A partir des données des registres américains des cancers portant sur 5 591 patients ayant survécu à un cancer après 65 ans, cette étude analyse l'impact d'un ensemble de diverses maladies chroniques, identifiées avant et après le diagnostic de cancer, sur leurs déficiences fonctionnelles

Chronic condition clusters and functional impairment in older cancer survivors: a population-based study

Kenzik, Kelly M. ; Kent, Erin E. ; Martin, Michelle Y. ; Bhatia, Smita ; Pisu, Maria

Purpose : The purpose of the study is to identify chronic condition clusters at pre- and post-cancer diagnosis, evaluate predictors of developing clusters post-cancer, and examine the impact on functional impairment among older cancer survivors. Methods : We identified 5991 survivors age 65 and older of prostate, breast, colorectal, lung, bladder, kidney, head and neck, and gynecologic cancer and non-Hodgkin lymphoma from the Surveillance, Epidemiology and End Results-Medicare Health Outcomes [...]

A partir d'une revue systématique de la littérature (447 essais, 37 revues systématiques), cette étude fait le point sur les différentes interventions destinées à la prise en charge de la fatigue liée au cancer et analyse leur efficacité

Interventions for cancer-related fatigue: a scoping review

Pearson, E. J. M. ; Morris, M. E. ; di Stefano, M. ; McKinstry, C. E.

Cancer-related fatigue (CRF) is common and can be distressing for some survivors. There is increasing interest in measuring levels of CRF, highlighting its impact on quality of life. This review describes the nature and scope of evidence relating to interventions for CRF. Scoping review methodology was used to identify studies, extract data, collate and summarise results. Data were collated according to cancer tumour streams, stage of illness and the types of trial interventions. A total of 447 [...]

Mené au Canada à partir de données portant sur 339 patients pédiatriques atteints d'une leucémie myéloïde aiguë, cet essai met en évidence l'inefficacité de mesures non pharmacologiques destinées à limiter le risque d'infections (réduction des contacts sociaux et avec les animaux domestiques, alimentation spécifique, ...)

Lack of Effectiveness of Neutropenic Diet and Social Restrictions as Anti-Infective Measures in Children With Acute Myeloid Leukemia: An Analysis of the AML-BFM 2004 Trial

Tramsen, Lars ; Salzmann-Manrique, Emilia ; Bochennek, Konrad ; Klingebiel, Thomas ; Reinhardt, Dirk ; Creutzig, Ursula ; Sung, Lillian ; Lehrnbecher, Thomas

Purpose : Although nonpharmacologic anti-infective measures are widely used in children treated for acute myeloid leukemia (AML), there is little evidence of their effectiveness. Patients and Methods : We analyzed infectious complications in children during intensive treatment of AML according to the AML-BFM 2004 trial and surveyed sites on institutional standards regarding recommended restrictions of social contacts (six items), pets (five items), and food (eight items). A scoring system was [...]

Menée aux Etats-Unis par questionnaire auprès de 81 patients atteints d'un cancer de la tête et du cou, cette étude évalue l'association entre un lymphœdème interne au niveau du pharynx ou de l'œsophage et le risque de dysphagie

Internal Lymphedema Correlates with Subjective and Objective Measures of Dysphagia in Head and Neck Cancer Patients

Jackson, Leanne K. ; Ridner, Sheila H. ; Deng, Jie ; Bartow, Carmin ; Mannion, Kyle ; Niermann, Ken ; Gilbert, Jill ; Dietrich, Mary S. ; Cmelak, Anthony J. ; Murphy, Barbara A.

Background: Tumor/treatment-related internal lymphedema (IL) and/or external lymphedema (EL) are associated with functional deficits and increased symptom burden in head and neck cancer patients (HNCP). Previously, we noted association between EL/IL and patient-reported dysphagia using the Vanderbilt Head and Neck Symptom Survey (VHNSS) version 1.0. Objective: To determine the relationship between IL/EL and subjective and objective measures of swallowing function. Methods: Eighty-one HNCP [...]

