Menée en Israël, cette étude de cohorte évalue l'association entre une obésité mesurée avant la grossesse et le risque à long terme de divers cancers, notamment le risque de cancer de l'ovaire et de cancer du sein (durée moyenne de suivi : 11,6 ans)

Prepregnancy obesity: a risk factor for future development of ovarian and breast cancer

Kessous, Roy ; Davidson, Ehud ; Meirovitz, Mihai ; Sergienko, Ruslan ; Sheiner, Eyal

The aim of this study was to investigate the association between a history of prepregnancy obesity and a woman's future long-term risk for the development of female malignancies. A population-based study compared the incidence of long-term female malignancies in a cohort of consecutive women with and without a diagnosis of prepregnancy obesity. Deliveries occurred between the years 1988 and 2013, with a mean follow-up duration of 11.6 years. Women with known malignancies before the index [...]

Menée aux Etats-Unis à partir des données de deux études (l'une incluant 1 982 cas et 2 218 témoins en population blanche non hispanique, l'autre 1 777 cas et 2 218 témoins en population hispanique), cette étude analyse les disparités ethniques dans l'association entre une consommation de viandes ou de poissons et le risque de cancer du sein

Red meat, poultry, and fish intake and breast cancer risk among Hispanic and Non-Hispanic white women: The Breast Cancer Health Disparities Study

Kim, Andre E. ; Lundgreen, Abbie ; Wolff, Roger K. ; Fejerman, Laura ; John, Esther M. ; Torres-Mejía, Gabriela ; Ingles, Sue A. ; Boone, Stephanie D. ; Connor, Avonne E. ; Hines, Lisa M. ; Baumgartner, Kathy B. ; Giuliano, Anna ; Joshi, Amit D. ; Slattery, Martha L. ; Stern, Mariana C.

Purpose : There is suggestive but limited evidence for a relationship between meat intake and breast cancer (BC) risk. Few studies included Hispanic women. We investigated the association between meats and fish intake and BC risk among Hispanic and NHW women. Methods : The study included NHW (1,982 cases and 2,218 controls) and the US Hispanics (1,777 cases and 2,218 controls) from two population-based case–control studies. Analyses considered menopausal status and percent Native American [...]

Menée en France auprès de 2 276 cas et 2 780 témoins entre 2001 et 2007, cette étude évalue l'association entre une exposition professionnelle à des solvants organiques et le risque de cancer du poumon

Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study

Mattei, Francesca ; Liverani, Silvia ; Guida, Florence ; Matrat, Mireille ; Cenée, Sylvie ; Azizi, Lamiae ; Menvielle, Gwenn ; Sanchez, Marie ; Pilorget, Corinne ; Lapôtre-Ledoux, Bénédicte ; Luce, Danièle ; Richardson, Sylvia ; Stücker, Isabelle ; ICARE study group

Background : The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used simultaneously, it is difficult to assess the role of individual substances. Objectives : The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and [...]

A partir des données d'un registre américain des cancers portant sur la période 1999-2008, cette étude évalue l'association entre une exposition à du benzène, en raison de la proximité du lieu de résidence avec des raffineries ou des usines rejetant du benzène, et le risque de lymphome non hodgkinien

Resolving uncertainty in the spatial relationships between passive benzene exposure and risk of non-Hodgkin lymphoma

Switchenko, Jeffrey M. ; Bulka, Catherine ; Ward, Kevin ; Koff, Jean L. ; Bayakly, A. Rana ; Ryan, P. Barry ; Waller, Lance A. ; Flowers, Christopher R.

Background : Benzene is a known occupational carcinogen associated with increased risk of hematologic cancers, but the relationships between quantity of passive benzene exposure through residential proximity to toxic release sites, duration of exposure, lag time from exposure to cancer development, and lymphoma risk remain unclear. Methods : We collected release data through the Environmental Protection Agency’s Toxics Release Inventory (TRI) from 1989 to 2003, which included location of [...]

Menée aux Etats-Unis auprès de 797 patients ayant survécu à long terme (plus de 10 ans) à une leucémie lymphocytaire chronique, cette étude analyse les facteurs associés au risque d'autres cancers

Incidence and Prognostic Impact of Other Cancers in a Population of Long-Term Survivors of Chronic Lymphocytic Leukemia

Falchi, L. ; Vitale, C. ; Keating, M. J. ; Lerner, S. ; Wang, X. ; Elhor Gbito, K. Y. ; Strom, S. ; Wierda, W. G. ; Ferrajoli, A.

