Menée aux Etats-Unis, cette étude analyse les comportements de santé, la qualité de vie et le bien-être psychologique de patients ayant survécu à un cancer diagnostiqué pendant l'enfance ou au début de l'âge adulte

Health behaviors, quality of life, and psychosocial health among survivors of adolescent and young adult cancers

Warner, EchoL ; Nam, GinaE ; Zhang, Yingying ; McFadden, Molly ; Wright, Jennifer ; Spraker-Perlman, Holly ; Kinney, AnitaY ; Oeffinger, KevinC ; Kirchhoff, AnneC

Purpose : Survivors of adolescent and young adult (AYA) cancer may engage in unhealthy lifestyles (e.g., smoking), potentially heightening their risk for long-term health problems. We assessed health behaviors and constructs including quality of life (QOL) and psychosocial well-being among survivors of AYA cancer compared to the general population. Methods : We used 2009 Behavioral Risk Factor Surveillance System data to evaluate health behaviors for survivors of AYA cancer compared to AYAs [...]

A partir d'une revue systématique de la littérature (11 études), cette étude analyse les effets indésirables d'une radiochimiothérapie chez les patients atteints d'un cancer de l'anus, ainsi que leur qualité de vie

Systematic review of the quality of life issues associated with anal cancer and its treatment with radiochemotherapy

Sodergren, SamanthaC ; Vassiliou, Vassilios ; Dennis, Kristopher ; Tomaszewski, KrzysztofA ; Gilbert, Alexandra ; Glynne-Jones, Robert ; Nugent, Karen ; Sebag-Montefiore, David ; Johnson, ColinD

Purpose : Radiochemotherapy is the standard of care for the treatment of anal carcinoma achieving good loco-regional control and sphincter preservation. This approach is however associated with acute and late toxicities including haematological, skin, bowel function and genito-urinary complications. This paper systematically reviews studies addressing the quality of life (QoL) implications of anal cancer and radiochemotherapy. The paper also evaluates how QoL is assessed in anal cancer. Methods [...]

Menée en Suède par questionnaire auprès de 518 patients ayant survécu à long terme à un cancer de la prostate (durée médiane de suivi : 5 ans), cette étude analyse les effets indésirables de nature sexuelle induits par la radiothérapie

Patient-reported sexual toxicity after radiation therapy in long-term prostate cancer survivors

Olsson, C. E. ; Alsadius, D. ; Pettersson, N. ; Tucker, S. L. ; Wilderäng, U. ; Johansson, K. A. ; Steineck, G.

Background: To present an overview of patient-reported sexual toxicity in sexually active long-term prostate cancer survivors treated with radiation therapy. Methods: We used patient-reported outcomes from a study-specific questionnaire surveying symptoms after prostate cancer radiation therapy. Data from 518 men treated at the Sahlgrenska University Hospital in Sweden from 1993 to 2006 were analysed. The men had undergone primary or salvage external beam radiation therapy (EBRT) or EBRT [...]

Menée aux Etats-Unis auprès de 358 patientes ayant survécu à un cancer du sein, cette étude prospective évalue l'association entre l'intensité d'une activité physique mesurée objectivement, des comportements sédentaires et leur qualité de vie

Objectively measured physical activity and sedentary behavior and quality of life indicators in survivors of breast cancer

Phillips, Siobhan M. ; Awick, Elizabeth A. ; Conroy, David E. ; Pellegrini, Christine A. ; Mailey, Emily L. ; McAuley, Edward

BACKGROUND The primary purpose of the current study was to determine prospective associations of accelerometer-assessed physical activity intensity and sedentary time with health-related quality of life (HRQOL) indicators among survivors of breast cancer. METHODS A total of 358 survivors of breast cancer wore an accelerometer for 7 days at baseline to assess different activity intensities (light, lifestyle, and moderate to vigorous) and sedentary behavior. Six months later, survivors completed [...]

Mené aux Etats-Unis auprès de 120 patientes ayant survécu à un cancer du sein, cet essai randomisé compare l'efficacité de l'électro-acupuncture et de la gabapentine pour réduire les bouffées de chaleur

Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial

Mao, Jun J. ; Bowman, Marjorie A. ; Xie, Sharon X. ; Bruner, Deborah ; DeMichele, Angela ; Farrar, John T.

