Menée aux Etats-Unis auprès d'une cohorte incluant 90 317 adultes (durée de suivi : 805 644 personnes-années), cette étude évalue l'association entre la consommation de café et la mortalité globale ou le risque de décès par cancer ou autres maladies

Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study

Loftfield, Erikka ; Freedman, Neal D. ; Graubard, Barry I. ; Guertin, Kristin A. ; Black, Amanda ; Huang, Wen-Yi ; Shebl, Fatma M. ; Mayne, Susan T. ; Sinha, Rashmi

Concerns about high caffeine intake and coffee as a vehicle for added fat and sugar have raised questions about the net impact of coffee on health. Although inverse associations have been observed for overall mortality, data for cause-specific mortality are sparse. Additionally, few studies have considered exclusively decaffeinated coffee intake or use of coffee additives. Coffee intake was assessed at baseline by self-report in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. [...]

Menée à partir de questionnaires auprès de 335 054 participantes de la cohorte EPIC (âge moyen : 51 ans ; durée médiane de suivi : 11,5 ans), cette étude évalue l'association entre la consommation de fruits et de légumes et le risque de cancer du sein (10 197 cas), selon le statut des récepteurs des estrogènes ou de la progestérone

Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort

Emaus, Marleen J ; Peeters, Petra HM ; Bakker, Marije F ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja ; Romieu, Isabelle ; Ferrari, Pietro ; Dossus, Laure ; Boutron-Ruault, Marie Christine ; Baglietto, Laura ; Fortner, Renée T ; Kaaks, Rudolf ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Masala, Giovanna ; Pala, Valeria ; Panico, Salvatore ; Tumino, Rosario ; Polidoro, Silvia ; Skeie, Guri ; Lund, Eiliv ; Weiderpass, Elisabete ; Quiros, J Ramon ; Travier, Noemie ; Sánchez, María-José ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Dorronsoro, Miren ; Winkvist, Anna ; Wennberg, Maria ; Bueno-de-Mesquita, H Bas ; Khaw, Kay-Tee ; Travis, Ruth C ; Key, Timothy J ; Aune, Dagfinn ; Gunter, Marc ; Riboli, Elio ; van Gils, Carla H

Background : The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor–negative breast cancer risk. Objective : This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor–defined breast cancer risk. Design : A total of 335,054 female participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were included in this [...]

Menée à partir de questionnaires auprès de 10 576 patientes présentant un risque élevé de cancer du sein et incluses dans un essai évaluant le tamoxifène en traitement prophylactique, cette étude évalue, en fonction de la présence de facteurs de risque comportementaux, l'association entre divers types de symptômes (gynécologiques, vasomoteurs, sexuels, ...), la qualité de vie des patientes (mesurée par un système de score) et l'observance du traitement

Symptoms and QOL as Predictors of Chemoprevention Adherence in NRG Oncology/NSABP Trial P-1

Land, Stephanie R. ; Walcott, Farzana L. ; Liu, Qing ; Wickerham, D. Lawrence ; Costantino, Joseph P. ; Ganz, Patricia A.

Background : Tamoxifen provides a 50% reduction in the incidence of breast cancer (BC) among high-risk women, yet many do not adhere to the five-year course of therapy. Using the prospective double-blind National Surgical Adjuvant Breast and Bowel Project P-1 study, we evaluated whether participant-reported outcomes were associated with drug adherence and whether baseline behavioral risk factors modified those associations. Methods : P-1 participants were randomly assigned to placebo vs [...]

Menée aux Etats-Unis auprès d'un échantillon de 241 adolescents, cette étude met en évidence l'intérêt, pour réduire le risque de tabagisme, de cacher les panneaux publicitaires présentant des produits tabagiques dans les points de vente

Hiding the tobacco power wall reduces cigarette smoking risk in adolescents: using an experimental convenience store to assess tobacco regulatory options at retail point-of-sale

Shadel, William G ; Martino, Steven C ; Setodji, Claude M ; Scharf, Deborah M ; Kusuke, Daniela ; Sicker, Angela ; Gong, Min

Objectives : This experiment tested whether changing the location or visibility of the tobacco power wall in a life sized replica of a convenience store had any effect on adolescents’ susceptibility to future cigarette smoking. Methods : The study was conducted in the RAND StoreLab (RSL), a life sized replica of a convenience store that was developed to experimentally evaluate how changing aspects of tobacco advertising displays in retail point-of-sale environments influences tobacco use risk [...]

Mené au Canada auprès de 400 femmes ménopausées pratiquant peu d'activités physiques (âge : 50 à 74 ans ; indice de masse corporelle : 22-40 kg/m2), cet essai évalue, en fonction du volume horaire hebdomadaire (150 ou 300 minutes par semaine), l'effet d'un programme annuel d'exercices d'aérobic sur le niveau sérique de marqueurs de l'inflammation (protéine C réactive, interleukine IL-6 et TNF-alpha)

Inflammatory marker changes in postmenopausal women after a year-long exercise intervention comparing high versus moderate volumes

Friedenreich, Christine M. ; O'Reilly, Rachel ; Shaw, Eileen ; Stanczyk, Frank Z. ; Yasui, Yutaka ; Brenner, Darren R. ; Courneya, Kerry S.

This randomized dose comparison trial examined if higher exercise volume decreased inflammatory biomarkers, associated with postmenopausal breast cancer risk, more than moderate exercise volume. The Breast Cancer and Exercise Trial in Alberta (BETA) was a two-center, two-armed randomized trial in 400 inactive, healthy, postmenopausal women, aged 50-74 years, with a body mass index of 22-40 kg/m2. Participants were randomized to high (300 minutes/week) or moderate (150 minutes/week) volumes of [...]

Menée sur 3 864 patientes présentant un risque accru de cancer du sein et incluses dans un essai de phase II évaluant l'anastrozole, cette étude évalue l'incidence du syndrome du canal carpien, puis identifie les facteurs de risque associés

Anastrozole-Induced Carpal Tunnel Syndrome: Results From the International Breast Cancer Intervention Study II Prevention Trial

Spagnolo, Francesco ; Sestak, Ivana ; Howell, Anthony ; Forbes, John F. ; Cuzick, Jack

Purpose : Carpal tunnel syndrome (CTS) occurs when the median nerve is compressed at the wrist in the carpal tunnel. It has been suggested that hormonal risk factors may be involved in the pathogenesis of CTS, and a higher incidence of CTS has been reported in randomized clinical trials with aromatase inhibitors (AIs) compared with tamoxifen. Patients and Methods : This was an exploratory analysis of the International Breast Cancer Intervention Study II, a double-blind randomized clinical trial [...]