; Schlaefer, Klaus ; Schlehofer, Brigitte ; Schüz, Joachim ; Siemiatycki, Jack ; Tongeren, Martie van ; Cardis, Elisabeth

Objectives : In absence of clear evidence regarding possible effects of occupational chemical exposures on brain tumour aetiology, it is worthwhile to explore the hypothesis that such exposures might act on brain tumour risk in interaction with occupational exposure to extremely low frequency magnetic fields (ELF). Methods : INTEROCC is a seven-country (Australia, Canada, France, Germany, Israel, New Zealand and UK), population-based, case–control study, based on the larger INTERPHONE study. [...]

Menée à l'aide d'une technique de séquençage de l'exome entier sur des échantillons prélevés sur des patients atteints d'un mélanome cutané d'origine héréditaire ou d'un mélanome oculaire, puis validée grâce à des données issues d'une cohorte participant au projet "The Cancer Genome Atlas", cette étude identifie de multiples mutations rares associées au risque familial de mélanome

Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing

Artomov, Mykyta ; Stratigos, Alexander J. ; Kim, Ivana ; Kumar, Raj ; Lauss, Martin ; Reddy, Bobby Y. ; Miao, Benchun ; Daniela Robles-Espinoza, Carla ; Sankar, Aravind ; Njauw, Ching-Ni ; Shannon, Kristen ; Gragoudas, Evangelos S. ; Marie Lane, Anne ; Iyer, Vivek ; Newton-Bishop, Julia A. ; Timothy Bishop, D. ; Holland, Elizabeth A. ; Mann, Graham J. ; Singh, Tarjinder ; Barrett, Jeffrey ; Adams, David J. ; Jönsson, Göran ; Daly, Mark J. ; Tsao, Hensin

Background: Extraordinary progress has been made in our understanding of common variants in many diseases, including melanoma. Because the contribution of rare coding variants is not as well characterized, we performed an exome-wide, gene-based association study of familial cutaneous melanoma (CM) and ocular melanoma (OM). Methods: Using 11 990 jointly processed individual DNA samples, whole-exome sequencing was performed, followed by large-scale joint variant calling using GATK (Genome [...]