Menée aux Pays-Bas par questionnaire auprès de 601 patients ayant survécu à un cancer et de 1 052 patients atteints d'une maladie chronique, cette étude compare, pour ces deux populations, leurs morbidités et leur qualité de vie

Health-related quality of life and health care use in cancer survivors compared with patients with chronic diseases

Heins, Marianne J. ; Korevaar, Joke C. ; Hopman, Petra E. P. C. ; Donker, Gé A. ; Schellevis, François G. ; Rijken, Mieke P. M.

BACKGROUND The number of cancer survivors is steadily increasing and these patients often experience long-lasting health problems. To make care for cancer survivors sustainable for the future, it would be relevant to put the effects of cancer in this phase into perspective. Therefore, the authors compared health-related quality of life (HRQOL) and health care use among cancer survivors with that of patients with chronic diseases. METHODS Patients diagnosed at age >18 years with a cancer with a [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (32 articles), cette étude analyse les déficiences fonctionnelles et les besoins en réadaptation de patients atteints d'un cancer du poumon inopérable

Identifying functional impairment and rehabilitation needs in patients newly diagnosed with inoperable lung cancer: a structured literature review

Bayly, JoanneLouise ; Lloyd-Williams, Mari

Purpose : Patients newly diagnosed with inoperable lung cancer experience a symptom distress burden that may impact upon functional performance in daily activities. This structured review examines empirical evidence to see how functional limitation and rehabilitation needs are represented in the supportive care literature in this population. Early access to rehabilitation services may ameliorate the impact, but evidence of need following diagnosis is required. Method : Electronic databases [...]

Mené auprès de 50 patients atteints d'un cancer de la prostate traité par hormonothérapie anti-androgénique, cet essai randomisé évalue l'efficacité d'une intervention de 12 semaines, à base d'exercices physiques et de conseils nutritionnels, pour diminuer leur risque de maladies cardiovasculaires et améliorer leur qualité de vie

Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer

Gilbert, Stephen E. ; Tew, Garry A. ; Fairhurst, Caroline ; Bourke, Liam ; Saxton, John M. ; Winter, Edward M. ; Rosario, Derek J.

Background: Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk. Methods: This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 men on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on [...]

Menée en Turquie auprès de 201 patientes atteintes d'un cancer du sein, cette étude transversale analyse les facteurs de risque et la prévalence associés à des déficiences des membres supérieurs, notamment un lymphœdème, et leur impact sur la qualité de vie

The risk factors and prevalence of upper extremity impairments and an analysis of effects of lymphoedema and other impairments on the quality of life of breast cancer patients

Kibar, S. ; Dalyan Aras, M. ; Ünsal Delialioğlu, S.

This study aimed to determine the prevalence and identify the risk factors associated with upper extremity impairments (UEIs) in breast cancer patients and to investigate the degree to which these impairments and other characteristics influence quality of life (QoL). A total of 201 women over the age of 18 who underwent breast cancer treatment at least 6 months were included in this cross-sectional study. All of the patients were evaluated for the presence of lymphoedema and any UEIs. UEIs [...]

A partir des données de la cohorte "Childhood Cancer Survivor Study" incluant 1 233 patients ayant survécu à des tumeurs cérébrales astrogliales dans l'enfance, cette étude analyse les effets psychologiques et socioéconomiques des déficiences visuelles des patients adultes

Impact of vision loss among survivors of childhood central nervous system astroglial tumors

de Blank, Peter M. K. ; Fisher, Michael J. ; Lu, Lu ; Leisenring, Wendy M. ; Ness, Kirsten K. ; Sklar, Charles A. ; Stovall, Marilyn ; Vukadinovich, Chris ; Robison, Leslie L. ; Armstrong, Gregory T. ; Krull, Kevin R.

BACKGROUND The impact of impaired vision on cognitive and psychosocial outcomes among long-term survivors of childhood low-grade gliomas has not been investigated previously but could inform therapeutic decision making. METHODS Data from the Childhood Cancer Survivor Study were used to investigate psychological outcomes (measures of cognitive/emotional function) and socioeconomic outcomes (education, income, employment, marital status, and independent living) among astroglial tumor survivors [...]

Menée en Autriche à partir de données portant sur 1 070 patients atteints de cancer, cette étude de cohorte prospective évalue l'association entre le niveau sérique d'albumine, le risque de maladie thrombo-embolique veineuse et la mortalité

Association Between Decreased Serum Albumin With Risk of Venous Thromboembolism and Mortality in Cancer Patients

Königsbrügge, Oliver ; Posch, Florian ; Riedl, Julia ; Reitter, Eva-Maria ; Zielinski, Christoph ; Pabinger, Ingrid ; Ay, Cihan

In cancer patients, reduced serum albumin has been described as a marker for global declining health and poor prognosis. Our aim was to investigate the association of albumin concentrations with the occurrence of venous thromboembolism (VTE) and mortality in patients with cancer.This investigation was performed in the framework of the Vienna Cancer and Thrombosis Study (CATS), a prospective observational cohort study. We included 1,070 patients with active cancer and assayed serum albumin from [...]

