Menée en Espagne auprès de 29 professionnels de santé, 17 patients adolescents et jeunes adultes ayant survécu à un cancer et 12 proches, cette étude analyse les besoins des patients après la fin de leurs traitements

What are the needs of adolescents and young adults after a cancer treatment? A Delphi study

Galán, S. ; de la Vega, R. ; Tomé Pires, C. ; Racine, M. ; Solé, E. ; Jensen, M. P. ; Miró, J.

Advances in the early detection of cancer and the development of more effective treatments have resulted in a larger number of adolescents and young adults (AYAs), becoming cancer survivors. However, knowledge regarding their needs and if those needs are adequately addressed remains limited. The aims of this study were to: (1) better understand the needs of AYAs after cancer treatment; (2) analyse the importance of those needs; (3) determine which needs are not adequately addressed; and (4) [...]

A partir d'une revue systématique des essais randomisés (68 études), cette étude analyse les diverses stratégies thérapeutiques pour prendre en charge la fièvre et la neutropénie chez des patients pédiatriques atteints de cancer et recevant une greffe de cellules souches hématopoïétiques

Strategies for Empiric Management of Pediatric Fever and Neutropenia in Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: A Systematic Review of Randomized Trials

Robinson, Paula D. ; Lehrnbecher, Thomas ; Phillips, Robert ; Dupuis, L. Lee ; Sung, Lillian

Purpose : To describe treatment failure and mortality rates with different antibiotic regimens and different management strategies for empirical treatment of fever and neutropenia (FN) in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients. Methods : We conducted a systematic review and performed searches of MEDLINE, Embase, PubMed, and Cochrane Central Register of Controlled Trials. Studies were included if pediatric patients had cancer or were HSCT [...]

Menée aux Etats-Unis à partir de données portant sur 1 105 patientes atteintes d'un cancer du sein (âge médian : 61 ans), cette étude rétrospective analyse les symptômes associés au développement de métastases osseuses

Burden of symptoms associated with development of metastatic bone disease in patients with breast cancer

Cleeland, Charles ; Moos, Roger ; Walker, Mark S. ; Wang, Yuanyuan ; Gao, Jianqing ; Chavez-MacGregor, Mariana ; Liede, Alexander ; Arellano, Jorge ; Balakumaran, Arun ; Qian, Yi

Purpose : Women with breast cancer frequently develop painful bone metastases. This retrospective study was designed to longitudinally characterize patterns of patient-reported symptoms among patients with breast cancer relative to the diagnosis of bone metastases. Methods : Patient records were identified from the Oncology Services Comprehensive Electronic Records (OSCER) database which includes outpatient oncology practices across the USA. Symptom burden was assessed by Patient Care Monitor [...]

Mené en France auprès de 215 patientes atteintes d'un cancer du sein de stade précoce, cet essai randomisé de phase III évalue les effets d'une supplémentation personnalisée en vitamine D à hautes doses, dispensée par voie orale, sur les niveaux sériques de vitamine D

Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study

Jacot, W. ; Firmin, N. ; Roca, L. ; Topart, D. ; Gallet, S. ; Durigova, A. ; Mirr, S. ; Abach, L. ; Pouderoux, S. ; D'Hondt, V. ; Bleuse, J.P. ; Lamy, P.J. ; Romieu, G.

Background : A minority of early breast cancer (EBC) patients treated with adjuvant or neoadjuvant chemotherapy have sufficient baseline vitamin D (vitD) level. This randomized phase III study assessed the safety and efficacy of a tailored, high-dose, oral vitD supplementation in restoring a normal 25-hydroxy vitD (25OHD) level in this population. Patients and Methods : Participants received a 6-month conventional (C) vitD and calcium supplementation or a 6-month high-dose oral vitD regimen [...]

