A partir d'une revue systématique de la littérature (22 études cas-témoins), cette méta-analyse évalue l'association entre une infection par le papillomavirus humain et le risque de cancer du sein

Human papillomavirus infection and risk of breast cancer: a meta-analysis of case-control studies

Bae, Jong-Myon ; Kim, Eun Hee

Background : Although systematic reviews (SR) report that human papillomavirus (HPV) increases the risk of breast cancer, there are still disputes regarding this association. In particular, it has been argued that the risk level differs depending on nationality, type of tissue, subtype of HPV, and publication year. Considering that the searching year of publication for the previous SRs was June 2013, a renewal meta-analysis needs to be conducted. Methods : Using articles selected in the [...]

A partir des données des registres américains des cancers portant sur 10 708 cas et 332 107 témoins entre 2000 et 2011, cette étude analyse la part attribuable à divers facteurs dans l'incidence du carcinome hépatocellulaire (troubles métaboliques, infection par le virus de l'hépatite C ou B, consommation d'alcool, tabagisme, polymorphismes génétiques, etc)

Population attributable fractions of risk factors for hepatocellular carcinoma in the United States

Makarova-Rusher, Oxana V. ; Altekruse, Sean F. ; McNeel, Tim S. ; Ulahannan, Susanna ; Duffy, Austin G. ; Graubard, Barry I. ; Greten, Tim F. ; McGlynn, Katherine A.

BACKGROUND Hepatocellular carcinoma (HCC) incidence has been increasing in the United States for several decades; and, as the incidence of hepatitis C virus (HCV) infection declines and the prevalence of metabolic disorders rises, the proportion of HCC attributable to various risk factors may be changing. METHODS Data from the Surveillance, Epidemiology, and End Results-Medicare linkage were used to calculate population attributable fractions (PAFs) for each risk factor over time. Patients with [...]

A partir d'une revue systématique de la littérature publiée entre 1995 et 2015 (26 études), cette méta-analyse évalue l'association entre divers facteurs liés au comportement (tabagisme, supplémentation en antioxydants, obésité, activité physique, alimentation, etc) et le risque de cancer de la vessie

Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses

Al-Zalabani, Abdulmohsen H. ; Stewart, Kelly F. J. ; Wesselius, Anke ; Schols, Annemie M. W. J. ; Zeegers, Maurice P.

Each year, 430,000 people are diagnosed with bladder cancer. Due to the high recurrence rate of the disease, primary prevention is paramount. Therefore, we reviewed all meta-analyses on modifiable risk factors of primary bladder cancer. PubMed, Embase and Cochrane database were systematically searched for meta-analyses on modifiable risk factors published between 1995 and 2015. When appropriate, meta-analyses (MA) were combined in meta–meta-analysis (MMA). If not, the most comprehensive MA was [...]

A partir des données des registres américains des cancers incluant 743 779 patients et 419 432 témoins âgés de plus de 65 ans, puis auprès de 836 947 cas et 172 869 témoins, cette étude de cohorte prospective évalue l'association entre une maladie de Parkinson et le risque de cancer

Associations between cancer and Parkinson’s disease in U.S. elderly adults

Freedman, D. Michal ; Wu, Jincao ; Chen, Honglei ; Engels, Eric A. ; Enewold, Lindsey R. ; Freedman, Neal D. ; Goedert, James J. ; Kuncl, Ralph W. ; Gail, Mitchell H. ; Pfeiffer, Ruth M.

Background: Several studies suggest that cancer is reduced before and after a Parkinson’s disease (PD) diagnosis. However, determining relationships among diseases of ageing is challenging due to possible biases in ascertaining disease. This study evaluates the PD and cancer relationship, addressing potential biases. Methods: Using Surveillance, Epidemiology, and End Results-Medicare linked data (1992–2005) of adults ≥ 65 years, we assessed PD risk after cancer comparing PD in 743 779 cancer [...]

Menée auprès de 7 243 femmes atteintes d'un cancer du sein, cette étude de cohorte internationale évalue le risque de leucémie associé à une mutation des gènes BRCA1 ou BRCA2

The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study

Iqbal, Javaid ; Nussenzweig, André ; Lubinski, Jan ; Byrski, Tomasz ; Eisen, Andrea ; Bordeleau, Louise ; Tung, Nadine M. ; Manoukian, Siranoush ; Phelan, Catherine M. ; Sun, Ping ; Narod, Steven A. ; The Hereditary Breast Cancer Research, Group

Background : Germline mutations in BRCA1 and BRCA2 increase the susceptibility to develop breast and ovarian cancers as well as increase the risk of some other cancers. Primary objective was to estimate the risk of leukaemia in BRCA1 and BRCA2 mutation carriers. Methods: We followed 7243 women with a BRCA1 or a BRCA2 mutation for incident cases of leukaemia. We used the standardised incidence ratio (SIR) to estimate the relative risk of leukaemia, according to mutation and history of breast [...]

A partir de données d'études d'association sur le génome entier incluant 1 816 patients atteints d'un lymphome hodgkinien, 9 772 patients atteints d'une sclérose en plaques et de 25 555 témoins, cette méta-analyse identifie des similitudes génétiques dans l'étiologie de ces deux maladies

Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis

Khankhanian, Pouya ; Cozen, Wendy ; Himmelstein, Daniel S. ; Madireddy, Lohith ; Din, Lennox ; van den Berg, Anke ; Matsushita, Takuya ; Glaser, Sally L. ; Moré, Jayaji M. ; Smedby, Karin E. ; Baranzini, Sergio E. ; Mack, Thomas M. ; Lizée, Antoine ; de Sanjose, Silvia ; Gourraud, Pierre-Antoine ; Nieters, Alexandra ; Hauser, Stephen L. ; Cocco, Pierluigi ; Maynadie, Marc ; Foretova, Lenka ; Staines, Anthony ; Delahaye-Sourdeix, Manon ; Li, Dalin ; Bhatia, Smita ; Melbye, Mads ; Onel, Kenan ; Jarrett, Ruth ; McKay, James D. ; Oksenberg, Jorge R. ; Hjalgrim, Henrik

Background: Based on epidemiological commonalities, multiple sclerosis (MS) and Hodgkin lymphoma (HL), two clinically distinct conditions, have long been suspected to be aetiologically related. MS and HL occur in roughly the same age groups, both are associated with Epstein-Barr virus infection and ultraviolet (UV) light exposure, and they cluster mutually in families (though not in individuals). We speculated if in addition to sharing environmental risk factors, MS and HL were also genetically [...]