Purpose : Hot flashes are a common and debilitating symptom among survivors of breast cancer. This study aimed at evaluating the effects of electroacupuncture (EA) versus gabapentin (GP) for hot flashes among survivors of breast cancer, with a specific focus on the placebo and nocebo effects. Patients and Methods : We conducted a randomized controlled trial involving 120 survivors of breast cancer experiencing bothersome hot flashes twice per day or greater. Participants were randomly assigned [...]

Menée en Norvège à partir de questionnaires auprès de 812 patients ayant survécu à long terme à un cancer du testicule, cette étude analyse la prévalence d'une fatigue chronique en lien avec les traitements reçus

Chronic fatigue in 812 testicular cancer survivors during long-term follow up: increasing prevalence and risk factors

Sprauten, M. ; Haugnes, H. S. ; Brydøy, M. ; Kiserud, C. ; Tandstad, T. ; Bjøro, T. ; Bjerner, J. ; Cvancarova, M. ; Fossa, S. D. ; Oldenburg, J.

Background : Chronic fatigue (CF) has been reported to be slightly more prevalent in Testicular Cancer Survivors (TCSs) than in the general population. In this study, we wanted to explore possible determinants of CF in TCSs median 12 (Survey I) and 19 years (Survey II) after treatment, in particular the relation to late effects after treatment. Patients & Methods : Overall, 812 TCSs treated between 1980-1994 provided blood samples (Testosterone and Luteinizing Hormone) and completed [...]

Menée en Ecosse par enquête auprès de 280 patients ayant survécu à un cancer de la tête et du cou, cette étude transversale analyse leur détresse psychologique et leurs besoins en soins de support durant les 5 années suivant les traitements

Distress, concerns and unmet needs in survivors of head and neck cancer: a cross-sectional survey

Wells, M. ; Cunningham, M. ; Lang, H. ; Swartzman, S. ; Philp, J. ; Taylor, L. ; Thomson, J.

The aim of this study was to identify the distress, unmet needs and concerns of head and neck cancer (HNC) survivors in the first 5 years after treatment. Two hundred and eighty HNC survivors from three Scottish health boards responded to a cross-sectional postal survey in 2011. Questionnaires included the Distress Thermometer, Patient Concerns Inventory (PCI) and an adapted version of the PCI to measure unmet needs. One-third of the survivors had moderate or severe levels of distress, and 74% [...]

Menée aux Etats-Unis à partir de données portant sur 24 810 patients ayant survécu à un cancer, cette étude analyse l'association entre leur état de santé et leur situation professionnelle

Working with Cancer: Health and Employment among Cancer Survivors

Clarke, Tainya C. ; Christ, Sharon L. ; Soler-Vila, Hosanna ; Lee, David J. ; Arheart, Kristopher L. ; Prado, Guillermo ; Fleming, Lora E.

Background : Cancer affects a growing proportion of US workers. Factors contributing to whether they continue or return to work after cancer diagnosis include: age, physical and mental health, health insurance, education, and cancer site. The purpose of this study was to assess the complex relationships between health indicators and employment status for adult cancer survivors. Methods : We analyzed pooled data from the 1997-2012 US National Health Interview Survey (NHIS). Our sample included [...]

A partir des données des registres anglais des cancers portant sur 1,9 million de patients atteints d'un cancer diagnostiqué entre 1995 et 2012, cette étude analyse l'évolution de la survie des patients et la compare à celles des patients vivant en Australie, Canada, Norvège et Suède

Is England closing the international gap in cancer survival ?

Walters, Sarah ; Benitez-Majano, Sara ; Muller, Patrick ; Coleman, Michel P. ; Allemani, Claudia ; Butler, John ; Peake, Mick ; Guren, Marianne Gronlie ; Glimelius, Bengt ; Bergstrom, Stefan ; Pahlman, Lars ; Rachet, Bernard

Background: We provide an up-to-date international comparison of cancer survival, assessing whether England is ‘closing the gap’ compared with other high-income countries. Methods: Net survival was estimated using national, population-based, cancer registrations for 1.9 million patients diagnosed with a cancer of the stomach, colon, rectum, lung, breast (women) or ovary in England during 1995–2012. Trends during 1995–2009 were compared with estimates for Australia, Canada, Denmark, Norway and [...]

