A partir d'une revue systématique de la littérature publiée entre 1996 et 2016 (104 études), cet article présente les recommandations sur la prévention et la prise en charge des dysfonctionnements et troubles cardiaques chez des patients adultes ayant survécu à un cancer

Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

Saro H. Armenian ; Christina Lacchetti ; Ana Barac ; Joseph Carver ; Louis S. Constine ; Neelima Denduluri ; Susan Dent ; Pamela S. Douglas ; Jean-Bernard Durand ; Michael Ewer ; Carol Fabian ; Melissa Hudson ; Mariell Jessup ; Lee W. Jones ; Bonnie Ky ; Erica L. Mayer ; Javid Moslehi ; Kevin Oeffinger ; Katharine Ray ; Kathryn Ruddy ; Daniel Lenihan

Purpose : Cardiac dysfunction is a serious adverse effect of certain cancer-directed therapies that can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. The purpose of this effort was to develop recommendations for prevention and monitoring of cardiac dysfunction in survivors of adult-onset cancers. Methods : Recommendations were developed by an expert panel with multidisciplinary representation using a systematic [...]

A partir d'une revue systématique de la littérature (34 essais randomisés, 4 519 patients), cette méta-analyse évalue les effets d'une activité physique sur les fonctions physiques et sur la qualité de vie de patients atteints d'un cancer, en prenant en compte des critères cliniques, démographiques et le type d'intervention

Effects and moderators of exercise on quality of life and physical function in patients with cancer: an individual patient data meta-analysis of 34 RCTs

Buffart, Laurien M. ; Kalter, Joeri ; Sweegers, Maike G. ; Courneya, Kerry S. ; Newton, Robert U. ; Aaronson, Neil K. ; Jacobsen, Paul B. ; May, Anne M. ; Galvão, Daniel A. ; Chinapaw, Mai J. ; Steindorf, Karen ; Irwin, Melinda L. ; M.Stuiver, Martijn ; Hayes, Sandi ; Griffith, Kathleen A. ; Lucia, Alejandro ; Mesters, Ilse ; van Weert, Ellen ; Knoop, Hans ; Goedendorp, Martine M. ; Mutrie, Nanette ; Daley, Amanda J. ; McConnachie, Alex ; Bohus, Martin ; Thorsen, Lene ; Schulz, Karl-Heinz ; Short, Camille E. ; James, Erica L. ; Plotnikoff, Ron C. ; Arbane, Gill ; Schmidt, Martina E. ; Potthoff, Karin ; van Beurden, Marc ; Oldenburg, Hester S. ; Sonke, Gabe S. ; van Harten, Wim H. ; Garrod, Rachel ; Schmitz, Kathryn H. ; Winters-Stone, Kerri M. ; Velthuis, Miranda J. ; Taaffe, Dennis R. ; van Mechelen, Willem ; Kersten, Marie-Jose ; Nollet, Frans ; Wenzel Jennifer, J. ; Wiskemann J, Joachim ; Verdonck-de Leeuw, I. M. ; Brug, J.

This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. [...]

Menée aux Pays-Bas par questionnaire auprès de 127 patients atteints de cancer, cette étude évalue la prévalence et les caractéristiques associées à une altération du goût (goût métallique) en lien avec un traitement systémique

Metallic Taste in Cancer Patients Treated with Systemic Therapy: A Questionnaire-based Study

Ijpma, Irene ; Timmermans, Erik R. ; Renken, Remco J. ; Ter Horst, Gert J. ; Reyners, Anna K. L.

ABSTRACTA metallic taste is reported by cancer patients as a side effect of systemic therapy. Despite the high prevalence, this taste alteration has received limited attention. The present study investigated: 1) the prevalence of metallic taste in cancer patients treated with systemic therapy; 2) possible predictors of metallic taste; and 3) characteristics of metallic taste. A heterogeneous population of 127 cancer patients, who had received systemic treatment in the past year or were still on [...]

Cette étude passe en revue les manifestations cliniques et les modalités de prise en charge des symptômes vasomoteurs chez des patientes atteintes d'un cancer du sein traité par suppression de la fonction ovarienne et anti-œstrogènes

Management of Hot Flashes in Women with Breast Cancer Receiving Ovarian Function Suppression

Leon-Ferre, Roberto A. ; Majithia, Neil ; Loprinzi, Charles L.