Menée à partir de données scandinaves portant sur 31 132 patients ayant survécu à un cancer pédiatrique et sur 207 041 témoins, cette étude de cohorte en population évalue l'impact des traitements sur le risque de maladies gastrointestinales et hépatiques

Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population-based cohort study

Asdahl, Peter Haubjerg ; Winther, Jeanette Falck ; Bonnesen, Trine Gade ; de Fine Licht, Sofie ; Gudmundsdottir, Thorgerdur ; Holmqvist, Anna Sällfors ; Malila, Nea ; Tryggvadottir, Laufey ; Wesenberg, Finn ; Dahlerup, Jens Frederik ; Olsen, Jørgen Helge ; Hasle, Henrik ; on behalf of the, ALiCCS study group

Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer-directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population-based cohort study included all 1-year survivors of childhood and adolescent cancer in Denmark, Finland, Iceland, Norway and [...]

A partir des données de la cohorte "Childhood Cancer Survivor Study" incluant 4 184 patients adultes ayant survécu à un cancer pédiatrique et 1 598 témoins, cette étude analyse les facteurs démographiques, psychologiques ou liés aux traitements associés à des comportements de santé à risque (tabagisme, consommation d'alcool, absence d'activité physique)

Patterns and predictors of clustered risky health behaviors among adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Lown, E. Anne ; Hijiya, Nobuko ; Zhang, Nan ; Srivastava, Deo Kumar ; Leisenring, Wendy M. ; Nathan, Paul C. ; Castellino, Sharon M. ; Devine, Katie A. ; Dilley, Kimberley ; Krull, Kevin R. ; Oeffinger, Kevin C. ; Hudson, Melissa M. ; Armstrong, Gregory T. ; Robison, Leslie L. ; Ness, Kirsten K.

BACKGROUND Health complications related to childhood cancer may be influenced by risky health behaviors (RHBs), particularly when RHBs co-occur. To the authors' knowledge, only limited information is available describing how RHBs cluster among survivors of childhood cancer and their siblings and the risk factors for co-occurring RHBs. METHODS Latent class analysis was used to identify RHB clusters using longitudinal survey data regarding smoking, alcohol use, and physical activity from adult [...]

A partir des données des registres américains des cancers, cette étude présente une projection, jusqu'en 2026, du nombre de patients ayant survécu à un cancer et évalue leurs besoins en soins de suivi

Cancer treatment and survivorship statistics, 2016

Miller, Kimberly D. ; Siegel, Rebecca L. ; Lin, Chun Chieh ; Mariotto, Angela B. ; Kramer, Joan L. ; Rowland, Julia H. ; Stein, Kevin D. ; Alteri, Rick ; Jemal, Ahmedin

The number of cancer survivors continues to increase because of both advances in early detection and treatment and the aging and growth of the population. For the public health community to better serve these survivors, the American Cancer Society and the National Cancer Institute collaborate to estimate the number of current and future cancer survivors using data from the Surveillance, Epidemiology, and End Results cancer registries. In addition, current treatment patterns for the most [...]

Menée aux Etats-Unis à partir de données portant sur 302 patients ayant survécu à une leucémie lymphoblastique aiguë pendant l'enfance, cette étude évalue les effets d'une chimiothérapie par méthotrexate sur leurs fonctions neurocognitives à long terme

Chemotherapy Pharmacodynamics and Neuroimaging and Neurocognitive Outcomes in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

Krull, Kevin R. ; Cheung, Yin Ting ; Liu, Wei ; Fellah, Slim ; Reddick, Wilburn E. ; Brinkman, Tara M. ; Kimberg, Cara ; Ogg, Robert ; Srivastava, Deokumar ; Pui, Ching-Hon ; Robison, Leslie L. ; Hudson, Melissa M.

Purpose : To examine associations among methotrexate pharmacodynamics, neuroimaging, and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy-only protocol. Patients and Methods : This longitudinal study linked pharmacokinetic assays collected during therapy to neurocognitive and brain imaging outcomes during long-term follow-up. A total of 218 (72.2%) of 302 eligible long-term survivors were recruited for outcome [...]

