Menée aux Etats-Unis à partir de données portant sur 611 patients atteints d'un cancer du poumon, sur 601 patients atteints d'un cancer des voies aérodigestives supérieures et sur 1 040 témoins, cette étude évalue l'association entre un indice d'exposition cumulée au goudron de cigarette et le risque de développer la maladie

Case-control study of cumulative cigarette tar exposure and lung and upper aerodigestive tract cancers

Meyers, Travis J. ; Chang, Shen-Chih ; Chang, Po-Yin ; Morgenstern, Hal ; Tashkin, Donald P. ; Rao, Jian-Yu ; Cozen, Wendy ; Mack, Thomas M. ; Zhang, Zuo-Feng

The development of comprehensive measures for tobacco exposure is crucial to specify effects on disease and inform public health policy. In this population-based case-control study, we evaluated the associations between cumulative lifetime cigarette tar exposure and cancers of the lung and upper aerodigestive tract (UADT). The study included 611 incident cases of lung cancer; 601 cases of UADT cancers (oropharyngeal, laryngeal and esophageal cancers); and 1,040 cancer-free controls. We [...]

A partir des données de deux études de cohortes prospectives incluant 409 796 participants, cette étude évalue l'association entre l'évolution du poids au long de la vie et le risque d'adénocarcinome de l'œsophage et du cardia gastrique

Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

Petrick, Jessica L. ; Kelly, Scott P. ; Liao, Linda M. ; Freedman, Neal D. ; Graubard, Barry I. ; Cook, Michael B.

Background: Elevated body mass index (BMI, kg m−2) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. Methods: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA). At [...]

A partir de données de 8 études portant sur 3 482 patients atteints d'un myélome multiple et sur 13 238 témoins, cette étude évalue l'association entre l'indice de masse corporelle, mesuré à l'âge adulte ou au début de l'âge adulte (entre 25 et 30 ans), et le risque de développer la maladie

Young adult and usual adult body mass index and multiple myeloma risk: a pooled analysis in the International Multiple Myeloma Consortium (IMMC)

Birmann, Brenda M. ; Andreotti, Gabriella ; De Roos, Anneclaire J. ; Camp, Nicola J. ; Chiu, Brian C. H. ; Spinelli, John J. ; Becker, Nikolaus ; Benhaim-Luzon, Veronique ; Bhatti, Parveen ; Boffetta, Paolo ; Brennan, Paul ; Brown, Elizabeth E. ; Cocco, Pierluigi ; Costas, Laura ; Cozen, Wendy ; de Sanjose, Silvia ; Foretova, Lenka ; Giles, Graham G. ; Maynadie, Marc ; Moysich, Kirsten B. ; Nieters, Alexandra ; Staines, Anthony ; Tricot, Guido ; Weisenburger, Dennis ; Zhang, Yawei ; Baris, Dalsu ; Purdue, Mark P.

Background: Multiple myeloma (MM) risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with MM. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric MM risk factors, including young adult BMI. Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 MM cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for [...]

Menée aux Etats-Unis à partir de données portant sur 462 patients atteints d'un cancer de la thyroïde et sur 498 témoins, cette étude évalue l'association entre une exposition professionnelle à des produits biocides et pesticides et le risque de développer la maladie

Occupational exposure to pesticides and other biocides and risk of thyroid cancer

Zeng, Fanhua ; Lerro, Catherine ; Lavoué, Jérôme ; Huang, Huang ; Siemiatycki, Jack ; Zhao, Nan ; Ma, Shuangge ; Deziel, Nicole C ; Friesen, Melissa C ; Udelsman, Robert ; Zhang, Yawei

Objectives : To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer. Methods : Using data from a population-based case–control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010–2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for [...]

Menée au Danemark auprès de 22 877 infirmières, cette étude de cohorte évalue l'association entre une exposition à long terme à des particules fines et le risque de cancer du sein

Long-term Exposure to Fine Particulate Matter and Breast Cancer Incidence in the Danish Nurse Cohort Study

Andersen, Zorana Jovanovic ; Ravnskjær, Line ; Andersen, Klaus Kaae ; Loft, Steffen ; Brandt, Jørgen ; Becker, Thomas ; Ketzel, Matthias ; Hertel, Ole ; Lynge, Elsebeth ; Bräuner, Elvira Vaclavik

Background: An association between air pollution and breast cancer risk has been suggested, but evidence is sparse and inconclusive. Methods: We included 22,877 female nurses from the Danish Nurse Cohort who were recruited in 1993 or 1999 and followed them for incidence of breast cancer (N = 1,145) until 2013 in the Danish Cancer Register. We estimated annual mean concentrations of particulate matter with diameter ;2.5 μg/m3 (PM2.5) and <10 μg/m3 (PM10), and nitrogen dioxide (NO2) at nurses’ [...]

Menée aux Etats-Unis à partir de données portant sur des patients atteints d'un carcinome à cellules rénales (643 cas de cancer et 443 témoins avec antécédents d'hypertension, puis 500 cas de cancer et 718 témoins sans antécédents), cette étude évalue l'association entre une utilisation de médicaments antihypertenseurs et le risque de développer un cancer du rein

Antihypertensive medication use and risk of renal cell carcinoma

Colt, Joanne S. ; Hofmann, Jonathan N. ; Schwartz, Kendra ; Chow, Wong-Ho ; Graubard, Barry I. ; Davis, Faith ; Ruterbusch, Julie ; Berndt, Sonja ; Purdue, Mark P.

