Menée aux Etats-Unis à partir de données portant sur 45 592 patients atteints de cancer, cette étude de cohorte rétrospective analyse le risque de neutropénie fébrile induite par la chimiothérapie en fonction du jour de l'administration d'un traitement prophylactique par pegfilgrastim

Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter?

Weycker, Derek ; Li, Xiaoyan ; Figueredo, Jacqueline ; Barron, Rich ; Tzivelekis, Spiros ; Hagiwara, May

Purpose : Contrary to the approved indication for pegfilgrastim prophylaxis, some patients receive it on the same day as the last administration of chemotherapy in clinical practice, which could adversely impact risk of febrile neutropenia (FN). An evaluation of the timing of pegfilgrastim prophylaxis and FN risk was undertaken. Methods : A retrospective cohort design and data from two US private health care claims repositories were employed. Study population comprised adults who received [...]

A partir des données d'une cohorte prospective nord-américaine incluant 142 patients atteints d'une compression médullaire d'origine métastatique, cette étude analyse leur qualité de vie (douleurs, fonctionnement neurologique) et leur survie après un traitement chirurgical

Survival and Clinical Outcomes in Surgically Treated Patients With Metastatic Epidural Spinal Cord Compression: Results of the Prospective Multicenter AOSpine Study

Fehlings, Michael G. ; Nater, Anick ; Tetreault, Lindsay ; Kopjar, Branko ; Arnold, Paul ; Dekutoski, Mark ; Finkelstein, Joel ; Fisher, Charles ; France, John ; Gokaslan, Ziya ; Massicotte, Eric ; Rhines, Laurence ; Rose, Peter ; Sahgal, Arjun ; Schuster, James ; Vaccaro, Alexander

Purpose : Although surgery is used increasingly as a strategy to complement treatment with radiation and chemotherapy in patients with metastatic epidural spinal cord compression (MESCC), the impact of surgery on health-related quality of life (HRQoL) is not well established. We aimed to prospectively evaluate survival, neurologic, functional, and HRQoL outcomes in patients with MESCC who underwent surgical management. Patients and Methods : One hundred forty-two patients with a single [...]

Menée au Japon par questionnaire auprès de 73 patients atteints d'un cancer du bas rectum, cette étude prospective analyse leur qualité de vie, six mois après une chirurgie sphinctérienne conservatrice

Health-related quality of life in patients with lower rectal cancer after sphincter-saving surgery: a prospective 6-month follow-up study

Kinoshita, Y. ; Nokes, K. M. ; Kawamoto, R. ; Kanaoka, M. ; Miyazono, M. ; Nakao, H. ; Chishaki, A. ; Mibu, R.

This longitudinal descriptive study examined whether rectal cancer patients report changes in health-related quality of life (HRQOL) over a 6-month period after different types of sphincter-saving surgery (SSS): intersphincteric resection (ISR), ultra-low anterior resection (ULAR) and low anterior resection (LAR). It also compares HRQOL among the three groups of patients. Seventy-three patients from two hospitals in Japan completed questionnaires on HRQOL and defecation symptoms immediately [...]

Menée à partir de données portant sur 1 334 patients atteints d'une maladie de Vaquez, un syndrome myéloprolifératif, cette étude analyse les facteurs, tels qu'une résistance ou une intolérance à l'hydroxyurée, la pratique d'une phlébotomie ou une splénomégalie, contribuant à la survenue de symptômes handicapants

Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease

Geyer, Holly ; Scherber, Robyn ; Kosiorek, Heidi ; Dueck, Amylou C. ; Kiladjian, Jean-Jacques ; Xiao, Zhijian ; Slot, Stefanie ; Zweegman, Sonja ; Sackmann, Federico ; Fuentes, Ana Kerguelen ; Hernández-Maraver, Dolores ; Döhner, Konstanze ; Harrison, Claire N. ; Radia, Deepti ; Muxi, Pablo ; Besses, Carlos ; Cervantes, Francisco ; Johansson, Peter L. ; Andreasson, Bjorn ; Rambaldi, Alessandro ; Barbui, Tiziano ; Bonatz, Karin ; Reiter, Andreas ; Boyer, Francoise ; Etienne, Gabriel ; Ianotto, Jean-Christophe ; Ranta, Dana ; Roy, Lydia ; Cahn, Jean-Yves ; Maldonado, Norman ; Barosi, Giovanni ; Ferrari, Maria L. ; Gale, Robert Peter ; Birgegard, Gunnar ; Xu, Zefeng ; Zhang, Yue ; Sun, Xiujuan ; Xu, Junqing ; Zhang, Peihong ; te Boekhorst, Peter A.W. ; Commandeur, Suzan ; Schouten, Harry ; Pahl, Heike L. ; Griesshammer, Martin ; Stegelmann, Frank ; Lehmann, Thomas ; Senyak, Zhenya ; Vannucchi, Alessandro M. ; Passamonti, Francesco ; Samuelsson, Jan ; Mesa, Ruben A.

Purpose : Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with disabling symptoms and a heightened risk of life-threatening complications. Recent studies have demonstrated the effectiveness of JAK inhibitor therapy in patients with PV patients who have a history of prior hydroxyurea (HU) use (including resistance or intolerance), phlebotomy requirements, and palpable splenomegaly. We aimed to determine how these features contribute alone and in aggregate to the PV [...]

Menée aux Etats-Unis à partir du questionnaire EORTC auprès de 215 patients atteints d'un cancer de la vessie, cette étude évalue l'intérêt d'ajouter des indicateurs idiographiques pour analyser leur qualité de vie avant une cystectomie radicale

Idiographic quality of life assessment before radical cystectomy

Anderson, Christopher B. ; Rapkin, Bruce ; Reaves, Brieyona C. ; Sun, Arony J. ; Morganstern, Bradley ; Dalbagni, Guido ; Donat, Machele ; Herr, Harry W. ; Laudone, Vincent P. ; Bochner, Bernard H.

Background : We sought to determine if idiographic, or self-defined, measures added to our understanding of patients with bladder cancer's quality of life (QOL) prior to radical cystectomy (RC). We tested whether idiographic measures increased prediction of global QOL beyond standard (nomothetic) measures of QOL components. Methods : We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (QLQ)-C30 and QLQ-BLM30, and our own idiographic [...]

Menée en France à partir des données du réseau Lymphopath incluant 300 patientes atteintes d'un lymphome du sein (âge médian : 61 ans), cette étude évalue l'association entre des implants mammaires et le risque de lymphome T périphérique (in situ ou infiltrant), ainsi que la survie des patientes

Breast Implant Associated Anaplastic Large cell Lymphoma: two distinct clinicopathological variants with different outcomes

Laurent, C. ; Delas, A. ; Gaulard, P. ; Haioun, C. ; Moreau, A. ; Xerri, L. ; Traverse-Glehen, A. ; Rousset, T. ; Quintin-Roue, I. ; Petrella, T. ; Emile, J. F. ; Amara, N. ; Rochaix, P. ; Chenard-Neu, M. P. ; Tasei, A. M. ; Menet, E. ; Chomarat, H. ; Costes, V. ; Andrac-Meyer, L. ; Michiels, J.F. ; Chassagne-Clement, C. ; de Leval, L. ; Brousset, P. ; Delsol, G. ; Lamant, L.

Background : ALK-negative Anaplastic Large Cell lymphoma associated with breast implant (i-ALCL) has been recently recognized as a distinct entity. Among 43830 lymphomas registered in the french Lymphopath network since 2010, 300 breast lymphomas comprising 25 peripheral T-cell lymphomas were reviewed. Among peripheral T-cell lymphomas, ALK-negative ALCL was the most frequent and all of them were associated with breast implants. Patients and Methods : Since 2010, all i-ALCL cases were collected [...]

