A partir des données de la cohorte européenne EPIC incluant 334 850 femmes âgées de 35 à 70 ans, cette étude prospective évalue l'association entre une consommation d'alcool et le risque de cancer du sein (11 576 cas)

Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

Romieu, Isabelle ; Scoccianti, Chiara ; Chajès, Veronique ; de Batlle, Jordi ; Biessy, Carine ; Dossus, Laure ; Baglietto, Laura ; Clavel-Chapelon, Françoise ; Overvad, Kim ; Olsen, Anja ; Tjønneland, Anne ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Vineis, Paolo ; Panico, Salvatore ; Bueno-de-Mesquita, H. Bas ; van Gils, Carla H. ; Peeters, Petra H. ; Lund, Eiliv ; Skeie, Guri ; Weiderpass, Elisabete ; Quiros Garcia, Jose Ramon ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Sánchez, María-José ; Duell, Eric J. ; Amiano, Pilar ; Borgquist, Signe ; Wirfalt, Elisabet ; Hallmans, Göran ; Johansson, Ingegerd ; Nilsson, Lena Maria ; Khaw, Kay-Tee ; Wareham, Nick ; Key, Timothy J. ; Travis, Ruth C. ; Murphy, Neil ; Wark, Petra A. ; Ferrari, Pietro ; Riboli, Elio

Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35–70 years at baseline, were recruited in [...]

Menée aux Etats-Unis auprès de 435 cas et 563 témoins, cette étude évalue l'association entre divers régimes alimentaires et le risque de lymphome hodgkinien

Dietary Pattern and Risk of Hodgkin Lymphoma in a Population-Based Case-Control Study

Epstein, Mara M. ; Chang, Ellen T. ; Zhang, Yawei ; Fung, Teresa T. ; Batista, Julie L. ; Ambinder, Richard F. ; Zheng, Tongzhang ; Mueller, Nancy E. ; Birmann, Brenda M.

Classic Hodgkin lymphoma (cHL) has few known modifiable risk factors, and the relationship between diet and cHL risk is unclear. We performed the first investigation of an association between dietary pattern and cHL risk in 435 cHL cases and 563 population-based controls from Massachusetts and Connecticut (1997–2000) who completed baseline diet questionnaires. We identified 4 major dietary patterns (“vegetable,” “high meat,” “fruit/low-fat dairy,” “desserts/sweets”) using principal components [...]

A partir des données de la cohorte française "Supplémentation en Vitamines et Minéraux Antioxydants" incluant 5 880 participants, cette étude évalue l'association entre une consommation alimentaire de folates et le risque total de cancer de la peau, le risque de cancer de la peau hors mélanome et le risque de carcinome basocellulaire

Prospective association between dietary folate intake and skin cancer risk: results from the Supplémentation en Vitamines et Minéraux Antioxydants cohort

Donnenfeld, Mathilde ; Deschasaux, Mélanie ; Latino-Martel, Paule ; Diallo, Abou ; Galan, Pilar ; Hercberg, Serge ; Ezzedine, Khaled ; Touvier, Mathilde

Background: The role of folate in skin carcinogenesis is unclear, with experimental data suggesting potentially protective but also deleterious effects. Objective: Our main objective was to investigate the prospective association between dietary folate intake and risks of skin cancer (overall), nonmelanoma skin cancer (NMSC), and basal cell carcinoma (BCC). As an exploratory analysis, we also investigated the prospective association between the erythrocyte folate concentration and skin cancer [...]

A partir des données de la cohorte "Women’s Health Initiative" incluant 87 602 femmes ménopausées, cette étude prospective évalue l'association entre une consommation de polyamines d'origine alimentaire, le risque de cancer colorectal et la mortalité spécifique

Dietary polyamine intake and colorectal cancer risk in postmenopausal women

Vargas, Ashley J ; Ashbeck, Erin L ; Wertheim, Betsy C ; Wallace, Robert A ; Neuhouser, Marian L ; Thomson, Cynthia A ; Thompson, Patricia A

Background: Putrescine, spermidine, and spermine (i.e., polyamines) are small cationic amines synthesized by cells or acquired from the diet or gut bacteria. Polyamines are required for both normal and colorectal cancer (CRC) cell growth. Objective: We investigated the association between dietary polyamines and risk of CRC incidence and mortality. Design: The study was a prospective analysis in 87,602 postmenopausal women in the Women’s Health Initiative Observational Study. Multivariate Cox [...]