Background : Information on the impact of other cancers (OC) in long-term survivors (LTS) of chronic lymphocytic leukemia (CLL) is limited. Patients and methods : Patients with CLL who survived >10 years were defined as LTS of CLL. We calculated standardized incidence ratios (SIR) to compare the incidence of OC in LTS of CLL vs. the general population. A multivariable model was used to identify independent predictors of OC. Overall survival was analyzed as a function of the presence of OC. [...]

Menée au Canada auprès de 14 164 cas et 69 051 témoins, cette étude en population évalue le risque de cancer colorectal chez des patients ayant survécu à un cancer de la prostate diagnostiqué entre 1987 et 2009

Risk of colorectal cancer after the diagnosis of prostate cancer: A population-based study

Desautels, Danielle ; Czaykowski, Piotr ; Nugent, Zoann ; Demers, Alain A. ; Mahmud, Salaheddin M. ; Singh, Harminder

BACKGROUND A rigorous assessment of the risk of colorectal cancer (CRC) among prostate cancer (PC) survivors that controls for important confounding factors and competing risks is necessary to determine the risk of CRC in this population and to inform screening guidelines. METHODS With data from Manitoba, Canada, subjects diagnosed with PC as their first cancer between 1987 and 2009 were age-matched with up to 5 men with no history of invasive cancer on the PC diagnosis date. Subjects were [...]

Menée au Japon auprès de 474 patients non cirrhotiques atteints d'une hépatite C chronique, cette étude évalue l'association entre une résistance à l'insuline et le risque de carcinome hépatocellulaire après un traitement par PEG-IFN alpha

Influence of insulin resistance on the development of hepatocellular carcinoma after antiviral treatment for non-cirrhotic patients with chronic hepatitis C

Hayashi, Takeo ; Ogawa, Eiichi ; Furusyo, Norihiro ; Murata, Masayuki ; Hayashi, Jun

Background : Insulin resistance is considered to be an important factor in the progression of fibrosis and the enhancement of the risk of hepatocellular carcinoma (HCC) for chronic hepatitis C patients. The aim of this study was to assess the effect of insulin resistance on the development of HCC by non-cirrhotic chronic hepatitis C patients treated with pegylated interferon alpha-2b (PEG-IFN

A partir d'une revue de la littérature, cette étude fait le point sur l'association entre l'obésité, le diabète et le risque de divers cancers

From obesity to diabetes and cancer: epidemiological links and role of therapies

Garcia-Jimenez, Custodia ; Gutierrez-Salmeron, Maria ; Chocarro-Calvo, Ana ; Garcia-Martinez, Jose Manuel ; Castano, Angel ; De la Vieja, Antonio

Increasing evidence suggests a complex relationship between obesity, diabetes and cancer. Here we review the evidence for the association between obesity and diabetes and a wide range of cancer types. In many cases the evidence for a positive association is strong, but for other cancer types a more complex picture emerges with some site-specific cancers associated with obesity but not to diabetes, and some associated with type I but not type II diabetes. The evidence therefore suggests the [...]

A partir d'une revue systématique de la littérature publiée entre 1984 et 2015, cette méta-analyse évalue l'association entre le polymorphisme rs9939609 du gène FTO et le risque de cancer

Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis

Huang, Xiaoyi ; Zhao, Jian ; Yang, Mingyuan ; Li, Ming ; Zheng, Jianming

Obesity is a risk factor of cancer. Several genes have been found to play an important role in aetiology of obesity and tumourigenesis. Recently, some studies suggested that rs9939609 polymorphism might be significantly associated with cancer risk, while the results of some other studies were controversial. Databases with time limitation from January 1984 to April 2015 were searched. The pooled odds ratio (OR) with 95% confidence interval was calculated to assess the associations, and subgroup [...]

Menée en Israël à partir des données portant sur 2 352 988 participants âgés de 16 à 19 ans, cette étude évalue l'association entre l'indice de masse corporelle et la taille à l'adolescence et le risque de lymphome non hodgkinien par sous-type (4 021 cas)

Adolescent weight and height are predictors of specific non-Hodgkin lymphoma subtypes among a cohort of 2,352,988 individuals aged 16 to 19 years

Leiba, Merav ; Leiba, Adi ; Keinan-Boker, Lital ; Avigdor, Abraham ; Derazne, Estela ; Levine, Hagai ; Kark, Jeremy D.