A partir des données du registre suisse des cancers pédiatriques, cette étude analyse l'évolution géographique de l'incidence des cancers chez des enfants âgés de moins de 16 ans, sur la période 1985-2010

Space-time clustering of childhood cancers in Switzerland: A nationwide study

Kreis, Christian ; Grotzer, Michael ; Hengartner, Heinz ; Daniel Spycher, Ben ; for the Swiss Paediatric Oncology, Group ; the Swiss National Cohort Study, Group

The aetiology of childhood cancers remains largely unknown. It has been hypothesized that infections may be involved and that mini-epidemics thereof could result in space-time clustering of incident cases. Most previous studies support spatio-temporal clustering for leukaemia, while results for other diagnostic groups remain mixed. Few studies have corrected for uneven regional population shifts which can lead to spurious detection of clustering. We examined whether there is space-time [...]

Menée au Royaume-Uni, cette étude analyse l'évolution de la mortalité par cancer, en fonction des régions, sur la période 1991-2007

Trends in UK regional cancer mortality 1991-2007

Marshall, Dominic C. ; Webb, Thomas E. ; Hall, Richard A. ; Salciccioli, Justin D. ; Ali, Raghib ; Maruthappu, Mahiben

Background: Until 1990, there was an upward trend in mortality from breast, lung, prostate, and colon cancers in the United Kingdom. With improvements in cancer treatment there has, in general, been a fall in mortality over the last 20 years. We evaluate regional cancer mortality trends in the United Kingdom between 1991 and 2007. Methods: We analysed mortality trends for breast, lung, prostate, and colon cancers using data obtained from the EUREG cancer database. We have described changes in [...]

Cette étude présente les estimations d'incidence de cancer et de mortalité spécifique pour les populations américaines d'origine asiatique, natives d'Hawaï et des îles pacifiques, pour l'année 2016 (57 740 nouveaux cas de cancer, 16 910 décès par cancer)

Cancer statistics for Asian Americans, Native Hawaiians, and Pacific Islanders, 2016: Converging incidence in males and females

Torre, Lindsey A. ; Sauer, Ann M. Goding ; Chen, Moon S. ; Kagawa-Singer, Marjorie ; Jemal, Ahmedin ; Siegel, Rebecca L.

Cancer is the leading cause of death among Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPIs). In this report, the American Cancer Society presents AANHPI cancer incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Among AANHPIs in 2016, there will be an estimated 57,740 new cancer cases and 16,910 cancer [...]

A partir de données de 14 études incluant 4 293 patientes et portant sur 227 892 variants génétiques, puis celles de 6 études incluant 1 744 patientes et 114 620 variants, cette étude d'association sur l'exome entier évalue l'association entre des polymorphismes de gènes et la survie globale chez des patientes atteintes d'un cancer de l'ovaire

Investigation of exomic variants associated with overall survival in ovarian cancer

Winham, Stacey J ; Pirie, Ailith ; Chen, Yian Ann ; Larson, Melissa C. ; Fogarty, Zachary C. ; Earp, Madalene A. ; Anton-Culver, Hoda ; Bandera, Elisa V. ; Cramer, Daniel ; Doherty, Jennifer A. ; Goodman, Marc T. ; Gronwald, Jacek ; Karlan, Beth Y. ; Kjaer, Susanne K. ; Levine, Douglas A ; Menon, Usha ; Ness, Roberta B. ; Pearce, Celeste L ; Pejovic, Tanja ; Rossing, Mary Anne ; Wentzensen, Nicolas ; Bean, Yukie T. ; Bisogna, Maria ; Brinton, Louise A. ; Carney, Michael E. ; Cunningham, Julie M. ; Cybulski, Cezary ; Defazio, Anna ; Dicks, Ed M. ; Edwards, Robert P. ; Gayther, Simon A ; Gentry-Maharaj, Aleksandra ; Gore, Martin ; Iversen, Edwin S. ; Jensen, Allan ; Johnatty, Sharon E. ; Lester, Jenny ; Lin, Hui-Yi ; Lissowska, Jolanta ; Lubinski, Jan ; Menkiszak, Janusz ; Modugno, Francesmary ; Moysich, Kirsten B. ; Orlow, Irene ; Pike, Malcolm C. ; Ramus, Susan J. ; Song, Honglin ; Terry, Kathryn L. ; Thompson, Pamela J. ; Tyrer, Jonathan P ; Van Den Berg, David J. ; Vierkant, Robert A. ; Vitonis, Allison F. ; Walsh, Christine ; Wilkens, Lynne R. ; Wu, Anna H. ; Yang, Hannah ; Ziogas, Argyrios ; Berchuck, Andrew ; Chenevix-Trench, Georgia ; Schildkraut, Joellen M. ; Permuth-Wey, Jennifer ; Phelan, Catherine M. ; Pharoah, Paul D.P. ; Fridley, Brooke L. ; Sellers, Thomas A. ; Goode, Ellen L.

