Menée au Danemark auprès de 1 006 219 participantes âgées de 50 à 79 ans, cette étude de cohorte évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause, en fonction de son type et de sa durée, et le risque de cancer du côlon ou du rectum (période de suivi : 1995-2009 ; 8 377 cas de cancer du côlon, 4 742 cas de cancer du rectum)

The influence of hormone therapies on colon and rectal cancer

Mørch, Lina Steinrud ; Lidegaard, Øjvind ; Keiding, Niels ; Løkkegaard, Ellen ; Kjær, Susanne Krüger

Exogenous sex hormones seem to play a role in colorectal carcinogenesis. Little is known about the influence of different types or durations of postmenopausal hormone therapy (HT) on colorectal cancer risk. A nationwide cohort of women 50–79 years old without previous cancer (n = 1,006,219) were followed 1995–2009. Information on HT exposures was from the National Prescription Register and updated daily, while information on colon (n = 8377) and rectal cancers (n = 4742) were from the National [...]

Couplée aux données de la cohorte européenne EPIC incluant 1 065 patients atteints d'un cancer colorectal (667 cas de cancer du côlon, 398 cas de cancer du rectum) et portant sur 1 065 témoins, cette étude prospective évalue l'association entre le niveau sérique de lipopolysaccharide et de flagelline et le risque de cancer colorectal

Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

Kong, So Yeon ; Tran, Hao Quang ; Gewirtz, Andrew T. ; McKeown-Eyssen, Gail ; Fedirko, Veronika ; Romieu, Isabelle ; Tjonneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Bastide, Nadia ; Affret, Aurélie ; Kühn, Tilman ; Kaaks, Rudolf ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Kritikou, Maria ; Vasilopoulou, Effie ; Palli, Domenico ; Krogh, Vittorio ; Mattiello, Amalia ; Tumino, Rosario ; Naccarati, Alessio ; Bueno-de-Mesquita, H. Bas ; Peeters, Petra H. ; Weiderpass, Elisabete ; Quiros, J Ramon ; Sala, Núria ; Sánchez, María-José ; Huerta Castaño, José-María ; Barricarte, Aurelio ; Dorronsoro, Miren ; Werner, Mårten ; Wareham, Nicholas J. ; Khaw, Kay-Tee ; Bradbury, Kathryn E. ; Freisling, Heinz ; Stavropoulou, Faidra ; Ferrari, Pietro ; Gunter, Marc J. ; Cross, Amanda J. ; Riboli, Elio ; Bruce, W. Robert ; Jenab, Mazda

Background: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer (CRC) development. These processes may be contributed to by leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody levels and CRC risk. Methods: 1,065 incident CRC cases (colon n=667; rectal n=398) were [...]

Menée en Italie auprès de 294 cas et 279 témoins, cette étude évalue l'association entre des facteurs liés au mode de vie (utilisation de teinture pour cheveux, consommation de thé, d'alcool, tabagisme) et le risque de leucémie ou de lymphome non hodgkinien chez une population adulte

Lifestyle factors and risk of leukemia and non-Hodgkin’s lymphoma: a case–control study

Parodi, Stefano ; Santi, Irene ; Marani, Enza ; Casella, Claudia ; Puppo, Antonella ; Garrone, Elsa ; Fontana, Vincenzo ; Stagnaro, Emanuele

Purpose : Risk factors for leukemia and lymphomas in adults are largely unknown. This study was aimed at evaluating the association between lifestyle factors and the risk of hematological malignancies in an adult population. Methods : Data were drawn from a population-based case–control study carried out in Italy and included 294 cases (199 lymphoid and 95 myeloid) and 279 controls. Analyses were performed using standard multivariable logistic regression. Results : Hair dye use for at least 15 [...]

