Menée aux Etats-Unis à partir des données de la cohorte "Carolina Breast Cancer Study", cette étude évalue l'association entre une pratique tabagique et le risque de cancer du sein par sous-type (luminal, "basal-like")

Active smoking and risk of Luminal and Basal-like breast cancer subtypes in the Carolina Breast Cancer Study

Butler, Eboneé N. ; Tse, Chiu-Kit ; Bell, Mary Elizabeth ; Conway, Kathleen ; Olshan, Andrew F. ; Troester, Melissa A.

Purpose : Growing evidence suggests an association between active cigarette smoking and increased breast cancer risk. However, the weak magnitude of association and conflicting results have yielded uncertainty and it is unknown whether associations differ by breast cancer subtype. Methods : Using population-based case–control data from phases I and II of the Carolina Breast Cancer Study, we examined associations between self-reported measures of smoking and risk of Luminal and Basal-like breast [...]

A partir des données de 3 cohortes prospectives américaines, cette étude analyse l'association entre une consommation d'alcool et le risque de carcinome épidermoïde de la peau

Alcohol Intake is Associated with Increased Risk of Squamous Cell Carcinoma of the Skin: Three US Prospective Cohort Studies

Siiskonen, Satu ; Han, Jiali ; Li, Tricia ; Cho, Eunyoung ; Nijsten, Tamar ; Qureshi, Abrar

The association between alcohol intake and cutaneous squamous cell carcinoma (cSCC) is unclear. We studied the association between alcohol intake and incident invasive cSCC in three cohorts of women and men with repeated assessments of alcohol intake in the US. Information on alcohol intake was collected repeatedly during follow-up. Cumulative average of alcohol intakes was used. Multivariable Cox proportional hazards models with time-dependent exposure were used to estimate relative risks [...]

A partir des données de 7 cohortes prospectives incluant 239 597 participants afro-américains, cette étude évalue l'association entre l'indice de masse corporelle, le risque de myélome multiple et la mortalité spécifique

Multiple Myeloma Mortality in Relation to Obesity Among African Americans

Sonderman, Jennifer S. ; Bethea, Traci N. ; Kitahara, Cari M. ; Patel, Alpa V. ; Harvey, Chinonye ; Knutsen, Synnøve F. ; Park, Yikyung ; Park, Song-Yi ; Fraser, Gary E. ; Teras, Lauren R. ; Purdue, Mark P. ; Stolzenberg-Solomon, Rachael Z. ; Gillanders, Elizabeth M. ; Palmer, Julie R. ; Kolonel, Laurence N. ; Blot, William J.

Multiple myeloma (MM) incidence and mortality are higher among African Americans (AAs) than among other population groups. The prevalence of obesity is also elevated among AAs, but few studies have examined risk of this cancer in relation to body size among AAs. We combined data from seven prospective cohorts tracking mortality among 239 597 AA adults and used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for death because of MM according [...]

A partir des données de 9 études incluant 8 309 cas et 12 612 témoins, cette étude évalue l'association entre une absence d'activité physique de loisirs et le risque de cancer épithélial de l'ovaire

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Cannioto, Rikki ; LaMonte, Michael J. ; Risch, Harvey A. ; Hong, Chi-Chen ; Sucheston-Campbell, Lara E. ; Eng, Kevin H. ; Szender, J. Brian ; Chang-Claude, Jenny ; Schmalfeldt, Barbara ; Klapdor, Rüdiger ; Gower, Emily ; Minlikeeva, Albina N ; Zirpoli, Gary R. ; Bandera, Elisa V. ; Berchuck, Andrew ; Cramer, Daniel ; Doherty, Jennifer A. ; Edwards, Robert P. ; Fridley, Brooke L. ; Goode, Ellen L. ; Goodman, Marc T. ; Hogdall, Estrid ; Hosono, Satoyo ; Jensen, Allan ; Jordan, Susan ; Kjaer, Susanne K. ; Matsuo, Keitaro ; Ness, Roberta B. ; Olsen, Catherine M ; Olson, Sara H. ; Pearce, Celeste Leigh ; Pike, Malcolm C. ; Rossing, Mary Anne ; Szamreta, Elizabeth A ; Thompson, Pamela J. ; Tseng, Chiu-Chen ; Vierkant, Robert A. ; Webb, Penelope ; Wentzensen, Nicolas ; Wicklund, Kristine G ; Winham, Stacey J ; Wu, Anna H. ; Modugno, Francesmary ; Schildkraut, Joellen M. ; Terry, Kathryn L. ; Kelemen, Linda E. ; Moysich, Kirsten B.

Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium (OCAC) to investigate the association between chronic recreational physical inactivity and EOC risk. [...]

Menée en Australie auprès de 2 021 participantes, cette étude prospective évalue l'association entre les acides gras d'origine alimentaire, les acides gras des phospholipides plasmatiques et le risque de cancer du sein (470 cas)

Plasma phospholipids fatty acids, dietary fatty acids, and breast cancer risk

Bassett, Julie K. ; Hodge, Allison M. ; English, Dallas R. ; MacInnis, Robert J. ; Giles, Graham G.

Purpose : This study prospectively investigates associations between fatty acids assessed in plasma phospholipids (PPL) and diet, and breast cancer risk, including subgroups defined by hormone receptor status. Methods : We performed a case-cohort analysis within the Melbourne Collaborative Cohort Study using a random sample of 2,021 women and 470 breast cancer cases. At baseline, fatty acids were assessed in PPL and estimated from diet using a 121-item food frequency questionnaire. Hazard [...]

Menée aux Etats-Unis à partir des données de la cohorte "Women’s Health Initiative" incluant 56 557 participantes (durée médiane de suivi : 11,9 ans), cette étude multicentrique compare l'association entre une exposition solaire, pendant l'enfance (à la naissance, à 15 ans) ou à l'âge adulte (35, 50 ans et âge au moment de l'inclusion dans la cohorte), et le risque de cancer de la peau après la ménopause chez des femmes de type caucasien

Impact of residential UV exposure in childhood versus adulthood on skin cancer risk in Caucasian, postmenopausal women in the Women’s Health Initiative

Ransohoff, Katherine J. ; Ally, Mina S. ; Stefanick, Marcia L. ; Keiser, Elizabeth ; Spaunhurst, Katrina ; Kapphahn, Kristopher ; Pagoto, Sherry ; Messina, Catherine ; Hedlin, Haley ; Manson, JoAnn E. ; Tang, Jean Y.

Background : Sun exposure is a major risk factor for skin cancer; however, the relative contribution of ultraviolet (UV) exposure during childhood versus adulthood on skin cancer risk remains unclear. Objective : Our goal was to determine the impact of residential UV, measured by AVerage daily total GLObal solar radiation (AVGLO), exposure during childhood (birth, 15 years) versus adulthood (35, 50 years, and present) on incident non-melanoma skin cancer (NMSC) and malignant melanoma (MM) in [...]

Menée en Australie à partir de données portant sur 34 080 patients, cette étude évalue l'association entre l'évolution de l'utilisation de la téléphonie mobile depuis 1987 et le risque de cancer du cerveau

Has the incidence of brain cancer risen in Australia since the introduction of mobile phones 29 years ago?

Chapman, Simon ; Azizi, Lamiae ; Luo, Qingwei ; Sitas, Freddy

Background : Mobile phone use in Australia has increased rapidly since its introduction in 1987 with whole population usage being 94% by 2014. We explored the popularly hypothesised association between brain cancer incidence and mobile phone use. Study methods : Using national cancer registration data, we examined age and gender specific incidence rates of 19,858 male and 14,222 females diagnosed with brain cancer in Australia between 1982 and 2012, and mobile phone usage data from 1987 to [...]

Menée dans trois Etats américains de la région de la Nouvelle-Angleterre (Maine, New Hampshire et Vermont) à partir de données portant sur 1 213 cas et 1 418 témoins, cette étude évalue l'association entre les niveaux d'arsenic contenus dans l'eau potable et le risque de cancer de la vessie

Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic

Baris, Dalsu ; Waddell, Richard ; Beane Freeman, Laura E. ; Schwenn, Molly ; Colt, Joanne S. ; Ayotte, Joseph D. ; Ward, Mary H. ; Nuckols, John ; Schned, Alan ; Jackson, Brian ; Clerkin, Castine ; Rothman, Nathaniel ; Moore, Lee E. ; Taylor, Anne ; Robinson, Gilpin ; Hosain, GM Monawar ; Armenti, Karla R. ; McCoy, Richard ; Samanic, Claudine ; Hoover, Robert N. ; Fraumeni, Joseph F. ; Johnson, Alison ; Karagas, Margaret R. ; Silverman, Debra T.