Menée en France à partir des données du registre des cancers du département de l'Hérault incluant 1 151 patientes atteintes d'un cancer invasif de l'ovaire diagnostiqué entre 1997 et 2011, cette étude en population analyse les différences de traitements reçus en fonction de l'âge des patientes (plus ou moins 70 ans)

Under-treatment of elderly patients with ovarian cancer: a population based study

Fourcadier, Elisabeth ; Tretarre, Brigitte ; Gras-Aygon, Claudine ; Ecarnot, Fiona ; Daures, Jean-Pierre ; Bessaoud, Faiza

BACKGROUND: Ovarian cancer is the fourth most common cancer among women in France, and mainly affects the elderly. The primary objective of this study was to compare treatment of ovarian cancer according to age. METHODS: All patients with invasive cancer (n=1151) diagnosed between 1997 and 2011 in the Herault Department of southern France were included. Demographic data (age, area of residence), cancer characteristics (stage, histology, grade) and treatment modality (type, period and location [...]

A partir des données de l'"International Agency for Research on Cancer ", cette étude analyse l'évolution de l'incidence du cancer de la prostate chez 43 populations sur cinq continents, en fonction de la période et de la tranche d'âge (durée médiane d'observation : 24 ans)

Prostate cancer incidence in 43 populations worldwide: An analysis of time trends overall and by age group

Zhou, Cindy Ke ; Check, David P. ; Lortet-Tieulent, Joannie ; Laversanne, Mathieu ; Jemal, Ahmedin ; Ferlay, Jacques ; Bray, Freddie ; Cook, Michael B. ; Devesa, Susan S.

Prostate cancer is a significant public health burden and a major cause of morbidity and mortality among men worldwide. Analyzing geographic patterns and temporal trends may help identify high-risk populations, suggest the degree of PSA testing, and provide clues to etiology. We used incidence data available from the International Agency for Research on Cancer (IARC) and certain cancer registries for 43 populations across five continents during a median period of 24 years. Trends in overall [...]

Menée aux Etats-Unis auprès de 1 468 patientes atteintes d'un cancer du sein de stade précoce diagnostiqué entre 2008 et 2014, cette étude analyse les disparités ethniques dans l'utilisation du test "Oncotype DX" analysant l'expression de 21 gènes dans la tumeur pour aider à la prise de décision relative au recours à une chimiothérapie adjuvante

Racial Variation in the Uptake of Oncotype DX Testing for Early-Stage Breast Cancer

Roberts, Megan C. ; Weinberger, Morris ; Dusetzina, Stacie B. ; Dinan, Michaela A. ; Reeder-Hayes, Katherine E. ; Carey, Lisa A. ; Troester, Melissa A. ; Wheeler, Stephanie B.

Purpose : Oncotype DX (ODX) is a tumor gene-profiling test that aids in adjuvant chemotherapy decision-making. ODX has the potential to improve quality of care; however, if not equally accessible across racial groups, disparities in cancer care quality may persist or worsen. We examined racial disparities in ODX testing uptake. Methods : We used data from the Carolina Breast Cancer Study, phase III, a longitudinal, population-based study of 2,998 North Carolina women who received a diagnosis of [...]

A partir de données nationales américaines portant sur 278 815 patientes atteintes d'un cancer du sein diagnostiqué en 2010 et 2011, cette étude analyse les disparités ethniques dans l'utilisation d'une chimiothérapie néoadjuvante et dans la survie des patientes

Racial Differences in the Use and Outcome of Neoadjuvant Chemotherapy for Breast Cancer: Results From the National Cancer Database

Killelea, Brigid K. ; Yang, Vicky Q. ; Wang, Shi-Yi ; Hayse, Brandon ; Mougalian, Sarah ; Horowitz, Nina R. ; Chagpar, Anees B. ; Pusztai, Lajos ; Lannin, Donald R.

