Menée en Europe auprès de 2 520 patients atteints d'un cancer de stade avancé, cette étude analyse l'association entre une inflammation systémique et la qualité de vie

Quality of Life in Patients With Advanced Cancer: Differential Association With Performance Status and Systemic Inflammatory Response

Laird, Barry J.A. ; Fallon, Marie ; Hjermstad, Marianne J. ; Tuck, Sharon ; Kaasa, Stein ; Klepstad, Pål ; McMillan, Donald C.

Purpose : Quality of life is a key component of cancer care; however, the factors that determine quality of life are not well understood. The aim of this study was to examine the relationship between quality of life parameters, performance status (PS), and the systemic inflammatory response in patients with advanced cancer. Methods : An international biobank of patients with advanced cancer was analyzed. Quality of life was assessed at a single time point by using the European Organisation for [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (11 études, 1 612 participants), cette méta-analyse évalue l'efficacité des probiotiques pour prévenir les diarrhées induites par la chimiothérapie chez les patients atteints d'un cancer de la zone abdominale ou pelvienne

The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: a systematic review and meta-analysis

Wang, Y. H. ; Yao, N. ; Wei, K. K. ; Jiang, L. ; Hanif, S. ; Wang, Z. X. ; Pei, C. X.

A systematic review and meta-analysis were designed to evaluate the efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer. We searched the Cochrane Library, PubMed, EMBASE and Web of Science up to November 2015. We also hand searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Odds ratio (OR) was used to compare efficacy, and the pooled OR was [...]

Menée aux Etats-Unis par enquête auprès de 465 patients atteints de cancer et âgés de 15 à 39 ans, cette étude analyse les effets de la maladie sur leurs fonctions sexuelles, jusqu'à 2 ans après le diagnostic

Cancer negatively impacts on sexual function in adolescents and young adults: The AYA HOPE study

Wettergren, Lena ; Kent, Erin E. ; Mitchell, Sandra A. ; Zebrack, Brad ; Lynch, Charles F. ; Rubenstein, Mara B. ; Keegan, Theresa H. M. ; Wu, Xiao-Cheng ; Parsons, Helen M. ; Smith, Ashley Wilder ; the, A. Y. A. Hope Study Collaborative Group

Objective : This cohort study examined the impact of cancer on sexual function and intimate relationships in adolescents and young adults (AYAs). We also explored factors predicting an increased likelihood that cancer had negatively affected these outcomes. Methods : Participants (n = 465, ages 15–39) in the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) study completed two surveys approximately 1 and 2 years post-cancer diagnosis. We used multivariable logistic [...]

A partir d'une revue de la littérature publiée jusqu'en 2015, cette étude fait le point sur le rôle des opioïdes pour traiter les symptômes de dyspnée épisodique chez des patients atteints d'un cancer de stade avancé

Opioids for management of episodic breathlessness or dyspnea in patients with advanced disease

Cabezón-Gutiérrez, Luis ; Khosravi-Shahi, Parham ; Custodio-Cabello, Sara ; Muñiz-González, Francisco ; Cano-Aguirre, Maria del Puerto ; Alonso-Viteri, Soledad

Background : Episodic breathlessness (EB) or dyspnea is a common symptom with a very negative impact on the quality of life of patients with cancer and with non-oncological advanced diseases, mainly cardiorespiratory and neurological. Objective : The purpose of this non-systematic review is to ascertain the role played by opioids in the management of episodic breathlessness. Methods : A non-systematic literature review was done in the databases MEDLINE, COCHRANE, and DATABASE, and articles of [...]

Menée aux Etats-Unis auprès de 126 patients adolescents (âge moyen : 14,6 ans) et 226 patients adultes (âge moyen : 25,4 ans) ayant survécu à une leucémie lymphoblastique aiguë pendant l'enfance et ayant été traités uniquement par chimiothérapie, cette étude évalue l'association entre le niveau d'acide urique, leur santé cardiovasculaire et leurs fonctions neurocognitives

Uric acid and neurocognitive function in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Cheung, Yin Ting ; Edelmann, Michelle N ; Mulrooney, Daniel A. ; Green, Daniel M. ; Chemaitilly, Wassim ; John, Neena ; Robison, Leslie L. ; Hudson, Melissa M. ; Krull, Kevin R.

