Menée à Taïwan auprès de 172 aidants familiaux de patients atteints d'un cancer de stade avancé, cette étude transversale analyse les facteurs associés à des troubles du sommeil

Sleep disturbances and related factors among family caregivers of patients with advanced cancer

Lee, Kwo-Chen ; Yiin, Jia-Jean ; Lin, Pi-Chu ; Lu, Shu-Hua

Objective : Sleep disturbances among family caregivers (FCs) are common in advanced cancer. The comprehensive factors for sleep disturbances among the FCs of patients with cancer have not been investigated in Taiwan. The purposes of this study were to investigate the sleep disturbances among the FCs of patients with advanced cancer and to determine predictors of sleep disturbance. Methods : A descriptive, cross-sectional study was conducted among 172 FCs. Data were collected using the [...]

Menée aux Etats-Unis à partir des dossiers médicaux de 58 patients pédiatriques ayant survécu à des tumeurs solides et n'ayant pas reçu de traitement affectant le système nerveux central, cette étude analyse les facteurs associés à leurs difficultés scolaires et cognitives

Neurocognitive Outcomes and School Performance in Solid Tumor Cancer Survivors Lacking Therapy to the Central Nervous System

Caroline Mohrmann ; Jennifer Henry ; Marnie Hauff ; Robert J. Hayashi

School performance in patients who have received therapy for childhood cancers has been studied in depth. Risk factors have historically included cranial radiation, intrathecal chemotherapy, and high doses of chemotherapy, including methotrexate and cytarabine. Leukemia and brain tumor survivors who receive such therapy have been the primary focus of this area of investigation. Extracranial solid tumor cancer patients lacking such risk factors have historically been expected to have normal [...]

A partir des données des registres américains des cancers, cette étude analyse les disparités de survie des patients âgés de 15 à 64 ans et atteints d'un lymphome non hodgkinien en fonction de leur couverture médicale, sur la période 2007-2011

Survival Disparities by Insurance Type for Patients Aged 15–64 Years With Non-Hodgkin Lymphoma

Pulte, Dianne ; Jansen, Lina ; Brenner, Hermann

Background. New treatment options and supportive care measures have greatly improved survival of patients with non-Hodgkin lymphoma (NHL) but may not be affordable for those with no insurance or inadequate insurance. Methods. Using data from the Surveillance, Epidemiology, and End Results database, we estimated overall and cause-specific survival according to insurance status within 3 years after diagnosis of patients diagnosed with NHL in the U.S. in the period 2007–2011. Because NHL is a [...]

Menée aux Etats-Unis à partir des données d'un registre des cancers portant sur 6 203 patients atteints d'un cancer localisé de la prostate diagnostiqué entre 2004 et 2011, cette étude analyse l'évolution des stratégies thérapeutiques

Trends in initial management of prostate cancer in New Hampshire

Ingimarsson, JohannP ; Celaya, MariaO ; Laviolette, Michael ; Rees, JudyR ; Hyams, EliasS

Purpose : Prostate cancer management strategies are evolving with increased understanding of the disease. Specifically, there is emerging evidence that “low-risk” cancer is best treated with observation, while localized “high-risk” cancer requires aggressive curative therapy. In this study, we evaluated trends in management of prostate cancer in New Hampshire to determine adherence to evidence-based practice. Methods : From the New Hampshire State Cancer Registry, cases of clinically localized [...]

A partir des données d'une cohorte multi-ethnique incluant 4 834 cas et 1 363 témoins, cette étude évalue l'association entre des allergies atopiques (asthme, rhume des foins) et le risque de cancer colorectal, en fonction de l'origine ethnique

Atopic Allergic Conditions and Colorectal Cancer Risk in the Multiethnic Cohort Study

Tambe, Neal A. ; Wilkens, Lynne R. ; Wan, Peggy ; Stram, Daniel O. ; Gilliland, Frank ; Park, S. Lani ; Cozen, Wendy ; Martinez-Maza, Otoniel ; Le Marchand, Loic ; Henderson, Brian E. ; Haiman, Christopher A.

Studies have provided evidence of an inverse association between atopic allergic conditions (AACs) and invasive colorectal cancer (CRC) incidence and mortality in predominantly white populations. We examined the association between AACs (asthma, hay fever, or allergy) and CRC among white, African-American, Native Hawaiian, Japanese-American, and Latino men and women in the Multiethnic Cohort Study within Hawaii and Los Angeles, California. The prospective analysis included 4,834 incident CRC [...]

A partir des données de plusieurs registres américains et asiatiques (Chine, Hong Kong, Corée, Taïwan, Singapour), cette étude analyse l'évolution de l'incidence du cancer du sein sur la période 1988-2009

Female Breast Cancer Incidence Among Asian and Western Populations: More Similar Than Expected

Sung, Hyuna ; Rosenberg, Philip S. ; Chen, Wan-Qing ; Hartman, Mikael ; Lim, Wei-Yen ; Chia, Kee Seng ; Wai-Kong Mang, Oscar ; Chiang, Chun-Ju ; Kang, Daehee ; Ngan, Roger Kai-Cheong ; Tse, Lap Ah ; Anderson, William F. ; Yang, Xiaohong R.