A partir de données de 11 registres allemands des cancers et de 13 registres américains des cancers, cette étude compare, pour ces deux pays, l'évolution de la survie des patients atteints d'une leucémie aiguë myéloblastique diagnostiquée entre 1997 et 2011

Survival in patients with acute myeloblastic leukemia in Germany and the United States: Major differences in survival in young adults

Pulte, Dianne ; Jansen, Lina ; Castro, Felipe A. ; Krilaviciute, Agne ; Katalinic, Alexander ; Barnes, Benjamin ; Ressing, Meike ; Holleczek, Bernd ; Luttmann, Sabine ; Brenner, Hermann ; for the, Gekid Cancer Survival Working Group

Previous epidemiologic studies on AML have been limited by the rarity of the disease. Here, we present population level data on survival of patients with AML in Germany and the United States (US). Data were extracted from 11 population-based cancer registries in Germany and the Surveillance, Epidemiology, and End Results (SEER13) database in the US. Patients diagnosed with AML in 1997–2011 were included. Period analysis was used to estimate 5-year relative survival (RS) and trends in survival [...]

Menée aux Etats-Unis auprès de 39 patientes enceintes et atteintes d'un lymphome hodgkinien ou non hodgkinien pendant leur grossesse (âge médian : 28 ans), cette étude rétrospective analyse l'impact des traitements sur l'issue de la grossesse, la survie sans progression et la survie globale

Maternal and fetal outcomes after therapy for Hodgkin or non-Hodgkin lymphoma diagnosed during pregnancy

Pinnix, C. C. ; Osborne, E. M. ; Chihara, D. ; et al.,

Importance : The management of lymphoma diagnosed during pregnancy is controversial and has been guided largely by findings from case reports and small series. Objective : To determine maternal and fetal outcomes of women diagnosed with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) during pregnancy. Design, Setting, and Participants : This retrospective analysis studied a cohort of 39 pregnant women diagnosed with HL and NHL (31 HL and 8 NHL) at a single specialized cancer institution [...]

A partir des données de la cohorte américaine "Genes, Environment and Melanoma study", cette étude évalue l'association entre le nombre de grains de beauté, des caractéristiques phénotypiques du patient (notamment la sensibilité au soleil), des caractéristiques histopathologiques de la tumeur et la survie, chez des patients atteints de mélanome

Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma

Taylor, Nicholas J. ; Thomas, Nancy E. ; Anton-Culver, Hoda ; Armstrong, Bruce K. ; Begg, Colin B. ; Busam, Klaus J. ; Cust, Anne E. ; Dwyer, Terence ; From, Lynn ; Gallagher, Richard P. ; Gruber, Stephen B. ; Nishri, Diane E. ; Orlow, Irene ; Rosso, Stefano ; Venn, Alison J. ; Zanetti, Roberto ; Berwick, Marianne ; Kanetsky, Peter A. ; on behalf of the, G. E. M. Study Group

Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, [...]

Menée au Royaume-Uni à partir de données médico-administratives portant sur 10 598 patients atteints d'un cancer du poumon diagnostiqué entre 1997 et 2006, cette étude évalue l'association entre des facteurs démographiques, des facteurs liés à la tumeur ou aux traitements et le risque de maladie thromboembolique veineuse

Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data

Walker, Alex J. ; Baldwin, David R. ; Card, Tim R. ; Powell, Helen A. ; Hubbard, Richard B. ; Grainge, Matthew J.

Background: Venous thromboembolism (VTE) is a potentially preventable cause of death in people with lung cancer. Identification of those most at risk and high-risk periods may provide the opportunity for better targeted intervention. Methods: We conducted a cohort study using the Clinical Practice Research Datalink linked to Hospital Episode Statistics and Cancer Registry data. Our cohort comprises 10 598 people with lung cancer diagnosed between 1997 and 2006 with follow-up continuing to the [...]

A partir d'une revue systématique de la littérature (25 études), cette méta-analyse évalue les disparités socioéconomiques dans le risque de cancer du sein et dans la mortalité spécifique en Europe

Socioeconomic inequalities in breast cancer incidence and mortality in Europe—a systematic review and meta-analysis

Lundqvist, Adam ; Andersson, Emelie ; Ahlberg, Ida ; Nilbert, Mef ; Gerdtham, Ulf

