A partir d'une revue systématique de la littérature, cette étude française analyse le risque d'événements indésirables dermatologiques induits par les thérapies ciblées et évalue leur impact sur la qualité de vie des patients atteints de cancer

Impact of dermatologic adverse events induced by targeted therapies on quality of life

Charles, Cécile ; Bungener, Catherine ; Razavi, Darius ; Mateus, Christine ; Routier, Emilie ; Lanoy, Emilie ; Verschoore, Michèle ; Robert, Caroline ; Dauchy, Sarah

Background : Investigations about the impact of dermatologic adverse events on quality of life in the context of targeted therapies are quite recent and results vary in some dimensions. This article aims to summarize the existing data and to clarify needs in terms of clinical management and future research. Methods : A literature review was done with Pubmed, Medline, Scopus and PsycInfo databases and it combined the empirical studies published in English and in French over the past ten years. [...]

Menée aux Etats-Unis auprès de 728 patients atteints d'un cancer de stade avancé, cette étude prospective évalue l'efficacité d'un outil d'évaluation personnalisée des symptômes, prenant en compte l'intensité de 10 symptômes différents sur une échelle de 0 à 10

Personalized symptom goals and response in patients with advanced cancer

Hui, David ; Park, Minjeong ; Shamieh, Omar ; Paiva, Carlos Eduardo ; Perez-Cruz, Pedro Emilio ; Muckaden, Mary Ann ; Bruera, Eduardo

BACKGROUND Improving symptoms is a major goal of cancer medicine; however, symptom response is often based on group differences and not individualized. In the current study, the authors examined the personalized symptom goal (PSG) for 10 common symptoms in patients with advanced cancer, and identified the factors associated with PSG response. METHODS In this prospective, longitudinal, multicenter study, patients from 5 tertiary care hospitals rated the intensity of 10 symptoms using a numeric [...]

Menée aux Etats-Unis à partir de données 2011, cette étude analyse les effets de difficultés financières, auto-déclarées par les patients ayant survécu à un cancer, sur leur qualité de vie physique et psychique

Self-reported financial burden of cancer care and its effect on physical and mental health-related quality of life among US cancer survivors

Kale, Hrishikesh P. ; Carroll, Norman V.

BACKGROUND Cancer-related financial burden has been linked to cancer survivors (CS) forgoing/delaying medical care, skipping follow-up visits, and discontinuing medications. To the authors' knowledge, little is known regarding the effect of financial burden on the health-related quality of life of CS. METHODS The authors analyzed 2011 Medical Expenditure Panel Survey data. Financial burden was present if one of the following problems was reported: borrowed money/declared bankruptcy, worried [...]

Menée aux Pays-Bas auprès de 28 patients atteints de leucémie et de 35 patients ayant reçu une greffe autologue de cellules souches, cette étude évalue les effets de foyers infectieux chroniques non traités sur le développement de complications infectieuses pendant une chimiothérapie intensive

Effect of leaving chronic oral foci untreated on infectious complications during intensive chemotherapy

Schuurhuis, J. M. ; Span, L. F. R. ; Stokman, M. A. ; van Winkelhoff, A. J. ; Vissink, A. ; Spijkervet, F. K. L.

Background: Leukaemic patients receiving intensive chemotherapy and patients undergoing autologous stem-cell transplantation (ASCT) are routinely screened for oral foci of infection to reduce infectious complications that could occur during therapy. In this prospective study we assessed the effect of leaving chronic oral foci of infection untreated on the development of infectious complications in intensively treated haematological patients. Methods: We included and prospectively evaluated all [...]

Menée aux Etats-Unis à partir de données portant sur 862 patients adultes ayant survécu à une leucémie lymphoblastique aiguë durant l'enfance (âge médian : 31,3 ans), cette étude évalue l'association entre des facteurs comportementaux (tabagisme, activité physique, consommation d'alcool), des déficits hormonaux et le risque de fragilité osseuse

Modifiable Factors Associated With Aging Phenotypes Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Wilson, Carmen L. ; Chemaitilly, Wassim ; Jones, Kendra E. ; Kaste, Sue C. ; Srivastava, Deo Kumar ; Ojha, Rohit P. ; Yasui, Yutaka ; Pui, Ching-Hon ; Robison, Leslie L. ; Hudson, Melissa M. ; Ness, Kirsten K.