Background: Previous reports suggested that female breast cancer is associated with earlier ages at onset among Asian than Western populations. However, most studies utilized cross-sectional analyses that may be confounded by calendar-period and/or birth cohort effects. We, therefore, considered a longitudinal (forward-looking) approach adjusted for calendar-period changes and conditioned upon birth cohort. Methods: Invasive female breast cancer data (1988–2009) were obtained from cancer [...]

Cette étude américaine passe en revue les divers facteurs associés aux disparités ethniques dans la survie, qu'il s'agisse de facteurs biologiques, génomiques, liés au dépistage ou à l'accès aux soins, chez des patientes atteintes d'un cancer du sein

A perfect storm: How tumor biology, genomics, and health care delivery patterns collide to create a racial survival disparity in breast cancer and proposed interventions for change

Daly, Bobby ; Olopade, Olufunmilayo I.

It is well known that there is a significant racial divide in breast cancer incidence and mortality rates. African American women are less likely to be diagnosed with breast cancer than white women but are more likely to die from it. This review explores the factors that may contribute to the racial survival disparity. Consideration is paid to what is known about the role of differences in tumor biology, genomics, cancer screening, and quality of cancer care. It is argued that it is the [...]

Menée en Italie par enquête auprès de radiothérapeutes travaillant dans 106 hôpitaux, cette étude analyse leurs pratiques en matière de supplémentation nutritionnelle et de mise en place précoce d'une gastrostomie endoscopique percutanée chez des patients atteints d'un cancer de la tête et du cou

Early percutaneous endoscopic gastrostomy and nutritional supplementation for patients with head and neck cancer: an Italian survey of head and neck radiation oncologists

Trignani, Marianna ; Di Pilla, Angelo ; Taraborrelli, Maria ; Perrotti, Francesca ; Caponigro, Giusy ; Santarelli, Giuseppe ; Campitelli, Giulio ; Croce, Adelchi ; De Nicola, Marta ; Genovesi, Domenico

Purpose : The aim of this paper is to survey among Italian radiation oncologists about the role of nutritional supplementation and an early placement of endoscopic percutaneous gastrostomy in head and neck cancer patients treated with radiotherapy or chemo-radiotherapy. Methods : The survey was carried out in 106 Italian centers of radiation oncology through a SurveyMonkey online interface questionnaire. Results : The response rate to the survey was of 63 %, with 67 analyzable questionnaires. [...]

A partir d'une revue systématique de la littérature (16 essais randomisés), cette méta-analyse évalue l'efficacité d'interventions basées sur "l'écriture expressive" pour améliorer la santé physique et psychologique de patients atteints de cancer

The effect of expressive writing intervention on psychological and physical health outcomes in cancer patients—a systematic review and meta-analysis

Zachariae, Robert ; O'Toole, Mia S.

Objective : This study aimed to evaluate the effectiveness of expressive writing intervention (EWI) for improving psychological and physical health in cancer patients and survivors. Methods : We searched databases and existing reviews for randomized controlled studies published between 1986 and 2014 that evaluated the effects of EWI on psychological and physical health outcomes. We computed and combined effect sizes and examined the role of methodological characteristics. Results : From 223 [...]

Menée au Royaume-Uni par entretiens auprès de 25 patients ayant survécu à un mélanome de l'uvée (de 6 à 60 mois après leur traitement), cette étude qualitative analyse la façon dont ils gèrent les incertitudes liées au pronostic de la maladie suite à la diffusion d'information

How do patients with uveal melanoma experience and manage uncertainty? A qualitative study

Hope-Stone, Laura ; Brown, Stephen L. ; Heimann, Heinrich ; Damato, Bertil ; Salmon, Peter

Objectives : Cancer survivors experience uncertainty about the future, which can be distressing. A prognostication tool is available for uveal melanoma survivors, which can provide accurate estimates of life expectancy – a key source of uncertainty. Accurate prognostic information has not previously been available for healthy cancer survivors. The aims of this study were to identify how patients experience prognostic information and how it affects their experience of uncertainty. Methods : [...]

Menée au Royaume-Uni par questionnaire auprès de 95 hommes avec des antécédents familiaux de cancer de la prostate, cette étude analyse leur état psychologique après avoir subi un examen de dépistage et un test génétique

The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer

Bancroft, Elizabeth K. ; Castro, Elena ; Bancroft, Gordon A. ; Ardern-Jones, Audrey ; Moynihan, Clare ; Page, Elizabeth ; Taylor, Natalie ; Eeles, Rosalind A. ; Rowley, Emma ; Cox, Karen

Background : The ability to identify men at genetically high-risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa-specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic-risk profiling, within a research study. Methods : A prospective exploratory approach was adopted, incorporating a sequential mixed-method design. [...]

Cette étude américaine analyse les coûts des traitements restant à charge du patient et évalue l'impact de ces difficultés financières sur leur adhésion aux traitements et sur leur qualité de vie

Addressing the financial burden of cancer treatment: From copay to can’t pay

Shankaran, V. ; Ramsey, S.