Background: Bladder cancer mortality rates have been elevated in northern New England for at least five decades. Incidence rates in Maine, New Hampshire, and Vermont are about 20% higher than the United States overall. We explored reasons for this excess, focusing on arsenic in drinking water from private wells, which are particularly prevalent in the region. Methods: In a population-based case-control study in these three states, 1213 bladder cancer case patients and 1418 control subjects [...]

Menée aux Etats-Unis auprès de 584 cas et 745 témoins, cette étude évalue l'association entre une utilisation, sur les zones génitales ou ailleurs, de poudre de talc et le risque de cancer de l'ovaire, chez des femmes afro-américaines

Association between body powder use and ovarian cancer: the African American Cancer Epidemiology Study (AACES)

Schildkraut, Joellen M. ; Abbott, Sarah E. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa L. ; Coté, Michele L. ; Funkhouser, Ellen ; Peres, Lauren C. ; Peters, Edward S ; Schwartz, Ann G. ; Terry, Paul ; Crankshaw, Sydnee ; Camacho, Fabian ; Wang, Frances ; Moorman, Patricia G.

Background: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship between use of genital powder and non-genital powder in invasive epithelial ovarian cancer (EOC). Methods: Subjects are 584 cases and 745 controls enrolled in the African American Epidemiology Cancer Study, an ongoing, population-based [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (1 220 cas, 1 576 témoins), cette méta-analyse fait le point sur l'association entre des polymorphismes du gène VEGF (facteur de croissance de l'endothélium vasculaire) et le risque d'ostéosarcome

The associations of vascular endothelial growth factor gene polymorphisms with susceptibility to osteosarcoma: evidence from a meta-analysis

Zhao, J. ; Chen, Z. Q. ; Li, G. W. ; Yang, M. ; Shao, J. ; Li, M.

Several studies have investigated the associations of the vascular endothelial growth factor (VEGF) gene polymorphisms with the susceptibility to osteosarcoma, while their conclusions are conflicting. This meta-analysis was performed to provide a comprehensive assessment on those associations. Electronic bibliographic databases were searched for potential studies focused on the relationship between VEGF polymorphisms and the susceptibility to osteosarcoma on 10 December 2015. Pooled odds ratios [...]

A partir des données de deux cohortes prospectives "The Nurses' Health Study" et "The Health Professionals Follow-up Study" incluant un total de 1 708 029 participants, cette étude évalue l'association entre l'indice de masse corporelle et le risque de cancer colorectal, en fonction du niveau d'infiltration lymphocytaire tumorale

Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate

Hanyuda, Akiko ; Ogino, Shuji ; Qian, Zhi Rong ; Nishihara, Reiko ; Song, Mingyang ; Mima, Kosuke ; Inamura, Kentaro ; Masugi, Yohei ; Wu, Kana ; Meyerhardt, Jeffrey A. ; Chan, Andrew T. ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Cao, Yin

Higher body mass index (BMI), higher body adiposity and obesity have been associated with increased risk of colorectal cancer. Evidence suggests that excess energy balance may influence systemic immune and inflammatory status. Thus, we hypothesized that the positive association between BMI and colorectal cancer risk might differ according to colorectal carcinoma subtypes according to levels of histopathological lymphocytic reaction to tumor. We collected biennial questionnaire data on weight [...]

