A partir d'une revue systématique de la littérature (8 études de cohorte, 13 études cas-témoins, 19 892 cas), cette méta-analyse évalue l'association entre une consommation de café et le risque de cancer du poumon

Coffee Drinking and Risk of Lung Cancer - A Meta-Analysis

Boffetta, Paolo ; Galarraga, Vania

Background: Previous epidemiologic results on coffee consumption and lung cancer risk have not been consistent. Furthermore, not all studies have addressed the potential role of tobacco as a confounder in this association. A meta-analysis was conducted to assess the effect of coffee consumption on lung cancer risk independent of tobacco use. Methods: A systematic review and a meta-analysis based on random effects models were performed using studies from the PubMed and EMBASE databases, and the [...]

Menée en Chine à partir de données portant sur 27 011 cas et 25 782 témoins entre 1950 et 1995, cette étude évalue l'association entre une exposition professionnelle à des rayonnements ionisants provenant d'appareils de diagnostic médical et le risque de tumeurs solides

Solid cancer incidence among Chinese medical diagnostic x-ray workers, 1950–1995: Estimation of radiation-related risks

Sun, Zhijuan ; Inskip, Peter D. ; Wang, Jixian ; Kwon, Deukwoo ; Zhao, Yongcheng ; Zhang, Liangan ; Wang, Qin ; Fan, Saijun

The objective of this study was to estimate solid cancer risk attributable to long-term, fractionated occupational exposure to low doses of ionizing radiation. Based on cancer incidence for the period 1950–1995 in a cohort of 27,011 Chinese medical diagnostic X-ray workers and a comparison cohort of 25,782 Chinese physicians who did not use X-ray equipment in their work, we used Poisson regression to fit excess relative risk (ERR) and excess absolute risk (EAR) dose–response models for [...]

A partir des données des deux cohortes "Nurses’ Health Studies", cette étude prospective évalue l'association entre des troubles anxieux et phobiques et le risque de cancer de l'ovaire (779 cas)

A prospective study of phobic anxiety, risk of ovarian cancer, and survival among patients

Poole, Elizabeth M. ; Kubzansky, Laura D. ; Sood, Anil K. ; Okereke, Olivia I. ; Tworoger, Shelley S.

Purpose : In ovarian cancer patients and mouse models, psychosocial stress is associated with higher circulating markers of angiogenesis and cell migration, impaired immune response, and increasing tumor burden and aggressiveness. In the Nurses’ Health Studies (NHS/NHSII), we assessed whether phobic anxiety, a marker of chronic distress, was associated with risk of incident ovarian cancer as well as survival among ovarian cancer patients. Methods : We used Cox proportional hazards regression to [...]

A partir des données d'une cohorte multi-ethnique incluant 4 086 cas et 3 698 témoins, cette étude évalue l'association entre 350 polymorphismes à simple nucléotide de l'ADN mitochondrial et le risque de cancer de la prostate

No association between the mitochondrial genome and prostate cancer risk: The Multiethnic Cohort

Giorgi, Elena E. ; Li, Yuqing ; Caberto, Christian P ; Beckman, Kenneth B ; Lum-Jones, Annette ; Haiman, Christopher A. ; Le Marchand, Loic ; Stram, Daniel O ; Saxena, Richa ; Cheng, Iona

Background: Mitochondria are involved in many processes that are central to the life and death of a cell. Oxidative phosphorylation (OXPHOS), in particular, is known to be altered in carcinogenesis, leading to an increase in the production of reactive oxidative species and glycolysis, one of the hallmarks of cancer cells. Because of this, genetic variation in the mitochondrial genome, which encodes for part of the OXPHOS pathway, has been suggested to play a role in many cancers, including [...]

Menée en Chine sur une cohorte comprenant 3 406 cas de cancer de la vessie et 4 645 témoins, cette étude d'association sur le génome entier identifie un nouveau locus de susceptibilité à la maladie sur la région chromosomique 5q12.3

Genome-wide association study of bladder cancer in a Chinese cohort reveals a new susceptibility locus at 5q12.3

Wang, Meilin ; Li, Zhiqiang ; Chu, Haiyan ; Lv, Qiang ; Ye, Dingwei ; Ding, Qiang ; Xu, Chuanliang ; Guo, Jianming ; Du, Mulong ; Chen, Jianhua ; Song, Zhijian ; Yin, Changjun ; Qin, Chao ; Gu, Chenyuan ; Zhu, Yao ; Xia, Guowei ; Liu, Fang ; Zhang, Zhengsheng ; Yuan, Lin ; Fu, Guangbo ; Hu, Zhibin ; Tong, Na ; Shen, Jiawei ; Liu, Ke ; Sun, Jielin ; Sun, Yinhao ; Li, Jun ; Li, Xingwang ; Shen, Hongbing ; Xu, Jianfeng ; Shi, Yongyong ; Zhang, Zhengdong

Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations, but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 cases of bladder cancer and 4,645 controls. We identified a new susceptibility locus for bladder cancer at 5q12.3, located in the intron of CWC27 (rs2042329), that was significantly [...]