Mené en Italie auprès de 520 patients atteints de cancer, cet essai multicentrique de phase IV compare l'efficacité, dans la durée et en fonction de la réponse individuelle du patient, de quatre opioïdes forts pour traiter la douleur liée au cancer

Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase 4 ‘real life’ trial on the variability of response to opioids

Corli, O. ; Floriani, I. ; Roberto, A. ; Montanari, M. ; Galli, F. ; Greco, M.T. ; Caraceni, A. ; Kaasa, S. ; Dragani, T.A. ; Azzarello, G. ; Luzzani, M. ; Cavanna, L. ; Bandieri, E. ; Gamucci, T. ; Lipari, G. ; Di Gregorio, R. ; Valenti, D. ; Reale, C. ; Pavesi, L. ; Iorno, V. ; Crispino, C. ; Pacchioni, M. ; Apolone, G.

Background : Guidelines tend to consider morphine and morphine-like opioids comparable and interchangeable in the treatment of chronic cancer pain but individual responses can vary. This study compared the analgesic efficacy, changes of therapy and safety profile over time of four strong opioids given for cancer pain. Patient and methods : In this four-arm multicenter, randomized, comparative, of superiority, phase IV trial, oncological patients with moderate to severe pain requiring WHO step [...]

Menée aux Etats-Unis par questionnaire auprès de patients atteints d'un cancer du poumon ou du côlon-rectum, cette étude évalue l'association entre leurs réserves financières, leurs symptômes liés à la maladie et leur qualité de vie

Association of Financial Strain With Symptom Burden and Quality of Life for Patients With Lung or Colorectal Cancer

Lathan, Christopher S. ; Cronin, Angel ; Tucker-Seeley, Reginald ; Zafar, S. Yousuf ; Ayanian, John Z. ; Schrag, Deborah

Purpose : To measure the association between patient financial strain and symptom burden and quality of life (QOL) for patients with new diagnoses of lung or colorectal cancer. Patients and Methods : Patients participating in the Cancer Care Outcomes Research and Surveillance study were interviewed about their financial reserves, QOL, and symptom burden at 4 months of diagnosis and, for survivors, at 12 months of diagnosis. We assessed the association of patient-reported financial reserves with [...]

A partir d'une revue systématique de la littérature (53 études), cette étude analyse les facteurs prédictifs de la qualité de vie chez des patients ayant survécu à un cancer colorectal

Candidate Predictors of Health-Related Quality of Life of Colorectal Cancer Survivors: A Systematic Review

Bours, Martijn J.L. ; van der Linden, Bernadette W.A. ; Winkels, Renate M. ; van Duijnhoven, Fränzel J. ; Mols, Floortje ; van Roekel, Eline H. ; Kampman, Ellen ; Beijer, Sandra ; Weijenberg, Matty P.

The population of colorectal cancer (CRC) survivors is growing and many survivors experience deteriorated health-related quality of life (HRQoL) in both early and late post-treatment phases. Identification of CRC survivors at risk for HRQoL deterioration can be improved by using prediction models. However, such models are currently not available for oncology practice. As a starting point for developing prediction models of HRQoL for CRC survivors, a comprehensive overview of potential candidate [...]

Menée en Italie auprès de 34 patientes atteintes d'un cancer du sein et souffrant de troubles psychiques, cette étude compare l'efficacité de la duloxétine et de l'escitalopram pour traiter les bouffées de chaleur

Duloxetine and escitalopram for hot flushes: efficacy and compliance in breast cancer survivors

Biglia, N. ; Bounous, V. E. ; Susini, T. ; Pecchio, S. ; Sgro, L. G. ; Tuninetti, V. ; Torta, R.

Selective serotonin reuptake inhibitors (SSRI) and serotonin–norepinephrine reuptake inhibitors (SNRI) might be an effective treatment for hot flushes (HFs) in breast cancer survivors (BCSs). This study aims to compare the efficacy and tolerability of duloxetine (SNRI) versus escitalopram (SSRI) in reducing frequency and severity of HFs in BCSs and to assess the effect on depression. Thirty-four symptomatic BCSs with emotional impairment received randomly duloxetine 60 mg daily or escitalopram [...]