Purpose : To explore racial differences in the use and outcome of neoadjuvant chemotherapy for breast cancer. Methods : The National Cancer Database was queried to identify women with stage 1 to 3 breast cancer diagnosed in 2010 and 2011. Chemotherapy use and rate of pathologic complete response (pCR) was determined for various racial/ethnic groups. Results : Of 278,815 patients with known race and ethnicity, 127,417 (46%) received chemotherapy, and of 121,446 where the timing of chemotherapy [...]

Menée en Chine auprès de 518 patientes atteintes d'un cancer du sein triplement négatif, cette étude de cohorte prospective évalue l'association entre l'indice de masse corporelle, des changements de poids, mesurés avant et après le diagnostic, et la survie des patientes

Body mass index and weight change in relation to triple-negative breast cancer survival

Bao, Ping-Ping ; Cai, Hui ; Peng, Peng ; Gu, Kai ; Su, Yinghao ; Shu, Xiao-Ou ; Zheng, Ying

The aim of this study was to evaluate the influence of body mass index (BMI), weight change on triple-negative breast cancer (TNBC) prognosis in a population-based prospective cohort study. The current analysis included 518 participants diagnosed with TNBC in Shanghai Breast Cancer Survival Study. Weight at 1 year prior to cancer diagnosis, at diagnosis, and at 6, 18 and 36 months after cancer diagnosis and height at 6 months after cancer diagnosis were assessed. Disease-free survival (DFS) and [...]

Menée aux Etats-Unis auprès de 198 patients atteints d'un cancer urothélial, métastatique ou non résécable, cette étude analyse l'incidence d'événements thrombo-emboliques artériels ou veineux associés à trois protocoles de chimiothérapie à base de sels de platine

The high incidence of vascular thromboembolic events in patients with metastatic or unresectable urothelial cancer treated with platinum chemotherapy agents

Tully, Christopher M. ; Apolo, Andrea B. ; Zabor, Emily C. ; Regazzi, Ashley M. ; Ostrovnaya, Irina ; Furberg, Helena F. ; Rosenberg, Jonathan E. ; Bajorin, Dean F.

BACKGROUND The current study compared the incidence of vascular thromboembolic events (VTEs) in patients with metastatic or unresectable urothelial carcinoma (UC) who were treated with gemcitabine and carboplatin (GCb); gemcitabine, carboplatin, and bevacizumab (GCbBev); or gemcitabine and cisplatin (GCis). METHODS Patients with UC who were treated with GCbBev on protocol were analyzed prospectively and 2 contemporary control cohorts receiving GCb or GCis were evaluated retrospectively. VTE was [...]

Menée aux Etats-Unis à partir de données portant sur 51 655 patients atteints d'un carcinome épidermoïde de la tête et du cou, cette étude analyse l'impact des délais entre le diagnostic et le début des traitements sur la survie globale

Survival Impact of Increasing Time to Treatment Initiation for Patients With Head and Neck Cancer in the United States

Murphy, Colin T. ; Galloway, Thomas J. ; Handorf, Elizabeth A. ; Egleston, Brian L. ; Wang, Lora S. ; Mehra, Ranee ; Flieder, Douglas B. ; Ridge, John A.

Purpose : To estimate the overall survival (OS) impact from increasing time to treatment initiation (TTI) for patients with head and neck squamous cell carcinoma (HNSCC). Methods : Using the National Cancer Data Base (NCDB), we examined patients who received curative therapy for the following sites: oral tongue, oropharynx, larynx, and hypopharynx. TTI was the number of days from diagnosis to initiation of curative treatment. The effect of TTI on OS was determined by using Cox regression models [...]

