A partir d'une revue systématique de la littérature publiée entre 2009 et 2016, cette étude analyse les facteurs associés à des changements du goût et de l'odorat chez les patients atteints de cancer et l'impact de ces altérations sur les comorbidités

Subjective and Objective Taste and Smell Changes In Cancer

L. E. Spotten; ; C. A. Corish; ; C. M. Lorton; ; P. M. Ui Dhuibhir; ; N. C. O’Donoghue; ; B. O’Connor; ; T. D. Walsh

Context: Malnutrition is highly prevalent in cancer patients and an important predictor of morbidity, mortality, treatment response and toxicity. Taste and smell changes (TSCs) are common and may contribute to malnutrition. Research has previously focused on patients receiving chemotherapy (CT) or head and neck radiotherapy (RT). However, TSCs may occur pre-treatment, with other treatment modalities, and in cancer survivors. This review evaluates objective and subjective assessment of taste and [...]

A partir d'une revue systématique de la littérature, cette étude évalue l'utilisation de bisphosphonates et d'autres agents prévenant la résorption osseuse en traitement adjuvant pour les patientes atteintes d'un cancer du sein, puis présente les recommandations de l'"American Society of Clinical Oncology" pour la pratique clinique

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: A Cancer Care Ontario and American Society of Clinical Oncology Clinical Practice Guideline

Sukhbinder Dhesy-Thind ; Glenn G. Fletcher ; Phillip S. Blanchette ; Mark J. Clemons ; Melissa S. Dillmon ; Elizabeth S. Frank ; Sonal Gandhi ; Rasna Gupta ; Mihaela Mates ; Beverly Moy ; Ted Vandenberg ; Catherine H. Van Poznak

Purpose : To make recommendations regarding the use of bisphosphonates and other bone-modifying agents as adjuvant therapy for patients with breast cancer. Methods : Cancer Care Ontario and ASCO convened a Working Group and Expert Panel to develop evidence-based recommendations informed by a systematic review of the literature. Results : Adjuvant bisphosphonates were found to reduce bone recurrence and improve survival in postmenopausal patients with nonmetastatic breast cancer. In this [...]

A partir des données de 15 registres italiens des cancers, cette étude présente une estimation, pour l'année 2010, du nombre de patients ayant survécu à un cancer diagnostiqué avant l'âge de 15 ans (44 135 cas)

An estimate of the number of people in Italy living after a childhood cancer

Francisci, Silvia ; Guzzinati, Stefano ; Dal Maso, Luigino ; Sacerdote, Carlotta ; Buzzoni, Carlotta ; Gigli, Anna ; Airtum working group

Cancers diagnosed in children below the age of 15 years represent 1.2% of all cancer cases, and survival after a childhood cancer has greatly improved over the past 40 years in all high income countries. This study aims to estimate the number of people living in Italy after a childhood cancer for all cancers combined and for a selection of cancer types. We computed 15-year prevalence using data from 15 Italian population-based cancer registries (covering 19% of Italian population) and estimated [...]

A partir des données des registres américains des cancers incluant 36 37 patients âgés de moins de 19 ans et atteints d'un cancer diagnostiqué entre 1992 et 2011, cette étude analyse les facteurs cliniques, démographiques et socioéconomiques associés au risque de décès prématuré (dans le mois suivant le diagnostic)

Death Within 1 Month of Diagnosis in Childhood Cancer: An Analysis of Risk Factors and Scope of the Problem

Adam L. Green ; Elissa Furutani ; Karina Braga Ribeiro ; Carlos Rodriguez Galindo

Purpose : Despite advances in childhood cancer care, some patients die soon after diagnosis. This population is not well described and may be under-reported. Better understanding of risk factors for early death and scope of the problem could lead to prevention of these occurrences and thus better survival rates in childhood cancer. Methods : We retrieved data from SEER 13 registries on 36,337 patients age 0 to 19 years diagnosed with cancer between 1992 and 2011. Early death was defined as [...]

Menée en Suède à partir de données portant sur la période 1973-2012, cette étude évalue l'association entre un diagnostic de cancer pendant la grossesse ou dans l'année suivant la naissance, le risque de décès à la naissance et la mortalité néonatale

Maternal Cancer During Pregnancy and Risks of Stillbirth and Infant Mortality

Donghao Lu ; Jonas F. Ludvigsson ; Karin E. Smedby ; Katja Fall ; Unnur Valdimarsdóttir ; Sven Cnattingius ; Fang Fang

Purpose : To examine whether maternal cancer during pregnancy is associated with increased risks of stillbirth and infant mortality. Methods : On the basis of nationwide health registers, we conducted a study of 3,947,215 singleton births in Sweden from 1973 through 2012. Exposure was defined as maternal cancer diagnosed during pregnancy (number of births = 984) or during the year after pregnancy (number of births = 2,723). We calculated incidence rate ratios (IRRs) for stillbirth and infant [...]