A partir des données du registre suisse des cancers pédiatriques incluant 1 602 patients atteints d'un cancer diagnostiqué entre 1991 et 2006, cette étude analyse les disparités socio-économiques dans la survie

Socioeconomic disparities in childhood cancer survival in Switzerland

Adam, Martin ; Rueegg, Corina S. ; Schmidlin, Kurt ; Spoerri, Adrian ; Niggli, Felix ; Grotzer, Michael ; von der Weid, Nicolas X. ; Egger, Matthias ; Probst-Hensch, Nicole ; Zwahlen, Marcel ; Kuehni, Claudia E. ; for the Swiss Paediatric Oncology, Group ; the Swiss National Cohort, Study

In this study, we investigated whether childhood cancer survival in Switzerland is influenced by socioeconomic status (SES), and if disparities vary by type of cancer and definition of SES (parental education, living condition, area-based SES). Using Cox proportional hazards models, we analyzed 5-year cumulative mortality in all patients registered in the Swiss Childhood Cancer Registry diagnosed 1991–2006 below 16 years. Information on SES was extracted from the Swiss census by probabilistic [...]

Cette étude présente les données d'incidence des cancers et de la mortalité spécifique en population afro-américaine en 2016, et propose des pistes de réflexion pour réduire les disparités ethniques dans les facteurs de risque de cancer, le dépistage et l'accès aux soins

Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities

DeSantis, Carol E. ; Siegel, Rebecca L. ; Sauer, Ann Goding ; Miller, Kimberly D. ; Fedewa, Stacey A. ; Alcaraz, Kassandra I. ; Jemal, Ahmedin

In this article, the American Cancer Society provides the estimated number of new cancer cases and deaths for blacks in the United States and the most recent data on cancer incidence, mortality, survival, screening, and risk factors for cancer. Incidence data are from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries, and mortality data are from the National Center for Health Statistics. Approximately [...]

A partir des données des registres américains des cancers incluant 13 107 patients atteints d'un lymphome T périphérique entre 2000 et 2012, cette étude analyse les disparités ethniques dans l'incidence et la survie

Racial Patterns of Peripheral T-Cell Lymphoma Incidence and Survival in the United States

Adams, Scott V. ; Newcomb, Polly A. ; Shustov, Andrei R.

Purpose : To compare incidence and survival of peripheral T-cell lymphoma (PTCL) subtypes among US racial/ethnic groups. Methods : Patients with PTCL (age ≥ 15 years; 2000 to 2012) were identified in the Surveillance, Epidemiology, and End Results (SEER) registries. Race/ethnicity was categorized as non-Hispanic white, black, Asian/Pacific Islander, Hispanic white, or American Indian/Alaskan native. Age-standardized annual incidence rates and incidence rate ratios were estimated with 95% CIs, [...]

A partir des données du registre suédois des mélanomes incluant 856 patients atteints d'un mélanome cutané malin de stade III-IV, cette étude analyse la survie et la proportion de patients guéris, en fonction du sexe, de l'âge, des caractéristiques de la tumeur, de l'ulcération et du stade de la maladie

The proportion cured of patients diagnosed with Stage III–IV cutaneous malignant melanoma in Sweden 1990–2007: A population-based study

Eriksson, Hanna ; Lyth, Johan ; Andersson, Therese M. L.

The survival in cutaneous malignant melanoma (CMM) is highly dependent on the stage of the disease. Stage III–IV CMM patients are at high risk of relapse with a heterogeneous outcome, but not all experience excess mortality due to their disease. This group is referred to as the cure proportion representing the proportion of patients who experience the same mortality rate as the general population. The aim of this study was to estimate the cure proportion of patients diagnosed with Stage III–IV [...]

Menée aux Etats-Unis auprès de 111 patients atteints d'un myélome multiple traité par bortézomib et/ou thalidomide, cette étude évalue l'association entre le niveau sérique de vitamine D et une neuropathie périphérique

Low serum vitamin D occurs commonly among multiple myeloma patients treated with bortezomib and/or thalidomide and is associated with severe neuropathy

Wang, James ; Udd, Kyle A. ; Vidisheva, Aleksandra ; Swift, Regina A. ; Spektor, Tanya M. ; Bravin, Eric ; Ibrahim, Emad ; Treisman, Jonathan ; Masri, Mohammed ; Berenson, James R.

Purpose : Previous studies have shown that low serum vitamin D levels have been associated with many skeletal and non-skeletal disorders. We studied the relationship between 25-hydroxyvitamin D (25D) levels and motor and sensory peripheral neuropathy (PN) among multiple myeloma (MM) patients who have been treated with bortezomib and/or thalidomide. Methods : We performed a study of 111 MM patients who had received at least one of these two agents for at least 12 weeks by correlating physical [...]