Most breast cancers express estrogen and/or progesterone receptors, allowing the opportunity to use anti-estrogen therapies, which have demonstrated substantial efficacy in both the metastatic and adjuvant settings. Young premenopausal women with early-stage high-risk or with metastatic hormone-receptor positive breast cancer may benefit from ovarian function suppression in addition to anti-estrogen medications. While these endocrine manipulations have successfully improved breast cancer [...]

Menée en France à partir de données portant sur 403 patients atteints de cancer, cette étude rétrospective évalue l'efficacité d'une perfusion de fer-saccharose et d'une transfusion sanguine pour prendre en charge une anémie

Use of iron sucrose and red blood cell transfusions in anaemic cancer patients in France (OncoFer study)

Luporsi, Elisabeth ; Toledano, Alain ; Spaëth, Dominique ; Scotté, Florian ; Espié, Marc ; Perot, Stéphanie ; Duvillié, Ladan ; Pithois Merli, Isabelle ; Bugat, Roland

Purpose : This report describes the results of an observational, retrospective cohort study, evaluating the use of iron sucrose (IS) and red blood cell (RBC) transfusions in patients with cancer in routine clinical practice in France. A parallel investigated cohort treated with ferric carboxymaltose (FCM) has been reported earlier. Methods : Data of patients with a solid tumour or haematological malignancy who have received IS or an RBC transfusion during 2010 from 3 months prior (M−3) to 3 [...]

Menée au Japon auprès de 122 patients atteints d'un cancer du poumon, cette étude rétrospective évalue l'efficacité d'une hydratation de courte durée avec une supplémentation en magnésium pour prévenir les néphrotoxicités induites par une chimiothérapie à base de cisplatine

Short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity in lung cancer: a retrospective analysis

Yamaguchi, Teppei ; Uozu, Sakurako ; Isogai, Sumito ; Hayashi, Masamichi ; Goto, Yasuhiro ; Nakanishi, Toru ; Imaizumi, Kazuyoshi

Purpose : The purpose of this study was to evaluate renal function in lung cancer patients who were administered cisplatin with continuous higher-volume hydration (CH) or a short hydration (SH) regimen. Methods : We retrospectively evaluated patients with lung cancer who were treated with chemotherapy regimens including >50 mg/m2 of cisplatin between August 2007 and March 2015. Between August 2007 and December 2012, patients received a continuous higher-volume hydration regimen without [...]

A partir des données d'un registre américain des cancers portant sur 453 patients ayant survécu à un cancer colorectal de stade II, cette étude de cohorte évalue l'association entre une supplémentation en antioxydants et leur qualité de vie

Antioxidant Supplementation Is Not Associated with Long-term Quality of Life in Stage-II Colorectal Cancer Survivors: A Follow-up of the Study of Colorectal Cancer Survivors Cohort

Tsinovoi, Cari Lewis ; Xun, Pengcheng ; He, Ka

Cancer survivors are motivated to change lifestyle following diagnosis, but studies investigating the outcomes are scarce. The purpose of this study was to examine the associations between antioxidant supplementation and quality of life (QoL) in stage-II colorectal cancer survivors. Four-hundred-fifty-three survivors were enrolled from the North Carolina Cancer Registry from 2009 to 2011. Interview data on demography, treatment, health behaviors, and QoL were collected at diagnosis, and at 12 [...]

Menée en Allemagne, cette étude analyse la prévalence et l'évolution de diverses comorbidités physiques et psychiques chez des patients atteints d'un sarcome des tissus mous

Patients with soft tissue sarcoma comprise a higher probability of comorbidities than cancer-free individuals. A secondary data analysis

Trautmann, F. ; Singer, S. ; Schmitt, J.

Soft tissue sarcoma comprises a heterogeneous group of solid malignant tumours. Comorbidities are important prognostic factors for survival and adversely impact quality of life. We examined the complex relationship between soft tissue sarcoma and comorbidities over time in a large population-based sample. The study uses routine data from the German statutory healthcare system (n = 2,615,865). Case identification of soft tissue sarcoma and comorbid diseases was based on ICD-10 codes and [...]

