Menée aux Etats-Unis auprès de 300 patients atteints de cancer et traités en ambulatoire, cette étude évalue l'efficacité d'une intervention pédagogique destinée à améliorer leurs pratiques relatives à l'utilisation des médicaments opioïdes pour prendre en charge la douleur liée à la maladie

The Impact of an Educational Program on Patient Practices for Safe Use, Storage, and Disposal of Opioids at a Comprehensive Cancer Center

de la Cruz, Maxine ; Reddy, Akhila ; Balankari, Vishidha ; Epner, Margeaux ; Frisbee-Hume, Susan ; Wu, Jimin ; Liu, Diane ; Yennurajalingam, Sriram ; Cantu, Hilda ; Williams, Janet ; Bruera, Eduardo

Improper use, storage, and disposal of prescribed opioids can lead to diversion or accidental poisoning. Our previous study showed a large proportion of cancer patients have unsafe opioid practices. Our objective was to determine whether an improvement occurred in the patterns of use, storage, and disposal of opioids among cancer outpatients after the implementation of a patient educational program.Our palliative care (PC) clinic provides every patient with educational material (EM) on safe [...]

Menée par enquête auprès de 742 professionnels de santé dans 14 pays, cette étude analyse leurs connaissances et pratiques relatives à la prise en charge de la cachéxie chez les patients atteints de cancer

Perspectives of health care professionals on cancer cachexia: results from three global surveys

Muscaritoli, M. ; Rossi Fanelli, F. ; Molfino, A.

Background : Cachexia has a high prevalence in cancer patients and negatively impacts prognosis, quality of life (QOL), and tolerance/response to treatments. This study reports the results of three surveys designed to gain insights into cancer cachexia (CC) awareness, understanding, and treatment practices among health care professionals (HCPs). Methods : Surveys were conducted globally among HCPs involved in CC management. Topics evaluated included definitions and synonyms of CC, diagnosis and [...]

A partir d'une revue systématique de la littérature, cette étude évalue l'efficacité et les effets indésirables des médicaments opioïdes (morphine, oxycodone, fentanyl, alfentanil, sufentanil) pour la prise en charge de la douleur chez les patients atteints de cancer et souffrant d'insuffisance rénale

The use of opioids in cancer patients with renal impairment—a systematic review

Sande, Tonje A. ; Laird, Barry J. A. ; Fallon, Marie T.

Purpose : Opioids are recommended for moderate to severe cancer pain; however, in patients with cancer, impaired renal function can affect opioid metabolism. The aim of this systematic review was to evaluate the current evidence for the use of opioids in cancer patients with renal impairment. Methods : A systematic review was conducted and the following databases were searched: MEDLINE (1966 to 2015), EMBASE (1980 2015) and Cochrane Central Register of Controlled Trials (up to 2015). Eligible [...]

Menée au Etats-Unis auprès de 48 patients atteints d'une leucémie myéloïde aiguë récidivante ou réfractaire, cette étude de cohorte rétrospective évalue l'efficacité d'un traitement prophylactique antibactérien à base de lévofloxacine pour réduire le taux d'infections pendant une chimiothérapie de réinduction

Impact of antibacterial prophylaxis during reinduction chemotherapy for relapse/refractory acute myeloid leukemia

Ganti, Beejal R. ; Marini, Bernard L. ; Nagel, Jerod ; Bixby, Dale ; Perissinotti, Anthony J.

Purpose : This study evaluated the impact of antibacterial prophylaxis with levofloxacin in relapsed/refractory acute myeloid leukemia (AML) patients. Methods : This was a retrospective, single-center, cohort study. Adult patients with relapsed/refractory AML admitted for reinduction chemotherapy between November 1, 2006 and June 15, 2015 were screened for inclusion. A protocol initiating levofloxacin prophylaxis was implemented on December 1, 2013. Patients receiving hypomethylating agents [...]

Mené sur 62 patients devant recevoir une greffe de cellules souches hématopoïétiques (âge : 20 à 68 ans), cet essai compare, du point de vue de l'absence de vomissements, d'utilisation de médicaments de secours et de la réduction d'au moins 50% du score de nausées, l'efficacité de l'olanzapine, du palonosétran et de l'ondansétron en perfusion dans le cadre d'une chimiothérapie de conditionnement en combinaison ou non avec une radiothérapie

A randomized trial of olanzapine versus palonosetron versus infused ondansetron for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients undergoing hematopoietic stem cell transplantation

Nakagaki, Midori ; Barras, Michael ; Curley, Cameron ; Butler, Jason P. ; Kennedy, Glen A.