Menée aux Etats-Unis auprès de 142 patients âgés de 12 à 32 ans et ayant survécu à des tumeurs cérébrales durant l'enfance, cette étude évalue l'efficacité d'un outil simplifié pour détecter une fatigue liée à la maladie

Screening for fatigue in adolescent and young adult pediatric brain tumor survivors: accuracy of a single-item screening measure

Brand, Sarah R. ; Chordas, Christine ; Liptak, Cori ; Manley, Peter ; Recklitis, Christopher

Purpose : Cancer-related fatigue (CRF) is one of the most commonly reported and distressing symptoms experienced by adolescent and young adult (AYA) cancer survivors. While national guidelines have recommended screening for CRF during routine follow-up appointments, the validity of using a one-item screening measure for fatigue has not been examined with AYA brain tumor survivors. The purpose of this study is to assess how well a single-item fatigue screen could identify clinically significant [...]

Menée aux Etats-Unis par enquête auprès de 663 patients atteints de tumeurs neuro-endocrines, cette étude analyse les effets de diverses stratégies thérapeutiques sur les symptômes et sur la qualité de vie du patient (chirurgie seule, chirurgie avec thérapies ciblées, chimiothérapies traditionnelles, etc)

Health-related quality of life in patients with neuroendocrine tumors: an investigation of treatment type, disease status, and symptom burden

Pearman, Timothy P. ; Beaumont, Jennifer L. ; Cella, David ; Neary, Maureen P. ; Yao, James

Introduction : Neuroendocrine tumors (NETs) are malignant solid tumors arising in hormone-secreting tissue. They have historically been very difficult to treat, and advanced NETs are considered incurable. Surgery is the only potentially curative treatment option, though research is ongoing, investigating the efficacy of targeted therapies combined with more traditional chemotherapies. Frequent bowel movements and episodes of flushing are the most common symptoms. Methods : The present study [...]

Menée en Suisse à partir de données portant sur 3 965 patients ayant survécu à un cancer pédiatrique diagnostiqué entre 1976 et 2007 avant l'âge de 15 ans, cette étude de cohorte en population analyse l'évolution de la mortalité (période de suivi : jusqu'en 2012)

Cause-specific long-term mortality in survivors of childhood cancer in Switzerland: A population-based study

Schindler, Matthias ; Spycher, Ben D. ; Ammann, Roland A. ; Ansari, Marc ; Michel, Gisela ; Kuehni, Claudia E. ; for the Swiss Paediatric Oncology, Group

Survivors of childhood cancer have a higher mortality than the general population. We describe cause-specific long-term mortality in a population-based cohort of childhood cancer survivors. We included all children diagnosed with cancer in Switzerland (1976–2007) at age 0–14 years, who survived ≥5 years after diagnosis and followed survivors until December 31, 2012. We obtained causes of death (COD) from the Swiss mortality statistics and used data from the Swiss general population to calculate [...]

A partir des données Globocan 2012, cette étude analyse l'évolution des disparités géographiques dans l'incidence mondiale du cancer de l'oesophage, ainsi que dans la mortalité

Worldwide incidence, mortality and time trends for cancer of the oesophagus

Gupta, Bhawna ; Kumar, Narinder

The incidence and mortality trends of oesophageal cancer are changing significantly across the world with considerable heterogeneity between sex, histological types, ethnic patterns and geographical distribution. Recent oesophageal cancer incidence and mortality trends have been analysed using data available from the WHO mortality database, the GLOBOCAN 2012 database and the Cancer Incidence in Five Continents database managed by the International Agency for Research on Cancer. Huge [...]

Menée au Royaume-Uni à partir de données portant sur 1,2 million de femmes sans antécédent de cancer (âge médian lors de l'inclusion dans la cohorte : 55 ans, durée de suivi : 14 ans), cette étude évalue l'association entre divers facteurs sociodémographiques, anthropométriques, hormonaux, alimentaires et le risque de cancer du poumon chez des femmes n'ayant jamais fumé

Lung cancer in never smokers in the UK Million Women Study

Pirie, Kirstin ; Peto, Richard ; Green, Jane ; Reeves, Gillian K. ; Beral, Valerie ; for the Million Women Study, Collaborators

To assess directly the effects of various risk factors on lung cancer incidence among never smokers, large prospective studies are needed. In a cohort of 1.2 million UK women without prior cancer, half (634,039) reported that they had never smoked. Mean age at recruitment was 55 (SD5) years, and during 14 (SD3) years of follow-up, 0.2% (1,469) of these never smokers developed lung cancer. Cox regression was used to estimate relative risks (RRs) of lung cancer for 34 potential risk factors, of [...]

