Menée en Suède par questionnaire auprès de 94 patients atteints de cancer et ayant reçu une greffe de cellules souches hématopoïétiques, cette étude analyse l'évolution de leurs symptômes et leur qualité de vie jusqu'à 3 ans après le traitement

Frequent and long-term follow-up of health-related quality of life following allogeneic haematopoietic stem cell transplantation

Frödin, U. ; Lotfi, K. ; Fomichov, V. ; Juliusson, G. ; Börjeson, S.

Health-related quality of life (HRQL) was evaluated in 94 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) after myeloablative (MAC, n = 18) or reduced intensity conditioning (RIC, n = 76). HRQL was assessed with the EORTC QLQ C-30 during the inpatient period as well as during the following 3 years, i.e. at baseline and 12 times thereafter. Functional status and global quality of life decreased from baseline to weeks 2 and 3, especially role and social functions. [...]

Menée au Japon par questionnaire auprès de 330 patientes ménopausées atteintes d'un cancer du sein, cette étude analyse la prévalence de douleurs et de raideurs articulaires après 5 ans de traitement par anastrozole

Joint symptoms and health-related quality of life in postmenopausal women with breast cancer who completed 5 years of anastrozole

Yagata, Hiroshi ; Ohtsu, Hiroshi ; Komoike, Yoshifumi ; Saji, Shigehira ; Takei, Hiroyuki ; Nakamura, Toshitaka ; Ohashi, Yasuo ; Iwase, Takuya ; Shimozuma, Kojiro

Purpose : To assess the joint symptoms and the impact on patients’ health-related quality of life (HRQOL) due to 5 years of anastrozole from the baseline data in the N-SAS BC 05 trial, a randomized clinical trial was designed to assess the efficacy of 5 additional years of anastrozole among women with breast cancer. Methods : Joint symptoms and HRQOL were evaluated using an original questionnaire for joint symptoms, the Short Form 36-item Health Survey (SF-36), the EuroQol EQ-5D-3L, and a [...]

Menée aux Etats-Unis par questionnaire auprès de 391 patientes atteintes d'un cancer du sein et recevant une chimiothérapie, cette étude analyse les facteurs démographiques et cliniques associés à leurs symptômes (douleur, fatigue, troubles du sommeil, symptômes dépressifs)

Comparison of subgroups of breast cancer patients on pain and co-occurring symptoms following chemotherapy

Langford, DaleJ ; Paul, StevenM ; Cooper, Bruce ; Kober, KordM ; Mastick, Judy ; Melisko, Michelle ; Levine, JonD ; Wright, Fay ; Hammer, MarilynJ ; Cartwright, Frances ; Lee, KathrynA ; Aouizerat, BradleyE ; Miaskowski, Christine

Purpose : The purposes of this study, in a sample of women with breast cancer receiving chemotherapy (CTX), were to identify subgroups of women with distinct experiences with the symptom cluster of pain, fatigue, sleep disturbance, and depressive symptoms and evaluate differences in demographic and clinical characteristics, differences in psychological symptoms, and differences in pain characteristics among these subgroups. Methods : Patients completed symptom questionnaires in the week [...]

A partir des données d'un registre canadien des cancers portant sur 20 275 cas et 101 344 témoins, cette étude de cohorte analyse les hospitalisations des patients ayant survécu à un cancer diagnostiqué entre 20 et 44 ans

Hospitalization Rates Among Survivors of Young Adult Malignancies

Richardson, Devon P. ; Daly, Corinne ; Sutradhar, Rinku ; Paszat, Lawrence F. ; Wilton, Andrew S. ; Rabeneck, Linda ; Baxter, Nancy N.

Purpose : There are limited data on health care use among survivors of young adult cancers. We aimed to describe patterns of hospitalization among a cohort of long-term survivors compared with noncancer controls. Methods : Persons diagnosed between the ages of 20 and 44 years with malignancies in Ontario, Canada, from 1992 to 1999, who lived at least 5 years recurrence free, were identified using the Ontario Cancer Registry and matched to noncancer controls. Hospitalizations were determined [...]

