Menée au Japon auprès de 30 patients ayant reçu une greffe allogénique de cellules souches hématopoïétiques, cette étude évalue l'association entre une activité physique, mesurée avec un accéléromètre, et leur qualité de vie

Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation

Morishita, S. ; Kaida, K. ; Yamauchi, S. ; Wakasugi, T. ; Ikegame, K. ; Ogawa, H. ; Domen, K.

In this study, we investigated the differences in physical activity before and after transplantation, and the relationship between physical activity and physical function and health-related quality of life (QOL) in 30 patients who underwent allogeneic haematopoietic stem cell transplantation (allo-HSCT). Duration and intensity of physical activity were quantified using a three-dimensional accelerometer. Physical function was quantified by handgrip and knee-extensor strength, with the 6-minute [...]

A partir d'une revue systématique de la littérature publiée entre 1999 et 2016 (113 études, 11 525 participants), cette méta-analyse évalue l'efficacité d'interventions ou de traitements de diverses natures -pharmaceutique, psychologique ou basée sur la pratique d'une activité physique- pour prendre en charge la fatigue liée au cancer

Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: A meta-analysis

Mustian, K. M. ; Alfano, C. M. ; Heckler, C. ; et al.,

Importance : Cancer-related fatigue (CRF) remains one of the most prevalent and troublesome adverse events experienced by patients with cancer during and after therapy. Objective : To perform a meta-analysis to establish and compare the mean weighted effect sizes (WESs) of the 4 most commonly recommended treatments for CRF—exercise, psychological, combined exercise and psychological, and pharmaceutical—and to identify independent variables associated with treatment effectiveness.Data Sources  [...]

Cette étude analyse les recommandations de l'"American Cancer Society" relatives à la prise en charge et au suivi de patients ayant survécu à un cancer de la tête et du cou

Head and Neck Cancer Survivorship Care Guideline: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Cancer Society Guideline

Larissa Nekhlyudov ; Christina Lacchetti ; Nancy B. Davis ; Thomas Q. Garvey ; David P. Goldstein ; J. Chris Nunnink ; Jose I. Ruades Ninfea ; Andrew L. Salner ; Talya Salz ; Lillian L. Siu

Purpose : This guideline provides recommendations on the management of adults after head and neck cancer (HNC) treatment, focusing on surveillance and screening for recurrence or second primary cancers, assessment and management of long-term and late effects, health promotion, care coordination, and practice implications. Methods : ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. The American Cancer [...]

A partir des données des registres américains des cancers portant sur la période 1975-2012, cette étude analyse l'évolution de l'incidence de cancer chez les adolescents âgés entre 15 et 19 ans

The increasing toll of adolescent cancer incidence in the US

Burkhamer, Jessica ; Kriebel, David ; Clapp, Richard

Cancer incidence is rising among adolescents (“teens”). The causes of the increase are unknown but studying incidence patterns and trends may produce insights into etiology. Using data from the US National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program we described trends of cancer incidence among teens (15–19 year olds). We reviewed and summarized incidence patterns for histologic cancer groups and the most frequently diagnosed sites of cancer among teens during [...]

Menée en Allemagne à partir de données portant sur 6 840 patients atteints d'un lymphome hodgkinien classique et inclus dans plusieurs essais cliniques, cette étude rétrospective analyse les facteurs associés à la survenue d'événements indésirables liés aux traitements et à une récidive tardive

Late Relapse of Classical Hodgkin Lymphoma: An Analysis of the German Hodgkin Study Group HD7 to HD12 Trials

Paul J. Bröckelmann ; Helen Goergen ; Charlotte Kohnhorst ; Bastian von Tresckow ; Alden Moccia ; Jana Markova ; Julia Meissner ; Andrea Kerkhoff ; Wolf-Dieter Ludwig ; Michael Fuchs ; Peter Borchmann ; Andreas Engert

Purpose : Clinical characteristics, therapeutic approaches, and prognosis of late relapse (LR) in patients with classic Hodgkin lymphoma (cHL) are poorly understood. We performed a comprehensive analysis of LR of Hodgkin lymphoma (LR-HL). Methods : To estimate the incidence of LR-HL, we retrospectively analyzed 6,840 patients with cHL included in the German Hodgkin Study Group trials HD7 to HD12. Patients who experienced a relapse > 5 years into remission were compared with patients in [...]