Menée en France à partir de données portant sur 14 596 patients atteints d'un cancer du poumon diagnostiqué entre 2009 et 2010, cette étude analyse les délais entre une bronchoscopie et le début des traitements, puis entre chaque phase thérapeutique

Timing in initiating lung cancer treatment after bronchoscopy in France: study from medico-administrative database

Kudjawu, Yao Cyril ; Chatellier, Gilles ; Decool, Elsa ; Maria, Florence de ; Beltzer, Nathalie ; Grémy, Isabelle ; Meyer, Guy ; Eilstein, Daniel

Background : Time-to-treatment of cancer is becoming a serious political and social issue. A greater understanding of the timeframes involved in cancer care is needed to reduce inequalities in access to care caused by delays. Objective : To describe time delays in each phase of lung cancer treatment after bronchoscopy. Method : Using the international classification of diseases and medical procedures codes, from national hospital discharge database we selected patients newly diagnosed for Lung [...]

Menée aux Etats-Unis, cette étude de cohorte prospective évalue l'association entre le lycopène d'origine alimentaire, une consommation de produits à base de tomates et la mortalité spécifique chez des patients atteints d'un cancer de la prostate non métastatique

Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort

Wang, Ying ; Jacobs, Eric J. ; Newton, Christina C. ; McCullough, Marjorie L.

While dietary lycopene and tomato products have been inversely associated with prostate cancer incidence, there is limited evidence for an association between consumption of lycopene and tomato products and prostate-cancer specific mortality (PCSM). We examined the associations of prediagnosis and postdiagnosis dietary lycopene and tomato product intake with PCSM in a large prospective cohort. This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the [...]

A partir des données des registres américains des cancer et de la base Medicare portant sur 6 955 patients atteints de syndromes myélodysplasiques, cette étude analyse l'intensité des soins administrés durant les 30 derniers jours de leur vie

Intensity of end-of-life care for patients with myelodysplastic syndromes: Findings from a large national database

Fletcher, Sean A. ; Cronin, Angel M. ; Zeidan, Amer M. ; Odejide, Oreofe O. ; Gore, Steven D. ; Davidoff, Amy J. ; Steensma, David P. ; Abel, Gregory A.

BACKGROUND As the population ages, the prevalence of myelodysplastic syndromes (MDS) will increase, and many patients with MDS will require end-of-life (EOL) care. Little is known about the intensity of EOL care received by patients with these malignancies. METHODS Using the Surveillance, Epidemiology, and End Results–Medicare database and standard EOL quality measures, we assessed the prevalence and predictors of intensive care unit (ICU) admission in the last 30 days of life, chemotherapy in [...]

A partir d'une revue systématique de la littérature (27 études, 12 327 cas), cette méta-analyse évalue les facteurs associés à la prévalence d'une fatigue sévère après les traitements chez des patientes atteintes d'un cancer du sein

Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: A meta-analysis involving 12,327 breast cancer survivors

Abrahams, H.J.G. ; Gielissen, M.F.M. ; Schmits, I.C. ; Verhagen, C.A.H.H.V.M. ; Rovers, M.M. ; Knoop, H.

Background : This meta-analysis aimed to (i) examine demographic, disease-related, and treatment-related risk factors, (ii) estimate the prevalence, and (iii) describe the course of severe fatigue following breast cancer treatment. Methods : PubMed, PsycINFO, Cochrane, CINAHL, and Web of Science were systematically searched from inception up to August 3th 2015. Risk factors and prevalence rates were analyzed with inverse variance random effects analyses. Heterogeneity was studied with [...]

Cette étude analyse l'évolution de l'incidence du cancer de la thyroïde et de la mortalité spécifique au Portugal, sur la période 1988-2012

Trends in thyroid cancer incidence and mortality in Portugal

Raposo, Luís ; Morais, Samantha ; Oliveira, Maria J. ; Marques, Ana P. ; José Bento, Maria ; Lunet, Nuno

The objective was to quantify thyroid cancer incidence and mortality trends in Portugal. The number of thyroid cancer cases and incidence rates were retrieved from the Regional Cancer Registries for the period 1989-2011. The number of deaths and mortality rates were obtained from the WHO cancer mortality database (1988-2003 and 2007-2012) and Statistics Portugal (2004-2006; 1988-2012 by region). Joinpoint regression of the standardized incidence and mortality rates was performed. A significant, [...]

A partir d'une revue systématique de la littérature (38 études), cette étude analyse les interventions psycho-sociales destinées aux patients ayant survécu à un cancer diagnostiqué entre 15 et 39 ans

Psychosocial outcomes and interventions among cancer survivors diagnosed during adolescence and young adulthood (AYA): a systematic review

Barnett, Marie ; McDonnell, Glynnis ; DeRosa, Antonio ; Schuler, Tammy ; Philip, Errol ; Peterson, Lisa ; Touza, Kaitlin ; Jhanwar, Sabrina ; Atkinson, Thomas M. ; Ford, Jennifer S.