A partir des données de la cohorte "Agricultural Health Study" incluant 30 003 femmes, cette étude prospective évalue l'association entre une exposition à des pesticides organophosphorés et le risque de cancer (718 cas)

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

Lerro, Catherine C ; Koutros, Stella ; Andreotti, Gabriella ; Friesen, Melissa C ; Alavanja, Michael C ; Blair, Aaron ; Hoppin, Jane A ; Sandler, Dale P ; Lubin, Jay H ; Ma, Xiaomei ; Zhang, Yawei ; Beane Freeman, Laura E

Objectives : Organophosphates (OPs) are among the most commonly used insecticides. OPs have been linked to cancer risk in some epidemiological studies, which have been largely conducted in predominantly male populations. We evaluated personal use of specific OPs and cancer incidence among female spouses of pesticide applicators in the prospective Agricultural Health Study cohort. Methods : At enrolment (1993–1997), spouses provided information about ever use of specific pesticides, including 10 [...]

Cet article présente la quatrième édition de l'"European Code against Cancer" sur l'association entre des expositions, environnementales ou professionnelles, à des polluants atmosphériques et le risque de cancer

European Code against Cancer 4th edition: Environment, occupation and cancer

Espina, Carolina ; Straif, Kurt ; Friis, Søren ; Kogevinas, Manolis ; Saracci, Rodolfo ; Vainio, Harri ; Schüz, Joachim

People are exposed throughout life to a wide range of environmental and occupational pollutants from different sources at home, in the workplace or in the general environment – exposures that normally cannot be directly controlled by the individual. Several chemicals, metals, dusts, fibres, and occupations have been established to be causally associated with an increased risk of specific cancers, such as cancers of the lung, skin and urinary bladder, and mesothelioma. Significant amounts of air [...]

Menée en Suède à partir d'échantillons sériques prélévés sur 74 000 mères durant la grossesse et de données des registres de cancer, cette étude évalue l'association entre une infection virale et le risque de leucémie ou de lymphome chez l'enfant (47 cas)

Viremia during pregnancy and risk of childhood leukemia and lymphomas in the offspring: Nested case–control study

Bzhalava, Davit ; Hultin, Emilie ; Arroyo Mühr, Laila Sara ; Ekström, Johanna ; Lehtinen, Matti ; de Villiers, Ethel-Michele ; Dillner, Joakim

A possible role for infections of the pregnant mother in the development of childhood acute leukemias and lymphomas has been suggested. However, no specific infectious agent has been identified. Offspring of 74,000 mothers who had serum samples taken during pregnancy and stored in a large-scale biobank were followed up to the age of 15 years (750,000 person years) through over-generation linkages between the biobank files, the Swedish national population and cancer registers to identify [...]

Menée à Taïwan à partir de données portant sur 55 318 patientes atteintes d'un cancer du sein (dont 28 187 ayant reçu une radiothérapie), cette étude de cohorte évalue l'association entre la radiothérapie et le risque subséquent de cancer de la thyroïde

Radiotherapy did not increase thyroid cancer risk among women with breast cancer: A nationwide population-based cohort study

Sun, Li-Min ; Lin, Cheng-Li ; Liang, Ji-An ; Huang, Wen-Sheng ; Kao, Chia-Hung

The aim of this study was to evaluate whether an increased risk of thyroid cancer exists among women with breast cancer in Taiwan, particularly among those receiving RT. We used data from the National Health Insurance system of Taiwan for the investigation. The breast cancer cohort contained 55,318 women (including 28,187 who received RT and 27,131 who received no RT), each of whom was randomly frequency matched according to age and index year with three women without breast cancer from the [...]

A partir des données de registres australiens, néo-zélandais, canadiens et américains portant sur 369 familles ayant au moins une personne porteuse d'une mutation d'un gène du système de réparation des mésappariements de l'ADN, cette étude évalue l'association entre un syndrome de Lynch et le risque de cancer du col de l'utérus (65 cas)

Lynch syndrome and cervical cancer

Antill, Yoland C. ; Dowty, James G. ; Win, Aung Ko ; Thompson, Tina ; Walsh, Michael D. ; Cummings, Margaret C. ; Gallinger, steven ; Lindor, Noralane M. ; Le Marchand, Loic ; Hopper, John L. ; Newcomb, Polly A. ; Haile, Robert W. ; Church, James ; Tucker, Katherine M. ; Buchanan, Daniel D. ; Young, Joanne P. ; Winship, Ingrid M. ; Jenkins, Mark A.

Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch syndrome). There is no substantial evidence that these mutations are associated with an increased risk of cervical cancer. A total of 369 families with at least one carrier of a mutation in a MMR gene (133 MLH1, 174 MSH2, 35 MSH6 and 27 PMS2) were ascertained via population cancer registries or via family cancer clinics in Australia, New [...]