A partir des données de la cohorte "Malmö Diet and Cancer Study" incluant 943 patients atteints d'un cancer de la prostate, cette étude évalue l'association entre les niveaux sériques de vitamine D, d'hormone parathyroïdienne et de calcium, mesurés avant le diagnostic, et la mortalité spécifique

Vitamin D, PTH, and calcium in relation to survival following prostate cancer

Brändstedt, Johan ; Almquist, Martin ; Manjer, Jonas ; Malm, Johan

Purpose : Epidemiological studies suggest that low levels of vitamin D constitute a risk factor for prostate cancer. However, the results are conflicting, perhaps because prostate cancer is a very heterogeneous disease. More recent studies have focused on cancer progression and mortality. Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three factors have been implicated in prostate cancer. Methods : We examined the associations between [...]

Menée aux Etats-Unis à partir de données portant sur 438 patients atteints d'un carcinome rénal à cellules claires, cette étude analyse les disparités ethniques dans la survie, en prenant en compte l'expression de certains gènes impliqués dans la réponse thérapeutique

Intrinsic genomic differences between African American and white patients with clear cell renal cell carcinoma

Krishnan, B. ; Rose, T. L. ; Kardos, J. ; Milowsky, M. I. ; Kim, W. Y.

Importance : There are well-documented racial disparities in outcomes for African American patients with clear cell renal cell carcinoma (ccRCC). Despite a dramatic improvement in overall survival in white patients since the advent of targeted therapy, survival for African Americans with advanced ccRCC has not changed. There is little known about potential racial differences in tumor biology of ccRCC. Objective  To determine if there are racial differences in the somatic mutation rate and gene [...]

A partir des données de la cohorte "British Childhood Cancer Survivor Study", cette étude analyse le risque d'événements indésirables ou de second cancer, les morbidités, la mortalité spécifique, chez des patients ayant survécu à une tumeur de Wilms (néphroblastome) durant l'enfance, 30 à 50 ans après le diagnostic

Risk of Adverse Health and Social Outcomes Up to 50 Years After Wilms Tumor: The British Childhood Cancer Survivor Study

Wong, Kwok F. ; Reulen, Raoul C. ; Winter, David L. ; Guha, Joyeeta ; Fidler, Miranda M. ; Kelly, Julie ; Lancashire, Emma R. ; Pritchard-Jones, Kathryn ; Jenkinson, Helen C. ; Sugden, Elaine ; Levitt, Gill ; Frobisher, Clare ; Hawkins, Michael M.

Purpose : Survivors of Wilms tumor (WT) are at risk for adverse health and social outcomes but risks beyond 30 years from diagnosis remain uncertain. We investigated the risks of adverse outcomes among 5-year survivors of WT, in particular, those between 30 and 50 years from diagnosis. Patients and Methods : The British Childhood Cancer Survivor Study includes 1,441 5-year survivors of WT. We investigated cause-specific mortality, risk of subsequent primary neoplasms (SPNs), and, for those who [...]

Menée aux Etats-Unis à partir de données portant sur 16 248 patients atteints d'un cancer de l'hypopharynx diagnostiqué entre 1998 et 2011, cette étude analyse l'effet de diverses modalités thérapeutiques sur la survie

Treatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base

Kuo, Phoebe ; Sosa, Julie A. ; Burtness, Barbara A. ; Husain, Zain A. ; Mehra, Saral ; Roman, Sanziana A. ; Yarbrough, Wendell G. ; Judson, Benjamin L.