Menée aux Etats-Unis auprès de 281 dyades patients-aidants, cette étude évalue l'efficacité d'un outil permettant de détecter la détresse psychologique d'enfants atteints de cancer ou de maladie grave

Validity, specificity, feasibility and acceptability of a brief pediatric distress thermometer in outpatient clinics

Wiener, Lori ; Battles, Haven ; Zadeh, Sima ; Widemann, Brigitte C. ; Pao, Maryland

Objective : Psychosocial distress is under-recognized in children with cancer and other serious medical illnesses because of a focus on pressing medical concerns. Aims : This study assessed the validity, inter-rater reliability, sensitivity/specificity, acceptability, and feasibility of administration of a pediatric distress thermometer (DT) designed to screen for the presence of psychosocial distress in youth with serious medical illnesses. Materials & Methods : Two hundred eighty-one [...]

Menée aux Pays-Bas par entretiens auprès de 23 médecins et de 17 patients ayant survécu à un cancer, cette étude qualitative analyse les facteurs entravant ou facilitant leur retour au travail après la perte de leur emploi

Barriers and facilitators for return to work in cancer survivors with job loss experience: a focus group study

van Egmond, M. P. ; Duijts, S. F. A. ; Loyen, A. ; Vermeulen, S. J. ; van der Beek, A. J. ; Anema, J. R.

Over 50% of cancer survivors lose their job or quit working. Cancer survivors who experience job loss may face different challenges regarding return to work, compared to cancer survivors with employers. This qualitative study aimed to explore barriers and facilitators for return to work in cancer survivors with job loss and in insurance physicians who assist cancer survivors in their return to work. We conducted five focus groups and one interview (cancer survivors, N = 17; insurance [...]

Menée aux Pays-Bas auprès de 364 patients atteints de cancer, cette étude de cohorte analyse l'efficacité d'un outil permettant d'évaluer les symptômes cognitifs des patients, pendant ou après les traitements, dans le cadre de leur vie professionnelle

The Cognitive Symptom Checklist-Work in cancer patients is related with work functioning, fatigue and depressive symptoms: a validation study

Dorland, H. F. ; Abma, F. I. ; Roelen, C. A. M. ; Smink, A. ; Feuerstein, M. ; Amick, B. C. ; Ranchor, A. V. ; Bültmann, U.

Purpose : The study objectives are to translate the 21-item Cognitive Symptom Checklist-Work (CSC-W21) to Dutch (CSC-W DV) and to validate the CSC-W DV in working cancer patients. Methods : The CSC-W21 was cross-culturally translated and adapted to a Dutch version. In this 19-item version, the dichotomous response option was changed to an ordinal five-point scale. A validation study of the CSC-W DV was conducted among cancer patients who had returned to work during or following cancer [...]

Menée en Angleterre à partir de données portant sur 77 173 patientes atteintes d'un cancer du sein diagnostiqué entre 2000 et 2009, cette étude évalue l'impact de symptômes dépressifs ou des troubles bipolaires sur leur survie

The association of mood disorders with breast cancer survival: an investigation of linked cancer registration and hospital admission data for South East England

Kanani, R. ; Davies, E. A. ; Hanchett, N. ; Jack, R. H.

Background : Data linkage studies find that depression before or after a breast cancer diagnosis predicts reduced survival. This study aimed to determine whether depression or bipolar recorded in routine hospital admission data independently predicts survival in English breast cancer patients and whether onset in relation to cancer diagnosis is significant. Methods : Data on 77 173 women diagnosed with breast cancer (ICD-10 C50) in South East England, 2000–2009, were included. Of these, 131 [...]

A partir d'une revue systématique de la littérature (27 études), cette étude analyse l'efficacité des réunions de concertation pluridisciplinaire en cancérologie pour améliorer la prise en charge et la survie des patients atteints de cancer

The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: A systematic review of the literature

Pillay, Brindha ; Wootten, Addie C. ; Crowe, Helen ; Corcoran, Niall ; Tran, Ben ; Bowden, Patrick ; Crowe, Jane ; Costello, Anthony J.

