Menée en Finlande à partir de données portant sur 11 372 jumeaux suivis de 1981 à 2012, cette étude de cohorte prospective évalue l'association entre des pratiques de consommation d'alcool, le risque de cancer de la prostate et la mortalité spécifique

Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins

Dickerman, Barbra A. ; Markt, Sarah Coseo ; Koskenvuo, Markku ; Pukkala, Eero ; Mucci, Lorelei A. ; Kaprio, Jaakko

Purpose : Alcohol intake may be associated with cancer risk, but epidemiologic evidence for prostate cancer is inconsistent. We aimed to prospectively investigate the association between midlife alcohol intake and drinking patterns with future prostate cancer risk and mortality in a population-based cohort of Finnish twins. Methods : Data were drawn from the Older Finnish Twin Cohort and included 11,372 twins followed from 1981 to 2012. Alcohol consumption was assessed by questionnaires [...]

Menée en Espagne à partir de données portant sur 374 patients atteints d'un adénocarcinome de l'estomac et de 2 481 témoins en population générale, cette étude évalue l'association entre un travail posté de nuit et le risque de développer la maladie

Night shift work and stomach cancer risk in the MCC-Spain study

Gyarmati, Georgina ; Turner, Michelle C ; Castaño-Vinyals, Gemma ; Espinosa, Ana ; Papantoniou, Kyriaki ; Alguacil, Juan ; Costas, Laura ; Pérez-Gómez, Beatriz ; Martin Sanchez, Vicente ; Ardanaz, Eva ; Moreno, Víctor ; Gómez-Acebo, Inés ; Fernández-Tardón, Guillermo ; Villanueva Ballester, Vicent ; Capelo, Rocio ; Chirlaque, María-Dolores ; Santibáñez, Miguel ; Pollan, Marina ; Aragonés, Nuria ; Kogevinas, Manolis

Objectives : Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach cancer risk in a population-based case–control study. Methods : A total of 374 incident stomach adenocarcinoma cases and 2481 population controls were included from the MCC-Spain [...]

A partir des données d'un registre italien (Lombardie) portant sur la période 2000-2012, cette étude évalue l'association entre une exposition, d'origine professionnelle ou non, à l'amiante et le risque de mésothéliome (4 442 cas), puis présente des projections d'incidence de la maladie pour la période 2013-2029

Incidence of mesothelioma in Lombardy, Italy: exposure to asbestos, time patterns and future projections

Mensi, Carolina ; De Matteis, Sara ; Dallari, Barbara ; Riboldi, Luciano ; Bertazzi, Pier Alberto ; Consonni, Dario

Objectives : In Italy, asbestos has been extensively used from 1945 to 1992. We evaluated the impact of exposure to asbestos on occurrence of malignant mesothelioma (MM) in the Lombardy Region, Northwest Italy, the most populated and industrialised Italian region. Methods : From the Lombardy Mesothelioma Registry, we selected all incident cases of MM diagnosed between 2000 and 2012. We described sources of exposure to asbestos and examined time trends of MM rates. Using Poisson age-cohort [...]

A partir des données de 3 études menées au Canada et aux Etats-Unis, cette étude évalue l'association entre une exposition à divers types de pesticides dans le cadre d'activités agricoles et le risque de myélome multiple chez les hommes (547 cas, 2 700 témoins)

Pesticide exposures and the risk of multiple myeloma in men: An analysis of the North American Pooled Project

Presutti, Roseanna ; Harris, Shelley A. ; Kachuri, Linda ; Spinelli, John J. ; Pahwa, Manisha ; Blair, Aaron ; Zahm, Shelia Hoar ; Cantor, Kenneth P. ; Weisenburger, Dennis D. ; Pahwa, Punam ; McLaughlin, John R. ; Dosman, James A. ; Freeman, Laura Beane

Multiple myeloma (MM) has been consistently linked with agricultural activities, including farming and pesticide exposures. Three case-control studies in the United States and Canada were pooled to create the North American Pooled Project (NAPP) to investigate associations between pesticide use and haematological cancer risk. This analysis used data from 547 MM cases and 2700 controls. Pesticide use was evaluated as follows: ever/never use; duration of use (years); and cumulative lifetime-days [...]