Purpose : Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for low bone mineral density (BMD) and frail health, outcomes potentially modifiable by altering health behaviors and/or treating endocrine abnormalities. We evaluated associations between lifestyle and hormonal deficits with risk of low BMD and frailty among survivors of ALL. Patients and Methods : Participants included 862 survivors of ALL (median age, 31.3 years [range, 18.4 to 59.7 years]) enrolled in the St [...]

Menée au Japon auprès de 47 patients atteints d'un cancer du poumon non à petites cellules avec des métastases osseuses, cette étude évalue l'efficacité d'un outil permettant de prédire le risque d'événements indésirables liés au squelette

Prediction of skeletal-related events in patients with non-small cell lung cancer

Aiba, Hisaki ; Kimura, Tomoki ; Yamagami, Takaya ; Watanabe, Nobuyuki ; Sakurai, Hironari ; Kimura, Hiroaki ; Shimozaki, Shingo ; Yamada, Satoshi ; Otsuka, Takanobu

Purpose : Advanced lung cancer frequently causes bone metastasis which can be associated with skeletal-related events (SREs) that may cause significant deterioration of the patient’s quality of life (QoL). The Spinal Instability Neoplastic Score (SINS) can be used to assist in standardizing evaluations of neoplastic spinal instability between spinal and non-spine surgeons. This research investigated the association between SREs and SINS for patients with non-small cell lung cancer (NSCLC). [...]

Menée aux Etats-Unis par entretiens, cette étude analyse les symptômes cognitifs et comportementaux associés à des troubles neurologiques chez des patients atteints d'un cancer de la prostate traité par hormonothérapie anti-androgénique

Cognitive and neurobehavioral symptoms in patients with non-metastatic prostate cancer treated with androgen deprivation therapy or observation: A mixed methods study

Wu, Lisa M. ; Tanenbaum, Molly L. ; Dijkers, Marcel P. J. M. ; Amidi, Ali ; Hall, Simon J. ; Penedo, Frank J. ; Diefenbach, Michael A.

BACKGROUND Few studies have investigated prostate cancer patients’ experiences of cognitive functioning or neurobehavioral symptoms (i.e., behavioral changes associated with neurological dysfunction) following androgen deprivation therapy (ADT). METHODS Semi-structured interviews conducted from the US by phone and in-person were used to explore and characterize the: 1) experience of cognitive and neurobehavioral functioning in non-metastatic prostate cancer patients undergoing ADT (n=19) [...]

Mené au Royaume-Uni auprès de 80 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'efficacité, en termes d'amélioration de leur qualité de vie, d'une intervention à domicile visant à développer l'activité physique

Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors

Lahart, Ian M. ; Metsios, George S. ; Nevill, Alan M. ; Kitas, George D. ; Carmichael, Amtul R.

Background : To improve adherence to physical activity (PA), behavioural support in the form of behavioural change counselling may be necessary. However, limited evidence of the effectiveness of home-based PA combined with counselling in breast cancer patients exists. The aim of this current randomised controlled trial with a parallel group design was to evaluate the effectiveness of a home-based PA intervention on PA levels, anthropometric measures, health-related quality of life (HRQoL), and [...]

A partir d'une revue systématique de la littérature (9 études, 1 288 patients), cette étude analyse l'association entre divers facteurs comportementaux (alimentation, activité physique, tabagisme) et la qualité de vie chez des patients ayant survécu à un cancer de la vessie

Lifestyle factors and health-related quality of life in bladder cancer survivors: a systematic review

Gopalakrishna, Ajay ; Longo, Thomas A. ; Fantony, Joseph J. ; Noord, Megan ; Inman, Brant A.

Purpose : Diet, physical activity, and smoking cessation are modifiable lifestyle factors that have been shown to improve health-related quality of life (HRQOL) in many cancer survivors. Our objective was to systematically review the literature on the associations between lifestyle factors, namely diet, physical activity, smoking status, and HRQOL in bladder cancer survivors. Methods : We queried PubMed, EMBASE, and Cochrane libraries. Two reviewers reviewed abstracts independently, and a third [...]

A partir des données des registres américains des cancers portant sur la période 1973-2012, cette étude analyse l'évolution de l'incidence du cholangiocarcinome en prenant en compte les cancers d'origine primitive inconnue

Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise

Saha, Supriya K. ; Zhu, Andrew X. ; Fuchs, Charles S. ; Brooks, Gabriel A.