BACKGROUND The age-adjusted annual incidence of non-Hodgkin lymphoma (NHL) has risen worldwide. This trend may be affected by the secular increase in height and the sharp upswing in adolescent overweight; these drive increased insulinlike growth factor 1 and chronic inflammation, which may play an etiologic role. This study examined the association of the body mass index (BMI) and height of adolescents with NHL subtypes, which have been insufficiently evaluated. METHODS Health-related data on [...]

A partir de données portant sur un total de 10 554 cas de cancer de la prostate et 13 618 témoins, cette méta-analyse identifie une association entre la concentration sanguine du facteur IGF-1 et un risque de cancer de la prostate

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

Travis, Ruth C. ; Appleby, Paul N. ; Martin, Richard M. ; Holly, Jeff MP ; Albanes, Demetrius ; Black, Amanda ; Bueno-de-Mesquita, H. Bas ; Chan, June M. ; Chen, Chu ; Chirlaque, María-Dolores ; Cook, Michael B ; Deschasaux, Mélanie ; Donovan, Jenny L. ; Ferrucci, Luigi ; Galan, Pilar ; Giles, Graham G ; Giovannucci, Edward L ; Gunter, Marc J. ; Habel, Laurel A. ; Hamdy, Freddie C. ; Helzlsouer, Kathy J ; Hercberg, Serge ; Hoover, Robert N. ; Janssen, Joseph AMJL ; Kaaks, Rudolf ; Kubo, Tatsuhiko ; Le Marchand, Loic ; Metter, E. Jeffrey ; Mikami, Kazuya ; Morris, Joan K. ; Neal, David E ; Neuhouser, Marian L. ; Ozasa, Kotaro ; Palli, Domenico ; Platz, Elizabeth A. ; Pollak, Michael N. ; Price, Alison J. ; Roobol, Monique ; Schaefer, Catherine ; Schenk, Jeannette M ; Severi, Gianluca ; Stampfer, Meir J ; Stattin, Pär ; Tamakoshi, Akiko ; Tangen, Catherine M. ; Touvier, Mathilde ; Wald, Nicholas J ; Weiss, Noel S ; Zeigler, Regina G ; Key, Timothy J. ; Allen, Naomi E.

The role of insulin-like growth factors (IGFs) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the odds ratios (ORs) for [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015, cette méta-analyse évalue l'association entre le poids à la naissance et le risque de cancer de la prostate, ainsi que la mortalité spécifique

Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis

Zhou, Cindy Ke ; Sutcliffe, Siobhan ; Welsh, Judith ; Mackinnon, Karen ; Kuh, Diana ; Hardy, Rebecca ; Cook, Michael B.

Background: It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. Methods: We investigated birthweight in relation to prostate cancer in the Medical Research Council (MRC) National Survey of Health and Development (NSHD) using Cox proportional [...]

Menée en Australie auprès de 230 605 participants (durée moyenne de suivi : 9 ans), cette étude de cohorte évalue l'association entre des changements de poids et de tour de taille au milieu de la vie, et le risque de cancer colorectal (373 cas)

Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

Karahalios, Amalia ; Simpson, Julie A. ; Baglietto, Laura ; MacInnis, Robert J. ; Hodge, Allison M. ; Giles, Graham G. ; English, Dallas R.

Background : Studies reporting the association between change in weight or body mass index during midlife and risk of colorectal cancer have found inconsistent results, and only one study to date has reported the association between change in waist circumference (a measure of central adiposity) and risk of colorectal cancer. Methods : We investigated the association between risk of colorectal cancer and changes in directly measured waist circumference and weight from baseline (1990-1994) to [...]

A partir de données issues de 3 cohortes internationales ayant inclus 118 616 femmes, cette étude identifie 5 variants situés sur la région chromosomique 6q25 en association avec un risque accru de divers sous-types de cancer du sein