Menée aux Etats-Unis à partir de données portant sur 14 364 patients ayant survécu à un cancer pédiatrique, cette étude analyse le risque de second cancer après l'âge de 40 ans

Risk of Subsequent Neoplasms During the Fifth and Sixth Decades of Life in the Childhood Cancer Survivor Study Cohort

Turcotte, Lucie M. ; Whitton, John A. ; Friedman, Debra L. ; Hammond, Sue ; Armstrong, Gregory T. ; Leisenring, Wendy ; Robison, Leslie L. ; Neglia, Joseph P.

Purpose : Survivors of childhood cancer have an increased risk for subsequent neoplasms (SNs), but the incidence beyond the age of 40 years and associations with therapeutic exposures have not been well described. Patients and Methods : Among 14,364 survivors of childhood cancer diagnosed between 1970 and 1986, 3,171 had an attained age of 40 years or older at the time of last contact. Cumulative incidence of SNs, standardized incidence ratios (SIRs), excess absolute risk of subsequent [...]

A partir des données de la cohorte "Childhood Cancer Survivor Study" incluant 625 patientes ayant survécu à un cancer de l'enfance traité par radiothérapie thoracique, cette étude analyse leur recours à des mammographies de dépistage en fonction de leur mode de vie

Health care utilization, lifestyle, and emotional factors and mammography practices in the Childhood Cancer Survivor Study

Rosenberg, Shoshana M ; Moskowitz, Chaya S ; Ford, Jennifer S. ; Henderson, Tara O. ; Frazier, A. Lindsay ; Diller, Lisa R. ; Hudson, Melissa M. ; Stanton, Annette L ; Chou, Joanne F ; Smith, Stephanie ; Leisenring, Wendy M. ; Mertens, Ann C. ; Cox, Cheryl L. ; Nathan, Paul C. ; Krull, Kevin R. ; Robison, Leslie L. ; Oeffinger, Kevin C.

Background: Women with a history of chest radiotherapy (RT) have an increased risk of breast cancer however many do not undergo annual recommended screening mammography. We sought to characterize the relationship between mammography and potentially modifiable factors, with the goal of identifying targets for intervention to improve utilization. Methods: Of 625 female participants sampled from the Childhood Cancer Survivor Study who were treated with chest RT, 551 responded to a survey about [...]

A partir des données de la cohorte "Childhood Cancer Survivor Study" incluant 12 316 patients et 4 023 témoins, cette étude analyse la prévalence à long terme d'une occlusion intestinale nécessitant un traitement chirurgical chez des patients adultes ayant survécu à un cancer pédiatrique

Intestinal Obstruction in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Madenci, Arin L. ; Fisher, Stacey ; Diller, Lisa R. ; Goldsby, Robert E. ; Leisenring, Wendy M. ; Oeffinger, Kevin C. ; Robison, Leslie L. ; Sklar, Charles A. ; Stovall, Marilyn ; Weathers, Rita E. ; Armstrong, Gregory T. ; Yasui, Yutaka ; Weldon, Christopher B.

Purpose : For adult survivors of childhood cancer, knowledge about the long-term risk of intestinal obstruction from surgery, chemotherapy, and radiotherapy is limited. Methods : Intestinal obstruction requiring surgery (IOS) occurring 5 or more years after cancer diagnosis was evaluated in 12,316 5-year survivors in the Childhood Cancer Survivor Study (2,002 with and 10,314 without abdominopelvic tumors) and 4,023 sibling participants. Cumulative incidence of IOS was calculated with second [...]

A partir des données du registre suédois des cancers portant sur 789 681 participants, cette étude analyse le risque de cancer d'origine primitive inconnue après une hospitalisation pour une maladie auto-immune, sur la période 1964-2012

Risk of cancer of unknown primary after hospitalization for autoimmune diseases

Hemminki, Kari ; Sundquist, Kristina ; Sundquist, Jan ; Ji, Jianguang

Cancer of unknown primary (CUP) is a heterogeneous syndrome diagnosed at metastatic sites. The etiology is unknown but immune dysfunction may be a contributing factor. Patients with autoimmune diseases were identified from the Swedish Hospital Discharge Register and linked to the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for subsequent CUP and compared with subjects without autoimmune diseases. A total of 789,681 patients were hospitalized for any of 32 [...]

