A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2014 (10 essais incluant au total 1 582 patients), cette méta-analyse évalue l'efficacité et les effets indésirables du méthylphénidate et du modafinil dans le traitement des symptômes de fatigue liés au cancer

Psychotropic drugs for the management of cancer-related fatigue: a systematic review and meta-analysis

Qu, D. ; Zhang, Z. ; Yu, X. ; Zhao, J. ; Qiu, F. ; Huang, J.

Cancer-related fatigue (CRF) is a common symptom affecting 60–90% of cancer survivors, and effective management for CRF is not yet available. Recently, an increasing number of trials examining the use of psychotropic drugs for the treatment of CRF have been performed, but these trials have yielded inconsistent results. Therefore, we conducted a meta-analysis aimed at assessing the effect and safety of psychotropic drugs for the management of CRF. Ten eligible trials of the psychotropic drugs [...]

Mené en Corée du Sud sur 299 patients atteints d'un cancer traité par chimiothérapie, cet essai multicentrique de phase III compare, du point de vue de l'absence de nausées ou de vomissements et du non recours à la médication lors du premier jour de traitement, l'efficacité du romasétron et de l'ondansétron en combinaison avec la dexaméthasone et un aprépitant

Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Randomized Phase III Trial, KCSG PC10-21

Kim, Hyo Jung ; Shin, Sang Won ; Song, Eun-Kee ; Lee, Na-Ri ; Kim, Jun Suk ; Ahn, Jin Seok ; Yun, Hwan-Jung ; Cho, Yo-Han ; Park, Keon Uk ; Kim, Si-Young ; Jang, Joung Soon ; Kim, Sang-We ; Lee, Hyun Woo ; Lee, Se Ryeon ; Kim, Yang Soo ; Lee, Soon Nam ; Ko, Yoon Ho ; Kim, Hwa Jung ; Kang, Jin-Hyoung

A combination of serotonin receptor (5-hydroxytryptamine receptor type 3) antagonists, NK-1 receptor antagonist, and steroid improves the complete response (CR) of chemotherapy-induced nausea and vomiting (CINV) in cancer patients. Ramosetron’s efficacy in this triple combination regimen has not been investigated. This prospective, multicenter, single-blind, randomized, phase III study compares a combination of ramosetron, aprepitant, and dexamethasone (RAD) with a combination of ondansetron, [...]

Mené sur 277 patients ayant survécu à un cancer, cet essai évalue l'efficacité, du point de vue de la capacité cardiorespiratoire, de la force musculaire et du niveau de fatigue, et la sécurité d'exercices physiques de résistance ou d'endurance en fonction de leur intensité

Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study

Kampshoff, Caroline ; Chinapaw, Mai ; Brug, Johannes ; Twisk, Jos ; Schep, Goof ; Nijziel, Marten ; van Mechelen, Willem ; Buffart, Laurien

Background : International evidence-based guidelines recommend physical exercise to form part of standard care for all cancer survivors. However, at present, the optimum exercise intensity is unclear. Therefore, we aimed to evaluate the effectiveness of a high intensity (HI) and low-to-moderate intensity (LMI) resistance and endurance exercise program compared with a wait list control (WLC) group on physical fitness and fatigue in a mixed group of cancer survivors who completed primary cancer [...]

Mené sur 47 patients ayant survécu à un cancer colorectal, cet essai randomisé compare l'efficacité de deux programmes d'exercices physiques d'intensité élevée ou modérée pour améliorer la capacité cardiorespiratoire des patients et réduire leur masse graisseuse

The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial

Devin, JamesL ; Sax, AndrewT ; Hughes, GarethI ; Jenkins, DavidG ; Aitken, JoanneF ; Chambers, SuzanneK ; Dunn, JeffreyC ; Bolam, KateA ; Skinner, TinaL

Purpose : Following colorectal cancer diagnosis and anti-cancer therapy, declines in cardiorespiratory fitness and body composition lead to significant increases in morbidity and mortality. There is increasing interest within the field of exercise oncology surrounding potential strategies to remediate these adverse outcomes. This study compared 4 weeks of moderate-intensity exercise (MIE) and high-intensity exercise (HIE) training on peak oxygen consumption (V̇O2peak) and body composition in [...]