Background: Hyperuricemia is implicated in cardiovascular and cerebrovascular diseases. This study evaluated associations between uric acid (UA), cardiovascular health and neurocognitive function in adolescent and adult survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Methods: 126 adolescent (mean[SD] age 14.6[5.0]; 7.8[1.7] years post-diagnosis) and 226 adult survivors (age 25.4[4.2] years; 18.1[4.4] years post-diagnosis) completed comprehensive [...]

Menée au Royaume-Uni à partir de données portant sur 258 patients atteints d'un cancer de l'œsophage traité par chimioradiothérapie, cette étude analyse l'efficacité d'une intervention à base de conseils alimentaires, d'une supplémentation orale ou d'alimentation entérale, pour diminuer le risque de malnutrition et améliorer la survie

Role of nutritional status and intervention in oesophageal cancer treated with definitive chemoradiotherapy: outcomes from SCOPE1

Cox, S. ; Powell, C. ; Carter, B. ; Hurt, C. ; Mukherjee, Somnath ; Crosby, Thomas David Lewis

Background: Malnutrition is common in oesophageal cancer. We aimed to identify nutritional prognostic factors and survival outcomes associated with nutritional intervention in the SCOPE1 (Study of Chemoradiotherapy in OesoPhageal Cancer with or without Erbitux) trial. Methods: Two hundred and fifty eight patients were randomly allocated to definitive chemoradiotherapy (dCRT) +/− cetuximab. Nutritional Risk Index (NRI) scores were calculated; NRI<100 identified patients at risk of malnutrition. [...]

Menée aux Etats-Unis à partir de données portant sur 488 patients ayant survécu à des tumeurs des cellules germinales apparues à l'âge adulte, cette étude évalue, en fonction des doses reçues, l'association entre une chimiothérapie à base de cisplatine, des bourdonnements d'oreille et la dégradation de leur audition

Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer

Frisina, Robert D. ; Wheeler, Heather E. ; Fosså, Sophie D. ; Kerns, Sarah L. ; Fung, Chunkit ; Sesso, Howard D. ; Monahan, Patrick O. ; Feldman, Darren R. ; Hamilton, Robert ; Vaughn, David J. ; Beard, Clair J. ; Budnick, Amy ; Johnson, Eileen M. ; Ardeshir-Rouhani-Fard, Shirin ; Einhorn, Lawrence H. ; Lipshultz, Steven E. ; Dolan, M. Eileen ; Travis, Lois B.

Purpose : Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer. Patients and Methods : Comprehensive audiological measures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumulative cisplatin dose, including audiograms (0.25 to 12 kHz), tests of middle ear function, and tinnitus. American Speech-Language-Hearing Association criteria [...]

Menée aux Etats-Unis auprès de 267 patients ayant survécu à un cancer de la prostate, cette étude analyse l'efficacité d'un programme à base d'exercices musculaires du plancher pelvien pour prendre en charge l'incontinence urinaire, et analyse l'intérêt d'inclure ce programme dans les recommandations relatives aux soins de suivi

Is a behavioral treatment for urinary incontinence beneficial to prostate cancer survivors as a follow-up care?

Zhang, Amy Y. ; Fu, Alex Z. ; Moore, Shirley ; Zhu, Hui ; Strauss, Gerald ; Kresevic, Denise ; Klein, Eric ; Ponsky, Lee ; Bodner, Donald R.

Purpose : The American Cancer Society (ACS) recommends a follow-up care plan for urinary incontinence of prostate cancer survivors that includes pelvic floor muscle exercise (PFME). We examined potential impacts and access barriers of this recommendation with consideration of patients who normally do not seek such care. Methods : We compared 267 participants of a clinical trial that tested a PFME-based treatment of urinary incontinence and 69 nonparticipants who declined the trial. All subjects [...]