Purpose : The primary aim of this study was to compare the effectiveness of olanzapine, palonosetron and ondansetron infusion (standard of care) for the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) in patients undergoing hematopoietic stem cell transplantation (HSCT). Method : It was a randomized open-label prospective study. Sixty-two patients were randomized to receive either ondansetron 32-mg infusion over 24 h, or olanzapine wafer 10 mg once daily in addition to [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2015 (17 essais), cette étude analyse les effets des interventions destinées à améliorer les comportements de santé (meilleure alimentation, pratique d'exercices physiques, réduction des comportements à risque, ...) sur la qualité de vie des patients atteints d'un cancer de la prostate

Lifestyle interventions to improve the quality of life of men with prostate cancer : A systematic review of randomized controlled trials

Menichetti, Julia ; Villa, Silvia ; Magnani, Tiziana ; Avuzzi, Barbara ; Bosetti, Davide ; Marenghi, Cristina ; Morlino, Sara ; Rancati, Tiziana ; van Poppel, Hein ; Salvioni, Roberto ; Valdagni, Riccardo ; Bellardita, Lara

Improving quality of life is a key issue for patients with prostate cancer (PCa). Lifestyle interventions could positively impact the quality of life of patients. However, there is no clear-cut understanding of the role of diet, exercise and risky behaviour reduction in improving the quality of life of men with PCa. The aim of this review was to systematically summarize randomized controlled trials on lifestyle in PCa patients with quality of life as main outcome. 17 trials were included. Most [...]

Mené à partir de questionnaires auprès de 413 patients atteints d'un cancer colorectal métastatique et ayant reçu pendant 24 semaines un traitement d'induction par fluoropyrimidine-oxaliplatine-bévacizumab, cette étude évalue l'intérêt d'un traitement d'entretien par bévacizumab, en combinaison ou non avec la fluoropyrimidine, pour améliorer la qualité de vie des patients

Quality of life assessment in patients with metastatic colorectal cancer receiving maintenance therapy after first-line induction treatment : a preplanned analysis of the phase III AIO KRK 0207 trial

Quidde, J. ; Hegewisch-Becker, S. ; Graeven, U. ; Lerchenmüller, C. A. ; Killing, B. ; Depenbusch, R. ; Steffens, C.-C. ; Lange, T. ; Dietrich, G. ; Stoehlmacher, J. ; Reinacher, A. ; Tannapfel, A. ; Trarbach, T. ; Marschner, N. ; Schmoll, H.-J. ; Hinke, A. ; Al-Batran, S.-E. ; Arnold, D.

Background : First-line maintenance strategies are a current matter of debate in the management of mCRC. Their impact on patient's health-related quality of life (HRQOL) has not yet been evaluated. The objective of this study was to assess whether differences in HRQOL during any active maintenance treatment compared with no maintenance treatment exist. Patient and methods : Eight hundred and thirty-seven patients were enrolled in the AIO KRK 0207 trial. Four hundred and seventy-two underwent [...]

A partir des données d'un essai de phase II incluant 188 patientes atteintes d'un cancer du sein métastatique et évaluant l'efficacité d'un traitement combinant paclitaxel et bevacizumab avec ou sans capécitabine en traitement palliatif de première ligne, cette étude évalue l'association entre des polymorphismes à simple nucléotide des gènes CYP2C8 et FGD4, le risque de neuropathie périphérique induite par le paclitaxel et la réduction précoce des doses de paclitaxel

Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients

Lam, Siu W. ; Frederiks, Charlotte N. ; van der Straaten, Tahar ; Honkoop, Aafke H. ; Guchelaar, Henk-Jan ; Boven, Epie

Background: The purpose of this study was to evaluate single-nucleotide polymorphisms (SNPs) in genes encoding key metabolising enzymes or involved in pharmacodynamics for possible associations with paclitaxel-induced peripheral neuropathy. Methods: The study population consists of 188 women from the multicenter, randomised, phase II ATX trial (BOOG2006-06; EudraCT number 2006-006058-83) that received paclitaxel and bevacizumab without or with capecitabine as first-line palliative therapy of [...]