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Dunning, Alison M. ; Michailidou, Kyriaki ; Kuchenbaecker, Karoline B. ; Thompson, Deborah ; French, Juliet D. ; Beesley, Jonathan ; Healey, Catherine S. ; Kar, Siddhartha ; Pooley, Karen A. ; Lopez-Knowles, Elena ; Dicks, Ed ; Barrowdale, Daniel ; Sinnott-Armstrong, Nicholas A. ; Sallari, Richard C. ; Hillman, Kristine M. ; Kaufmann, Susanne ; Sivakumaran, Haran ; Marjaneh, Mahdi Moradi ; Lee, Jason S. ; Hills, Margaret ; Jarosz, Monika ; Drury, Suzie ; Canisius, Sander ; Bolla, Manjeet K. ; Dennis, Joe ; Wang, Qin ; Hopper, John L. ; Southey, Melissa C. ; Broeks, Annegien ; Schmidt, Marjanka K. ; Lophatananon, Artitaya ; Muir, Kenneth ; Beckmann, Matthias W. ; Fasching, Peter A. ; dos-Santos-Silva, Isabel ; Peto, Julian ; Sawyer, Elinor J. ; Tomlinson, Ian ; Burwinkel, Barbara ; Marme, Frederik ; Guénel, Pascal ; Truong, Thérèse ; Bojesen, Stig E. ; Flyger, Henrik ; Gonzalez-Neira, Anna ; Perez, Jose I. A. ; Anton-Culver, Hoda ; Eunjung, Lee ; Arndt, Volker ; Brenner, Hermann ; Meindl, Alfons ; Schmutzler, Rita K. ; Brauch, Hiltrud ; Hamann, Ute ; Aittomaki, Kristiina ; Blomqvist, Carl ; Ito, Hidemi ; Matsuo, Keitaro ; Bogdanova, Natasha ; Dörk, Thilo ; Lindblom, Annika ; Margolin, Sara ; Kosma, Veli-Matti ; Mannermaa, Arto ; Tseng, Chiu-Chen ; Wu, Anna H. ; Lambrechts, Diether ; Wildiers, Hans ; Chang-Claude, Jenny ; Rudolph, Anja ; Peterlongo, Paolo ; Radice, Paolo ; Olson, Janet E. ; Giles, Graham G. ; Milne, Roger L. ; Haiman, Christopher A. ; Henderson, Brian E. ; Goldberg, Mark S. ; Teo, Soo H. ; Yip, Cheng Har ; Nord, Silje ; Borresen-Dale, Anne-Lise ; Kristensen, Vessela ; Long, Jirong ; Zheng, Wei ; Pylkas, Katri ; Winqvist, Robert ; Andrulis, Irene L. ; Knight, Julia A. ; Devilee, Peter ; Seynaeve, Caroline ; Figueroa, Jonine ; Sherman, Mark E. ; Czene, Kamila ; Darabi, Hatef ; Hollestelle, Antoinette ; van den Ouweland, Ans M. W. ; Humphreys, Keith ; Gao, Yu-Tang ; Shu, Xiao-Ou ; Cox, Angela ; Cross, Simon S. ; Blot, William ; Cai, Qiuyin ; Ghoussaini, Maya ; Perkins, Barbara J. ; Shah, Mitul ; Choi, Ji-Yeob ; Kang, Daehee ; Lee, Soo Chin ; Hartman, Mikael ; Kabisch, Maria ; Torres, Diana ; Jakubowska, Anna ; Lubinski, Jan ; Brennan, Paul ; Sangrajrang, Suleeporn ; Ambrosone, Christine B. ; Toland, Amanda E. ; Shen, Chen-Yang ; Wu, Pei-Ei ; Orr, Nick ; Swerdlow, Anthony ; McGuffog, Lesley ; Healey, Sue ; Lee, Andrew ; Kapuscinski, Miroslav ; John, Esther M. ; Terry, Mary Beth ; Daly, Mary B. ; Goldgar, David E. ; Buys, Saundra S. ; Janavicius, Ramunas ; Tihomirova, Laima ; Tung, Nadine ; Dorfling, Cecilia M. ; van Rensburg, Elizabeth J. ; Neuhausen, Susan L. ; Ejlertsen, Bent ; Hansen, Thomas V. O. ; Osorio, Ana ; Benítez, Javier ; Rando, Rachel ; Weitzel, Jeffrey N. ; Bonanni, Bernardo ; Peissel, Bernard ; Manoukian, Siranoush ; Papi, Laura ; Ottini, Laura ; Konstantopoulou, Irene ; Apostolou, Paraskevi ; Garber, Judy ; Rashid, Muhammad Usman ; Frost, Debra ; Embrace, ; Izatt, Louise ; Ellis, Steve ; Godwin, Andrew K. ; Arnold, Norbert ; Niederacher, Dieter ; Rhiem, Kerstin ; Bogdanova-Markov, Nadja ; Sagne, Charlotte ; Stoppa-Lyonnet, Dominique ; Damiola, Francesca ; Gemo Study Collaborators ; Sinilnikova, Olga M. ; Mazoyer, Sylvie ; Isaacs, Claudine ; Claes, Kathleen B. M. ; De Leeneer, Kim ; de la Hoya, Miguel ; Caldes, Trinidad ; Nevanlinna, Heli ; Khan, Sofia ; Mensenkamp, Arjen R. ; Hebon, ; Hooning, Maartje J. ; Rookus, Matti A. ; Kwong, Ava ; Olah, Edith ; Díez, Orland ; Brunet, Joan ; Pujana, Miquel Angel ; Gronwald, Jacek ; Huzarski, Tomasz ; Barkardottir, Rosa B. ; Laframboise, Rachel ; Soucy, Penny ; Montagna, Marco ; Agata, Simona ; Teixeira, Manuel R. ; kConFab, Investigators ; Park, Sue Kyung ; Lindor, Noralane ; Couch, Fergus J. ; Tischkowitz, Marc ; Foretova, Lenka ; Vijai, Joseph ; Offit, Kenneth ; Singer, Christian F. ; Rappaport, Christine ; Phelan, Catherine M. ; Greene, Mark H. ; Mai, Phuong L. ; Rennert, Gad ; Imyanitov, Evgeny N. ; Hulick, Peter J. ; Phillips, Kelly-Anne ; Piedmonte, Marion ; Mulligan, Anna Marie ; Glendon, Gord ; Bojesen, Anders ; Thomassen, Mads ; Caligo, Maria A. ; Yoon, Sook-Yee ; Friedman, Eitan ; Laitman, Yael ; Borg, Ake ; von Wachenfeldt, Anna ; Ehrencrona, Hans ; Rantala, Johanna ; Olopade, Olufunmilayo I. ; Ganz, Patricia A. ; Nussbaum, Robert L. ; Gayther, Simon A. ; Nathanson, Katherine L. ; Domchek, Susan M. ; Arun, Banu K. ; Mitchell, Gillian ; Karlan, Beth Y. ; Lester, Jenny ; Maskarinec, Gertraud ; Woolcott, Christy ; Scott, Christopher ; Stone, Jennifer ; Apicella, Carmel ; Tamimi, Rulla ; Luben, Robert ; Khaw, Kay-Tee ; Helland, Aslaug ; Haakensen, Vilde ; Dowsett, Mitch ; Pharoah, Paul D. P. ; Simard, Jacques ; Hall, Per ; Garcia-Closas, Montserrat ; Vachon, Celine ; Chenevix-Trench, Georgia ; Antoniou, Antonis C. ; Easton, Douglas F. ; Edwards, Stacey L.