A partir de 3 études d'assocation sur le génome entier ayant inclus un total de 7 737 cas de cancer de l'endomètre et 37 144 témoins en population européenne, cette méta-analyse identifie 5 nouveaux loci de susceptibilité à la maladie

Five endometrial cancer risk loci identified through genome-wide association analysis

Cheng, Timothy H. T. ; Thompson, Deborah J. ; O'Mara, Tracy A. ; Painter, Jodie N. ; Glubb, Dylan M. ; Flach, Susanne ; Lewis, Annabelle ; French, Juliet D. ; Freeman-Mills, Luke ; Church, David ; Gorman, Maggie ; Martin, Lynn ; National Study of Endometrial Cancer Genetics, Group ; Hodgson, Shirley ; Webb, Penelope M. ; The Australian National Endometrial Cancer Study, Group ; Attia, John ; Holliday, Elizabeth G. ; McEvoy, Mark ; Scott, Rodney J. ; Henders, Anjali K. ; Martin, Nicholas G. ; Montgomery, Grant W. ; Nyholt, Dale R. ; Ahmed, Shahana ; Healey, Catherine S. ; Shah, Mitul ; Dennis, Joe ; Fasching, Peter A. ; Beckmann, Matthias W. ; Hein, Alexander ; Ekici, Arif B. ; Hall, Per ; Czene, Kamila ; Darabi, Hatef ; Li, Jingmei ; Dörk, Thilo ; Dürst, Matthias ; Hillemanns, Peter ; Runnebaum, Ingo ; Amant, Frederic ; Schrauwen, Stefanie ; Zhao, Hui ; Lambrechts, Diether ; Depreeuw, Jeroen ; Dowdy, Sean C. ; Goode, Ellen L. ; Fridley, Brooke L. ; Winham, Stacey J. ; Njolstad, Tormund S. ; Salvesen, Helga B. ; Trovik, Jone ; Werner, Henrica M. J. ; Ashton, Katie ; Otton, Geoffrey ; Proietto, Tony ; Liu, Tao ; Mints, Miriam ; Tham, Emma ; Rendocas, ; Chibcha Consortium ; Li, Mulin Jun ; Yip, Shun H. ; Wang, Junwen ; Bolla, Manjeet K. ; Michailidou, Kyriaki ; Wang, Qin ; Tyrer, Jonathan P. ; Dunlop, Malcolm ; Houlston, Richard ; Palles, Claire ; Hopper, John L. ; Aocs Group ; Peto, Julian ; Swerdlow, Anthony J. ; Burwinkel, Barbara ; Brenner, Hermann ; Meindl, Alfons ; Brauch, Hiltrud ; Lindblom, Annika ; Chang-Claude, Jenny ; Couch, Fergus J. ; Giles, Graham G. ; Kristensen, Vessela N. ; Cox, Angela ; Cunningham, Julie M. ; Pharoah, Paul D. P. ; Dunning, Alison M. ; Edwards, Stacey L. ; Easton, Douglas F. ; Tomlinson, Ian ; Spurdle, Amanda B.

We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (rs13328298, in LOC643623 and near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in [...]

Menée au Japon à partir de 876 échantillons tumoraux et de données portant sur des patients fumeurs (441) et non fumeurs (435), cette étude prospective analyse l'association entre des mutations somatiques de 72 gènes liés au cancer, diverses expositions environnementales, dont le tabagisme, et le risque de cancer du poumon non à petites cellules

Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study

Kawaguchi, Tomoya ; Koh, Yasuhiro ; Ando, Masahiko ; Ito, Norimasa ; Takeo, Sadanori ; Adachi, Hirofumi ; Tagawa, Tsutomu ; Kakegawa, Seiichi ; Yamashita, Motohiro ; Kataoka, Kazuhiko ; Ichinose, Yukito ; Takeuchi, Yukiyasu ; Serizawa, Masakuni ; Tamiya, Akihiro ; Shimizu, Shigeki ; Yoshimoto, Naoki ; Kubo, Akihito ; Isa, Shun-ichi ; Saka, Hideo ; Matsumura, Akihide

Purpose : Oncogenic driver mutations are critical for lung cancer development and serve as therapeutic targets. However, their associations with environmental factors are not fully understood. We aimed to elucidate the relationship between tumor developmental biology and exposure to environmental factors. Patients and Methods : This was a prospective, multicenter, molecular epidemiology study. Eligible patients were those with newly diagnosed stages I to IIIB non–small-cell lung cancer (NSCLC) [...]