A partir d'une revue systématique de la littérature publiée entre 1974 et 2015 (13 études prospectives), cette étude compare l'association entre l'indice de masse corporelle, des indicateurs mesurant l'adiposité abdominale, et le risque de cancer

Comparison of anthropometric measurements of adiposity in relation to cancer risk: a systematic review of prospective studies

Ridder, Josefine ; Julián-Almárcegui, Cristina ; Mullee, Amy ; Rinaldi, Sabina ; Herck, Koen ; Vicente-Rodríguez, German ; Huybrechts, Inge

Purpose : In epidemiology, the relationship between increased adiposity and cancer risk has long been recognized. However, whether the association is the same for measures of abdominal or whole body adiposity is unclear. The aim of this systematic review is to compare cancer risk, associated with body mass index (BMI), an indicator of whole body adiposity, with indicators of abdominal adiposity in studies in which these indicators have been directly measured. Methods : We conducted a systematic [...]

A partir de données de 10 études incluant 10 835 femmes ménopausées (5 419 cas et 5 416 témoins), cette étude évalue l'influence d'un variant proche du gène CYP24A1 sur la modification de l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause, à base d'œstrogènes uniquement ou combinant œstrogènes et progestérone, et le risque de cancer colorectal

CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk

Garcia-Albeniz, Xabier ; Rudolph, Anja ; Hutter, Carolyn ; White, Emily ; Lin, Yi ; Rosse, Stephanie A. ; Figueiredo, Jane C. ; Harrison, Tabitha A. ; Jiao, Shuo ; Brenner, Hermann ; Casey, Graham ; Hudson, Thomas J. ; Thornquist, Mark ; Le Marchand, Loic ; Potter, John ; Slattery, Martha L. ; Zanke, Brent ; Baron, John A. ; Caan, Bette J. ; Chanock, Stephen J. ; Berndt, Sonja I. ; Stelling, Deanna ; Fuchs, Charles S. ; Hoffmeister, Michael ; Butterbach, Katja ; Du, Mengmeng ; James Gauderman, W. ; Gunter, Marc J. ; Lemire, Mathieu ; Ogino, Shuji ; Lin, Jennifer ; Hayes, Richard B. ; Haile, Robert W. ; Schoen, Robert E. ; Warnick, Greg S. ; Jenkins, Mark A. ; Thibodeau, Stephen N. ; Schumacher, Fredrick R. ; Lindor, Noralane M. ; Kolonel, Laurence N. ; Hopper, John L. ; Gong, Jian ; Seminara, Daniela ; Pflugeisen, Bethann M. ; Ulrich, Cornelia M. ; Qu, Conghui ; Duggan, David ; Cotterchio, Michelle ; Campbell, Peter T. ; Carlson, Christopher S. ; Newcomb, Polly A. ; Giovannucci, Edward ; Hsu, Li ; Chan, Andrew T. ; Peters, Ulrike ; Chang-Claude, Jenny

Background: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene–environment interaction analysis to identify genetic modifiers of CRC risk associated with use of MHT. Methods: We included 10 835 postmenopausal women (5419 cases and 5416 controls) from 10 studies. We evaluated use of any MHT, oestrogen-only (E-only) and combined oestrogen–progestogen (E+P) hormone preparations. To [...]

A partir d'une revue de la littérature (études ayant inclus 30 000 cas et 30 000 témoins), cette étude analyse les interactions entre des variants génétiques communs, des expositions à divers facteurs environnementaux et comportementaux et le risque de cancer du sein

Gene-environment interaction and risk of breast cancer

Rudolph, Anja ; Chang-Claude, Jenny ; Schmidt, Marjanka K.

Hereditary, genetic factors as well as lifestyle and environmental factors, for example, parity and body mass index, predict breast cancer development. Gene-environment interaction studies may help to identify subgroups of women at high-risk of breast cancer and can be leveraged to discover new genetic risk factors. A few interesting results in studies including over 30 000 breast cancer cases and healthy controls indicate that such interactions exist. Explorative gene-environment interaction [...]