Menée au Danemark à partir de données portant sur 3 055 patients atteints d'une leucémie myéloïde aiguë, cette étude de cohorte identifie les caractéristiques cliniques des leucémies secondaires et des leucémies liées aux traitements

Epidemiology and Clinical Significance of Secondary and Therapy-Related Acute Myeloid Leukemia: A National Population-Based Cohort Study

Granfeldt Østgård, Lene Sofie ; Medeiros, Bruno C. ; Sengeløv, Henrik ; Nørgaard, Mette ; Andersen, Mette Klarskov ; Dufva, Inge Høgh ; Friis, Lone Smidstrup ; Kjeldsen, Eigil ; Marcher, Claus Werenberg ; Preiss, Birgitte ; Severinsen, Marianne ; Nørgaard, Jan Maxwell

Purpose : Secondary and therapy-related acute myeloid leukemia (sAML and tAML, respectively) remain therapeutic challenges. Still, it is unclear whether their inferior outcome compared with de novo acute myeloid leukemia (AML) varies as a result of previous hematologic disease or can be explained by differences in karyotype and/or age. Patients and Methods : In a Danish national population-based study of 3,055 unselected patients with AML diagnosed from 2000 to 2013, we compared the frequencies [...]

A partir des données d'un registre américain des cancers portant sur 772 patients atteints d'une leucémie aiguë promyélocytaire diagnostiquée avant 39 ans, cette étude analyse les disparités dans la mortalité précoce (dans les 30 jours suivant le diagnostic) selon l'âge des patients et l'origine ethnique

Disparities in early death and survival in children, adolescents and young adults with acute promyelocytic leukemia in California

Abrahão, Renata ; Ribeiro, Raul C. ; Medeiros, Bruno C. ; Keogh, Ruth H. ; Keegan, Theresa H. M.

BACKGROUND Findings from clinical trials and population-based studies have differed with regard to whether mortality within 30 days of diagnosis (early death) of acute promyelocytic leukemia (APL) has decreased in the era of all-trans retinoic acid and anthracycline-based chemotherapy. METHODS Using data from the California Cancer Registry, the authors investigated 7-day and 30-day mortality and survival in 772 patients who were aged birth to 39 years when they were diagnosed with APL during [...]

A partir des données des registres américains des cancers portant sur 44 870 patients ayant survécu à un lymphome non hodgkinien (âge au diagnostic : 66-83 ans), cette étude analyse les facteurs associés au risque ultérieur de mélanome

Risk Factors for Melanoma Among Survivors of Non-Hodgkin Lymphoma

Lam, Clara J.K. ; Curtis, Rochelle E. ; Dores, Graça M. ; Engels, Eric A. ; Caporaso, Neil E. ; Polliack, Aaron ; Warren, Joan L. ; Young, Heather A. ; Levine, Paul H. ; Elmi, Angelo F. ; Fraumeni, Joseph F. ; Tucker, Margaret A. ; Morton, Lindsay M.

Purpose : Previous studies have reported that survivors of non-Hodgkin lymphoma (NHL) have an increased risk of developing cutaneous melanoma; however, risks associated with specific treatments and immune-related risk factors have not been quantified. Patients and Methods : We evaluated second melanoma risk among 44,870 1-year survivors of first primary NHL diagnosed at age 66 to 83 years from 1992 to 2009 and included in the Surveillance, Epidemiology, and End Results-Medicare database. [...]

Menée en Italie à partir de données portant sur 3 900 patients atteints d'un mélanome cutané, cette étude analyse le risque de décès par mélanome en fonction du sexe

Melanoma survival: sex does matter, but we do not know how

Crocetti, Emanuele ; Fancelli, Laura ; Manneschi, Gianfranco ; Caldarella, Adele ; Pimpinelli, Nicola ; Chiarugi, Alessandra ; Nardini, Paolo ; Buzzoni, Carlotta

The objective of this study was to provide further insights into the prognostic role of female sex in skin melanoma. The prognostic effect of sex in a population-based case series of 3900 skin melanomas in central Italy has been evaluated considering the possible confounding role of many demographic and clinical variables (age, period of diagnosis, Breslow's thickness, Clark level, ulceration, lymph node status, metastasis, histological type, skin site, and pathological T and N). Multiple [...]