Menée en Corée auprès de 271 patientes atteintes d'un cancer du sein et ayant reçu un traitement chirurgical, cette étude analyse les facteurs associés au risque de capsulite rétractile de l'épaule, 13 à 18 mois après la chirurgie

Prevalence and risk factors of adhesive capsulitis of the shoulder after breast cancer treatment

Yang, Seoyon ; Park, Dae Hwan ; Ahn, Sei Hyun ; Kim, Jisun ; Lee, Jong Won ; Han, Jun Young ; Kim, Dong Kyu ; Jeon, Jae Yong ; Choi, Kyoung Hyo ; Kim, Won

Purpose : The present study investigated the prevalence and risk factors of adhesive capsulitis of the shoulder in breast cancer patients between 13 and 18 months after surgery. Methods : This study included 271 women who underwent surgery for breast cancer with a postoperative period of 13–18 months. Current adhesive capsulitis was defined as restriction of external rotation and one or more additional directional restrictions with history of shoulder pain. Cumulative adhesive capsulitis was [...]

Menée aux Pays-Bas auprès de 194 patientes ayant survécu à un cancer de l'utérus, âgées de 25 à 69 ans et vivant en couple, cette étude multicentrique analyse leurs symptômes de nature sexuelle associés à leur détresse psychologique

Sexual distress and associated factors among cervical cancer survivors: A cross-sectional multicenter observational study

Bakker, R. M. ; Kenter, G. G. ; Creutzberg, C. L. ; Stiggelbout, A. M. ; Derks, M. ; Mingelen, W. ; Kroon, C. D. ; Vermeer, W. M. ; ter Kuile, M. M.

Background: To assess whether sexual distress among cervical cancer (CC) survivors is associated with frequently reported vaginal sexual symptoms, other proposed biopsychosocial factors and whether worries about painful intercourse mediate the relation between vaginal sexual symptoms and sexual distress. Methods: A cross-sectional study was conducted among 194 sexually active partnered CC survivors aged 25 to 69 years. Sexual distress, vaginal sexual symptoms, sexual pain worry, anxiety, [...]

Menée au Danemark auprès de 5 131 hommes (âge moyen : 48,8 ans ; durée de suivi : 44 ans), cette étude évalue l'association entre la capacité cardiorespiratoire et le risque de décès par cancer (1 527 cas) ou la mortalité toutes causes confondues (4 486 cas)

Cardiorespiratory fitness and death from cancer: a 42-year follow-up from the Copenhagen Male Study

Jensen, Magnus Thorsten ; Holtermann, Andreas ; Bay, Hans ; Gyntelberg, Finn

Objectives : Poor cardiorespiratory fitness (CRF) is associated with death from cancer. If follow-up time is short, this association may be confounded by subclinical disease already present at the time of CRF assessment. This study investigates the association between CRF and death from cancer and any cause with 42 years and 44 years of follow-up, respectively. Setting, participants and main outcome measures : Middle-aged, employed and cancer-free Danish men from the prospective Copenhagen Male [...]

A partir des données des registres américains des cancers portant sur la période 1992-2013, cette étude analyse l'évolution de l'incidence de cinq types de cancer (sein, œsophage, rein, poumon, thyroïde) et évalue la survie

Cancer incidence and survival trends by subtype using data from the Surveillance Epidemiology and End Results Program, 1992-2013

Noone, Anne-Michelle ; Cronin, Kathleen A. ; Altekruse, Sean F. ; Howlader, Nadia ; Lewis, Denise R. ; Petkov, Valentina I ; Penberthy, Lynne

Background:Cancers are heterogeneous comprising of distinct tumor subtypes. Therefore, presenting the burden of cancer in the population and trends over time by these tumor subtypes is important to identify patterns and differences in the occurrence of these subtypes, especially to generalize findings to the US general population. Methods:Using SEER cancer registry data, we present incidence rates according to subtypes for diagnosis years (1992-2013) among men and women for five major cancer [...]

Menée en Allemagne à partir de données portant sur 1 633 patients atteints de cancer, cette étude évalue l'association entre divers indicateurs liés au niveau socio-économique et la survie (durée de suivi : 10 ans)

Socio-economic disparities in long-term cancer survival—10 year follow-up with individual patient data

Singer, Susanne ; Bartels, Michael ; Briest, Susanne ; Einenkel, Jens ; Niederwieser, Dietger ; Papsdorf, Kirsten ; Stolzenburg, Jens-Uwe ; Künstler, Sophie ; Taubenheim, Sabine ; Krauß, Oliver

Purpose : Reasons for the social gradient in cancer survival are not fully understood yet. Previous studies were often only able to determine the socio-economic status of the patients from the area they live in, not from their individual socio-economic characteristics. Methods : In a multi-centre cohort study with 1633 cancer patients and 10-year follow-up, individual socio-economic position was measured using the indicators: education, job grade, job type, and equivalence income. The effect on [...]