Menée à partir de données portant sur 179 520 patients atteints d'un lymphome sur la période 2004-2011, cette étude évalue les effets d'une infection par le VIH et d'un traitement antirétroviral hautement actif sur la survie

HIV Infection and Survival of Lymphoma Patients in the Era of Highly Active Antiretroviral Therapy

Han, Xuesong ; Jemal, Ahmedin ; Hulland, Erin ; Simard, Edgar P. ; Nastoupil, Loretta ; Ward, Elizabeth ; Flowers, Christopher R.

Background: Highly active antiretroviral therapy (HAART) has extended the life expectancy of patients with HIV/AIDS to approach that of the general population. However, it remains unclear whether HIV infection affects the survival of patients with lymphoma in the HAART era. Methods: Patients diagnosed with Hodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma, peripheral T-cell lymphoma (PTCL), or follicular lymphoma during 2004–2011 were identified from the National Cancer [...]

Menée aux Etats-Unis à partir de données portant sur des patients atteints d'un cancer du poumon non à petites cellules de stade métastatique entre 1990 et 2015, cette étude analyse l'évolution de la survie en lien avec les traitements systémiques et les soins de support reçus

Survival Gains from First-Line Systemic Therapy in Metastatic Non-Small Cell Lung Cancer in the U.S., 1990–2015: Progress and Opportunities

Roth, Joshua A. ; Goulart, Bernardo H. L. ; Ravelo, Arliene ; Kolkey, Holli ; Ramsey, Scott D.

Background : Approximately 190,000 Americans are diagnosed with non‐small cell lung cancer (NSCLC) annually, and about half have metastatic (Stage IV) disease. These patients have historically had poor survival prognosis, but several new therapies introduced since 2000 provide options for improved outcomes. The objectives of this study were to quantify survival gains from 1990, when best supportive care (BSC) only was standard, to 2015 and to estimate the impact of expanded use of systemic [...]

A partir des données d'un registre australien des cancers portant sur la période 1985-2009, cette étude analyse l'évolution de l'incidence du cancer du poumon chez les femmes en fonction de leur statut socioéconomique

Contrasting temporal trends in lung cancer incidence by socioeconomic status among women in New South Wales, Australia, 1985-2009

Yu, Xue Qin ; Luo, Qingwei ; Kahn, Clare ; Grogan, Paul ; O’Connell, Dianne L. ; Jemal, Ahmedin

Objective : We examined long-term trends in lung cancer incidence for women by socioeconomic groups in New South Wales (NSW), Australia. Methods : Data on lung cancer incidence for women were extracted from the NSW Cancer Registry database. We divided the study cohort into five quintiles according to an area-based index of education and occupation (IEO) and calculated annual age-standardised incidence rates by IEO quintile for the period 1985-2009. The age-standardised incidence ratio (SIR) was [...]

A partir des données des registres américains des cancers portant sur la période 1974-2003, cette étude analyse l'évolution de l'incidence du cancer colorectal, en fonction de l'âge du patient et de la localisation de la maladie

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

Siegel, Rebecca L. ; Fedewa, Stacey A. ; Anderson, William F. ; Miller, Kimberly D. ; Ma, Jiemin ; Rosenberg, Philip S. ; Jemal, Ahmedin

Background: Colorectal cancer (CRC) incidence in the United States is declining rapidly overall but, curiously, is increasing among young adults. Age-specific and birth cohort patterns can provide etiologic clues, but have not been recently examined. Methods: CRC incidence trends in Surveillance, Epidemiology, and End Results areas from 1974 to 2013 (n = 490 305) were analyzed by five-year age group and birth cohort using incidence rate ratios (IRRs) and age-period-cohort modeling. Results: [...]

A partir des données des registres américains des cancers sur la période 2000-2013, cette étude met à jour les données d'incidence du cancer colorectal ainsi que la mortalité spécifique

Colorectal cancer statistics, 2017

Siegel, Rebecca L. ; Miller, Kimberly D. ; Fedewa, Stacey A. ; Ahnen, Dennis J. ; Meester, Reinier G. S. ; Barzi, Afsaneh ; Jemal, Ahmedin

Colorectal cancer (CRC) is one of the most common malignancies in the United States. Every 3 years, the American Cancer Society provides an update of CRC incidence, survival, and mortality rates and trends. Incidence data through 2013 were provided by the Surveillance, Epidemiology, and End Results program, the National Program of Cancer Registries, and the North American Association of Central Cancer Registries. Mortality data through 2014 were provided by the National Center for Health [...]