A partir de données portant sur 253 patients atteints d'une tumeur solide, présentant des métastases osseuses et traités par dénosumab afin de réduire le risque d'événements indésirables liés au squelette, cette étude rétrospective analyse les facteurs associés à la survenue d'une fracture atypique du fémur

Retrospective Review of Atypical Femoral Fracture in Metastatic Bone Disease Patients Receiving Denosumab Therapy

Yang, Samantha Peiling ; Kim, Tae Won B. ; Boland, Patrick J. ; Farooki, Azeez

Background : Denosumab therapy is used to reduce skeletal‐related events in metastatic bone disease (MBD). There have been reports of atypical femoral fracture (AFF) in osteoporotic patients treated with denosumab but none in the context of higher dose and more frequent denosumab therapy for MBD. The goal of this study was to assess the incidence of AFF in MBD. Patients and Methods : We conducted a retrospective review of 253 patients who received a minimum of 12 doses of denosumab at 120 mg [...]

A partir des données de 15 études incluant des patientes atteintes d'un carcinome épithélial de l'ovaire de stade invasif, cette étude évalue l'association entre des comorbidités (hypertension, maladie cardiaque, diabète) et leurs traitements médicamenteux, et la survie globale ou la survie sans progression

History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium

Minlikeeva, Albina N. ; Freudenheim, Jo L. ; Cannioto, Rikki A. ; Szender, J. Brian ; Eng, Kevin H. ; Modugno, Francesmary ; Ness, Roberta B. ; LaMonte, Michael J. ; Friel, Grace ; Segal, Brahm H. ; Odunsi, Kunle ; Mayor, Paul ; Zsiros, Emese ; Schmalfeldt, Barbara ; Klapdor, Rüdiger ; Dӧrk, Thilo ; Hillemanns, Peter ; Kelemen, Linda E. ; Kӧbel, Martin ; Steed, Helen ; de Fazio, Anna ; Jordan, Susan J. ; Nagle, Christina M. ; Risch, Harvey A. ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Goodman, Marc T. ; Edwards, Robert ; Matsuo, Keitaro ; Mizuno, Mika ; Karlan, Beth Y. ; Kjær, Susanne K. ; Høgdall, Estrid ; Jensen, Allan ; Schildkraut, Joellen M. ; Terry, Kathryn L. ; Cramer, Daniel W. ; Bandera, Elisa V. ; Paddock, Lisa E. ; Kiemeney, Lambertus A. ; Massuger, Leon F. ; Kupryjanczyk, Jolanta ; Berchuck, Andrew ; Chang-Claude, Jenny ; Diergaarde, Brenda ; Webb, Penelope M. ; Moysich, Kirsten B.

Purpose : Survival following ovarian cancer diagnosis is generally low; understanding factors related to prognosis could be important to optimize treatment. The role of previously diagnosed comorbidities and use of medications for those conditions in relation to prognosis for ovarian cancer patients has not been studied extensively, particularly according to histological subtype. Methods : Using pooled data from fifteen studies participating in the Ovarian Cancer Association Consortium, we [...]

A partir des données de 12 études de cohorte portant sur 23 882 patients atteints d'un cancer du poumon, cette étude prospective évalue l'association entre une consommation de calcium avant le diagnostic et la survie

Prediagnostic Calcium Intake and Lung Cancer Survival: A Pooled Analysis of 12 Cohort Studies

Yu, Danxia ; Takata, Yumie ; Smith-Warner, Stephanie A. ; Blot, William ; Sawada, Norie ; White, Emily ; Freedman, Neal ; Robien, Kim ; Giovannucci, Edward L. ; Zhang, Xuehong ; Park, Yikyung ; Gao, Yu-Tang ; Chlebowski, Rowan T. ; Langhammer, Arnulf ; Yang, Gong ; Severi, Gianluca ; Manjer, Jonas ; Khaw, Kay-Tee ; Weiderpass, Elisabete ; Liao, Linda M. ; Caporaso, Neil E. ; Krokstad, Steinar ; Hveem, Kristian ; Sinha, Rashmi ; Ziegler, Regina G. ; Tsugsane, Shoichiro ; Xiang, Yong-Bing ; Johannson, Mattias ; Zheng, Wei ; Shu, Xiao-Ou

Background: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival. Methods: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort studies. Dietary calcium intake was assessed using food-frequency questionnaires at baseline in each cohort and [...]