Menée aux Etats-Unis auprès de 303 cas et 307 témoins, cette étude prospective compare les changements de poids chez des patientes ayant survécu à un cancer du sein et chez des femmes n'ayant pas eu de cancer, mais présentant toutes un risque familial de cancer

Weight Change in Breast Cancer Survivors Compared to Cancer-Free Women: A Prospective Study in Women at Familial Risk of Breast Cancer

Gross, Amy L. ; May, Betty J. ; Axilbund, Jennifer E. ; Armstrong, Deborah K. ; Roden, Richard B.S. ; Visvanathan, Kala

Background: This study prospectively examines weight gain in breast cancer survivors compared with cancer-free women from a familial risk cohort. Methods: Absolute and percent weight change over 4 years was compared among 303 breast cancer survivors and 307 cancer-free women matched on age and menopausal status, from the same familial risk cohort. Linear and logistic regression was used to estimate the association between survivor status and weight gain. Results: Overall, breast cancer [...]

Menée en Norvège auprès de 274 patients ayant survécu à un lymphome et ayant reçu une greffe autologue de cellules souches hématopoïétiques, cette étude analyse les facteurs associés à une dysfonction systolique ventriculaire gauche, symptomatique (arrêt cardiaque) ou non

Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study

Murbraech, Klaus ; Smeland, Knut B. ; Holte, Harald ; Loge, Jon Håvard ; Lund, May Brit ; Wethal, Torgeir ; Holte, Espen ; Rösner, Assami ; Dalen, Håvard ; Kvaløy, Stein ; Falk, Ragnhild S. ; Aakhus, Svend ; Kiserud, Cecilie E.

Purpose : We aimed to determine the prevalence of left ventricular systolic dysfunction (LVSD), including symptomatic (ie, heart failure [HF]) and asymptomatic LVSD in adult lymphoma survivors (LSs) after autologous hematopoietic stem-cell transplantation (auto-HCT) and to identify risk factors for LVSD in this population. Patients and Methods : All LSs treated with auto-HCT as adults in Norway from 1987 to 2008 were eligible for this national cross-sectional study. Asymptomatic LVSD was [...]

A partir des données du registre suédois des cancers portant sur 26 938 patients atteints de mélanome cutané, cette étude transversale analyse la distribution anatomique des nævi chez les enfants et des mélanomes cutanés chez les jeunes adultes, en fonction de la latitude du lieu de vie

Similar anatomical distributions of childhood naevi and cutaneous melanoma in young adults residing in northern and southern Sweden

Karlsson, Maria A. ; Rodvall, Ylva ; Wahlgren, Carl-Fredrik ; Wiklund, Kerstin ; Lindelöf, Bernt

Background : Common melanocytic naevi are considered early biomarkers associated with risk of cutaneous malignant melanoma. We sought to investigate if residing at different latitudes in Sweden influences the population’s anatomical distribution of naevi in children and melanoma in adults. Methods : The nationwide Swedish Cancer Registry 1990–2012 gave cumulative number of invasive melanomas per body site, stratified by sex and age in northern (62–69 °N) (n = 2823) and southern (55–58 °N) [...]

A partir de données de 21 études incluant 12 390 patientes atteintes d'un carcinome de l'ovaire, cette étude évalue l'association entre l'indice de masse corporelle au diagnostic, la survie sans progression, la survie spécifique et la survie globale

Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium

Nagle, C. M. ; Dixon, S. C. ; Jensen, A. ; Kjaer, S. K. ; Modugno, F. ; DeFazio, A. ; Fereday, S. ; Hung, J. ; Johnatty, S. E. ; Australian Ovarian Cancer Study, Group ; Fasching, P. A. ; Beckmann, M. W. ; Lambrechts, D. ; Vergote, I. ; Van Nieuwenhuysen, E. ; Lambrechts, S. ; Risch, H. A. ; Rossing, M. A. ; Doherty, J. A. ; Wicklund, K. G. ; Chang-Claude, J. ; Goodman, M. T. ; Ness, R. B. ; Moysich, K. ; Heitz, F. ; du Bois, A. ; Harter, P. ; Schwaab, I. ; Matsuo, K. ; Hosono, S. ; Goode, E. L. ; Vierkant, R. A. ; Larson, M. C. ; Fridley, B. L. ; Hogdall, C. ; Schildkraut, J. M. ; Weber, R. P. ; Cramer, D. W. ; Terry, K. L. ; Bandera, E. V. ; Paddock, L. ; Rodriguez-Rodriguez, L. ; Wentzensen, N. ; Yang, H. P. ; Brinton, L. A. ; Lissowska, J. ; Hogdall, E. ; Lundvall, L. ; Whittemore, A. ; McGuire, V. ; Sieh, W. ; Rothstein, J. ; Sutphen, R. ; Anton-Culver, H. ; Ziogas, A. ; Pearce, C. L. ; Wu, A. H. ; Webb, P. M.

Background: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among [...]

A partir d'une revue systématique de la littérature (46 études), cette étude analyse les facteurs associés aux disparités socioéconomiques dans la survie des patients atteints d'un cancer de la prostate

Socioeconomic inequalities in prostate cancer survival: a review of the evidence and explanatory factors

Klein, Jens ; Knesebeck, Olaf von dem

Although survival rates after prostate cancer diagnosis have improved in the past two decades, survival analyses regarding the socioeconomic status (SES) suggest inequalities indicating worse prognosis for lower SES groups. An overview of the current literature is lacking and moreover, there is an ongoing discussion about the underlying causes but evidence is comparatively sparse. Several patient, disease and health care related factors are discussed to have an important impact on disparities [...]

A partir des données des registres néerlandais des cancers portant sur 37 056 patients (dont 1 102 âgés de moins de 40 ans), cette étude analyse la survie de patients atteints d'un cancer du rectum, en fonction de leur âge, du stade de la maladie et des caractéristiques de la tumeur

Comparable survival for young rectal cancer patients, despite unfavourable morphology and more advanced-stage disease

Orsini, Ricardo G. ; Verhoeven, Rob H. A. ; Lemmens, Valery E. P. P. ; van Steenbergen, Liza N. ; de Hingh, Ignace H. J. T. ; Nieuwenhuijzen, Grard A. P. ; Rutten, Harm J. T.

Background : Young patients with rectal cancer tend to present with more advanced-stage disease and unfavourable tumour morphology. The effects of these tumour characteristics on survival in this particular patient group are unclear. Methods : Population-based data from the Netherlands Cancer Registry (NCR) were used. Data from patients diagnosed with rectal cancer between 1989 and 2010 were selected. Younger patients (⩽40 years) were compared with middle-aged patients (41–70 years) with [...]

Menée aux Etats-Unis, cette étude analyse les disparités géographiques dans l'incidence du cancer colorectal et la mortalité, en prenant en compte les facteurs de risque et le recours au dépistage

State disparities in colorectal cancer rates: Contributions of risk factors, screening, and survival differences

Lansdorp-Vogelaar, Iris ; Goede, S. Lucas ; Ma, Jiemin ; Xiau-Cheng, Wu ; Pawlish, Karen ; van Ballegooijen, Marjolein ; Jemal, Ahmedin

BACKGROUND Northeastern states of the United States have shown more progress in reducing colorectal cancer (CRC) incidence and mortality rates than Southern states, and this has resulted in considerable disparities. This study quantified how the disparities in CRC rates between Louisiana (a Southern state) and New Jersey (a Northeastern state) would be affected if differences in risk factors, screening, and stage-specific CRC relative survival between the states were eliminated. METHODS This [...]