A partir d'une revue systématique de la littérature (22 études), cette étude évalue l'association entre le tissu adipeux viscéral, évalué par diverses méthodes d'imagerie, et la survie chez des patients atteints de divers types de cancer

Visceral adiposity and cancer survival: a review of imaging studies

Xiao, J. ; Mazurak, V. C. ; Olobatuyi, T. A. ; Caan, B. J. ; Prado, C. M.

Although obesity is a well-known risk factor for cancer, the association between obesity and cancer survival remains controversial. This is partially due to the inability of conventional obesity measures to directly assess adiposity or adipose tissue distribution. As a metabolic organ, visceral adipose tissue (VAT) secrets a variety of cytokines and cytokine-like factors, potentially affecting cancer survival. The objective of this review was to investigate the influence of imaging-assessed VAT [...]

Menée aux Pays-Bas à partir de données portant sur 483 patients pédiatriques atteints d'une tumeur neuro-endocrine entre 1991 et 2013, cette étude analyse les caractéristiques liées au patient et à la tumeur, puis évalue le rôle d'une prédisposition génétique dans l'étiologie de la maladie

Childhood neuroendocrine tumours: a descriptive study revealing clues for genetic predisposition

Diets, I. J. ; Nagtegaal, I. D. ; Loeffen, J. ; de Blaauw, I. ; Waanders, E. ; Hoogerbrugge, N. ; Jongmans, M. C. J.

Background: Neuroendocrine tumours (NETs) are rare in children and limited data are available. We aimed to specify tumour and patient characteristics and to investigate the role of genetic predisposition in the aetiology of paediatric NETs. Methods: Using the Dutch Pathology Registry PALGA, we collected patient- and tumour data of paediatric NETs in the Netherlands between 1991 and 2013 (N=483). Results: The incidence of paediatric NETs in the Netherlands is 5.40 per one million per year. The [...]

A partir d'une revue systématique de la littérature (23 études), cette étude analyse les effets d'une surveillance active de l'évolution de la maladie sur la santé psychique de patients atteints d'un cancer de la prostate à faible risque de récidive

Active surveillance for favorable-risk prostate cancer: Is there a greater psychological impact than previously thought? A systematic, mixed studies literature review

Ruane-McAteer, Eimear ; Porter, Sam ; O'Sullivan, Joe M. ; Santin, Olinda ; Prue, Gillian

Objective: Active surveillance (AS) allows men with favorable-risk prostate cancer to avoid or postpone active treatment and hence spares potential adverse effects for a significant proportion of these patients. Active surveillance may create an additional emotional burden for these patients. The aim of the review was to determine the psychological impact of AS to inform future study in this area and to provide recommendations for clinical practice. Methods: Studies were identified through [...]

Menée en Ecosse par enquête auprès de 205 patients ayant survécu à un cancer colorectal, cette étude analyse les facteurs associés au risque de stress post-traumatique, notamment le faible soutien social et des contraintes familiales (famille peu réceptive, fermée, critique,...)

The role of social support, family identification, and family constraints in predicting posttraumatic stress after cancer

Swartzman, Samantha ; Sani, Fabio ; Munro, Alastair J.

Objective: We compared social support with other potential psychosocial predictors of posttraumatic stress after cancer. These included family identification, or a sense of belonging to and commonality with family members, and family constraints, or the extent to which family members are closed, judgmental, or unreceptive in conversations about cancer. We also tested the hypothesis that family constraints mediate the relationship between family identification and cancer-related posttraumatic [...]