We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor [alpha]) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER+ or ER-) and human ERBB2 (HER2+ or HER2-) tumor subtypes, mammographic density and tumor grade. The best candidate causal variants for ER- tumors lie in four separate enhancer elements, and their [...]

Menée aux Etats-Unis auprès de 47 267 femmes afro-américaines, cette étude prospective évalue l'association entre des antécédents de léiomyome utérin et un risque de cancer de l'endomètre

History of uterine leiomyoma and risk of endometrial cancer in black women

Wise, Lauren A. ; Sponholtz, Todd R. ; Rosenberg, Lynn ; Adams-Campbell, Lucile L. ; Kuohung, Wendy ; LaValley, Michael P. ; Palmer, Julie R.

Background : Previous studies have found an association between uterine leiomyomata (UL) and uterine malignancies. This relation has not been studied in black women, who are disproportionately affected by UL. Methods : We investigated prospectively the association between self-reported physician-diagnosed UL and endometrial cancer in the Black Women’s Health Study. During 1995–2013, 47,267 participants with intact uteri completed biennial health questionnaires. Reports of endometrial cancer [...]

A partir d'une revue systématique (13 études, 2 248 cas et 3 079 témoins), cette méta-analyse évalue l'association entre le polymorphisme MSpl du gène CYP1A1, le tabagisme et le risque de cancer du poumon en population chinoise

The interaction between smoking and CYP1A1 MspI polymorphism on lung cancer: a meta-analysis in the Chinese population

Zhang, L. P. ; Wang, C. P. ; Li, L. H. ; Tang, Y. F. ; Li, W. C.

Many studies have examined the interaction between CYP1A1 MspI gene polymorphism and smoking for the risk of lung cancer risk in Chinese, but their results have been inconsistent. Therefore, a meta-analysis was performed to ascertain this issue. PubMed, Springer Link, Ovid and other Chinese databases were searched to include all the relevant studies. Smoking status was categorised as ‘smokers’ and ‘non-smokers.’ The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated [...]