Menée dans le cadre du système italien de santé publique et à partir des données de 16 essais cliniques portant sur 3 670 patients atteints d'un cancer du poumon, du sein ou de l'ovaire, cette étude évalue l'association entre les difficultés financières rencontrées et le risque de décès ou la qualité de vie globale

The association of financial difficulties with clinical outcomes in cancer patients : secondary analysis of 16 academic prospective clinical trials conducted in Italy

Perrone, F. ; Jommi, C. ; Di Maio, M. ; Gimigliano, A. ; Gridelli, C. ; Pignata, S. ; Ciardiello, F. ; Nuzzo, F. ; de Matteis, A. ; Del Mastro, L. ; Bryce, J. ; Daniele, G. ; Morabito, A. ; Piccirillo, M. C. ; Rocco, G. ; Guizzaro, L. ; Gallo, C.

Background : Cancer may cause financial difficulties, but its impact in countries with public health systems is unknown. We evaluated the association of financial difficulties with clinical outcomes of cancer patients enrolled in academic clinical trials performed within the Italian public health system. Patients and methods : Data were pooled from 16 prospective multicentre trials in lung, breast or ovarian cancer, using the EORTC quality of life (QOL) C30 questionnaire. Question 28 scores [...]

Menée à partir des données des registres américains des cancers portant sur 5 271 patients atteints d'un adénocarcinome de l'œsophage diagnostiqué entre 1994 et 2009 (âge au diagnostic : 68 ans ou plus), cette étude montre que le caractère agressif et la progression de la maladie diffèrent selon que les patients présentent ou non avant diagnostic un endobrachyœsophage (œsophage de Barrett)

Pathogenesis and progression of oesophageal adenocarcinoma varies by prior diagnosis of Barrett/'s oesophagus

Cook, Michael B. ; Drahos, Jennifer ; Wood, Shannon ; Enewold, Lindsey ; Parsons, Ruth ; Freedman, Neal D. ; Taylor, Philip R. ; Ricker, Winnie ; Abnet, Christian C.

Background : The absolute risk of oesophageal adenocarcinoma (EA) among individuals with Barrett’s oesophagus (BE) is low and a majority of EA cases are diagnosed among individuals with no prior BE diagnosis. To ensure that insights from EA case–control studies are transferable to clinical management of BE populations, we conducted a case–case study to compare the clinical presentation, medical history and survival of EA cases with and without a prior BE diagnosis in the Surveillance, [...]

Menée à partir de données portant sur 386 patientes atteintes d'un cancer épithélial de l'ovaire lié à une mutation du gène BRCA1 ou BRCA2 diagnostiqué entre 1980 et 2015, cette étude évalue la survie des patientes en fonction de l'existence d'antécédents personnels de cancer du sein

Outcome of ovarian cancer after breast cancer in BRCA1 and BRCA2 mutation carriers

Zaaijer, Leendert H. ; van Doorn, Helena C. ; Mourits, Marian J. E. ; van Beurden, Marc ; de Hullu, Joanne A. ; Adank, Muriel A. ; van Lonkhuijzen, Luc R. C. W. ; Vasen, Hans F. A. ; Slangen, Brigitte F. M. ; Gaarenstroom, Katja N. ; Zweemer, Ronald P. ; Vencken, Peggy M. L. H. ; Seynaeve, Caroline ; Kriege, Mieke

Background : It is unknown whether a history of breast cancer (BC) affects the outcome of BRCA1/2-associated epithelial ovarian cancer (EOC). This was investigated in the current analysis. Methods : We included 386 BRCA1/2-associated EOC patients diagnosed between 1980 and 2015. Progression-free survival (PFS), progression-free interval (PFI), overall survival (OS) and ovarian cancer-specific survival (OCSS) were compared between EOC patients with and without previous BC. Results : [...]

Menée à partir de l'analyse des résultats d'examens de santé et de coloscopies réalisés sur 25 409 personnes (âge médian : 60 ans), cette étude montre que les facteurs de risque ne peuvent expliquer la prévalence plus élevée des lésions colorectales précancéreuses chez les hommes

Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men

Waldmann, Elisabeth ; Heinze, Georg ; Ferlitsch, Arnulf ; GessI, Irina ; Sallinger, Daniela ; Jeschek, Philip ; Britto-Arias, Martha ; Salzl, Petra ; Fasching, Elisabeth ; Jilma, Bernd ; Kundi, Michael ; Trauner, Michael ; Ferlitsch, Monika

Background : Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact of risk factors. Methods : A cross-sectional study analysing health check-up examinations and screening colonoscopies performed within a national quality assurance program. [...]