Mené en Espagne auprès de 81 patientes ayant survécu à un cancer du sein de stade I à IIIA et ayant terminé leur thérapie adjuvante, cet essai randomisé évalue l'efficacité d'une intervention en ligne destinée à améliorer leur qualité de vie et faciliter leur réadaptation physique (prise en charge de la douleur, force musculaire) et diminuer leurs symptômes de fatigue

Telehealth system: A randomized controlled trial evaluating the impact of an internet-based exercise intervention on quality of life, pain, muscle strength, and fatigue in breast cancer survivors

Galiano-Castillo, Noelia ; Cantarero-Villanueva, Irene ; Fernández-Lao, Carolina ; Ariza-García, Angélica ; Díaz-Rodríguez, Lourdes ; Del-Moral-Ávila, Rosario ; Arroyo-Morales, Manuel

BACKGROUND The chronicity status of breast cancer survivors suggests a growing need for cancer rehabilitation. Currently, the use of technology is a promising strategy for providing support, as reflected in the emergence of research interest in Web-based interventions in cancer survivorship. METHODS A randomized controlled trial was conducted that included a total of 81 participants who had completed adjuvant therapy (except hormone treatment) for stage I to IIIA breast cancer. Participants [...]

Mené au Danemark auprès de 129 patientes atteintes d'un cancer du sein, cet essai randomisé évalue l'efficacité d'une psychothérapie basée sur le concept de la pleine conscience pour soulager les douleurs après les traitements

Efficacy of Mindfulness-Based Cognitive Therapy on Late Post-Treatment Pain in Women Treated for Primary Breast Cancer: A Randomized Controlled Trial

Johannsen, Maja ; O’Connor, Maja ; O’Toole, Mia Skytte ; Jensen, Anders Bonde ; Højris, Inger ; Zachariae, Robert

Purpose : To assess the efficacy of mindfulness-based cognitive therapy (MBCT) for late post-treatment pain in women treated for primary breast cancer. Methods : A randomized wait list–controlled trial was conducted with 129 women treated for breast cancer reporting post-treatment pain (score ≥ 3 on pain intensity or pain burden assessed with 10-point numeric rating scales). Participants were randomly assigned to a manualized 8-week MBCT program or a wait-list control group. Pain was the [...]

A partir de données internationales, cette étude analyse l'évolution de l'incidence du cancer du foie, par sous-type histologique, dans les cinq continents sur la période 1978-2007

International trends in liver cancer incidence, overall and by histologic subtype, 1978–2007

Petrick, Jessica L. ; Braunlin, Megan ; Laversanne, Mathieu ; Valery, Patricia C. ; Bray, Freddie ; McGlynn, Katherine A.

Primary liver cancer, the most common histologic types of which are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is the second leading cause of cancer death worldwide. While rising incidence of liver cancer in low-risk areas and decreasing incidence in some high-risk areas has been reported, trends have not been thoroughly explored by country or by histologic type. We examined liver cancer incidence overall and by histology by calendar time and birth cohort for [...]

A partir des données de l'Organisation Mondiale de la Santé portant sur 43 pays économiquement développés, cette étude évalue les disparités, selon les pays, dans l'incidence des cancers et dans la mortalité, sur la période 2003-2007

Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century

Arnold, Melina ; Renteria, Elisenda ; Conway, David I. ; Bray, Freddie ; Van Ourti, Tom ; Soerjomataram, Isabelle

Purpose : Inequalities in the burden of cancer have been well documented, and a variety of measures exist to analyse disease disparities. While previous studies have focused on inequalities within countries, the aim of the present study was to quantify existing inequalities in cancer incidence and mortality between countries. Methods : Data on total and site-specific cancer incidence and mortality in 2003–2007 were obtained for 43 countries with medium-to-high levels of human development via [...]