Background : Conducting regular multidisciplinary team (MDT) meetings requires significant investment of time and finances. It is thus important to assess the empirical benefits of such practice. A systematic review was conducted to evaluate the literature regarding the impact of MDT meetings on patient assessment, management and outcomes in oncology settings. Methods : Relevant studies were identified by searching OVID MEDLINE, PsycINFO, and EMBASE databases from 1995 to April 2015, using the [...]

Menée aux Etats-Unis auprès de 10 998 patients ayant survécu à un cancer, cette étude analyse les disparités ethniques dans l'abandon des soins à cause de difficultés financières liées aux coûts des traitements

Racial and ethnic disparities in cost-related medication non-adherence among cancer survivors

Lee, Minjee ; Salloum, RamziG

Purpose : Cancer survivors are delaying or avoiding necessary care due to costs, and medication non-adherence is an important aspect of deferred treatment. This study estimates the prevalence of cost-related medication non-adherence (CRN) by race and ethnicity and examines factors associated with CRN among cancer survivors. Methods : Using the 2006–2013 National Health Interview Survey, we examine self-reported CRN among cancer survivors compared with cancer-free controls. Descriptive [...]

Menée en France à partir des données du registre des cancers de la région Poitou-Charentes incluant 367 patients atteints de myélome multiple entre 2008 et 2010, cette étude analyse les facteurs géographiques et organisationnels associés à la qualité des soins et au respect des recommandations internationales

Multiple myeloma: the quality of care is linked to geographical and organisational determinants. A study in a French registry

Puyade, M. ; Gautier, D. ; Guilhot, F. ; Ingrand, P.

Multiple myeloma is a haematological malignancy whose care is spread over several specialities and provided by centres that various sizes, which raises the issue of equal opportunities in care access. Incident cases of myeloma between 2008 and 2010 were exhaustively identified by the Poitou-Charentes Cancer Registry. To ascertain the quality of care, the diagnosis, staging, and treatment administered were compared to international recommendations. Three hundred and sixty-seven patients were [...]

Menée aux Etats-Unis, cette étude analyse le rapport coût-efficacité d'un test permettant d'aider les décisions relatives à l'administration d'une chimiothérapie adjuvante pour des patients atteints d'un cancer du poumon non à petites cellules de stade précoce

Cost-Utility of a Prognostic Test Guiding Adjuvant Chemotherapy Decisions in Early-Stage Non-Small Cell Lung Cancer

Stenehjem, David D. ; Bellows, Brandon K. ; Yager, Kraig M. ; Jones, Joshua ; Kaldate, Rajesh ; Siebert, Uwe ; Brixner, Diana I.

A prognostic test was developed to guide adjuvant chemotherapy (ACT) decisions in early-stage non-small cell lung cancer (NSCLC) adenocarcinomas. The objective of this study was to compare the cost-utility of the prognostic test to the current standard of care (SoC) in patients with early-stage NSCLC.Lifetime costs (2014 U.S. dollars) and effectiveness (quality-adjusted life-years [QALYs]) of ACT treatment decisions were examined using a Markov microsimulation model from a U.S. third-party [...]

A partir des données d'un registre américain des cancers portant sur 7 287 patientes atteintes d'un cancer du sein de stade précoce diagnostiqué entre 2007 et 2010, cette étude de cohorte rétrospective évalue les coûts associés à l'utilisation d'un test analysant l'expression de 21 gènes dans la tumeur pour prescrire une chimiothérapie ajduvante

Adjuvant Chemotherapy Use and Health Care Costs After Introduction of Genomic Testing in Breast Cancer

Epstein, Andrew J. ; Wong, Yu-Ning ; Mitra, Nandita ; Vachani, Anil ; Hin, Sakhena ; Yang, Lin ; Smith-McLallen, Aaron ; Armstrong, Katrina ; Groeneveld, Peter W.

Purpose : We assessed the associations between the 21-gene recurrence score assay (RS) receipt, subsequent chemotherapy use, and medical expenditures among patients with early-stage breast cancer. Patients and Methods : Data from the Pennsylvania Cancer Registry were used to assemble a retrospective cohort of women with early-stage breast cancer from 2007 to 2010 who underwent initial surgical treatment. These data were merged with administrative claims from the 12-month periods before and [...]