Menée au Canada à partir de données portant sur 541 patients atteints d'un cancer colorectal métastatique traité par bévacizumab, cette étude identifie les facteurs associés au risque de maladie thrombo-embolique veineuse et analyse sa prise en charge

Risk and management of venous thromboembolisms in bevacizumab-treated metastatic colorectal cancer patients

Yu, Irene ; Chen, Leo ; Ruan, JennyY ; Chang, JenniferT ; Cheung, WinsonY

Purpose : Bevacizumab may potentiate the risk of venous thromboembolisms (VTEs) in cancer patients, who are already predisposed to pro-thrombotic states. We aimed to characterize the incidence of VTEs in a population-based cohort of metastatic colorectal cancer (mCRC) patients treated with bevacizumab, describe patient and treatment factors associated with VTEs, and examine how VTEs are managed. Methods : Patients diagnosed with mCRC from 2006 to 2009 and offered bevacizumab were included. [...]

A partir des données des registres néerlandais des cancers portant sur 992 patientes atteintes d'un cancer du sein et présentant des métastases, synchrones ou métachrones, au niveau du système nerveux central, cette étude analyse leur survie en fonction des types de métastases et de tumeur primitive

Survival of breast cancer patients with synchronous or metachronous central nervous system metastases

Ho, V. K. Y. ; Gijtenbeek, J. M. M. ; Brandsma, D. ; Beerepoot, L. V. ; Sonke, G. S. ; van der Heiden-van der Loo, M.

Background : Central nervous system (CNS) metastases represent a devastating complication for advanced breast cancer patients. This observational study examines the influence of patient, tumour and treatment characteristics on overall survival after synchronous or metachronous CNS metastases. Methods : Information on 992 breast cancer patients with CNS metastases (whose primary tumour was diagnosed between 2004 and 2010) was retrieved from the Netherlands Cancer Registry (NCR). Overall survival [...]

A partir des données de 39 registres américains des cancers, cette étude analyse les disparités géographiques et ethniques dans l'incidence des tumeurs germinales du testicule, sur la période 1998-2011

Incidence of testicular germ cell tumors among US men by census region

Ghazarian, Armen A. ; Trabert, Britton ; Graubard, Barry I. ; Schwartz, Stephen M. ; Altekruse, Sean F. ; McGlynn, Katherine A.

BACKGROUND The incidence of testicular germ cell tumors (TGCTs) in the United States is notably higher among white men versus other men. Previously, however, it was reported that rates were rising among Hispanics in certain areas. To determine whether this finding was evident in a wider area of the United States, data from 39 US cancer registries were examined. METHODS Racial/ethnic-specific incidence rates per 100,000 man-years were calculated overall and by census region for the period of [...]

A partir des données des registres américains des cancers sur la période 2000-2011, cette étude analyse les disparités ethniques dans l'incidence du cancer de l'endomètre et dans la mortalité spécifique

The Growing Burden of Endometrial Cancer: A Major Racial Disparity Affecting Black Women

Coté, Michele L. ; Ruterbusch, Julie J. ; Olson, Sara H. ; Lu, Karen ; Ali-Fehmi, Rouba

Background: In contrast with the decreasing incidence seen for most cancers, endometrial cancer has been increasing in the United States. We examined whether the increasing incidence and mortality from endometrial cancer are equally distributed by race/ethnicity and tumor histologic subtype. Methods: Surveillance, Epidemiology, and End Results (SEER) endometrial cancer incidence and mortality data were obtained from 2000 to 2011. Age-adjusted incidence and incidence-based mortality rates, 95% [...]

Menée aux Etats-Unis à partir de données portant sur 4 643 patients ayant survécu à un cancer après une greffe de cellules souches hématopoïétiques, cette étude évalue l'association entre des indicateurs de résilience, de détresse psychologique, de croissance post-traumatique et de qualité de vie

Resilience, health, and quality of life among long-term survivors of hematopoietic cell transplantation

Rosenberg, Abby R. ; Syrjala, Karen L. ; Martin, Paul J. ; Flowers, Mary E. ; Carpenter, Paul A. ; Salit, Rachel B. ; Baker, K. Scott ; Lee, Stephanie J.