Background: While numerous susceptibility loci for epithelial ovarian cancer (EOC) have been identified, few associations have been reported with overall survival. In the absence of common prognostic genetic markers, we hypothesize that rare coding variants may be associated with overall EOC survival and assessed their contribution in two exome-based genotyping projects of the Ovarian Cancer Association Consortium (OCAC). Methods: The primary patient set (Set 1) included 14 independent EOC [...]

A partir des données de la cohorte "National Health and Nutrition Examination Survey Epidemiologic Follow-up Study" incluant 4 316 participants âgés de 25 à 74 ans (durée médiane de suivi : 21 ans ; 3 284 décès), cette étude prospective évalue l'association entre une calvitie et la mortalité par cancer de la prostate

Male Pattern Baldness in Relation to Prostate Cancer–Specific Mortality: A Prospective Analysis in the NHANES-Epidemiologic Follow-up Study

Zhou, Cindy Ke ; Levine, Paul H. ; Cleary, Sean D. ; Hoffman, Heather J. ; Graubard, Barry I. ; Cook, Michael B.

We used male pattern baldness as a proxy for long-term androgen exposure and investigated the association of dermatologist-assessed hair loss with prostate cancer–specific mortality in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. From the baseline survey (1971–1974), we included 4,316 men who were 25–74 years of age and had no prior cancer diagnosis. We estimated hazard ratios and used Cox proportional hazards regressions with age as the time metric [...]

Menée au Royaume-Uni à partir de données portant sur 350 patientes atteintes d'un cancer du sein de stade précoce, cette étude de cohorte évalue l'impact de la présence de micrométastases dans la moelle osseuse sur la survie globale (durée médiane de suivi : 30 ans)

Bone marrow micrometastases in early breast cancer-30-year outcome

Mansi, J. ; Morden, J. ; Bliss, J. M. ; Neville, M. ; Coombes, R. C.

Background: Micrometastases in bone marrow of women with early breast cancer were first identified immunocytochemically in the 1980s. We report on the original cohort of women with a median follow-up of 30 years. Patients and Methods: In total, 350 women with primary breast cancer had eight bone marrow aspirates examined with antibody to epithelial membrane antigen. Data on long-term mortality were obtained via record linkage to death certification. Results: At a 30-year median follow-up, 79 [...]

A partir d'une revue systématique de la littérature publiée entre1999 et 2015 (15 articles, 11 526 cas), cette méta-analyse évalue la prévalence d'une infection par le papillomavirus de type 16 et 18, en fonction de l'âge des patientes atteintes d'un cancer du col de l'utérus

Age-specific prevalence of HPV16/18 genotypes in cervical cancer: A systematic review and meta-analysis

Hammer, Anne ; Rositch, Anne ; Qeadan, Fares ; Gravitt, Patti E. ; Blaakaer, Jan

The prevalence of HPV16/18 in cervical cancer has been reported to decline with age in some papers. However, whether this decline in proportion of cancers positive for HPV16/18 is consistently observed across studies remains to be elucidated. Thus, the aim of this study was to identify papers reporting data on age-specific prevalence of HPV16/18 in cervical cancer and to summarize the results. We employed MEDLINE and Embase for a systematic literature search and thereby identified a total of [...]

Menée en Corée par enquête auprès de 296 dyades patients-soignants, cette étude analyse les effets d'une absence de dialogue et de soutien social avec la famille et les professionnels de santé sur les symptômes d'anxiété et de dépression chez les patients atteints de cancer

Avoidance of cancer communication, perceived social support, and anxiety and depression among patients with cancer

Jeong, Ansuk ; Shin, Dong Wook ; Kim, So Young ; Yang, Hyung Kook ; Park, Jong-Hyock

Purpose : Patients with cancer are reported to experience high anxiety and depression related to their medical status. The current study aimed to investigate the effects of avoidance of cancer communication and of social support from family and medical professionals on the patients' anxiety and depression. Methods : A national survey was conducted through regional branches of the National Cancer Center of South Korea, which yielded 296 patient–caregiver dyads. Patients' medical records [...]