Menée aux Etats-Unis auprès de 25 111 patientes atteintes d'un cancer du sein et bénéficiant de la couverture sociale Medicare, cette étude analyse les disparités ethniques dans l'adhésion aux prescriptions d'hormonothérapie

Medicare D Subsidies and Racial Disparities in Persistence and Adherence With Hormonal Therapy

Biggers, Alana ; Shi, Yushu ; Charlson, John ; Smith, Elizabeth C. ; Smallwood, Alicia J. ; Nattinger, Ann B. ; Laud, Purushottam W. ; Neuner, Joan M.

Purpose : To investigate the role of out-of-pocket cost supports through the Medicare Part D Low-Income Subsidy on disparities in breast cancer hormonal therapy persistence and adherence by race or ethnicity. Methods : A nationwide cohort of women age ≥ 65 years with a breast cancer operation between 2006 and 2007 and at least one prescription filled for oral breast cancer hormonal therapy was identified from all Medicare D enrollees. The association of race or ethnicity with nonpersistence (90 [...]

Menée en Angleterre à partir des données 2008-2010 portant sur 9 194 résections de tumeur cérébrale, sur 163 neurochirurgiens et 30 centres hospitaliers, cette étude analyse la corrélation entre le volume hospitalier d'interventions chirurgicales ou le nombre d'opérations pratiquées par le chirurgien et la mortalité post-opératoire à 30 jours

Surgeon volume and 30 day mortality for brain tumours in England

Williams, Matt ; Treasure, Peter ; Greenberg, David ; Brodbelt, Andrew ; Collins, Peter

Background : There is evidence that surgeons who perform more operations have better outcomes. However, in patients with brain tumours, all of the evidence comes from the USA. Methods : We examined all English patients with an intracranial neoplasm who had an intracranial resection in 2008–2010. We included surgeons who performed at least six operations over 3 years, and at least one operation in the first and last 6 months of the period. Results : The analysis data set comprised 9194 [...]

A partir des données du registre norvégien des cancers entre 1981 et 2014, cette étude analyse l'évolution de l'incidence du carcinome urothélial de la vessie et évalue la survie

Incidence and Survival of urothelial carcinoma of the urinary bladder in Norway 1981-2014

Andreassen, B. K. ; Aagnes, B. ; Gislefoss, R. ; Andreassen, M. ; Wahlqvist, R.

Background : Urothelial carcinoma of the urinary bladder (UCB) is the 4th most common cancer type in men in developed countries, and tumor recurrence or progression occurs in more than half of the patients. Previous studies report contradictory trends in incidence and survival over the past decades. This article describes the trends of UCB incidence and survival from 1981 to 2014, including both invasive and non-invasive UCB using data from the Cancer Registry of Norway. Methods : In Norway, [...]

A partir des données du Centre International de recherche sur le Cancer et des données de la base "GLOBOCAN", cette étude analyse, pour l'année 2012, l'incidence globale des cancers de la lèvre, de la cavité buccale et du pharynx en Europe (notamment en France) et dans les différentes régions du monde, puis l'estime pour l'année 2035

The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012

Shield, Kevin D. ; Ferlay, Jacques ; Jemal, Ahmedin ; Sankaranarayanan, Rengaswamy ; Chaturvedi, Anil K. ; Bray, Freddie ; Soerjomataram, Isabelle

By using data from the International Agency for Research on Cancer publication Cancer Incidence in 5 Continents and GLOBOCAN, this report provides the first consolidated global estimation of the subsite distribution of new cases of lip, oral cavity, and pharyngeal cancers by country, sex, and age for the year 2012. Major geographically based, sex-based, and age-based variations in the incidence of lip, oral cavity, and pharyngeal cancers by subsite were observed. Lip cancers were highly [...]

A partir d'une revue systématique de la littérature (10 études qualitatives), cette méta-synthèse fait le point sur les relations entre le médecin et les parents d'un enfant atteint de cancer

Towards understanding problems in the parent–practitioner relationship when a child has cancer: meta-synthesis of the qualitative literature

Davies, Sarah ; Young, Bridget ; Salmon, Peter

Objective: This review aimed to synthesise qualitative research on problems in the parent–practitioner relationship in childhood cancer, to understand how these problems arise, how they are conceptualised and how they might be resolved. Methods: A systematic search of five electronic databases identified 2863 articles. After screening, 81 full text papers were assessed for eligibility, and four were included in the review. Six further papers were identified through searching reference lists and [...]