BACKGROUND The current study was performed to characterize trends and survival outcomes for chemotherapy in the definitive and adjuvant treatment of hypopharyngeal cancer in the United States. METHODS A total of 16,248 adult patients diagnosed with primary hypopharyngeal cancer without distant metastases between 1998 and 2011 were identified in the National Cancer Data Base. The association between treatment modality and overall survival was analyzed using Kaplan-Meier survival curves and [...]

A partir des données d'un registre suédois des cancers incluant 10 353 patients et 74 592 témoins, cette étude évalue les effets d'un diagnostic de cancer sur la santé physique et psychique du partenaire de vie du patient (troubles de l'humeur, stress sévère, maladies cardiaques, etc)

The effects of a cancer diagnosis on the health of a patient's partner: a population-based registry study of cancer in Sweden

Möllerberg, M. L. ; Sandgren, A. ; Lithman, T. ; Noreen, D. ; Olsson, H. ; Sjövall, K.

The aim of this population-based registry study was to explore how cancer influences the health of partners, by examining the onset of new diagnoses for partners, health care use and health care costs among partners living with patients with cancer. The sample consisted of partners of patients with cancer (N = 10 353) and partners of age- and sex-matched controls who did not have cancer (N = 74 592). Diagnoses, health care use and health care costs were studied for a continuous period starting [...]

Menée aux Etats-Unis auprès de 160 patients âgés de 2 à 9 ans et atteints d'une leucémie lymphoblastique à risque standard, cette étude prospective analyse les facteurs prédictifs d'une anxiété ou d'une dépression après la fin des traitements

Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study

Kunin-Batson, Alicia S. ; Lu, Xiaomin ; Balsamo, Lyn ; Graber, Kelsey ; Devidas, Meenakshi ; Hunger, Stephen P. ; Carroll, William L. ; Winick, Naomi J. ; Mattano, Leonard A. ; Maloney, Kelly W. ; Kadan-Lottick, Nina S.

BACKGROUND The months immediately after the completion of treatment for childhood acute lymphoblastic leukemia (ALL) are often regarded as a stressful time for children and families. In this prospective, longitudinal study, the prevalence and predictors of anxiety and depressive symptoms after the completion of treatment were examined. METHODS Participants included 160 children aged 2 to 9 years with standard-risk ALL who were enrolled on Children's Oncology Group protocol AALL0331. Parents [...]

Menée au Royaume-Uni par questionnaire auprès de 50 000 femmes éligibles au dépistage du cancer du sein, cette étude analyse l'association entre leurs perceptions du risque de cancer et leurs comportements de dépistage

Breast cancer risk feedback to women in the UK NHS breast screening population

Evans, D. Gareth R. ; Donnelly, Louise S. ; Harkness, Elaine F. ; Astley, Susan M. ; Stavrinos, Paula ; Dawe, Sarah ; Watterson, Donna ; Fox, Lynne ; Sergeant, Jamie C. ; Ingham, Sarah ; Harvie, Michelle N. ; Wilson, Mary ; Beetles, Ursula ; Buchan, Iain ; Brentnall, Adam R. ; French, David P. ; Cuzick, Jack ; Howell, Anthony

Introduction: There are widespread moves to develop risk-stratified approaches to population-based breast screening. The public needs to favour receiving breast cancer risk information, which ideally should produce no detrimental effects. This study investigates risk perception, the proportion wishing to know their 10-year risk and whether subsequent screening attendance is affected. Methods: Fifty thousand women attending the NHS Breast Screening Programme completed a risk assessment [...]

Menée par questionnaire auprès de 47 895 participantes âgées de 18 à 45 ans et vivant au Danemark, en Suède ou en Norvège, cette étude analyse leurs connaissances relatives au papillomavirus humain (HPV) après l'introduction de la vaccination contre le HPV

Awareness of human papillomavirus after introduction of HPV vaccination: a large population-based survey of Scandinavian women

Thomsen, Louise T. ; Nygård, Mari ; Stensen, Signe ; Terning Hansen, Bo ; Arnheim Dahlström, Lisen ; Liaw, Kai-Li ; Munk, Christian ; Kjaer, Susanne K.

