Couplée aux données de la cohorte européenne EPIC et portant sur 334 cas et 417 témoins, cette étude évalue l'association entre l'acrylamide d'origine alimentaire, mesurée par les adduits acrylamide-hémoglobine, et le risque de cancer épithélial de l'ovaire chez des femmes ménopausées non fumeuses

Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort

Obón-Santacana, Mireia ; Luján-Barroso, Leila ; Travis, Ruth C. ; Freisling, Heinz ; Ferrari, Pietro ; Severi, Gianluca ; Baglietto, Laura ; Boutron-Ruault, Marie-Christine ; Fortner, Renée T ; Ose, Jennifer ; Boeing, Heiner ; Menéndez, Virginia ; Sánchez-Cantalejo, Emilio ; Chamosa, Saioa ; Huerta Castaño, José María ; Ardanaz, Eva ; Khaw, Kay-Tee ; Wareham, Nick ; Merritt, Melissa A. ; Gunter, Marc J. ; Trichopoulou, Antonia ; Papatesta, Eleni-Maria ; Klinaki, Eleni ; Saieva, Calogero ; Tagliabue, Giovanna ; Tumino, Rosario ; Sacerdote, Carlotta ; Mattiello, Amalia ; Bueno-de-Mesquita, H. Bas ; Peeters, Petra H. ; Onland-Moret, N. Charlotte ; Idahl, Annika ; Lundin, Eva ; Weiderpass, Elisabete ; Vesper, Hubert W. ; Riboli, Elio ; Duell, Eric J.

Background: Acrylamide was classified as 'probably carcinogenic to humans (group 2A)' by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and [...]

A partir des données de deux cohortes européennes, "EPIC" et "Netherlands Cohort Study", cette méta-analyse évalue l'association entre 57 facteurs alimentaires ou nutriments et le risque de cancer épithélial de l'ovaire

Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Merritt, Melissa A ; Tzoulaki, Ioanna ; van den Brandt, Piet A ; Schouten, Leo J ; Tsilidis, Konstantinos K ; Weiderpass, Elisabete ; Patel, Chirag J ; Tjønneland, Anne ; Hansen, Louise ; Overvad, Kim ; His, Mathilde ; Dartois, Laureen ; Boutron-Ruault, Marie-Christine ; Fortner, Renée T ; Kaaks, Rudolf ; Aleksandrova, Krasimira ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Bamia, Christina ; Palli, Domenico ; Krogh, Vittorio ; Tumino, Rosario ; Ricceri, Fulvio ; Mattiello, Amalia ; Bueno-de-Mesquita, H Bas ; Onland-Moret, N Charlotte ; Peeters, Petra H ; Skeie, Guri ; Jareid, Mie ; Quiros, J Ramon ; Obón-Santacana, Mireia ; Sánchez, María-José ; Chamosa, Saioa ; Huerta, José M ; Barricarte, Aurelio ; Dias, Joana A ; Sonestedt, Emily ; Idahl, Annika ; Lundin, Eva ; Wareham, Nicholas J ; Khaw, Kay-Tee ; Travis, Ruth C ; Ferrari, Pietro ; Riboli, Elio ; Gunter, Marc J

Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. Objective: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. Design: We [...]

A partir des données de la cohorte "Women’s Circle of Health Study" incluant 831 cas et 1 620 témoins, cette étude évalue l'association entre des facteurs reproductifs et liés au mode de vie et le risque de carcinome canalaire, qu'il soit in situ, invasif ou mixte

Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case–control and case–case analyses

Ruszczyk, Melanie ; Zirpoli, Gary ; Kumar, Shicha ; Bandera, ElisaV ; Bovbjerg, DanaH ; Jandorf, Lina ; Khoury, Thaer ; Hwang, Helena ; Ciupak, Gregory ; Pawlish, Karen ; Schedin, Pepper ; Masso-Welch, Patricia ; Ambrosone, ChristineB ; Hong, Chi-Chen

Purpose : Invasive ductal carcinoma (IDC) is diagnosed with or without a ductal carcinoma in situ (DCIS) component. Previous analyses have found significant differences in tumor characteristics between pure IDC lacking DCIS and mixed IDC with DCIS. We will test our hypothesis that pure IDC represents a form of breast cancer with etiology and risk factors distinct from mixed IDC/DCIS. Methods : We compared reproductive risk factors for breast cancer risk, as well as family and smoking history [...]

A partir de données danoises portant sur 217 227 enfants nés entre 1936 et 1980, cette étude de cohorte évalue, en fonction du sexe, l'association entre le poids à la naissance et le risque de cancer du foie à l'âge adulte

Sex-specific associations between birth weight and adult primary liver cancer in a large cohort of Danish children

Zimmermann, Esther ; Berentzen, Tina L. ; Gamborg, Michael ; Sørensen, Thorkild I. A. ; Baker, Jennifer L.

Whether the prenatal period is critical for the development of adult primary liver cancer (PLC) is sparsely investigated. Recently, attention has been drawn to potential sex-differences in the early origins of adult disease. The association between birth weight and adult PLC, separately in men and women was investigated, using a large cohort of 217,227 children (51% boys), born from 1936 to 1980, from the Copenhagen School Health Records Register, and followed them until 2010 in national [...]