BACKGROUND Low patient-reported resilience is associated with an ongoing risk of poor health and psychosocial outcomes. Using a large cross-sectional sample of survivors of hematopoietic cell transplantation (HCT), this study explored associations between patient-reported resilience, psychological distress, posttraumatic growth, and health-related quality of life. METHODS Between July 1, 2013 and June 30, 2014, the annual Fred Hutchinson Cancer Research Center (FHCRC) posttransplant [...]

Menée en Australie auprès de 255 participants âgés de 12 à 24 ans dont l'un des parents est atteint de cancer, cette étude analyse leur détresse psychologique et leurs besoins en soins de support

Correlates of unmet needs and psychological distress in adolescent and young adults who have a parent diagnosed with cancer

McDonald, F. E. J. ; Patterson, P. ; White, K. J. ; Butow, P. N. ; Costa, D. S. J. ; Kerridge, I.

Objective : Young people who have a parent with cancer experience elevated levels of psychological distress and unmet needs. In this study, we examined the associations between demographics, cancer variables and family functioning and levels of distress and unmet needs amongst young people who have a parent diagnosed with cancer. Methods : Young people aged 12–24 years with a parent with cancer (n = 255) completed the Offspring Cancer Needs Instrument (unmet needs), the Kessler-10 (distress) [...]

A partir d'une revue systématique de la littérature (11 études), cette méta-analyse évalue, dans le cadre d'une greffe de cellules souches hématopoïétiques, l'intérêt d'interventions de nature psychosociale destinées aux patients adultes atteints de cancer

Psychological interventions for distress in adults undergoing haematopoietic stem cell transplantation: a systematic review with meta-analysis

Baliousis, Michael ; Rennoldson, Michael ; Snowden, John A.

Objectives : To investigate the characteristics, methodology, quality, and efficacy of psychological interventions for distress in adult patients undergoing haematopoietic stem cell transplantation (HSCT). Methods : A systematic review of relevant studies was conducted using six databases with supplementary hand searching. Included studies employed an experimental or quasi-experimental design, interventions included at least one psychological component, and outcomes involved psychological [...]

Menée en Angleterre par questionnaire auprès de 21 802 participants, cette étude analyse les facteurs associés à des difficultés socio-économiques chez des patients ayant survécu à un cancer colorectal, 12 à 36 mois après le diagnostic

Identifying Social Distress: A Cross-Sectional Survey of Social Outcomes 12 to 36 Months After Colorectal Cancer Diagnosis

Wright, Penny ; Downing, Amy ; Morris, Eva J.A. ; Corner, Jessica L. ; Richards, Mike A. ; Sebag-Montefiore, David ; Finan, Paul ; Glaser, Adam W.

Purpose : To establish the prevalence and determinants of poor social outcomes after a diagnosis of colorectal cancer (CRC). Patients and Methods : All 12- to 36-month survivors of CRC (International Classification of Diseases [10th revision] codes C18 to C20) diagnosed in 2010 or 2011 and treated in the English National Health Service were identified and sent a questionnaire from their treating cancer hospital. This included the Social Difficulties Inventory, a 16-item scale of social distress [...]

Menée aux Etats-Unis, cette étude analyse le rapport coût-efficacité du régorafénib en traitement de troisième ligne chez les patients atteints d'un cancer colorectal métastatique

Cost-Effectiveness Analysis of Regorafenib for Metastatic Colorectal Cancer

Goldstein, Daniel A. ; Ahmad, Bilal B. ; Chen, Qiushi ; Ayer, Turgay ; Howard, David H. ; Lipscomb, Joseph ; El-Rayes, Bassel F. ; Flowers, Christopher R.

Purpose : Regorafenib is a standard-care option for treatment-refractory metastatic colorectal cancer that increases median overall survival by 6 weeks compared with placebo. Given this small incremental clinical benefit, we evaluated the cost-effectiveness of regorafenib in the third-line setting for patients with metastatic colorectal cancer from the US payer perspective. Methods : We developed a Markov model to compare the cost and effectiveness of regorafenib with those of placebo in the [...]