Using a large, population-based survey, we assessed the levels and correlates of human papillomavirus (HPV) awareness among Scandinavian women after introduction of HPV vaccination. In 2011-2012, a random sample of women aged between 18 and 45 years from Denmark, Sweden and Norway received a questionnaire on lifestyle, health and HPV awareness. We included 47 895 women (response rate 60.6%) in our study. Country-specific and age-specific proportions of women who had heard of HPV in 2011-2012 [...]

Menée au Japon entre 2012 et 2014 à partir de données portant sur 2 426 patients atteints d'un cancer de stade avancé et recevant des soins palliatifs, à domicile ou en milieu hospitalier, cette étude de cohorte prospective analyse l'association entre le lieu du décès (domicile ou hôpital) et la durée de la survie

Multicenter cohort study on the survival time of cancer patients dying at home or in a hospital: Does place matter?

Hamano, Jun ; Yamaguchi, Takashi ; Maeda, Isseki ; Suga, Akihiko ; Hisanaga, Takayuki ; Ishihara, Tatsuhiko ; Iwashita, Tomoyuki ; Kaneishi, Keisuke ; Kawagoe, Shohei ; Kuriyama, Toshiyuki ; Maeda, Takashi ; Mori, Ichiro ; Nakajima, Nobuhisa ; Nishi, Tomohiro ; Sakurai, Hiroki ; Shimoyama, Satofumi ; Shinjo, Takuya ; Shirayama, Hiroto ; Yamada, Takeshi ; Morita, Tatsuya

BACKGROUND Although the place of death has a great influence on the quality of death and dying for cancer patients, whether the survival time differs according to the place of death is unclear. The primary aim of this study was to explore potential differences in the survival time of cancer patients dying at home or in a hospital. METHODS This multicenter, prospective cohort study was conducted in Japan from September 2012 through April 2014 and involved 58 specialist palliative care services. [...]

Menée en Argentine, cette étude analyse l'utilisation de méthadone en traitement de première ligne de la douleur chez des patients atteints de cancer et recevant des soins palliatifs dans des centres de soins tertiaires

Methadone as first-line opioid treatment for cancer pain in a developing country palliative care unit

Peirano, Gabriela P. ; Mammana, Guillermo P. ; Bertolino, Mariela S. ; Pastrana, Tania ; Vega, Gloria F. ; Russo, Jorgelina ; Varela, Gabriela ; Vignaroli, Ernesto ; Ruggiero, Raúl ; Armesto, Arnaldo ; Camerano, Gabriela ; Dran, Graciela

Purpose : The use of methadone for cancer pain is limited by the need of expertise and close titration due to variable half-life. Yet, it is a helpful palliative strategy in low-resources countries given its long-acting effect at low cost and worth additional study. Our aim was to describe the prescription and outcomes of methadone as a first-line treatment for cancer pain in a tertiary palliative care unit (PCU) in Argentina. Methods : Retrospective review of medical records of patients with [...]

Mené en Italie auprès de 190 patientes atteintes d'un cancer du sein, cet essai randomisé évalue l'efficacité de l'acupuncture pour traiter les bouffées de chaleur

Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women With Breast Cancer: A Prospective Multicenter Randomized Controlled Trial (AcCliMaT)

Lesi, Grazia ; Razzini, Giorgia ; Musti, Muriel Assunta ; Stivanello, Elisa ; Petrucci, Chiara ; Benedetti, Benedetta ; Rondini, Ermanno ; Ligabue, Maria Bernadette ; Scaltriti, Laura ; Botti, Alberto ; Artioli, Fabrizio ; Mancuso, Pamela ; Cardini, Francesco ; Pandolfi, Paolo

Purpose : To determine the effectiveness of acupuncture for the management of hot flashes in women with breast cancer. Patients and Methods : We conducted a pragmatic, randomized controlled trial comparing acupuncture plus enhanced self-care versus enhanced self-care alone. A total of 190 women with breast cancer were randomly assigned. Random assignment was performed with stratification for hormonal therapy; the allocation ratio was 1:1. Both groups received a booklet with information about [...]