Menée au Royaume-Uni par questionnaire puis par entretiens auprès de patients atteints de myélome multiple, cette étude analyse l'association entre leur degré de connaissances relatives à la chimiothérapie orale et leur adhésion au traitement

Do patients on oral chemotherapy have sufficient knowledge for optimal adherence? A mixed methods study

Arber, A. ; Odelius, A. ; Williams, P. ; Lemanska, A. ; Faithfull, S.

A new treatment paradigm has emerged with many patients now receiving oral chemotherapy (OC) as first-line treatment for cancer. Treatment with OC has resulted in reduced hospital costs, more autonomy for patients but with added responsibilities for patient self-management. Little is known about patient's knowledge following patient education to enable optimal adherence with OC. A mixed methods study was carried out using a self-report questionnaire to patients on OC for multiple myeloma (MM) [...]

Menée aux Etats-Unis, cette étude analyse les caractéristiques de l'utilisation de services et de soins palliatifs dans un centre de lutte contre le cancer

Use of Palliative Care Services in a Tertiary Cancer Center

Dalal, Shalini ; Bruera, Sebastian ; Hui, David ; Yennu, Sriram ; Dev, Rony ; Williams, Janet ; Masoni, Charles ; Ihenacho, Ijeoma ; Obasi, Emmanuel ; Bruera, Eduardo

Despite increasing prevalence of palliative care (PC) services in cancer centers, most referrals to the service occur exceedingly late in the illness trajectory. Over the years, we have made several attempts to promote earlier patient access to our PC program, such as changing the name of our service from PC to supportive care (SC). This study was conducted to determine the use of PC/SC service over the past 8 years.We reviewed billing data for all PC/SC encounters. We examined five metrics for [...]

Menée à Hong Kong, cette étude passe en revue les enjeux liés à l'administration d'une chimiothérapie palliative pour des patients en fin de vie et à l'articulation entre les services oncologiques et palliatifs

Chemotherapy at end-of-life: an integration of oncology and palliative team

Chan, Wing-lok ; Lam, Ka-on ; Siu, Wai-kwan ; Yuen, Kwok-keung

Palliative chemotherapy is increasingly used in cancer patients near end of life. With the development of newer anticancer agents which have less side effects and higher expected efficacy, the decision on palliative chemotherapy in patients near end of life is complex. This article illustrates how oncologist and palliative care physicians can work together effectively. This article also gives an overview about the risks of palliative chemotherapy near end of life, patients’ and physicians’ [...]

Menée à partir d'une revue systématique de la littérature et par questionnaire adressé à 339 professionnels de santé en oncologie, cette étude américaine analyse l'utilisation de médecines traditionnelles à base de plantes et ses effets indésirables chez les patients atteints de cancer

Potential risks associated with traditional herbal medicine use in cancer care: A study of MiddleEastern oncology health care professionals

Ben-Arye, Eran ; Samuels, Noah ; Goldstein, Lee Hilary ; Mutafoglu, Kamer ; Omran, Suha ; Schiff, Elad ; Charalambous, Haris ; Dweikat, Tahani ; Ghrayeb, Ibtisam ; Bar-Sela, Gil ; Turker, Ibrahim ; Hassan, Azza ; Hassan, Esmat ; Saad, Bashar ; Nimri, Omar ; Kebudi, Rejin ; Silbermann, Michael

BACKGROUND The authors assessed the use of herbal medicine by Middle Eastern patients with cancer, as reported by their oncology health care professionals (HCPs). Herbal products identified by the study HCPs were evaluated for potential negative effects. METHODS Oncology HCPs from 16 Middle Eastern countries received a 17-item questionnaire asking them to list 5 herbal products in use by their patients with cancer. A literature search (PubMed, Micromedex, AltMedDex, and the Natural Medicine [...]