Menée en Israël par questionnaire auprès de 79 oncologues, cette étude analyse les facteurs émotionnels associés à une discussion sur la fin de vie avec les patients et leur famille

Oncologists' communication about end of life: the relationship among secondary traumatic stress, compassion satisfaction, and approach and avoidance communication

Granek, Leeat ; Nakash, Ora ; Cohen, Michal ; Ben-David, Merav ; Ariad, Samuel

Background: Oncologists must communicate effectively with patients and their families about end of life (EOL). Despite the importance of communicating on this topic, many oncologists avoid these conversations. The objective of this study was to examine the associations between secondary traumatic stress and compassion satisfaction and approach and avoidant communication about EOL with cancer patients. Methods: A convenience sample of 79 oncologists (n = 27 men, n = 52 women) participated in the [...]

Menée à partir d'une revue systématique de la littérature publiée entre 2005 et 2015 (25 articles), cette méta-analyse évalue, par rapports aux pratiques de soins usuelles, l'efficacité de programmes thérapeutiques, caractérisés par la collaboration active de plusieurs professionnels de santé, pour traiter les dépressions chez les patients atteints d'un cancer

Systematic review and meta-analysis of collaborative care interventions for depression in patients with cancer

Li, Madeline ; Kennedy, Erin B. ; Byrne, Nelson ; Gérin-Lajoie, Caroline ; Katz, Mark R. ; Keshavarz, Homa ; Sellick, Scott ; Green, Esther

Background : Previous systematic reviews have found limited evidence for the effectiveness of pharmacological and psychological interventions for the management of depression in patients with cancer. This paper provides the first meta-analysis of newer collaborative care interventions, which may include both types of treatment, as well as integrated delivery and follow-up. Meta-analyses of pharmacological and psychological interventions are included as a comparison. Methods : A search of [...]

Menée en Australie par questionnaire auprès de 314 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre la peur de la récidive, leurs perceptions des causes de la maladie, leur sentiment d'optimisme et leur bien-être psychologique

Fear of cancer recurrence and psychological well-being in women with breast cancer: The role of causal cancer attributions and optimism

Dumalaon-Canaria, J. A. ; Prichard, I. ; Hutchinson, A. D. ; Wilson, C.

This study aims to examine the association between cancer causal attributions, fear of cancer recurrence (FCR) and psychological well-being and the possible moderating effect of optimism among women with a previous diagnosis of breast cancer. Participants (N = 314) completed an online self-report assessment of causal attributions for their own breast cancer, FCR, psychological well-being and optimism. Simultaneous multiple regression analyses were conducted to explore the overall contribution [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2015 (45 études), cette étude identifie l'origine des difficultés financières des patients américains ayant survécu à un cancer, analyse l'impact psychologique de ces difficultés ainsi que leurs effets sur l'adhésion thérapeutique

Financial Hardships Experienced by Cancer Survivors : A Systematic Review

Altice, Cheryl K. ; Banegas, Matthew P. ; Tucker-Seeley, Reginald D. ; Yabroff, K. Robin

Background : With rising cancer care costs, including high-priced cancer drugs, financial hardship is increasingly documented among cancer survivors in the United States; research findings have not been synthesized. Methods : We conducted a systematic review of articles published between 1990 and 2015 describing the financial hardship experienced by cancer survivors using PubMed, Embase, Scopus, and CINAHL databases. We categorized measures of financial hardship into: material conditions (eg, [...]

Cette étude analyse les enjeux économiques associés aux nouveaux traitements pour les patients atteints de myélome multiple

Next-generation multiple myeloma treatment: a pharmacoeconomic perspective

Rajkumar, S. Vincent ; Harousseau, Jean Luc

Advances in the diagnosis and treatment of multiple myeloma have come at a rapid pace, especially with several new drugs entering the market in the last few years. However access and affordability to new treatments poses a major challenge, both in the United States and around the world. High costs of life-saving drugs are detrimental to both the personal finances of the individual patient, as well as society which must bear the increasing costs in terms of increased health insurance premiums, [...]

Menée en Angleterre à partir des données du registre national des cancers portant sur 86 852 patientes atteintes d'un cancer du sein diagnostiqué entre 2012 et 2013, cette étude analyse, dans le cadre d'une réorganisation de l'enregistrement des cancers, l'exhaustivité des variables collectées

Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: national cohort study in England

Moller, Henrik ; Henson, Katherine ; Lüchtenborg, Margreet ; Broggio, John ; Charman, Jackie ; Coupland, Victoria H. ; Davies, Elizabeth ; Jack, Ruth H. ; Sullivan, Richard ; Vedsted, Peter ; Horgan, Kieran ; Pearce, Neil ; Purushotham, Arnie

Background : In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items. Methods : We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012–2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death [...]