Menée aux Etats-Unis à partir des données de la cohorte "Women's Health Initiative" incluant 123 560 participantes, cette étude de cohorte évalue l'association entre le fait de posséder un animal domestique (chien, chat, oiseau) et le risque de cancer

Pet Ownership and Cancer Risk in the Women's Health Initiative

Garcia, David O. ; Lander, Eric M ; Wertheim, Betsy C. ; Manson, JoAnn E ; Volpe, Stella L ; Chlebowski, Rowan T ; Stefanick, Marcia L. ; Lessin, Lawrence S. ; Kuller, Lewis H. ; Thomson, Cynthia A.

Background:Pet ownership and cancer are both highly prevalent in the U.S. Evidence suggest associations may exist between this potentially modifiable factor and cancer prevention, though studies are sparse. The present report examined whether pet ownership (dog, cat, or bird) is associated with lower risk for total cancer and site-specific obesity-related cancers. Methods: A prospective analysis of 123,560 participants (20,981 dog owners; 19,288 cat owners; 1,338 bird owners; and 81,953 non-pet [...]

Menée en Italie à partir de données portant sur 571 patients atteints d'un lymphome non hodgkinien et sur 1 004 témoins, cette étude évalue l'association entre une infection par le virus de l'hépatite B ou de l'hépatite C et le risque de développer la maladie

Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy

Taborelli, Martina ; Polesel, Jerry ; Montella, Maurizio ; Libra, Massimo ; Tedeschi, Rosamaria ; Battiston, Monica ; Spina, Michele ; Di Raimondo, Francesco ; Pinto, Antonio ; Crispo, Anna ; Grimaldi, Maria ; Franceschi, Silvia ; Dal Maso, Luigino ; Serraino, Diego

Background : Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. Methods : We conducted a case-control study in Italy in 1999–2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % [...]

A partir des données de la cohorte américaine "The Sister Study" incluant 50 884 participantes, cette étude évalue l'association entre des douches vaginales, une utilisation de talc sur la zone périnéale et le risque de cancer de l'ovaire

Douching, Talc Use, and Risk of Ovarian Cancer

Gonzalez, Nicole L ; O’Brien, Katie M ; D’Aloisio, Aimee A ; Sandler, Dale P ; Weinberg, Clarice R

Background: Douching was recently reported to be associated with elevated levels of urinary metabolites of endocrine disrupting phthalates, but there is no literature on douching in relation to ovarian cancer. Numerous case-control studies of genital talc use have reported an increased risk of ovarian cancer, but prospective cohort studies have not uniformly confirmed this association. Behavioral correlation between talc use and douching could produce confounding. Methods: The Sister Study [...]

A partir de données de 21 études incluant 1,3 million de femmes et 5 584 patientes atteintes d'un cancer épithélial invasif de l'ovaire, cette étude évalue l'association entre 14 facteurs hormonaux, reproductifs ou liés au mode de vie et le risque de développer la maladie, par sous-type histologique

Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium

Wentzensen, Nicolas ; Poole, Elizabeth M. ; Trabert, Britton ; White, Emily ; Arslan, Alan A. ; Patel, Alpa V. ; Setiawan, V. Wendy ; Visvanathan, Kala ; Weiderpass, Elisabete ; Adami, Hans-Olov ; Black, Amanda ; Bernstein, Leslie ; Brinton, Louise A. ; Buring, Julie ; Butler, Lesley M. ; Chamosa, Saioa ; Clendenen, Tess V. ; Dossus, Laure ; Fortner, Renee ; Gapstur, Susan M. ; Gaudet, Mia M. ; Gram, Inger T. ; Hartge, Patricia ; Hoffman-Bolton, Judith ; Idahl, Annika ; Jones, Michael ; Kaaks, Rudolf ; Kirsh, Victoria ; Koh, Woon-Puay ; Lacey, James V. ; Lee, I-Min ; Lundin, Eva ; Merritt, Melissa A. ; Onland-Moret, N. Charlotte ; Peters, Ulrike ; Poynter, Jenny N. ; Rinaldi, Sabina ; Robien, Kim ; Rohan, Thomas ; Sandler, Dale P. ; Schairer, Catherine ; Schouten, Leo J. ; Sjöholm, Louise K. ; Sieri, Sabina ; Swerdlow, Anthony ; Tjonneland, Anna ; Travis, Ruth ; Trichopoulou, Antonia ; van den Brandt, Piet A. ; Wilkens, Lynne ; Wolk, Alicja ; Yang, Hannah P. ; Zeleniuch-Jacquotte, Anne ; Tworoger, Shelley S.

Purpose : An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3). Patients and Methods : Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using [...]