Menée au Canada à partir de données portant sur 7 553 patientes atteintes d'un cancer du sein et âgées entre 20 et 45 ans au moment du diagnostic, cette étude de cohorte rétrospective évalue la survie des patientes dont le cancer a été diagnostiqué pendant ou après une grossesse

Association of the timing of pregnancy with survival in women with breast cancer

Iqbal, J. ; Amir, E. ; Rochon, P. A. ; Giannakeas, V. ; Sun, P. ; Narod, S. A.

Importance : Increasing numbers of women experience pregnancy around the time of, or after, a diagnosis of breast cancer. Understanding the effect of pregnancy on survival in women with breast cancer will help in the counseling and treatment of these women. Objective  To compare the overall survival of women diagnosed with breast cancer during pregnancy or in the postpartum period with that of women who had breast cancer but did not become pregnant. Design, Setting, and Participants : This [...]

Menée aux Pays-Bas à partir de données portant sur 6 478 patientes atteintes d'un cancer du sein et âgées de moins de 50 ans, cette étude de cohorte analyse la survie chez les patientes présentant une mutation BRCA1 ou BRCA2

Breast Cancer Survival of BRCA1/BRCA2 Mutation Carriers in a Hospital-Based Cohort of Young Women

Schmidt, Marjanka K. ; van den Broek, Alexandra J. ; Tollenaar, Rob A. E. M. ; Smit, Vincent T. H. B. M. ; Westenend, Pieter J. ; Brinkhuis, Mariël ; Oosterhuis, Wolter J. W. ; Wesseling, Jelle ; Janssen-Heijnen, Maryska L. ; Jobsen, Jan J. ; Jager, Agnes ; Voogd, Adri C. ; van Leeuwen, Flora E. ; van ’t Veer, Laura J.

Background: The primary aim of the study was to investigate prognosis and long-term survival in young breast cancer patients with a BRCA1 or BRCA2 germline mutation compared with noncarriers. The secondary aim was to investigate whether differences in survival originate from associations with tumor characteristics, second cancers, and/or treatment response. Methods: We established a cohort of invasive breast cancer patients diagnosed younger than age 50 years in 10 Dutch hospitals between 1970 [...]

A partir des données portant sur 8 381 patientes atteintes d'un cancer du sein HER2+ et incluses dans un essai de phase III, cette étude évalue l'association entre un diabète, une utilisation de metformine et la survie (durée médiane de suivi : 4,5 ans)

Impact of Diabetes, Insulin, and Metformin Use on the Outcome of Patients With Human Epidermal Growth Factor Receptor 2–Positive Primary Breast Cancer: Analysis From the ALTTO Phase III Randomized Trial

Amir Sonnenblick ; Dominique Agbor-Tarh ; Ian Bradbury ; Serena Di Cosimo ; Hatem A. AzimJr ; Debora Fumagalli ; Severine Sarp ; Antonio C. Wolff ; Michael Andersson ; Judith Kroep ; Tanja Cufer ; Sergio D. Simon ; Pamela Salman ; Masakazu Toi ; Lyndsay Harris ; Julie Gralow ; Maccon Keane ; Alvaro Moreno-Aspitia ; Martine Piccart-Gebhart ; Evandro de Azambuja

Purpose : Previous studies have suggested an association between metformin use and improved outcome in patients with diabetes and breast cancer. In the current study, we aimed to explore this association in human epidermal growth factor receptor 2 (HER2 ) –positive primary breast cancer in the context of a large, phase III adjuvant trial. Patients and Methods : The ALTTO trial randomly assigned patients with HER2-positive breast cancer to receive 1 year of either trastuzumab alone, lapatinib [...]

Menée aux Etats-Unis à partir de données portant sur 6 235 patientes ayant survécu à un cancer du sein, cette étude évalue l'association entre une consommation d'isoflavone d'origine alimentaire et la mortalité toutes causes confondues

Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry

Zhang, Fang Fang ; Haslam, Danielle E. ; Terry, Mary Beth ; Knight, Julia A. ; Andrulis, Irene L. ; Daly, Mary B. ; Buys, Saundra S. ; John, Esther M.

BACKGROUND: Soy foods possess both antiestrogenic and estrogen-like properties. It remains controversial whether women diagnosed with breast cancer should be advised to eat more or less soy foods, especially for those who receive hormone therapies as part of cancer treatment. METHODS: The association of dietary intake of isoflavone, the major phytoestrogen in soy, with all-cause mortality was examined in 6235 women with breast cancer enrolled in the Breast Cancer Family Registry. Dietary intake [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2016 (17 études, 2 314 participants âgés de 13 à 39 ans), cette étude évalue les effets d'interventions menées auprès de patients adolescents et jeunes adultes ayant survécu à un cancer pour améliorer leur santé physique et psychologique

Health promotion and psychological interventions for adolescent and young adult cancer survivors: a systematic literature review

Natalie Katrina Bradford ; Raymond Javan Chan

Background : The effects of cancer and treatment have severe and long lasting negative impacts on quality of life. Adolescents and Young Adults (AYA) have high survival rates but may not reach their full life potential because of these consequences. This review aims to identify, appraise and synthesise the effects of health promotion and psychological interventions for AYA after cancer treatment. Methods : The review was undertaken using the preferred reporting items for systematic reviews and [...]