Background: Breast cancer is the leading cause of female cancer in Europe and is estimated to affect more than one in 10 women. Higher socioeconomic status has been linked to higher incidence but lower case fatality, while the impact on mortality is ambiguous. Methods: We performed a systematic literature review and meta-analysis on studies on association between socioeconomic status and breast cancer outcomes in Europe, with a focus on effects of confounding factors. Summary relative risks [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (14 études, 75 684 femmes), cette méta-analyse évalue l'association entre une utilisation de statines, le risque de récidive de la maladie et la survie chez des patientes atteintes d'un cancer du sein

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta-analysis

Manthravadi, Sashidhar ; Shrestha, Anuj ; Madhusudhana, Sheshadri

Statins have shown antineoplastic properties in preclinical studies with breast cancer cells. They inhibit the enzyme “HMG CoA reductase” and the expression of this enzyme in cancer cells has been implicated as a favorable prognostic factor in patients with breast cancer. After a search of MEDLINE and Embase from inception through November 2015, 817 abstracts were reviewed to identify studies that described an association between statin use and outcomes in breast cancer. A total of 14 studies [...]

Menée au Danemark à partir de données portant sur 87 782 femmes ayant subi une conisation pour traiter des lésions cervicales précancéreuses, cette étude évalue l'association entre une infection par le papillomavirus humain et le risque de cancer du sein

Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer

Sogaard, Mette ; Farkas, Dora K. ; Ording, Anne G. ; Sorensen, Henrik T. ; P Cronin-Fenton, Deirdre

Background: Human papillomavirus (HPV) infection may increase breast cancer (BC) risk. Methods: To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (n=87 782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates. Results: Conisation was [...]

Menée en Suède, cette étude évalue l'association entre une infection par le VIH, le lieu de naissance et le risque de néoplasie intraépithéliale, d'adénocarcinome in situ ou de cancer invasif du col de l'utérus, chez une population immigrée

Impact of immunosuppression and region of birth on risk of cervical intraepithelial neoplasia among migrants living with HIV in Sweden

Carlander, Christina ; Wagner, Philippe ; Svedhem, Veronica ; Elfgren, Kristina ; Westling, Katarina ; Sönnerborg, Anders ; Sparén, Pär

Little is known about the incidence and risk of cervical intraepithelial neoplasia (CIN) grade 3, adenocarcinoma in situ and invasive cervical cancer (CIN3+) among migrants living with HIV in a European setting. We assessed the cumulative incidence (CuI) and hazard ratio (HR) of CIN2+ and CIN3+ in a cohort of women living with HIV (WLWH) (n = 893) identified from the Swedish national HIV register and HIV-negative women (n = 205,842) identified from the Swedish Population Register, matched on [...]

Menée aux Etats-Unis auprès de 2 376 patientes atteintes d'un cancer et âgées de 18 à 79 ans, cette étude analyse l'impact, sur leur qualité de vie ainsi que sur leurs symptômes de stress et de dépression, des comportements de leur partenaire de vie durant les traitements

Partner interfering behaviors affecting cancer quality of life

Coker, Ann L. ; Follingstad, Diane R. ; Garcia, Lisandra S. ; Bush, Heather M.

Objective : Because partners are an important and unpaid resource in cancer care, understanding how destructive, controlling or interfering partner behaviors influence women's cancer care may be particularly relevant for health care providers seeking to provide cancer care and enhance recovery. Using a new measure of partner interfering behaviors in cancer care (PIB-C), we investigated whether women with a recent cancer diagnosis who additionally endorsed any PIB-C would report (a) more [...]

A partir d'une revue systématique de littérature, cette étude analyse la peur de la récidive de la maladie chez les patients ayant survécu à un cancer, et son impact sur leur qualité de vie

Fear of cancer recurrence: a theoretical review and its relevance for clinical presentation and management

Simonelli, Laura E. ; Siegel, Scott D. ; Duffy, Nicole M.

Background : There is increasing recognition of the unique physical and psychosocial concerns of the growing population of cancer survivors. An emerging literature demonstrates that fear of cancer recurrence (FCR) is a problematic long-term and late effect for cancer survivors. In fact, FCR is a top concern, and this article provides a necessary synthesis of the extant research evidence and theory. Methods : Literature searches were conducted using databases including MEDLINE and PsychINFO [...]