Menée aux Etats-Unis à partir de données portant sur 56 aidants de patients atteints de métastases cérébrales, cette étude évalue l'association entre des dysfonctionnements cognitifs chez les patients et les capacités de résilience chez leurs aidants

Cognitive dysfunction in patients with brain metastases: influences on caregiver resilience and coping

Saria, Marlon Garzo ; Courchesne, Natasia ; Evangelista, Lorraine ; Carter, Joshua ; MacManus, Daniel A. ; Gorman, Mary Kay ; Nyamathi, Adeline M. ; Phillips, Linda R. ; Piccioni, David ; Kesari, Santosh ; Maliski, Sally

Purpose : Neurologic deficits that may be manifested as cognitive impairment contribute to the challenges faced by caregivers of patients with brain metastases. To better address their needs, we examined how caregivers respond to these challenges and explore the relationship between the patient’s cognitive impairment and caregiver resilience and coping. Methods : We conducted a descriptive, cross-sectional study using self-reported data from 56 caregivers of patients with brain metastases. [...]

Menée aux Pays-Bas auprès de 156 patients atteints d'un cancer du poumon ou d'un cancer de la tête et du cou, cette étude analyse le rapport coût-efficacité d'un programme organisé en plusieurs étapes d'intensité progressive pour améliorer la prise en charge de leur détresse psychologique

Cost-Utility of Stepped Care Targeting Psychological Distress in Patients With Head and Neck or Lung Cancer

Femke Jansen ; Anna M.H. Krebber ; Veerle M.H. Coupé ; Pim Cuijpers ; Remco de Bree ; Annemarie Becker-Commissaris ; Egbert F. Smit ; Annemieke van Straten ; Guus M. Eeckhout ; Aartjan T.F. Beekman ; C. René Leemans ; Irma M. Verdonck-de Leeuw

Purpose : A stepped care (SC) program in which an effective yet least resource-intensive treatment is delivered to patients first and followed, when necessary, by more resource-intensive treatments was found to be effective in improving distress levels of patients with head and neck cancer or lung cancer. Information on the value of this program for its cost is now called for. Therefore, this study aimed to assess the cost-utility of the SC program compared with care-as-usual (CAU) in patients [...]

Menée en France à partir de données portant sur 529 patients atteints d'un cancer de stade avancé (âge moyen : 54 ans) et inclus dans l'essai clinique MOSCATO, cette étude prospective analyse les coûts associés aux technologies de diagnostic moléculaire et aux thérapies ciblées

The cost of molecular-guided therapy in oncology: a prospective cost study alongside the MOSCATO trial

Pages, Arnaud ; Foulon, Stéphanie ; Zou, Zhaomin ; Lacroix, Ludovic ; Lemare, Francois ; De Baere, Thierry ; Massard, Christophe ; Soria, Jean-Charles ; Bonastre, Julia

Aim: There is increasing use of molecular technologies to guide cancer treatments, but few cost data are available. Our objective was to assess the costs of molecular-guided therapy for patients with advanced solid tumors alongside the Molecular Screening for Cancer Treatment and Optimization (MOSCATO) trial. Materials and methods: The study population consisted of 529 patients. The molecular diagnosis included seven steps from tumor biopsy to the multidisciplinary molecular tumor board. The [...]

Menée aux Etats-Unis à partir de données portant sur 169 patients atteints d'un mélanome, cette étude évalue l'effet de discussions entre le médecin, le patient et sa famille relatives à des pratiques de prévention des risques (protection solaire, auto-examination, ..) et des changements de comportements après le diagnostic et les traitements

Communication about melanoma and risk reduction after melanoma diagnosis

Rodríguez, Vivian M. ; Berwick, Marianne ; Hay, Jennifer L.

Background: Melanoma patients are advised to perform regular risk-reduction practices, including sun protection as well as skin self-examinations (SSEs) and physician-led examinations. Melanoma-specific communication regarding family risk and screening may promote such behaviors. To this end, associations between patients' melanoma-specific communication and risk reduction were examined. Methods: Melanoma patients (N = 169) drawn from a population-based cancer registry reported their current [...]

Cette étude analyse la mise à jour des recommandations du Conseil des organisations internationales des sciences médicales en matière de recherches en santé impliquant des êtres humains

Revised CIOMS international ethical guidelines for health-related research involving humans

van Delden, J. M. ; van der Graaf, R.

The Council for International Organizations of Medical Sciences (CIOMS) was established jointly by the World Health Organization (WHO) and the United Nations Educational, Scientific and Cultural Organization (UNESCO) in 1949 as an international, nongovernmental, nonprofit organization and now includes 45 international, national, and associate member organizations, representing many of the biomedical disciplines, national academies of sciences, and medical research councils. CIOMS recently [...]