Menée aux Etats-Unis à partir de données portant sur 1 280 patientes âgées de plus de 65 ans ayant survécu à un cancer du sein (durée médiane de suivi : 4,5 ans), cette étude analyse l'association entre leur personnalité, le soutien social dont elles bénéficient et l'évolution de leur qualité de vie

Personality, coping, and social support as predictors of long-term quality-of-life trajectories in older breast cancer survivors: CALGB protocol 369901 (Alliance)

Durá-Ferrandis, Estrella ; Mandelblatt, Jeanne S. ; Clapp, Jonathan ; Luta, George ; Faul, LeighAnne ; Kimmick, Gretchen ; Cohen, Harvey Jay ; Yung, Rachel L. ; Hurria, Arti

Background: To determine long-term quality-of-life (QOL) trajectories among breast cancer survivors aged 65+ (older) evaluating the effects of personality and social support. Methods: Older women (N = 1280) newly examined with invasive, nonmetastatic breast cancer completed baseline assessments. Follow-up data were collected 6 and 12 months later and then annually for up to 7 years (median 4.5 years). Quality of life was assessed using EORTC-QLQ-C30 emotional, physical, and cognitive scales. [...]

Menée au Royaume-Uni par questionnaire auprès de 148 patientes ayant subi une reconstruction mammaire après une mastectomie, cette étude analyse les facteurs cliniques et psychologiques associés à leur qualité de vie et à leur satisfaction vis-à-vis de leur apparence

Predictors of satisfaction and quality of life following post-mastectomy breast reconstruction

Hannah Matthews, ; Natalie Carroll, ; Derek Renshaw, ; Andrew Turner, ; Alan Park, ; Jo Skillman, ; Kate McCarthy, ; Elizabeth A. Grunfeld

Objective : Breast reconstruction is associated with multiple psychological benefits. However, few studies have identified clinical and psychological factors associated with improved satisfaction and quality of life. This study examined factors, which predict satisfaction with breast appearance, outcome satisfaction and quality of life following post-mastectomy breast reconstruction. Methods : Women who underwent post-mastectomy breast reconstruction between 2010 and 2016 received a postal [...]

Menée aux Etats-Unis à partir de données portant sur 2 005 patients atteints d'une leucémie myéloïde chronique traitée par inhibiteurs de la tyrosine kinase BCR-ABL1, cette étude analyse les coûts associés à la survenue et à la prise en charge des événements indésirables sévères liés aux traitements

Healthcare and economic burden of adverse events among patients with chronic myelogenous leukemia treated with BCR-ABL1 tyrosine kinase inhibitors

Lin, Jay ; Makenbaeva, Dinara ; Lingohr-Smith, Melissa ; Bilmes, Robyn

Objectives: BCR-ABL1 tyrosine kinase inhibitors (TKIs) are established treatments for chronic myelogenous leukemia (CML); however, they are associated with infrequent, but clinically serious adverse events (AEs). The objective of this analysis was to assess healthcare resource utilization and costs associated with AEs, previously identified using the FDA Adverse Event Reporting System (FAERS) in another study, among TKI-treated patients. Methods: Adult patients with ≥1 inpatient or ≥2 [...]

A partir des données des registres américains des cancers portant sur 199 963 patientes atteintes d'un cancer du sein résécable sur la période 1990-2007, cette étude évalue le biais lié au nombre de décès non spécifiques dans l'estimation de la survie globale des patientes

Real-world impact of non–breast cancer–specific death on overall survival in resectable breast cancer

Fu, Jianfei ; Wu, Lunpo ; Jiang, Mengjie ; Li, Dan ; Jiang, Ting ; Fu, Wei ; Wang, Liangjing ; Du, Jinlin

BACKGROUND: The real-world occurrence rate of non–breast cancer–specific death (non-BCSD) and its impact on patients with breast cancer are poorly recognized. METHODS: Women with resectable breast cancer from 1990 to 2007 in the Surveillance, Epidemiology, and End Results database (n = 199,963) were analyzed. The outcome events of breast cancer were classified as breast cancer–specific death (BCSD), non-BCSD, or survival. Binary logistics was used to estimate the occurrence rates of non-BCSD [...]