Menée en Australie par enquête auprès de 1 414 patients ayant survécu à un cancer hématologique, cette étude analyse les facteurs associés à des symptômes d'anxiété, de stress ou de dépression, en fonction de leur lieu d'habitation (zone rurale ou urbaine)

Prevalence and associates of psychological distress in haematological cancer survivors

Hall, Alix E. ; Sanson-Fisher, Rob W. ; Carey, Mariko L. ; Paul, Chris ; Williamson, Anna ; Bradstock, Ken ; Campbell, H. Sharon

Purpose : To explore outcomes of psychological distress, including anxiety, depression and stress, amongst adult haematological cancer survivors, with a specific focus on potential differences between rural and urban survivors. Methods : One thousand four hundred fourteen urban and rural survivors were recruited from five Australian population-based cancer registries and completed a self-report pen-and-paper survey on their well-being, including the Depression Anxiety and Stress Scale 21-item [...]

Mené aux Etats-Unis auprès de 322 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'efficacité d'un programme psychothérapeutique utilisant le concept de la pleine conscience et visant à diminuer le stress pour améliorer leur qualité de vie et réduire leurs symptômes physiques (fatigue, douleur) et psychologiques (dépression, anxiété, peur de la récidive)

Examination of Broad Symptom Improvement Resulting From Mindfulness-Based Stress Reduction in Breast Cancer Survivors: A Randomized Controlled Trial

Lengacher, Cecile A. ; Reich, Richard R. ; Paterson, Carly L. ; Ramesar, Sophia ; Park, Jong Y. ; Alinat, Carissa ; Johnson-Mallard, Versie ; Moscoso, Manolete ; Budhrani-Shani, Pinky ; Miladinovic, Branko ; Jacobsen, Paul B. ; Cox, Charles E. ; Goodman, Matthew ; Kip, Kevin E.

Purpose : The purpose of this randomized trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program in improving psychological and physical symptoms and quality of life among breast cancer survivors (BCSs) who completed treatment. Outcomes were assessed immediately after 6 weeks of MBSR(BC) training and 6 weeks later to test efficacy over an extended timeframe. Patients and Methods : A total of 322 BCSs were randomly assigned to either a [...]

Menée en Nouvelle-Zélande par questionnaire auprès de 78 aidants de patients atteints d'un cancer de la tête et du cou, cette étude analyse l'association entre leurs perceptions de la maladie, leurs stratégies pour y faire face et le risque de stress post-traumatique

Illness perceptions and coping predict post-traumatic stress in caregivers of patients with head and neck cancer

Richardson, Amy E. ; Morton, Randall P. ; Broadbent, Elizabeth A.

Purpose : There is evidence to suggest that caregivers of patients with head and neck cancer (HNC) are susceptible to post-traumatic stress disorder (PTSD) symptoms. The aim of this study was to investigate whether illness perceptions and coping strategies contribute to the development of these symptoms. Methods : Seventy-eight caregivers completed questionnaires to assess distress, illness perceptions, and coping at diagnosis. Six months later, PTSD symptoms were assessed. Correlation and [...]

Menée dans 4 pays européens auprès de 599 patients atteints de cancer, cette étude analyse les caractéristiques socio-démographiques associées à leurs perceptions des soins infirmiers personnalisés reçus en milieu hospitalier

Hospitalised cancer patients’ perceptions of individualised nursing care in four European countries

Suhonen, R. ; Charalambous, A. ; Berg, A. ; Katajisto, J. ; Lemonidou, C. ; Patiraki, E. ; Sjövall, K. ; Stolt, M. ; Radwin, L. E.

The aim of this study was to describe hospitalised cancer patients’ perceptions of individualised care in four European countries and compare these perceptions using the patients’ socio-demographic characteristics and the Individualized Care Scale. The patients’ socio-demographic characteristics used were: education, age, gender, type of hospital admission, previous hospitalisation and hospital length of stay. The Individualized Care Scale has two parts (1) nurses’ support of individuality and [...]

Menée au Royaume-Uni par entretiens auprès de 41 patientes atteintes d'un cancer, cette étude analyse l'importance d'une information sur le consentement éclairé comme support d'aide à la décision pour participer à des essais cliniques

Identifying components in consent information needed to support informed decision making about trial participation: An interview study with women managing cancer

Abhyankar, Purva ; Velikova, Galina ; Summers, Barbara ; Bekker, Hilary L.