Menée sur 262 patientes ménopausées atteintes d'un cancer du sein de stade I à IIIA traité par chirurgie puis anastrozole seul ou en combinaison avec une chimiothérapie et menée sur 106 témoins sains, cette étude analyse l'évolution des capacités cognitives auto-rapportées au cours des 18 premiers mois de traitement, puis identifie les facteurs prédictifs associés à une dégradation de ces capacités

Trajectories of self-reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer

Merriman, John D. ; Sereika, Susan M. ; Brufsky, Adam M. ; McAuliffe, Priscilla F. ; McGuire, Kandace P. ; Myers, Jamie S. ; Phillips, Mary L. ; Ryan, Christopher M. ; Gentry, Amanda L. ; Jones, Lindsay D. ; Bender, Catherine M.

Objective : In a sample of 368 postmenopausal women, we (1) determined within-cohort and between-cohort relationships between adjuvant systemic therapy for breast cancer and self-reported cognitive function during the first 18 months of therapy and (2) evaluated the influence of co-occurring symptoms, neuropsychological function, and other covariates on relationships. Methods : We evaluated self-reported cognitive function, using the Patient Assessment of Own Functioning Inventory (PAOFI), and [...]

Menée à partir des données de plusieurs vagues d'enquêtes réalisées entre 1990 et 2009 auprès d'un échantillon représentatif de la population américaine, cette étude estime l'impact économique du cancer dans les foyers concernés par la maladie

Employment and income losses among cancer survivors: Estimates from a national longitudinal survey of American families

Zajacova, Anna ; Dowd, Jennifer B. ; Schoeni, Robert F. ; Wallace, Robert B.

BACKGROUND : Cancer presents a substantial hardship for patients and their families in multiple domains beyond health and survival. Relatively little is known about the economic impact of cancer. The authors present estimates of the aggregate effects of a cancer diagnosis on employment and income in a prospective, nationally representative sample of US adults. METHODS : The authors used data from the 1990 through 2009 waves of the Panel Study of Income Dynamics, a nationally representative, [...]

A partir de l'analyse des courbes d'évolution de l'incidence des cancers métastatiques du sein et de la prostate aux Etats-Unis sur la période 1975-2012 et de trois paradigmes sur la progression des cancers, cet article formule des hypothèses permettant d'expliquer pourquoi l'incidence de certains cancers métastatiques, en particulier du sein, ne diminue pas malgré la mise en place de programmes de dépistage

Trends in Metastatic Breast and Prostate Cancer — Lessons in Cancer Dynamics

Welch, H. Gilbert ; Gorski, David H. ; Albertsen, Peter C.

Patients who present with metastatic cancer serve as powerful motivators for efforts to detect cancer early. Screening offers hope that cancer can be detected in an early, localized phase when it's more amenable to treatment. This hope is based on a paradigm attributed to William Stewart Halsted, which holds that cancer arises at a single location, grows there, and eventually migrates to local lymph nodes and then to more distant organs. If the Halstedian paradigm is correct, effective [...]

Menée notamment à partir des données de l'Organisation Mondiale de la Santé, cette étude évalue sur la période 2002-2012 l'évolution du nombre de cas de cancer et de décès par cancer attribuables à la consommation d'alcool

Cancer incidence and mortality attributable to alcohol consumption

Praud, Delphine ; Rota, Matteo ; Rehm, Jürgen ; Shield, Kevin ; Zatonski, Witold ; Hashibe, Mia ; La Vecchia, Carlo ; Boffetta, Paolo

Alcohol consumption is a major cause of disease and death. In a previous study, we reported that in 2002, 3.6% of all cases of cancer and a similar proportion of cancer deaths were attributable to the consumption of alcohol. We aimed to update these figures to 2012 using global estimates of cancer cases and cancer deaths, data on the prevalence of drinkers from the World Health Organization (WHO) global survey on alcohol and health, and relative risks for alcohol-related neoplasms from a recent [...]