Couplée aux données de la cohorte américaine "Molecular And Genetic Epidemiology study" et portant sur 259 cas et 461 témoins, cette étude évalue les disparités ethniques dans l'association entre des antécédents familiaux de cancer hématologique et le risque de myélome multiple

Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features

VanValkenburg, MaryAnnE ; Pruitt, GwendolynI ; Brill, IleneK ; Costa, Luciano ; Ehtsham, Maryam ; Justement, IanT ; Innis-Shelton, RacquelD ; Salzman, Donna ; Reddy, E. ShyamP ; Godby, KellyN ; Mikhail, FadyM ; Carroll, AndrewJ ; Reddy, VishnuB ; Sanderson, RalphD ; Justement, LouisB ; Sanders, PaulW ; Brown, ElizabethE

Purpose : Multiple myeloma (MM) is the most common hematologic malignancy affecting Blacks in the USA, with standardized incidence rates that are twofold to threefold higher than Whites. The rationale for the disparity is unclear. Methods : Using participants enrolled in the Molecular And Genetic Epidemiology study of myeloma (259 MM cases; 461 controls), we examined the risk of MM associated with family history of cancer, differences by race and among cases, defining clinical features. Risk [...]

Menée en population d'origine européeene sur 5 164 cas de cancer du poumon et 5 716 témoins, cette étude identifie plusieurs variants sur la région chromosomique 5p15.33 en association avec un risque accru de la maladie

Fine-mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci

Kachuri, Linda ; Amos, Christopher I. ; McKay, James D. ; Johansson, Mattias ; Vineis, Paolo ; Bueno-de-Mesquita, H. Bas ; Boutron-Ruault, Marie-Christine ; Johansson, Mikael ; Quiros, J Ramon ; Sieri, Sabina ; Travis, Ruth C. ; Weiderpass, Elisabete ; Le Marchand, Loic ; Henderson, Brian E. ; Wilkens, Lynne ; Goodman, Gary ; Chen, Chu ; Doherty, Jennifer A. ; Christiani, David C. ; Wei, Yongyue ; Su, Li ; Tworoger, Shelley ; Zhang, Xuehong ; Kraft, Peter ; Zaridze, David ; Field, John K. ; Marcus, Michael W. ; Davies, Michael P.A. ; Hyde, Russell ; Caporaso, Neil E. ; Landi, Maria Teresa ; Severi, Gianluca ; Giles, Graham G. ; Liu, Geoffrey ; McLaughlin, John R. ; Li, Yafang ; Xiao, Xiangjun ; Fehringer, Gord ; Zong, Xuchen ; Denroche, Robert E. ; Zuzarte, Philip C. ; McPherson, John D. ; Brennan, Paul ; Hung, Rayjean J.

Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study [...]

A partir des données du registre national taïwanais des cancers incluant 1 013 participants, cette étude prospective évalue l'association entre un polymorphisme du gène HO-1 et le risque de cancer lié à une exposition à de l'arsenic contenu dans l'eau potable

Effect of heme oxygenase-1 gene promoter polymorphism on cancer risk by histological subtype: A prospective study in arseniasis-endemic areas in Taiwan

Wu, Meei-Maan ; Lee, Chih-Hung ; Hsu, Ling- I. ; Cheng, Wen-Fang ; Lee, Te-Chang ; Wang, Yuang-Hung ; Chiou, Hung-Yi ; Chen, Chien-Jen

Heme oxygenase (HO)−1 is upregulated by many stressful stimuli, including arsenic. A GT-repeat ((GT)n) polymorphism in the HO-1 gene promoter inversely modulates the levels of HO-1 induction. Previous HO-1 (GT)n polymorphism studies in relation to cancer risk have shown disparate results. We prospectively investigated the associations between HO-1 (GT)n polymorphism and cancer risk related to arsenic from drinking water. Totally, 1,013 participants from community-based cohorts of [...]

A partir d'une revue systématique de la littérature, cette étude évalue l'influence de syndromes de prédisposition au cancer (syndrome de Down, syndrome de Noonan, etc) sur l'association entre une exposition à des rayonnements induits par des scanners durant l'enfance et le risque de leucémie ou de tumeurs cérébrales

Confounding of the association between radiation exposure from CT scans and risk of leukemia and brain tumors by cancer susceptibility syndromes

Meulepas, Johanna M ; Ronckers, Cecile M. ; Merks, Johannes ; Weijerman, Michel E. ; Lubin, Jay H. ; Hauptmann, Michael

Background: Recent studies linking radiation exposure from pediatric computed tomography (CT) to increased risks of leukemia and brain tumors lacked data to control for cancer susceptibility syndromes (CSS). These syndromes might confound the association since they are associated with an increased cancer risk and may increase the likelihood of CT scans performed in children. Methods: We identify CSS predisposing to leukemia and brain tumors through a systematic literature search and summarize [...]