Purpose : A cancer diagnosis during adolescence or young adulthood (AYA; defined as ages 15–39) generates unique medical and psychosocial needs as developmental milestones are simultaneously impacted. Past research highlights that AYAs’ experiences and psychosocial outcomes are different, and more research and attention is needed. We aimed to identify and synthesize literature regarding psychosocial outcomes, unique needs, and existing psychosocial interventions pertaining to individuals [...]

Menée aux Etats-Unis auprès de 98 patients atteints de cancer et devant recevoir une chimiothérapie hyperthermique intrapéritonéale avec une chirurgie cytoréductrice, cette étude prospective évalue l'association entre des symptômes dépressifs pré-opératoires, les morbidités à court terme et la survie globale (durée médiane de suivi : 49 mois)

Depressive Symptoms in Patients Scheduled for Hyperthermic Intraperitoneal Chemotherapy With Cytoreductive Surgery: Prospective Associations With Morbidity and Mortality

Low, Carissa A. ; Bovbjerg, Dana H. ; Ahrendt, Steven ; Alhelo, Sara ; Choudry, Haroon ; Holtzman, Matthew ; Jones, Heather L. ; Pingpank, James F. ; Ramalingam, Lekshmi ; Zeh, Herbert J. ; Zureikat, Amer H. ; Bartlett, David L.

Purpose : The current study examined prospective relationships between preoperative depressive symptoms and short-term (30-day morbidity and readmission) and long-term (overall survival) outcomes after hyperthermic intraperitoneal chemotherapy with cytoreductive surgery (HIPEC + CS). Methods : Ninety-eight patients scheduled for HIPEC + CS completed the Center for Epidemiologic Studies–Depression (CES-D) scale before surgery. Demographic and disease-specific factors and information about [...]

Menée aux Etats-Unis par enquête auprès de167 dyades constitutées de patientes ayant survécu à un cancer du sein et de leurs aidants, cette étude analyse leurs peurs de la récidive selon leur orientation sexuelle

Fear of cancer recurrence in survivor and caregiver dyads: differences by sexual orientation and how dyad members influence each other

Boehmer, Ulrike ; Tripodis, Yorghos ; Bazzi, Angela R. ; Winter, Michael ; Clark, Melissa A.

Purpose : The purpose of this study was to identify explanatory factors of fear of recurrence (FOR) in breast cancer survivors of different sexual orientations and their caregivers and to assess the directionality in the survivor and caregiver dyads’ FOR. Methods : We recruited survivors of non-metastatic breast cancer of different sexual orientations and invited their caregivers into this study. Using a telephone survey, we collected data from 167 survivor and caregiver dyads. Using [...]

Menée en Norvège par questionnaire auprès de 1 418 patients ayant survécu à long terme à un cancer du testicule (11 et 19 ans après le diagnostic), cette étude longitudinale analyse les facteurs associés à un stress post-traumatique

Aspects of posttraumatic stress disorder in long-term testicular cancer survivors: cross-sectional and longitudinal findings

Dahl, Alv A. ; Østby-Deglum, Marie ; Oldenburg, Jan ; Bremnes, Roy ; Dahl, Olav ; Klepp, Olbjørn ; Wist, Erik ; Fosså, Sophie D.

Purpose : The purpose of this research is to study the prevalence of posttraumatic stress disorder (PTSD) and variables associated with PTSD in Norwegian long-term testicular cancer survivors (TCSs) both cross-sectionally and longitudinally. Methods : At a mean of 11 years after diagnosis, 1418 TCSs responded to a mailed questionnaire, and at a mean of 19 years after diagnosis, 1046 of them responded again to a modified questionnaire. Posttraumatic symptoms related to testicular cancer were [...]

A partir d'une revue systématique de la littérature publiée entre 2004 et 2015 (19 études, 2 263 cas), cette étude analyse les facteurs psychologiques associés à la qualité de vie de patients atteints d'un cancer de la tête et du cou après leurs traitements

Psychological variables associated with quality of life following primary treatment for head and neck cancer: a systematic review of the literature from 2004 to 2015

Dunne, Simon ; Mooney, Orla ; Coffey, Laura ; Sharp, Linda ; Desmond, Deirdre ; Timon, Conrad ; O'Sullivan, Eleanor ; Gallagher, Pamela

Objective : There has been a recent proliferation of research on quality of life (QoL) in head and neck cancer (HNC). The objective of this review was to systematically examine the evidence on psychological factors associated with QoL outcomes for HNC survivors in the post-treatment period published during 2004–2015. Methods : Five databases were searched for studies investigating psychological factors associated with QoL in HNC survivors. Empirical studies published between January 2004 and [...]