A partir de données de 23 études incluant 1 401 patients atteints de cancer et âgés de plus de 65 ans, cette étude évalue l'association entre des comorbidités et une neuropathie périphérique induite par une chimiothérapie

Comorbidities and Risk of Chemotherapy-Induced Peripheral Neuropathy Among Participants 65 Years or Older in Southwest Oncology Group Clinical Trials

Hershman, Dawn L. ; Till, Cathee ; Wright, Jason D. ; Awad, Danielle ; Ramsey, Scott D. ; Barlow, William E. ; Minasian, Lori M. ; Unger, Joseph

Background : Neuropathy is a debilitating toxicity associated with various chemotherapy agents. We evaluated the association between common comorbid conditions and the development of peripheral neuropathy in patients treated with taxane-based chemotherapy. Methods : We examined the Southwest Oncology Group database to identify phase II and III trials that included taxane therapy from 1999 to 2011. We linked the Southwest Oncology Group clinical records to Medicare claims data according to [...]

Menée en Suède à partir de données portant sur 217 364 participants atteints d'un diabète de type 2 et âgés de moins de 70 ans, cette étude évalue l'association entre le statut socioéconomique et la mortalité par maladies cardiovasculaires ou par cancer

Association between socioeconomic status and mortality, cardiovascular disease, and cancer in patients with type 2 diabetes

Rawshani, A. ; Svensson, A. ; Zethelius, B. ; Eliasson, B. ; Rosengren, A. ; Gudbjörnsdottir, S.

Importance : The association between socioeconomic status and survival based on all-cause, cardiovascular (CV), diabetes-related, and cancer mortality in type 2 diabetes has not been examined in a setting of persons with equitable access to health care with adjustment for important confounders. Objective : To determine whether income, educational level, marital status, and country of birth are independently associated with all-cause, CV, diabetes-related, and cancer mortality in persons with [...]

A partir des données du registre suédois des cancers portant sur la période 1973-2013 et incluant 2 662 patients atteints d'une leucémie myéloïde chronique, cette étude analyse l'évolution de la survie depuis l'introduction des inhibiteurs de la tyrosine kinase

Life Expectancy of Patients With Chronic Myeloid Leukemia Approaches the Life Expectancy of the General Population

Bower, Hannah ; Björkholm, Magnus ; Dickman, Paul W. ; Höglund, Martin ; Lambert, Paul C. ; Andersson, Therese M.-L.

Purpose : A dramatic improvement in the survival of patients with chronic myeloid leukemia (CML) occurred after the introduction of imatinib mesylate, the first tyrosine kinase inhibitor (TKI). We assessed how these changes affected the life expectancy of patients with CML and life-years lost as a result of CML between 1973 and 2013 in Sweden. Materials and Methods : Patients recorded as having CML in the Swedish Cancer Registry from 1973 to 2013 were included in the study and followed until [...]

Menée en Belgique à partir de données portant sur 94 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë diagnostiquée entre 1990 et 1997 avant l'âge de 12 ans, cette étude multicentrique analyse leur developpement intellectuel et leurs fonctions cognitives

Intellectual development of childhood ALL patients: a multicenter longitudinal study

Sleurs, Charlotte ; Lemiere, Jurgen ; Vercruysse, Trui ; Nolf, Nathalie ; Van Calster, Ben ; Deprez, Sabine ; Renard, Marleen ; Vandecruys, Els ; Benoit, Yves ; Uyttebroeck, Anne

Background : In childhood acute lymphoblastic leukemia (ALL), radiotherapy for CNS prophylaxis is not used in frontline therapy anymore. Standard treatment for ALL nowadays consists of polychemotherapy. Therefore, assessment of potential chemotherapy-induced cognitive side effects becomes important. Although neurotoxicity was demonstrated in cross-sectional studies, longitudinal studies remain scarce. Procedure : We evaluated intellectual development of 94 pediatric ALL patients between 1990 [...]