Challenges in the diagnosis and classification of cholangiocarcinoma have made it difficult to quantify the true incidence of this highly aggressive malignancy.We analyzed the Surveillance, Epidemiology, and End Results data to assess long-term trends in the age-standardized incidence of intrahepatic and extrahepatic cholangiocarcinoma between 1973 and 2012, correcting for systematic coding errors. Because intrahepatic cholangiocarcinoma (ICC) may frequently be misdiagnosed as cancer of unknown [...]

A partir des données des registres américains des cancers, cette étude présente une première estimation de l'incidence des cancers pour l'année 2013

Preliminary estimates of SEER cancer incidence for 2013

Lewis, Denise Riedel ; Chen, Huann-Sheng ; Cockburn, Myles ; Wu, Xiao-Cheng ; Stroup, Antoinette M. ; Midthune, Douglas N. ; Krapcho, Martin F. ; Miller, Daniel G. ; Penberthy, Lynne ; Feuer, Eric J.

BACKGROUND This article presents a first look at rates and trends for cases in the Surveillance, Epidemiology, and End Results (SEER) program diagnosed through 2013 using the February 2015 submission, and a validation of rates and trends from the February 2014 submission using the subsequent November 2014 submission. To the authors' knowledge, this is the second time SEER has published trends based on the early February submission. Three new cancer sites were added: cervix, thyroid, and liver/ [...]

A partir des données de la cohorte "The Childhood Cancer Survivor Study", cette étude analyse les disparités ethniques dans la survenue d'événements indésirables et de morbidités liés aux traitements, chez des patients ayant survécu à un cancer pédiatrique

Racial/Ethnic Differences in Adverse Outcomes Among Childhood Cancer Survivors: The Childhood Cancer Survivor Study

Liu, Qi ; Leisenring, Wendy M. ; Ness, Kirsten K. ; Robison, Leslie L. ; Armstrong, Gregory T. ; Yasui, Yutaka ; Bhatia, Smita

Purpose : Childhood cancer survivors carry a high burden of treatment-related morbidity; however, race/ethnicity–specific risks of adverse outcomes are not well understood. Methods : Data from the Childhood Cancer Survivor Study, a cohort of survivors of at least 5 years, were used to compare Hispanic (n = 750, 5.4%) and non-Hispanic black (NHB: n = 694, 5.0%) survivors to non-Hispanic white patients (NHW: n = 12,397, 89.6%) for late mortality, subsequent neoplasms, and chronic health [...]

Menée en France à partir de données portant sur 240 patients atteints de cancer, cette étude de cohorte rétrospective analyse le respect, dans la pratique clinique, des recommandations relatives au traitement et à la prise en charge d'une thrombose veineuse associée au cancer

Adherence to treatment guidelines for cancer-associated thrombosis: a French hospital-based cohort study

Mahé, I. ; Puget, H. ; Buzzi, J. C. ; Lamuraglia, M. ; Chidiac, J. ; Strukov, A. ; Helfer, Hélène ; Perozziello, A.

Purpose : French 2008 treatment guidelines recommend low-molecular-weight heparins (LMWH) for the treatment of cancer-associated thrombosis (CAT) with treatment duration of at least 3 months and up to 6 months and beyond if cancer remains active. Our aim was to assess adherence to guidelines in hospital clinical practice. Methods : The French hospital database (PMSI) was used to identify patients with CAT admitted to three hospitals of the Paris region to be included in a retrospective cohort [...]

Menée aux Etats-Unis auprès de 6 099 patients ayant survécu à un cancer, 2, 6 ou 10 ans après le diagnostic, cette étude analyse le risque de séparation conjuguale en fonction du sexe du patient diagnostiqué et des types de difficultés liées à la maladie (difficultés émotionnelles, financières, professionnelles)

Gender differences in associations between cancer-related problems and relationship dissolution among cancer survivors

Stephens, Cristina ; Westmaas, J. Lee ; Kim, Jihye ; Cannady, Rachel ; Stein, Kevin

Purpose : Research suggests that a cancer diagnosis predicts marital dissolution more strongly for women survivors than men, but there is a paucity of research on potential processes underlying this vulnerability. The present cross-sectional study examined whether specific cancer-related problems were associated with the odds of relationship breakup following diagnosis and whether these relationships differed between male and female cancer survivors. Methods : A national cross-sectional quality [...]