Menée aux Pays-Bas par questionnaire auprès de 74 patients ayant survécu à un cancer de la tête et du cou, cette étude transversale analyse l'association entre une croissance post-traumatique et des symptômes de détresse psychologique (anxiété, dépression, tabagisme, consommation d'alcool, etc)

Posttraumatic growth among head and neck cancer survivors with psychological distress

Holtmaat, K. ; van der Spek, N. ; Cuijpers, P. ; Leemans, C. R. ; Verdonck-de Leeuw, I. M.

Background : Information on posttraumatic growth (PTG) among head and neck cancer (HNC) survivors with a high level of distress is limited. The aim of this cross-sectional study was to investigate the occurrence of PTG among distressed HNC survivors and its association with anxiety, depressive, nicotine, and alcohol use disorders and health-related quality of life. Methods : Seventy-four HNC survivors with psychological distress (Hospital Anxiety and Depression Scale (HADS) anxiety > 7 and/or [...]

Menée en Suède auprès de 56 patients ayant survécu à un cancer de la tête et du cou (durée de suivi : 24 mois), cette étude qualitative analyse leurs expériences de vie quotidienne après les traitements

Living an everyday life with head and neck cancer 2–2.5 years post-diagnosis – A qualitative prospective study of 56 patients

Isaksson, Joakim ; Salander, Pär ; Lilliehorn, Sara ; Laurell, Göran

Rationale : There are many studies available describing how patients are affected by head and neck cancer (HNC) and its treatment. Usually these studies are quantitative and focus on assessing patients’ quality of life or distress post-treatment. These studies are important, but they are of limited value if we are interested in understanding more about HNC in an everyday life context. Objective : The purpose was to determine how life was lived and valued during and after treatment for HNC and [...]

Menée en Allemagne auprès de 41 patients atteints de cancer en phase terminale, cette étude prospective analyse les effets d'une musicothérapie durant leur hospitalisation en unité de soins palliatifs

Prospective Study on Music Therapy in Terminally Ill Cancer Patients during Specialized Inpatient Palliative Care

Kordovan, Sarah ; Preissler, Pia ; Kamphausen, Anne ; Bokemeyer, Carsten ; Oechsle, Karin

Objective: This study was a prospective evaluation of feasibility, acceptance, and potential beneficial effects of music therapy in terminally ill cancer patients on a specialized palliative care inpatient ward. Methods: Intervention had to consist of at least two sessions, but frequency and duration was left to the patients` decision. Different music therapy methods were offered to the patient at the beginning of every session. Patients rated their subjective benefit. Disease-related and [...]

Menée au Japon par questionnaire auprès de 44 infirmières de 123 patients atteints d'un cancer de stade avancé et recevant des soins palliatifs à domicile, cette étude analyse les facteurs individuels et environnementaux, liés au type de symptômes (douleur, dyspnée, délire...), influant sur le lieu du décès

Do Symptoms among Home Palliative Care Patients with Advanced Cancer Decide the Place of Death? Focusing on the Presence or Absence of Symptoms during Home Care

Okamoto, Yuko ; Fukui, Sakiko ; Yoshiuchi, Kazuhiro ; Ishikawa, Takako

Objective: Our goal was to investigate the association between actual place of death among Japanese home end-of-life care patients with advanced cancer and individual, illness, and environmental factors, including the presence or absence of symptoms. Methods: Using structured interviews, we asked 44 nurses from 19 home-visit nursing agencies about changes in status of all 123 of their home end-of-life care patients with advanced cancer between April and September 2013. The main outcome variable [...]

Menée aux Etats-Unis par enquête auprès de 2 977 cas et 30 551 témoins, cette étude analyse l'utilisation et les coûts de médecines complémentaires et alternatives (vitamines, minéraux) chez des patients ayant survécu à un cancer

Complementary and alternative medicine use among US cancer survivors

John, Gabriella M. ; Hershman, Dawn L. ; Falci, Laura ; Shi, Zaixing ; Tsai, Wei-Yann ; Greenlee, Heather

Purpose : US cancer survivors commonly use vitamins/minerals and complementary and alternative medicine (CAM). We compare use of vitamins/minerals and CAM between adult cancer survivors and cancer-free adults and estimate annual out-of-pocket expenses. Methods : Data on self-reported vitamin/mineral and CAM use in the past 12 months from the cross-sectional 2012 US National Health Interview Survey were used to estimate prevalence of use and out-of-pocket expenditures. The cohort included adults [...]