Patients with cancer spend a substantial amount of money on health care services and are at higher risk for financial hardship, including personal bankruptcy, than the general population.1 Evidence that this so-called financial toxicity has a negative impact on clinical outcomes is emerging. High out-of-pocket spending on cancer treatment has been shown in recent studies to be associated with decreased treatment adherence and poorer quality of life.2- 4 The growing intersection between the [...]

Menée aux Etats-Unis par questionnaire auprès de 8 parents d'un enfant atteint de cancer, cette étude analyse l'efficacité d'un support d'information pour améliorer la communication avec le médecin et leur compréhension des enjeux associés à l'inclusion de leur enfant dans un essai clinique de phase I

Practical communication guidance to improve phase 1 informed consent conversations and decision-making in pediatric oncology

Johnson, Liza-Marie ; Leek, Angela C. ; Drotar, Dennis ; Noll, Robert B. ; Rheingold, Susan R. ; Kodish, Eric D. ; Baker, Justin N.

BACKGROUND It can be difficult to explain pediatric phase 1 oncology trials to families of children with refractory cancer. Parents may misunderstand the information presented to them, and physicians may assume that certain topics are covered in the informed consent document and need not be discussed. Communication models can help to ensure effective discussions. METHODS Suggestions for improving the informed consent process were first solicited from phase 1 study clinicians via questionnaire. [...]

Menée en Italie par questionnaires auprès de 54 patients atteints de cancer, cette étude analyse l'efficacité d'un outil pour aider les jeunes patients à prendre des décisions en matière de préservation de la fertilité et de tests génétiques

Difficult choices for young patients with cancer: the supportive role of decisional counseling

Chiavari, Leonora ; Gandini, Sara ; Feroce, Irene ; Guerrieri-Gonzaga, Aliana ; Russell-Edu, William ; Bonanni, Bernardo ; Peccatori, FedroAlessandro

Purpose : The aim of patient decisional support interventions is to promote shared decision making. Many of these interventions are comprehensive of information and guidance. In this pilot study, we evaluate the effects of a decision-making support (decision counseling (DeCo)) on decision making, decisional conflict, and anxiety in cancer patients facing with values-based decisions on fertility and procreation or genetic testing and risk reduction options in oncology. Methods : DeCo was [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (13 essais randomisés), cette étude analyse l'efficacité d'outils destinés à améliorer les connaissances du public sur le dépistage du cancer de la prostate par dosage du PSA et les aider dans leur décision d'y recourir

Assessing the effectiveness of decision aids for decision making in prostate cancer testing: a systematic review

Ilic, Dragan ; Jammal, Walid ; Chiarelli, Pauline ; Gardiner, Robert A. ; Hughes, Suzanne ; Stefanovic, Dana ; Chambers, Suzanne K.

Background : Prostate cancer is a leading disease affecting men worldwide. Conflicting evidence within the literature provides little guidance to men contemplating whether or not to be screened for prostate cancer. This systematic review aimed to determine whether decision aids about early detection of prostate cancer improve patient knowledge and decision making about whether to undergo prostate-specific antigen testing. Methods : Medline, EMBASE, CINAHL, PsychINFO, Cochrane Database of [...]

A partir d'une revue systématique de la littérature (26 études), cette méta-analyse fait le point sur l'utilisation et l'efficacité de médecines complémentaires ou alternatives pour améliorer la qualité de vie de patients atteints de cancer et ayant reçu une greffe de cellules souches hématopoïétiques

A perspective on complementary/alternative medicine use among survivors of hematopoietic stem cell transplant: Benefits and uncertainties

Chakraborty, Rajshekhar ; Savani, Bipin N. ; Litzow, Mark ; Mohty, Mohamad ; Hashmi, Shahrukh

The widespread use of complementary and alternative medicine (CAM) in cancer survivors is well known despite a paucity of scientific evidence to support its use. The number of survivors of hematopoietic stem cell transplant (HCT) is growing rapidly and HCT clinicians are aware that many of their patients use CAM therapies consistently. However, due to a paucity of data regarding the benefits and harms of CAM therapies in these survivors, clinicians are reluctant to provide specific [...]

Menée au Royaume-Uni auprès de patients âgés de plus de 70 ans et inclus dans deux cohortes disctinctes, cette étude évalue l'efficacité d'interventions menées par le médecin gériatre pour la prise en charge globale du patient afin d'améliorer la tolérance à la chimiothérapie

The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people

Kalsi, T. ; Babic-Illman, G. ; Ross, P. J. ; Maisey, N. R. ; Hughes, S. ; Fields, P. ; Martin, F. C. ; Wang, Y. ; Harari, D.

Background: Although comorbidities are identified in routine oncology practice, intervention plans for the coexisting needs of older people receiving chemotherapy are rarely made. This study evaluates the impact of geriatrician-delivered comprehensive geriatric assessment (CGA) interventions on chemotherapy toxicity and tolerance for older people with cancer. Methods: Comparative study of two cohorts of older patients (aged 70+ years) undergoing chemotherapy in a London Hospital. The [...]