Menée en Finlande auprès de 136 femmes atteintes d'un syndrome de Lynch, cette étude de cohorte rétrospective évalue l'association entre des facteurs hormonaux, reproductifs, médicaux ou liés au mode de vie, et le risque de cancer de l'endomètre

Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study

Staff, Synnove ; Aaltonen, Mari ; Huhtala, Heini ; Pylvanainen, Kirsi ; Mecklin, Jukka-Pekka ; Maenpaa, Johanna

Background: Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. Methods: The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model was used to estimate the associations between lifestyle, hormonal, reproductive and medical factors and the risk of EC. Results: Increased EC risk was associated with type II [...]

A partir des données de la cohorte "Million Women Study" incluant 1,3 million de participantes âgées de 19 à 65 ans, cette étude évalue l'association entre des antécédents de néoplasies intraépithéliales de grade 3, une obésité, une ménopause précoce et le risque de cancer de la vulve

Past cervical intraepithelial neoplasia grade 3, obesity, and earlier menopause are associated with an increased risk of vulval cancer in postmenopausal women

Coffey, Kate ; Gaitskell, Kezia ; Beral, Valerie ; Canfell, Karen ; Green, Jane ; Reeves, Gillian ; Barnes, Isobel

Background:Vulval cancer predominantly affects postmenopausal women. A smaller proportion of vulval cancers, particularly at older ages, are now thought to be associated with human papillomavirus infection than previously reported, but other risk factors have not been well examined in prospective cohort studies. Methods : A total of 1.3 million women aged 49–65 years were followed for incident vulval cancer (ICD-10 C51). Adjusted Cox regression models were used to examine the relationship [...]

Menée sur un total de 6 558 patients atteints d'un cancer colorectal familial et 8 401 témoins, cette étude de séquençage de l'exome identifie 3 gènes (POT1, POLE2 et MRE11) dont les mutations sont associées à un risque de cancer colorectal

Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

Chubb, Daniel ; Broderick, Peter ; Dobbins, Sara E. ; Frampton, Matthew ; Kinnersley, Ben ; Penegar, Steven ; Price, Amy ; Ma, Yussanne P. ; Sherborne, Amy L. ; Palles, Claire ; Timofeeva, Maria N. ; Bishop, D. Timothy ; Dunlop, Malcolm G. ; Tomlinson, Ian ; Houlston, Richard S.

Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. In this study, we assay the impact of rare germline mutations on CRC, analysing high-coverage exome sequencing data on 1,006 early-onset familial CRC cases and 1,609 healthy controls, with additional sequencing and array data on up to 5,552 cases and 6,792 controls. We [...]

Menée à partir de données portant sur 9 254 patients atteints d'un cancer colorectal et de 18 386 témoins, cette étude évalue l'association entre des polymorphismes à simple nucléotide liés à l'indice de masse corporelle, au rapport taille-hanches, au poids de naissance ou à une obésité pédiatrique et le risque de développer la maladie

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Jarvis, David ; Mitchell, Jonathan S. ; Law, Philip J. ; Palin, Kimmo ; Tuupanen, Sari ; Gylfe, Alexandra ; Hanninen, Ulrika A. ; Cajuso, Tatiana ; Tanskanen, Tomas ; Kondelin, Johanna ; Kaasinen, Eevi ; Sarin, Antti-Pekka ; Kaprio, Jaakko ; Eriksson, Johan G. ; Rissanen, Harri ; Knekt, Paul ; Pukkala, Eero ; Jousilahti, Pekka ; Salomaa, Veikko ; Ripatti, Samuli ; Palotie, Aarno ; Jarvinen, Heikki ; Renkonen-Sinisalo, Laura ; Lepisto, Anna ; Bohm, Jan ; Meklin, Jukka-Pekka ; Al-Tassan, Nada A. ; Palles, Claire ; Martin, Lynn ; Barclay, Ella ; Farrington, Susan M. ; Timofeeva, Maria N. ; Meyer, Brian F. ; Wakil, Salma M. ; Campbell, Harry ; Smith, Christopher G. ; Idziaszczyk, Shelley ; Maughan, Timothy S. ; Kaplan, Richard ; Kerr, Rachel ; Kerr, David ; Buchanan, Daniel D. ; Win, Aung K. ; Hopper, John L. ; Jenkins, Mark A. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Gallinger, Steve ; Conti, David ; Schumacher, Fred ; Casey, Graham ; Taipale, Jussi ; Aaltonen, Lauri A. ; Cheadle, Jeremy P. ; Dunlop, Malcolm G. ; Tomlinson, Ian P. ; Houlston, Richard S.

Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. Methods: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC [...]