Purpose : Use of antihypertensive medications has been associated with renal cell carcinoma (RCC), but it is unclear whether specific types of medications increase RCC risk independent of the effect of hypertension, or whether the association varies by histologic subtype. To address this question, we analyzed data from a U.S. population-based case–control study of RCC. Methods : We collected information on participants’ use of drugs to treat hypertension, heart problems, weight control, and [...]

Mené en Finlande à partir de données portant sur 7 616 femmes, cette étude évalue l'association entre un lichen scléreux et le risque de cancer (812 cas de cancer)

Lichen sclerosus and risk of cancer

Halonen, Pia ; Jakobsson, Maija ; Heikinheimo, Oskari ; Riska, Annika ; Gissler, Mika ; Pukkala, Eero

Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection. We identified all women with the diagnosis of LS (n = 7,616) listed in the Finnish Hospital Discharge Registry from 1970 to 2012. The cohort was followed through the Finnish Cancer Registry for subsequent cancer diagnoses until 2014. Standardized incidence ratios (SIRs) were calculated for different cancers by [...]

A partir de données de deux études de cohorte incluant 442 patientes atteintes d'un cancer de l'ovaire et 727 témoins, cette étude évalue l'association entre la longueur des télomères dans les leucocytes, mesurée avant le diagnostic, et le risque de développer la maladie

Prediagnosis Leukocyte Telomere Length and Risk of Ovarian Cancer

Yang, Meng ; Prescott, Jennifer ; Poole, Elizabeth M. ; Rice, Megan S. ; Kubzansky, Laura D. ; Idahl, Annika ; Lundin, Eva ; De Vivo, Immaculata ; Tworoger, Shelley S.

Background: The associations between telomere length and cancer risk are equivocal, and none have examined the association between prediagnosis leukocyte telomere length (LTL) and the risk of developing ovarian cancer. Methods: We prospectively measured LTL collected from 442 ovarian cancer cases and 727 controls in the Nurses’ Health Studies and the Northern Sweden Health and Disease Study. Cases were matched to one or two controls on age, menopausal status, and date of blood collection. Odds [...]

A partir de données de 5 études de cohorte incluant 3 811 patients atteints d'un cancer de la prostate et 2 980 témoins, cette étude évalue l'association entre 46 polymorphimes à simple nucléotide de gènes précédemment identifiés dans des études d'association sur le génome entier, le niveau sanguin de vitamine D et le risque de développer la maladie

Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3

Vasiliki I. Dimitrakopoulou; ; Ruth C. Travis; ; Irene M. Shui; ; Alison Mondul; ; Demetrius Albanes; ; Jarmo Virtamo; ; Antonio Agudo; ; Heiner Boeing; ; H. Bas Bueno-de-Mesquita; ; Marc J. Gunter

Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by vitamin D. We investigated the associations of 46 GWAS-identified SNPs, [...]

A partir de données portant sur 50 884 participantes âgées de 35 à 74 ans, cette étude de cohorte évalue l'association entre un diabète gestationnel et le risque de cancer du sein

Gestational diabetes mellitus may be associated with increased risk of breast cancer

Park, Yong-Moon Mark ; O'Brien, Katie M. ; Zhao, Shanshan ; Weinberg, Clarice R. ; Baird, Donna D. ; Sandler, Dale P.

Background: Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear. Methods: The Sister Study enroled 50 884 women aged 35–74 years, from 2003 through 2009. Cox proportional hazards models were used to estimate breast cancer risk in relation to GDM. Results: Ever having GDM was not associated with breast cancer overall (hazards ratio (HR)=1.10, 95% confidence interval (CI)=0.88–1.36), but [...]

A partir des données de la cohorte "Nurses’ Health Study II" incluant 86 972 participantes, cette étude prospective évalue l'association entre des antécédents de diabète gestationnel (5 188 cas) et le risque de développer un cancer du sein invasif (2 377 cas de cancer, dont 100 avec des antécédents de diabète gestationnel)

History of Gestational Diabetes Mellitus and Risk of Incident Invasive Breast Cancer among Parous Women in the Nurses’ Health Study II Prospective Cohort

Powe, Camille E. ; Tobias, Deirdre K. ; Michels, Karin B. ; Chen, Wendy Y. ; Eliassen, A. Heather ; Manson, JoAnn E. ; Rosner, Bernard ; Willett, Walter C. ; Hu, Frank B. ; Zhang, Cuilin ; Rich-Edwards, Janet W. ; Rexrode, Kathryn M.

Background: Type II diabetes is associated with breast cancer in epidemiologic studies. Pregnancy also modifies breast cancer risk. We hypothesized that women with a history of gestational diabetes mellitus (GDM), which shares pathogenesis and risk factors with type II diabetes, would have greater invasive breast cancer risk than parous women without a history of GDM. Methods: We conducted a prospective analysis among parous women in the Nurses’ Health Study II, with mean age 35 years in 1989. [...]

A partir de données portant sur 3 001 patients atteints d'un cancer de la thyroïde non médullaire et sur 287 550 témoins, cette étude d'association sur le génome entier met en évidence 5 nouveaux loci de susceptibilité à la maladie

A genome-wide association study yields five novel thyroid cancer risk loci

Julius Gudmundsson ; Gudmar Thorleifsson ; Kari Stefansson

The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10−8): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), [...]