Background : Research governance requires patients give informed consent to participate in clinical trials. However, there are concerns that consent information may not support patient participation decisions. This study investigates the utility of consent information in supporting women's trial participation decisions when receiving treatment for cancer. Design : An interview study with women receiving cancer treatments at a medical oncology outpatient clinic in Yorkshire (UK). All women over [...]

Menée aux Etats-Unis par enquête téléphonique auprès de 441 patients ayant survécu à un cancer après 65 ans, cette étude analyse l'association entre les informations contenues dans leur dossier médical personnel résumant leur parcours de soins, le respect des instructions pour les soins de suivi et leur sentiment d'auto-efficacité relatif à la prise en charge de leur santé

Treatment Summaries and Follow-Up Care Instructions for Cancer Survivors: Improving Survivor Self-Efficacy and Health Care Utilization

Kenzik, Kelly M. ; Kvale, Elizabeth A. ; Rocque, Gabrielle B. ; Demark-Wahnefried, Wendy ; Martin, Michelle Y. ; Jackson, Bradford E. ; Meneses, Karen ; Partridge, Edward E. ; Pisu, Maria

Treatment summaries and follow-up care plan information should be provided to cancer survivors. This study examines the association of receiving summaries and care plans with cancer survivor self-efficacy for chronic illness management, and whether self-efficacy was associated with health care utilization.441 cancer survivors (≥2 years from diagnosis and had completed treatment) ≥65 years old from 12 cancer centers across 5 states completed telephone surveys. Survivors responded to three [...]

Menée aux Etats-Unis par entretiens auprès de 42 patients atteints d'un cancer de stade avancé et ayant un enfant ou plus à charge, cette étude analyse leurs préférences et leurs besoins relatifs aux soins palliatifs et de fin de vie

Concerns underlying treatment preferences of advanced cancer patients with children

Check, Devon K. ; Park, Eliza M. ; Reeder-Hayes, Katherine E. ; Mayer, Deborah K. ; Deal, Allison M. ; Yopp, Justin M. ; Rosenstein, Donald L. ; Hanson, Laura C.

Background : Decision-making about advanced cancer treatment is complex and may be influenced by patients' family context, including the presence of children. We explored how parental values and concerns motivate patients' preferences about aggressiveness of advanced cancer treatment as well as preferences for palliative care and hospice services. Methods : We conducted semi-structured interviews with 42 patients with advanced cancer who had at least one child under 18 years. We created and [...]

Cet article plaide pour le développement et l'amélioration des soins palliatifs, en particulier pour les patients atteints de cancer

Better palliative care for all: Improving the lived experience with cancer

Kamal, A. H. ; LeBlanc, T. W. ; Meier, D. E.

The recent announcement by Vice President Joseph Biden of a cancer cures “moonshot” has brought renewed attention to the goals of 21st-century cancer care. Not since the late President Nixon’s declaration of War on Cancer has so much focus been directed toward the experiences of the 1.66 million persons diagnosed with cancer annually in the United States.1 The framing of this initiative is focused on accelerating scientific progress against cancer as a disease, with little attention to equity2 [...]

Menée en Australie auprès de 64 patients pédiatriques ayant survécu à un cancer et auprès de leurs parents, cette étude analyse leurs choix relatifs à l'utilisation de tests génétiques pour prédire le risque d'effets indésirables à long terme liés aux traitements

Genetic testing for the risk of developing late effects among survivors of childhood cancer: Consumer understanding, acceptance, and willingness to pay

Georgiou, Gabrielle ; Wakefield, Claire E. ; McGill, Brittany C. ; Fardell, Joanna E. ; Signorelli, Christina ; Hanlon, Lucy ; Tucker, Kathy ; Patenaude, Andrea F. ; Cohn, Richard J.

BACKGROUND Genetic testing to determine cancer survivors' risk of developing late effects from their cancer treatment will be increasingly used in survivorship care. This 2-stage study with 64 survivors of childhood cancer and their parents investigated the preferences and acceptability of testing among those who may be at risk of developing late effects. METHODS The first stage (Stage 1) identified the most commonly perceived benefits and concerns regarding genetic testing for the risk of late [...]