A partir des données de l'essai randomisé "PHARE" de phase III incluant 3 380 patientes atteintes d'un cancer du sein, cette étude analyse la survenue d'événements cardiaques indésirables associés à un traitement adjuvant par trastuzumab, dispensé pendant 6 ou 12 mois

Cardiac toxicity events in the PHARE trial, an adjuvant trastuzumab randomised phase III study

Pivot, Xavier ; Suter, Thomas ; Nabholtz, Jean Marc ; Pierga, Jean Yves ; Espié, Marc ; Lortholary, Alain ; Khayat, David ; Pauporté, Iris ; Romieu, Gilles ; Kramar, Andrew ; Fumoleau, Pierre

Background : This article reports the cardiac toxicity according to 6- versus 12-month durations of adjuvant trastuzumab in PHARE randomised trial (NCT00381901). Patients and methods : Cardiac follow-up and Left Ventricular Ejection Fraction (LVEF) assessment by echocardiography or multigated acquisition scan were performed every 3 months while patients received trastuzumab and after completion of treatment over the first 2 years and every 6 months afterwards. The primary cardiac end-point was [...]

Menée à partir de données portant sur 2 833 patientes atteintes d'un cancer invasif du sein, cette étude évalue l'effet d'un diabète préexistant sur le pronostic de la maladie

Pre-existing diabetes and breast cancer prognosis among elderly women

Luo, J. ; Hendryx, M. ; Virnig, B. ; Wen, S. ; Chlebowski, R. ; Chen, C. ; Rohan, T. ; Tinker, L. ; Wactawski-Wende, J. ; Lessin, L. ; Margolis, K. L.

Background : The objective of this study was to assess the impact of pre-existing diabetes on breast cancer prognosis. Methods : Women (n=2833) with centrally confirmed invasive breast cancer in the Women’s Health Initiative, who were linked to Medicare claims data (CMS) were followed from the date of breast cancer diagnosis to date of death or 20 September 2013. Information on diabetes was identified through the CMS Chronic Condition Warehouse algorithm. Cox proportional hazard regression was [...]

Menée en Corée auprès de 299 aidants familiaux de patients atteints d'un cancer en phase terminale et traités dans des unités de soins palliatifs, cette étude transversale analyse les facteurs associés à leur détresse émotionnelle et leur qualité de vie

Factors associated with quality of life among family caregivers of terminally ill cancer patients

Choi, Youn Seon ; Hwang, Sun Wook ; Hwang, In Cheol ; Lee, Yong Ju ; Kim, Young Sung ; Kim, Hyo Min ; Youn, Chang Ho ; Ahn, Hong Yup ; Koh, Su-Jin

Objective : Limited research has examined the quality of life (QOL) and its correlates among family caregivers (FCs) during the final stage of terminal cancer. The purpose of this study was to investigate the determinants of overall QOL and its subdomains among Korean FCs at the very end of life. Methods : For this cross-sectional study, we enrolled 299 FCs of terminal cancer patients from seven palliative care units. To assess FCs' QOL and its predictors, we used the Caregiver Quality Of Life [...]

Menée au Royaume-Uni par entretiens auprès de 7 médecins généralistes, cette étude qualitative analyse leurs expériences relatives à la prise en charge de la détresse psychologique des patients atteints de cancer

General practitioners' ‘lived experience’ of assessing psychological distress in cancer patients: an exploratory qualitative study

Carolan, C. M. ; Campbell, K.

While psychological distress in cancer patients is common, little is known about how general practitioners (GPs) assess distress. Using semi-structured interviews, a phenomenological study of seven GPs was conducted to explore GPs' experiences of assessing distress. Findings revealed five themes: (1) Being in the Relay Team – receiving and passing the baton: where the assessment of distress was conceptualised as a relay baton passed between a team of health care professionals, with GPs most [...]

Menée aux Etats-Unis auprès de 366 aidants familiaux de patients atteints d'un cancer du poumon non à petites cellules de stade I à IV, cette étude prospective analyse l'efficacité d'une intervention multidisciplinaire pour soulager leur détresse psychologique et leur qualité de vie

Effectiveness of an interdisciplinary palliative care intervention for family caregivers in lung cancer

Sun, Virginia ; Grant, Marcia ; Koczywas, Marianna ; Freeman, Bonnie ; Zachariah, Finly ; Fujinami, Rebecca ; Ferraro, Catherine Del ; Uman, Gwen ; Ferrell, Betty

BACKGROUND Family caregivers (FCGs) experience significant deteriorations in quality of life while caring for patients with lung cancer. In this study, the authors tested the effectiveness of an interdisciplinary palliative care intervention for FCGs of patients diagnosed with stage I through IV nonsmall cell lung cancer. METHODS FCGs who were identified by patients as their primary caregivers were enrolled in a prospective, quasi-experimental study in which the usual care group was accrued [...]