A partir d'une revue systématique de la littérature publiée entre 1994 et 2015 (13 études), cette méta-analyse évalue l'association entre le type d'attachement caractérisant la relation entre un patient atteint de cancer et son soignant (attachement de type anxieux ou évitant), la présence d'un soutien social et des symptômes de dépression et d'anxiété

Correlates of self-rated attachment in patients with cancer and their caregivers: a systematic review and meta-analysis

Nissen, Kathrine G.

Background : This study aimed to evaluate the association between an anxious/avoidant attachment style and psychosocial variables in patients with cancer and their caregivers. Methods : PsycINFO, PubMed, Google Scholar, and SCOPUS were searched for empirical studies published in peer-reviewed journals between 1994 and 2015, and unpublished data from one cohort were added. Meta-analyses synthesized results from studies investigating the correlates of attachment styles, measured with validated [...]

Menée aux Etats-Unis auprès de 61 patients adolescents et jeunes adultes atteints d'un cancer du sang (leucémie aiguë, lymphome), cette étude analyse la prévalence de morbidités psychologiques pendant et juste après les traitements

Psychological morbidities in adolescent and young adult blood cancer patients during curative-intent therapy and early survivorship

Muffly, Lori S. ; Hlubocky, Fay J. ; Khan, Niloufer ; Wroblewski, Kristen ; Breitenbach, Katherine ; Gomez, Joseline ; McNeer, Jennifer L. ; Stock, Wendy ; Daugherty, Christopher K.

BACKGROUND Adolescents and young adults (AYAs) with cancer face unique psychosocial challenges. This pilot study was aimed at describing the prevalence of psychological morbidities among AYAs with hematologic malignancies during curative-intent therapy and early survivorship and at examining provider perceptions of psychological morbidities in their AYA patients. METHODS Patients aged 15 to 39 years with acute leukemia, non-Hodgkin lymphoma, or Hodgkin lymphoma who were undergoing [...]

Mené au Danemark auprès de 157 patientes ayant survécu à un cancer du sein, cet essai randomisé analyse l'efficacité d'un programme en ligne pour réduire leurs troubles cognitifs auto-rapportés, améliorer leur fonctionnement neuropsychologique et leurs capacités mnésiques

Web-based cognitive training for breast cancer survivors with cognitive complaints—a randomized controlled trial

Damholdt, M. F. ; Mehlsen, M. ; O'Toole, M. S. ; Andreasen, R. K. ; Pedersen, A. D. ; Zachariae, R.

Background : Cognitive complaints are common amongst breast cancer survivors, and no standard treatment exists. The present study evaluates whether web-based cognitive training can alleviate subjectively reported and objectively assessed cognitive complaints in a sample of breast cancer survivors. The primary and secondary outcomes were an objective measure of working memory and a measure of perceived cognitive functioning. Additional outcomes were neuropsychological tests of memory, ex ecutive [...]

Menée en Australie par enquête auprès de 244 patients atteints de cancer, cette étude analyse leurs préférences en matière d'organisation et de qualité des soins (prise en charge de symptômes physiques et psychologiques, implication dans la prise de décision thérapeutique, implication de la famille et des amis, planification des rendez-vous médicaux, etc.)

The first step in ensuring patient-centred quality of care: ask the patient

Zucca, A. ; Sanson-Fisher, R. ; Waller, A. ; Carey, M. ; Boadle, D.

Health providers may not be aware of their patients' needs or preferences, and patients reluctant to raise their concerns. Consequently, the first step in ensuring quality of care is to ask the patient about the care that they would like. A cross-sectional sample of 244 medical oncology outpatients were surveyed about provider-asking behaviours across six dimensions of patient-centred care defined by the Institute of Medicine. Specifically, were patients asked by clinic staff at the treatment [...]

Menée au Royaume-Uni, cette étude analyse l'efficacité d'une analyse qualitative du contenu des réseaux sociaux pour comprendre les effets de la maladie et des traitements sur la vie quotidienne de jeunes gens atteints de cancer, ainsi que leur façon de faire face à la maladie

How young people describe the impact of living with and beyond a cancer diagnosis: feasibility of using social media as a research method

Gibson, F. ; Hibbins, S. ; Grew, T. ; Morgan, S. ; Pearce, S. ; Stark, D. ; Fern, L. A.

Objective : Young people with cancer exhibit unique needs. During a time of normal physical and psychological change, multiple disease and treatment-related symptoms cause short and long-term physical and psychosocial effects. Little is known about how young people cope with the impact of cancer and its treatment on daily routines and their strategies to manage the challenges of cancer and treatments. We aimed to determine how young people describe these challenges through a social media site. [...]