Menée aux Etats-Unis à partir de données portant sur 6 706 patients atteints d'un cancer du pancréas et ayant subi une résection chirurgicale et sur 4 392 patients ayant commencé une chimiothérapie adjuvante, cette étude évalue l'association entre le début de la chimiothérapie (plus ou moins 12 semaines après le traitement chirurgical) et la survie

Time to the initiation of adjuvant chemotherapy does not impact survival in patients with resected pancreatic cancer

Mirkin, Katelin A. ; Greenleaf, Erin K. ; Hollenbeak, Christopher S. ; Wong, Joyce

BACKGROUND Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuvant chemotherapy. METHODS The National Cancer Data Base (2003-2011) was retrospectively reviewed for patients with clinical American Joint Committee on Cancer stages I to III [...]

A partir des données du registre américain des cancers portant sur 95 941 patients atteints d'un cancer de la prostate à risque intermédiaire ou élevé de récidive, cet article analyse l'utilisation de l'hormonothérapie anti-androgénique en combinaison avec une radiothérapie

Use of androgen deprivation therapy with radiotherapy for intermediate- and high-risk prostate cancer across the United States

Falchook, A. D. ; Basak, R. ; Mohiuddin, J. J. ; Chen, R. C.

For aggressive, localized prostate cancer, the combination of androgen deprivation therapy (ADT) with radiotherapy (RT) is one of the best-studied treatments. Multiple randomized clinical trials have consistently demonstrated that adding ADT to RT improves survival.1- 5 Despite this large amount of level 1 evidence, controversy remains regarding the role of ADT. There are concerns that ADT may not benefit (or may even harm) patients with comorbidities and that the survival benefit from ADT may [...]

Menée aux Etats-Unis auprès de 206 patientes atteintes d'un cancer du sein de stade I à III récemment diagnostiqué et âgées de plus de 65 ans, cette étude évalue l'efficacité d'un outil permettant d'évaluer la diminution de leurs capacités fonctionnelles et leur risque de décès, en association avec leur statut socioéconomique

Vulnerable elders survey and socioeconomic status predict functional decline and death among older women with newly diagnosed nonmetastatic breast cancer

Owusu, Cynthia ; Margevicius, Seunghee ; Schluchter, Mark ; Koroukian, Siran M. ; Schmitz, Kathryn H. ; Berger, Nathan A.

BACKGROUND The purpose of this study was to determine the ability of the Vulnerable Elders Survey (VES-13) to predict the composite outcome of functional decline and death within 12 months of breast cancer treatment among women 65 years old or older with newly diagnosed stage I to III breast cancer. METHODS Two hundred and six participants were recruited from ambulatory oncology clinics at an academic center between April 2008 and April 2013. Participants competed the VES-13 at baseline just [...]

Menée aux Etats-Unis par enquête auprès de 78 patients atteints d'un cancer de stade avancé, cette étude de cohorte analyse l'association entre des symptômes de dépression et la participation à un essai clinique de phase précoce

Interest in initiating an early phase clinical trial: results of a longitudinal study of advanced cancer patients

Dunn, Laura B. ; Wiley, Jim ; Garrett, Sarah ; Hlubocky, Fay ; Daugherty, Christopher ; Trupin, Laura ; Munster, Pamela ; Dohan, Daniel

Objective :Enhanced recruitment of patients with advanced cancer (ACP) to early phase (EP) trials is needed. However, selective recruitment may affect the kinds of patients who are recruited. To address whether ACP who initiate EP trial enrollment differ from those who do not, we prospectively surveyed ACP well in advance of potential trial recruitment and followed them over time to identify those who initiated the recruitment process. Methods : EP trial initiation was defined as a patient [...]