Mené auprès de 150 patientes atteintes d'un cancer du sein, cet essai multicentrique randomisé évalue l'efficacité d'une intervention en ligne pour les aider à prendre en charge leurs difficultés psychologiques et réduire leur détresse émotionnnelle après les traitements

BREATH: Web-Based Self-Management for Psychological Adjustment After Primary Breast Cancer—Results of a Multicenter Randomized Controlled Trial

van den Berg, Sanne W. ; Gielissen, Marieke F.M. ; Custers, José A.E. ; van der Graaf, Winette T.A. ; Ottevanger, Petronella B. ; Prins, Judith B.

Purpose : Early breast cancer survivors (BCSs) report high unmet care needs, and easily accessible care is not routinely available for this growing population. The Breast Cancer E-Health (BREATH) trial is a Web-based self-management intervention to support the psychological adjustment of women after primary treatment, by reducing distress and improving empowerment. Patients and Methods : This multicenter, randomized, controlled, parallel-group trial evaluated whether care as usual (CAU) plus [...]

Menée au Danemark par questionnaire auprès de 1 889 patientes ayant survécu à un cancer du sein (durée de suivi : 7-9 ans après une chirurgie), cette étude de cohorte analyse les effets des thérapies systémiques adjuvantes sur leurs capacités cognitives

Long-term subjective cognitive functioning following adjuvant systemic treatment: 7-9 years follow-up of a nationwide cohort of women treated for primary breast cancer

Amidi, A. ; Christensen, S. ; Mehlsen, M. ; Jensen, A. B. ; Pedersen, A. D. ; Zachariae, R.

Background: There is growing concern among breast cancer (BC) patients and survivors about cognitive impairment following systemic treatments. The aim of the present study was to investigate the long-term effects of standard systemic adjuvant therapies on subjective cognitive impairment (SCI) in a large nationwide cohort of BC survivors 7–9 years after primary surgery. Methods: Participants were recruited from the nationwide Psychosocial Factors and Breast Cancer inception cohort of Danish [...]

Menée en Suisse auprès de 71 patients atteints d'un cancer de la thyroïde et de 40 partenaires de vie, cette étude analyse leurs perceptions relatives à l'impact du diagnostic et des traitements sur leur détresse psychologique (anxiété, dépression) et leur fatigue

Perception of treatment burden, psychological distress, and fatigue in thyroid cancer patients and their partners – effects of gender, role, and time since diagnosis

Drabe, Natalie ; Steinert, Hans ; Moergeli, Hanspeter ; Weidt, Steffi ; Strobel, Klaus ; Jenewein, Josef

Objectives : The aim of this study was to examine diagnosis and treatment burden as well as psychological distress (anxiety and depression) and fatigue in thyroid cancer patients and their partners, focusing on the effects of gender, role, and time since diagnosis. Methods : Seventy-one patients diagnosed and treated for differentiated thyroid cancer within the past 7 years, participated in this online study, as well as 40 partners. Standardized questionnaires were used rating anxiety, [...]

Menée en Irlande par questionnaire auprès de 700 patients ayant survécu à un cancer du sein ou de la prostate, cette étude analyse les facteurs associés à des difficultés financières liées à la maladie

Pre-diagnosis employment status and financial circumstances predict cancer-related financial stress and strain among breast and prostate cancer survivors

Sharp, Linda ; Timmons, Aileen

Purpose : Cancer may have a significant financial impact on patients, but the characteristics that predispose patients to cancer-related financial hardship are poorly understood. We investigated factors associated with cancer-related financial stress and strain in breast and prostate cancer survivors in Ireland, which has a complex mixed public-private healthcare system. Methods : Postal questionnaires were distributed to 1373 people diagnosed with cancer 3–24 months previously identified from [...]