Menée aux Etats-Unis à partir de données portant sur 2 932 patients atteints d'un cancer de la thyroïde et ayant subi une thyroïdectomie (âge médian : 44 ans), cette étude analyse le rapport coût-efficacité d'une stratégie de suivi chez des patients à faible risque, risque intermédiaire ou risque élevé de récidive

Cost-effectiveness analysis of papillary thyroid cancer surveillance

Wang, Laura Y. ; Roman, Benjamin R. ; Migliacci, Jocelyn C. ; Palmer, Frank L. ; Tuttle, R. Michael ; Shaha, Ashok R. ; Shah, Jatin P. ; Patel, Snehal G. ; Ganly, Ian

BACKGROUND The recent overdiagnosis of subclinical, low-risk papillary thyroid cancer (PTC) coincides with a growing national interest in cost-effective health care practices. The aim of this study was to measure the relative cost-effectiveness of disease surveillance of low-risk PTC patients versus intermediate- and high-risk patients in accordance with American Thyroid Association risk categories. METHODS Two thousand nine hundred thirty-two patients who underwent thyroidectomy for [...]

Menée en France dans le cadre d'un essai randomisé de phase III, cette étude analyse le rapport coût-efficacité de deux stratégies d'ablation à l'iode radioactif chez des patients atteints d'un cancer de la thyroïde et évalue leur qualité de vie

Quality of Life and Cost-Effectiveness Assessment of Radioiodine Ablation Strategies in Patients With Thyroid Cancer: Results From the Randomized Phase III ESTIMABL Trial

Borget, Isabelle ; Bonastre, Julia ; Catargi, Bogdan ; Deandreis, Desiree ; Zerdoud, Slimane ; Rusu, Daniela ; Bardet, Stephane ; Leenhardt, Laurence ; Bastie, Delphine ; Schvartz, Claire ; Vera, Pierre ; Morel, Olivier ; Benisvy, Daniele ; Bournaud, Claire ; Bonichon, Françoise ; Kelly, Antony ; Toubert, Marie-Elisabeth ; Leboulleux, Sophie ; Journeau, Florence ; Benhamou, Ellen ; Schlumberger, Martin

Purpose : In the ESTIMABL phase III trial, the thyroid ablation rate was equivalent for the two thyroid-stimulating hormone (TSH) stimulation methods (thyroid hormone withdrawal [THW] and recombinant human TSH [rhTSH]) and the two iodine-131 (131I) activities (1.1 or 3.7 GBq). The objectives of this article were to present health-related quality-of-life (HRQoL) results and a cost-effectiveness evaluation performed alongside this trial. Patients and Methods : HRQoL and utility were [...]

A partir d'une revue systématique de la littérature (8 études), cette étude analyse l'efficacité de l'acupuncture pour réduire les bouffées de chaleur induites par les traitements chez les patients atteints de cancer

Systematic review of acupuncture to control hot flashes in cancer patients

Garcia, M. Kay ; Graham-Getty, Leslie ; Haddad, Robin ; Li, Yisheng ; McQuade, Jennifer ; Lee, Richard T. ; Spano, Michael ; Cohen, Lorenzo

Hot flashes (HFs) are a common side effect of cancer treatment. The purpose of this systematic review was to evaluate evidence related to the use of acupuncture for HFs in cancer patients. EMBASE, MEDLINE, Cochrane (all databases), PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched from their inception through December 2014. Included studies had to be randomized controlled trials with a usual-care and/or placebo comparison group that investigated [...]

Mené aux Etats-Unis auprès de 72 médecins généralistes, cet essai randomisé évalue l'efficacité d'une procédure basée sur l'analyse des dossiers médicaux électroniques pour accélérer la réalisation des examens de diagnostic chez les patients dont les symptômes évoquent un cancer

Electronic Trigger-Based Intervention to Reduce Delays in Diagnostic Evaluation for Cancer: A Cluster Randomized Controlled Trial

Murphy, Daniel R. ; Wu, Louis ; Thomas, Eric J. ; Forjuoh, Samuel N. ; Meyer, Ashley N.D. ; Singh, Hardeep

Purpose : We tested whether prospective use of electronic health record-based c to identify patients at risk of diagnostic delays could prevent delays in diagnostic evaluation for cancer. Methods : We performed a cluster randomized controlled trial of primary care providers (PCPs) at two sites to test whether triggers that prospectively identify patients with potential delays in diagnostic evaluation for lung, colorectal, or prostate cancer can reduce time to follow-up diagnostic evaluation. [...]