Menée aux Etats-Unis à partir d'échantillons plasmatiques de 1 042 patients atteints de mélanome, cette étude prospective évalue l'association entre les niveaux de vitamine D, les niveaux de protéine C-réactive et la survie

Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein

Fang, Shenying ; Sui, Dawen ; Wang, Yuling ; Liu, Huey ; Chiang, Yi-Ju ; Ross, Merrick I. ; Gershenwald, Jeffrey E. ; Cormier, Janice N. ; Royal, Richard E. ; Lucci, Anthony ; Wargo, Jennifer ; Hu, Mimi I. ; Gardner, Julie M. ; Reveille, John D. ; Bassett, Roland L. ; Wei, Qingyi ; Amos, Christopher I. ; Lee, Jeffrey E.

Purpose : To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement. Materials and Methods : Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a [...]

Menée en France à partir des données des registres du réseau Francim, cette étude analyse l'évolution de l'incidence des cancers hématologiques, par sous-type, sur la période 1980-2012

Cancer incidence in France over the 1980–2012 period: Hematological malignancies

Le Guyader-Peyrou, S. ; Belot, A. ; Maynadié, M. ; Binder-Foucard, F. ; Remontet, L. ; Troussard, X. ; Bossard, N. ; Monnereau, A.

Background : The classification of hematological malignancies (HMs) has changed in recent decades. For the first time, the French network of cancer registries (Francim) provides estimates for incidence and trends of HM in France between 1980 and 2012 for major HM subtypes. Methods : Incidence was directly estimated by modeling the incidence rates measured in the cancer registry area. For each HM subtype, a “usable incidence period” was defined a priori, corresponding to the years for which all [...]

A partir des données médicales de 534 patientes atteintes d'un cancer du sein et ayant développé des métastases osseuses entre 1999 et 2011, cette étude japonaise analyse les facteurs associés au risque de survenue d'événements indésirables liés au squelette

Risk Factors for Developing Skeletal-Related Events in Breast Cancer Patients With Bone Metastases Undergoing Treatment With Bone-Modifying Agents

Tanaka, Ryota ; Yonemori, Kan ; Hirakawa, Akihiro ; Kinoshita, Fumie ; Takahashi, Naoki ; Hashimoto, Jun ; Kodaira, Makoto ; Yamamoto, Harukaze ; Yunokawa, Mayu ; Shimizu, Chikako ; Fujimoto, Manabu ; Fujiwara, Yasuhiro ; Tamura, Kenji

Bone-modifying agents (BMAs) reduce the incidence of skeletal-related events (SREs) and are thus recommended for breast cancer patients with bone metastases. However, the risk factors for SREs during BMA treatment are not well-understood. This study evaluated the number and timing of SREs from case studies to identify these factors.The medical records of 534 women with breast cancer who developed bone metastases between 1999 and 2011 were reviewed. SREs were defined as a pathologic fracture, [...]

Menée aux Etats-Unis à partir de données portant sur 4 042 patients âgés de plus de 70 ans et atteints d'un cancer de la tête et du cou localisé, cette étude analyse les effets d'une chimioradiothérapie sur la survie globale (durée médiane de suivi : 19 mois)

Survival outcomes with concurrent chemoradiation for elderly patients with locally advanced head and neck cancer according to the National Cancer Data Base

Amini, Arya ; Jones, Bernard L. ; McDermott, Jessica D. ; Serracino, Hilary S. ; Jimeno, Antonio ; Raben, David ; Ghosh, Debashis ; Bowles, Daniel W. ; Karam, Sana D.

BACKGROUND The overall survival (OS) benefit of concurrent chemoradiotherapy (CRT) for head and neck squamous cell carcinoma patients older than 70 years is debated. This study examines the outcomes of elderly patients receiving CRT versus radiotherapy (RT) alone. METHODS The National Cancer Data Base was queried for patients older than 70 years with nonmetastatic oropharyngeal, laryngeal, or hypopharyngeal cancer (T3-4 or N(+)). CRT was defined as chemotherapy started within 14 days of the [...]