Menée en Norvège à partir des données 2002-2011 du registre national des cancers portant sur 24 324 patients atteints d'un cancer du poumon, cette étude met en évidence une association entre des facteurs économiques ou socio-démographiques (revenu, niveau d'éducation, âge et lieu de résidence) et les traitements reçus, cela malgré l'existence d'une couverture maladie universelle

Lung cancer treatment is influenced by income, education, age and place of residence in a country with universal health coverage

Nilssen, Yngvar ; Strand, Trond-Eirik ; Fjellbirkeland, Lars ; Bartnes, Kristian ; Brustugun, Odd Terje ; O'Connell, Dianne L. ; Yu, Xue Qin ; Møller, Bjørn

Selection of lung cancer treatment should be based on tumour characteristics, physiological reserves and preferences of the patient. Our aims were to identify and quantify other factors associated with treatment received. Lung cancer patient data from 2002 to 2011 were obtained from the national population-based Cancer Registry of Norway, Statistics Norway and the Norwegian Patient Register. Multivariable logistic regression examined whether year of diagnosis, age, sex, education, income, [...]

Menée à partir des données des registres allemands des cancers portant sur 132 612 patients atteints d'un cancer du poumon diagnostiqué entre 2002 et 2010, cette étude évalue la survie relative à 5 ans en fonction de l'âge, du sexe, du type histologique ou du stade de la tumeur

Lung Cancer Survival in Germany: a population-based Analysis of 132,612 Lung Cancer Patients

Eberle, Andrea ; Jansen, Lina ; Castro, Felipe ; Krilaviciute, Agne ; Luttmann, Sabine ; Emrich, Katharina ; Holleczek, Bernd ; Nennecke, Alice ; Katalinic, Alexander ; Brenner, Hermann

Objectives : Lung cancer is the most common cancer-related death worldwide. In Germany it accounts for 25% of cancer deaths in men, and 14% in women. The aim of this study is to provide an overview of 5-year relative survival by sex, age, histology, and tumour stage in Germany representing a population of 26.7 million people. Materials and methods : The study is based on a pooled German dataset including data from 12 population-based cancer registries covering around one third of the German [...]

Cet article décrit les mécanismes européens permettant d'accélérer le processus d'autorisation de mise sur le marché de médicaments anti-cancéreux répondant à des besoins médicaux non satisfaits et compare les décisions prises en matière de remboursement dans les principaux marchés de l'Union Européenne

Early market access of oncologic drugs in the EU

Martinalbo, J. ; Bowen, D. ; Camarero, J. ; Chapelin, M. ; Démolis, P. ; Foggi, P. ; Jonsson, B. ; Llinares, J. ; Moreau, A. ; O'Connor, D. ; Oliveira, J. ; Vamvakas, S. ; Pignatti, F.

Patient access to new oncologic drugs in the EU involves centralised licensing decisions by regulators as well as reimbursement recommendations in the context of national healthcare systems. Differences in assessment criteria and evidence requirements may result in divergent decisions at central and national levels, ultimately compromising effective access to patients. Early access decisions are particularly challenging due to the limited clinical evidence available to conclude on the [...]

Menée aux Pays-Bas à partir de données portant sur 1 067 patients atteints d'un cancer du poumon non à petites cellules de stade I à IV diagnostiqué entre 2009 et 2011, cette étude évalue les coûts moyens hospitaliers par patient durant leur maladie

Costs of non-small cell lung cancer in the Netherlands

Linden, N. van der ; Bongers, M. L. ; Coupe, V. M. H. ; Smit, E. F. ; Groen, H. J. M. ; Welling, A. ; Schramel, F. M. N. H. ; Uyl-de Groot, C. A.

Objectives : Real-world resource use and cost data on non-small cell lung cancer (NSCLC) are scarce. This data is needed to inform health-economic modelling to assess the impact of new diagnostic and/or treatment technologies. This study provides detailed insight into real-world medical resource use and costs of stage I-IV NSCLC in the Netherlands. Materials and methods : A random sample of patients newly diagnosed with NSCLC (2009-2011) was selected from four Dutch hospitals. Data was [...]

Menée à partir de données épidémiologiques et financières des pays de l'Union Européenne, cette étude estime pour l'année 2012 les coûts associés aux soins des patients atteints d'un cancer de la vessie

Economic Burden of Bladder Cancer Across the European Union

Leal, Jose ; Luengo-Fernandez, Ramon ; Sullivan, Richard ; Witjes, J. Alfred

Background : More than 120 000 people are diagnosed annually with bladder cancer in the 28 countries of the European Union (EU). With >40 000 people dying of it each year, it is the sixth leading cause of cancer. However, to date, no systematic cost-of-illness study has assessed the economic impact of bladder cancer in the EU. Objective : To estimate the annual economic costs of bladder cancer in the EU for 2012. Design, setting, and participants : Country-specific cancer cost data were [...]