Cette étude analyse le rapport coût-efficacité, en fonction de l'âge et du sexe de l'individu, de la recherche des mutations du gène PTEN, facteurs de risque de cancer, chez des patients atteints d'un syndrome de Cowden

Detecting Germline PTEN Mutations Among at-Risk Patients With Cancer: An Age- and Sex-Specific Cost-Effectiveness Analysis

Ngeow, Joanne ; Liu, Chang ; Zhou, Ke ; Frick, Kevin D. ; Matchar, David B. ; Eng, Charis

Purpose : Cowden syndrome (CS) is an autosomal dominant disorder characterized by benign and malignant tumors. One-quarter of patients who are diagnosed with CS have pathogenic germline PTEN mutations, which increase the risk of the development of breast, thyroid, uterine, renal, and other cancers. PTEN testing and regular, intensive cancer surveillance allow for early detection and treatment of these cancers for mutation-positive patients and their relatives. Individual CS-related features, [...]

Mené aux Etats-Unis auprès de 72 patients atteints d'un cancer de stade avancé et recevant des soins palliatifs, cet essai randomisé évalue l'efficacité de la mélatonine pour diminuer leurs symptômes de fatigue physique

Effects of melatonin on physical fatigue and other symptoms in patients with advanced cancer receiving palliative care: A double-blind placebo-controlled crossover trial

Lund Rasmussen, Charlotte ; Klee Olsen, Marc ; Thit Johnsen, Anna ; Aagaard Petersen, Morten ; Lindholm, Helena ; Andersen, Line ; Villadsen, Birgit ; Groenvold, Mogens ; Pedersen, Lise

BACKGROUND Patients with advanced cancer often experience fatigue and other symptoms that negatively impact their quality of life. The current trial investigated the effect of melatonin on fatigue and other symptoms in patients with advanced cancer. METHODS Patients who were aged ≥18 years, had a histologically confirmed stage IV cancer (TNM Classification), and who reported feeling significantly tired were recruited from the palliative care unit at the study institution. The study was a [...]

Menée en Suède par questionnaire auprès de 485 patients atteints de cancer et traités dans des unités de soins palliatifs, cette étude identifie les facteurs associés au risque de constipation

Constipation in specialized palliative care: factors related to constipation when applying different definitions

Erichsén, E. ; Milberg, A. ; Jaarsma, T. ; Friedrichsen, M.

Context : For patients in palliative care, constipation is primarily a result of opioid treatment. Impacts from other factors related to constipation in palliative care are rarely studied. Objectives : The aim was to identify factors related to constipation in patients in palliative care, and then to compare these factors between patients with different types of constipation and patients without constipation. Methods : Cross-sectional data on constipation was collected with a 26-item [...]

Menée à Taïwan auprès de 574 patients atteints d'un cancer de stade avancé, cette étude prospective multicentrique évalue l'association entre des facteurs liés à l'autonomie du patient (degré de conscience, soutien psychologique, communication, etc) et la qualité de prise en charge de son décès

Cancer patient autonomy and quality of dying–a prospective nationwide survey in Taiwan

Cheng, Shao-Yi ; Lin, Wen-Yuan ; Cheng, Ya-Hui ; Huang, Chien Hsiun ; Chen, Ching-Yu ; Hwang, Shinn-Jang ; Tsai, Shih-Tzu ; Chiu, Tai-Yuan

Background : Patient autonomy is an essential factor in the measurement of quality of dying. We aimed to conduct a study to investigate the factors affecting the autonomy of advanced cancer patients in Taiwan. Methods : We conducted a prospective, multicenter study and recruited 574 advanced cancer patients from four inpatient hospice wards in Taiwan; their quality of dying was measured using the validated good death scale and the audit scale. Physician-assessed autonomy and the other scales [...]