A partir des données de la cohorte "Childhood Cancer Survivor Study" portant sur 404 patients adultes ayant survécu à un sarcome d'Ewing diagnostiqué pendant l'enfance et traité entre 1970 et 1986, cette étude analyse les effets des traitements à long terme sur leur état de santé

Longitudinal follow-up of adult survivors of Ewing sarcoma: A report from the Childhood Cancer Survivor Study

Marina, Neyssa M. ; Liu, Qi ; Donaldson, Sarah S. ; Sklar, Charles A. ; Armstrong, Gregory T. ; Oeffinger, Kevin C. ; Leisenring, Wendy M. ; Ginsberg, Jill P. ; Henderson, Tara O. ; Neglia, Joseph P. ; Stovall, Marilyn A. ; Yasui, Yutaka ; Randall, R. Lor ; Geller, David S. ; Robison, Leslie L. ; Ness, Kirsten K.

BACKGROUND: Ewing sarcoma survivors (ESSs) are at increased risk for treatment-related complications. The incidence of treatment-related morbidity and late mortality with aging is unknown. METHODS: This study reports survival probabilities, estimated with the Kaplan-Meier method, and the cumulative incidence of cause-specific mortality and chronic conditions among ESSs in the Childhood Cancer Survivor Study who were treated between 1970 and 1986. Piecewise exponential models were used to [...]

A partir des données des registres américains des cancers sur la période 1999-2012 portant sur des hommes âgés entre 15 et 59 ans, cette étude évalue l'évolution des disparités ethniques dans l'incidence d'une tumeur germinale du testicule et présente des projections jusqu'en 2026

Future of testicular germ cell tumor incidence in the United States: Forecast through 2026

Ghazarian, Armen A. ; Kelly, Scott P. ; Altekruse, Sean F. ; Rosenberg, Philip S. ; McGlynn, Katherine A.

BACKGROUND: Testicular germ cell tumors (TGCTs) are rare tumors in the general population but are the most commonly occurring malignancy among males between ages 15 and 44 years in the United States (US). Although non-Hispanic whites (NHWs) have the highest incidence in the US, rates among Hispanics have increased the most in recent years. To forecast what these incidence rates may be in the future, an analysis of TGCT incidence in the Surveillance, Epidemiology, and End Results program and the [...]

A partir d'une revue systématique de la littérature (45 études), cette étude analyse les facteurs associés à la persistance d'une infection par le papillomavirus humain chez les patientes atteintes d'une néoplasie cervicale intraépithéliale après divers types de traitements

Patterns of persistent HPV infection after treatment for cervical intraepithelial neoplasia (CIN): A systematic review

Hoffman, Sarah R. ; Le, Tam ; Lockhart, Alexandre ; Sanusi, Ayodeji ; Dal Santo, Leila ; Davis, Meagan ; McKinney, Dana A. ; Brown, Meagan ; Poole, Charles ; Willame, Corinne ; Smith, Jennifer S.

A systematic review of the literature was conducted to determine the estimates of and definitions for human papillomavirus (HPV) persistence in women following treatment of cervical intra-epithelial neoplasia (CIN). A total of 45 studies presented data on post-treatment HPV persistence among 6,106 women. Most studies assessed HPV persistence after loop excision (42%), followed by conization (7%), cryotherapy (11%), laser treatment (4%), interferon-alpha, therapeutic vaccination, and [...]

Menée en Australie auprès de 97 patients atteints d'un cancer de la prostate, cette étude évalue l'association entre le taux salivaire de cortisol, la présence et la sévérité de troubles anxieux et d'un stress chronique

Neurobiological and psychological evidence of chronic stress in prostate cancer patients

Sharpley, C. F. ; Christie, D. R. H. ; Bitsika, V. ; Agnew, L. L. ; Andronicos, N. M. ; McMillan, M. E. ; Richards, T. M.

To measure the prevalence and severity of Generalised Anxiety Disorder (GAD), hypo- and hypercortisolaemia, and their association in a sample of prostate cancer (PCa) patients, 97 Australian PCa patients completed a background questionnaire and the GAD-7, and provided a sample of saliva collected 30–45 min after waking. The mean GAD7 score was 9.67 (SD = 3.09), and prevalence rates for current anxiety were higher than those reported for non-PCa males of a similar age. Mean salivary cortisol [...]