Menée à partir de données de registres suédois portant sur la période 1970-2009, cette étude évalue l'association entre amygdalectomie (227 996 cas ; âge moyen : 17,8 ans) et risque de cancers oropharyngés

Tonsillectomy and incidence of oropharyngeal cancers

Chaturvedi, Anil K. ; Song, Huan ; Rosenberg, Philip S ; Ramqvist, Torbjörn ; Anderson, William F. ; Munck-Wikland, Eva ; Ye, Weimin ; Dalianis, Tina

Background : Rising incidence of oropharyngeal cancers in numerous countries since the 1970s has been attributed to increased oral HPV exposure. However, the contribution of coincidental declines in the surgical removal of the tonsils (tonsillectomy) is unknown. We quantified the association of tonsillectomy with risk of tonsillar, other oropharyngeal, and other head and neck cancers and the contribution of declines in tonsillectomies to cancer incidence trends. Methods : We conducted a [...]

Menée auprès de 306 cas et 1 378 témoins, cette étude évalue l'association entre une amygdalectomie et le risque de cancer des amygdales ou de cancer de la base de la langue

Previous tonsillectomy modifies odds of tonsil and base of tongue cancer

Zevallos, Jose P. ; Mazul, Angela L. ; Rodriguez, Nidia ; Weissler, Mark C. ; Brennan, Paul ; Anantharaman, Devasena ; Abedi-Ardekani, Behnoush ; Neil Hayes, D. ; Olshan, Andrew F.

Background: Tonsillectomy is a commonly performed surgical procedure that involves removal of the palatine tonsils. The purpose of this study is to examine the association between previous tonsillectomy and odds of oropharyngeal squamous cell carcinoma (OPSCC) in a large population-based case–control study. We hypothesise that previous tonsillectomy is associated with a decreased odds of tonsil cancer with no impact on the odds of developing base of tongue (BOT) cancer. Methods: This was a [...]

A partir des données des registres néerlandais des cancers incluant 1 552 patients ayant survécu à un cancer colorectal, cette étude évalue l'association entre leurs perceptions relatives à la maladie, leurs comportements vis-à-vis de la prise en charge de leurs symptômes et la mortalité

Illness perceptions are associated with mortality among 1552 colorectal cancer survivors: a study from the population-based PROFILES registry

Thong, Melissa S. Y. ; Kaptein, Adrian A. ; Vissers, Pauline A. J. ; Vreugdenhil, Gerard ; Poll-Franse, Lonneke V.

Purpose : Cancer survivors construct perceptions of illness as a (mal)adaptive mechanism. These perceptions motivate/drive subsequent self-management behaviors toward symptoms and treatment that influence health outcomes. Negative illness perceptions have been associated with increased mortality in other chronically ill groups. However, this association is under-researched in cancer survivors. We aimed to explore the association between illness perceptions and mortality in stage I–III [...]

Menée à partir d'un modèle mathématique, cette étude estime, en fonction de l'âge des patientes et de la présence de facteurs de risque cardiaque, le rapport coût-efficacité d'une protonthérapie dans la prise en charge d'un cancer du sein

Establishing cost-effective allocation of proton therapy for breast irradiation

Vega, R. Mailhot ; Ishaq, O. ; Raldow, A. ; Perez, C. A. ; Jimenez, R. ; Scherrer-Crosbie, M. ; Bussiere, M. ; Taghian, A. ; Sher, D. J. ; MacDonald, S. M.

Background : Cardiac toxicity due to conventional breast radiotherapy (RT) has been extensively reported, and it impacts both life expectancy and quality-of-life for affected women. Given the favorable oncologic outcomes in the majority of women irradiated for breast cancer, it is increasingly paramount to minimize treatment side effects and improve survivorship for these patients. Proton RT offers promise in limiting heart dose, but the modality is costly and access is limited. Using [...]

A partir des données des registres américains des cancers et de la base Medicare portant sur la période 2006-2012, cette étude analyse l'association entre une utilisation précoce de médicaments pour traiter des symptômes habituels de patientes atteintes d'un cancer du sein de stade avancé (douleur, insomnie, anxiété, dépression) et une utilisation des soins de fin de vie

Early supportive medication use and end-of-life care among Medicare beneficiaries with advanced breast cancer

Check, Devon K. ; Rosenstein, Donald L. ; Dusetzina, Stacie B.

Purpose : A randomized controlled trial of cancer patients has linked early supportive care with improved hospice use and less-aggressive end-of-life care. In practice, the early use of supportive interventions and potential impact on end-of-life care are poorly understood. We sought to describe early use of medications to treat common breast cancer symptoms (pain, insomnia, anxiety, and depression) and to assess the relationship between early use of these treatments and end-of-life care. [...]