Menée au Royaume-Uni auprès de 33 patients âgés de 8 à 16 ans et ayant survécu à des tumeurs cérébrales, et auprès de 34 témoins, de parents et d'enseignants, cette étude analyse leurs comportements sociaux (capacités intellectuelles, difficultés émotionnelles et comportementales, interactions sociales, etc)

Social competence in children and young people treated for a brain tumour

Emond, Alice ; Edwards, Lesley ; Peacock, Samantha ; Norman, Catherine ; Evangeli, Michael

Purpose : The purposes of this study were to provide a multi-informant assessment of social competence in 8–16-year olds treated for a brain tumour (BT) and then to compare these assessment outcomes to peers. Method : A cross-sectional, mixed (within and between group) design was used to compare a paediatric BT survivor group (n = 33) with an age-matched control group (n = 34) on two multi-informant (self-report, parent, teacher) social competence questionnaires: Social Skills Improvement [...]

Cette étude compare, dans plusieurs pays européens (Angleterre, France, Allemagne, Pays-Bas, Ecosse, Pologne), les recommandations sur les modalités d'évaluation des médicaments en oncologie pour définir leur prix ou leur remboursement

Relative effectiveness assessments of oncology medicines for pricing and reimbursement decisions in European countries

Kleijnen, S. ; Lipska, I. ; Leonardo Alves, T. ; Meijboom, K. ; Elsada, A. ; Vervölgyi, V. ; d'Andon, A. ; Timoney, A. ; Leufkens, H.G. ; De Boer, A. ; Goettsch, W.G.

Background : There is a debate on the added clinical value of new, expensive, anticancer treatments. Among European decision makers, the relevance of commonly used endpoints in trials, especially overall survival (OS), progression-free survival (PFS) and quality of life (QoL) varies, leading to the available evidence being valued differently. This research studies the extent to which the value of endpoints for cancer medicines differs among European decision makers. Methods : We compared [...]

Mené aux Etats-Unis auprès de participantes à risque élevé de cancer du sein et/ou de l'ovaire, cet essai randomisé compare l'efficacité de conseils portant sur le test génétique BRCA1/2, qu'ils soient dispensés par téléphone ou par entretiens en face-à-face

Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up

Kinney, Anita Y. ; Steffen, Laurie E. ; Brumbach, Barbara H. ; Kohlmann, Wendy ; Du, Ruofei ; Lee, Ji-Hyun ; Gammon, Amanda ; Butler, Karin ; Buys, Saundra S. ; Stroup, Antoinette M. ; Campo, Rebecca A. ; Flores, Kristina G. ; Mandelblatt, Jeanne S. ; Schwartz, Marc D.

Purpose : The ongoing integration of cancer genomic testing into routine clinical care has led to increased demand for cancer genetic services. To meet this demand, there is an urgent need to enhance the accessibility and reach of such services, while ensuring comparable care delivery outcomes. This randomized trial compared 1-year outcomes for telephone genetic counseling with in-person counseling among women at risk of hereditary breast and/or ovarian cancer living in geographically diverse [...]

Menée aux Etats-Unis auprès de 112 patients afro-américains et 18 oncologues d'une origine ethnique différente, cette étude analyse l'association entre des préjugés raciaux implicites chez le médecin, la qualité de la communication avec son patient et les perceptions du patient relatives aux traitements

The Effects of Oncologist Implicit Racial Bias in Racially Discordant Oncology Interactions

Penner, Louis A. ; Dovidio, John F. ; Gonzalez, Richard ; Albrecht, Terrance L. ; Chapman, Robert ; Foster, Tanina ; Harper, Felicity W.K. ; Hagiwara, Nao ; Hamel, Lauren M. ; Shields, Anthony F. ; Gadgeel, Shirish ; Simon, Michael S. ; Griggs, Jennifer J. ; Eggly, Susan

Purpose : Health providers’ implicit racial bias negatively affects communication and patient reactions to many medical interactions. However, its effects on racially discordant oncology interactions are largely unknown. Thus, we examined whether oncologist implicit racial bias has similar effects in oncology interactions. We further investigated whether oncologist implicit bias negatively affects patients’ perceptions of recommended treatments (i.e., degree of confidence, expected difficulty). [...]