Mené sur 169 patientes ayant survécu à un cancer du sein et souffrant de troubles de nature sexuelle, cet essai randomisé évalue l'efficacité d'une psychothérapie comportementale en ligne pour améliorer leur satisfaction vis-à-vis de leur vie amoureuse et sexuelle, améliorer leur image corporelle et leur qualité de vie

Efficacy of Internet-Based Cognitive Behavioral Therapy in Improving Sexual Functioning of Breast Cancer Survivors: Results of a Randomized Controlled Trial

Susanna B. Hummel ; Jacques J.D.M. van Lankveld ; Hester S.A. Oldenburg ; Daniela E.E. Hahn ; Jacobien M. Kieffer ; Miranda A. Gerritsma ; Marianne A. Kuenen ; Nina Bijker ; Paul J. Borgstein ; Gijsbert Heuff ; Alexander M.F. Lopes Cardozo ; Peter W. Plaisier ; Herman Rijna ; Suzan van der Meij ; Eric J. van Dulken ; Bart C. Vrouenraets ; Eva Broomans ; Neil K. Aaronson

Purpose : We evaluated the effect of Internet-based cognitive behavioral therapy (CBT) on sexual functioning and relationship intimacy (primary outcomes) and body image, menopausal symptoms, marital functioning, psychological distress, and health-related quality of life (secondary outcomes) in breast cancer survivors (BCSs) with a DSM-IV diagnosis of a sexual dysfunction. Patients and Methods : We randomly assigned 169 BCSs to either Internet-based CBT or a waiting-list control group. The CBT [...]

Menée aux Pays-Bas, cette étude analyse le rapport coût-efficacité de l'ajout du bévacizumab à un traitement à base de taxanes pour les patientes atteintes d'un cancer du sein HER2- de stade métastatique

Real-world and trial-based cost-effectiveness analysis of bevacizumab in HER2-negative metastatic breast cancer patients: a study of the Southeast Netherlands Breast Cancer Consortium

van Kampen, R. J. W. ; Ramaekers, B. L. T. ; Lobbezoo, D. J. A. ; de Boer, M. ; Dercksen, M. W. ; van den Berkmortel, F. ; Smilde, T. J. ; van de Wouw, A. J. ; Peters, F. P. J. ; van Riel, J. M. G. ; Peters, N. A. J. B. ; Tjan-Heijnen, V. C. G. ; Joore, M. A.

Introduction : The aim of our analysis was to assess the real-world cost-effectiveness of bevacizumab in addition to taxane treatment versus taxane monotherapy for HER2-negative metastatic breast cancer compared with the cost-effectiveness based on the efficacy results from a trial. Methods : A state transition model was built to estimate costs, life years (LYs) and quality-adjusted life years (QALYs) for both treatments. Two scenarios were examined: a real-world scenario and a trial-based [...]

Menée au Japon à partir de données portant sur 207 patients atteints d'un cancer de stade avancé et traités avec des corticostéroïdes, cette étude prospective évalue les facteurs associés à un délire

Predictors of Delirium in Corticosteroid-Treated Patients with Advanced Cancer: An Exploratory, Multicenter, Prospective, Observational Study

Matsuo, Naoki ; Morita, Tatsuya ; Matsuda, Yoshinobu ; Okamoto, Kenichiro ; Matsumoto, Yoshihisa ; Kaneishi, Keisuke ; Odagiri, Takuya ; Sakurai, Hiroki ; Katayama, Hideki ; Mori, Ichiro ; Yamada, Hirohide ; Watanabe, Hiroaki ; Yokoyama, Taro ; Yamaguchi, Takashi ; Nishi, Tomohiro ; Shirado, Akemi ; Hiramoto, Shuji ; Watanabe, Toshio ; Kohara, Hiroyuki ; Shimoyama, Satofumi ; Aruga, Etsuko ; Baba, Mika ; Sumita, Koki ; Iwase, Satoru

Background: Corticosteroids are often used to treat fatigue and anorexia, but occasionally produce delirium. Information on the predictors of delirium in corticosteroid-treated cancer patients remains limited. Objective: To identify potential factors predicting the development of delirium in corticosteroid-treated cancer patients. Design: An exploratory, multicenter, prospective, observational study. Setting/Subjects: Inclusion criteria for this study were patients who had metastatic or locally [...]

Menée au Japon à partir de données portant sur 415 patients atteints d'un cancer de stade avancé, cette étude rétrospective analyse les facteurs associés au temps passé à leur domicile durant leur dernier mois de vie

Factors Associated with Length of Stay at Home in the Final Month of Life among Advanced Cancer Patients: A Retrospective Chart Review

Otsuka, Masatomo

Background: Living at home is an important factor for maintaining high quality of life among patients. Many studies have discussed parameters associated with place of death, but no studies have yet clarified which factors influence the length of stay at home during the end of life. Objective: The aim of this study was to identify factors influencing the amount of time spent at home during the final month of life among patients with advanced cancer. Methods: A retrospective chart review was [...]