A partir de données de deux études, l'une menée en Italie et l'autre menée en Suisse incluant 1 569 cas et 3 147 témoins, cette étude ré-évalue l'association entre une consommation d'alcool, le tabagisme et le risque de cancers de la tête et du cou en utilisant un modèle mathématique bidimensionnel

Combined effect of tobacco smoking and alcohol drinking in the risk of head and neck cancers: a re-analysis of case–control studies using bi-dimensional spline models

Dal Maso, Luigino ; Torelli, Nicola ; Biancotto, Elisa ; di Maso, Matteo ; Gini, Andrea ; Franchin, Gianni ; Levi, Fabio ; La Vecchia, Carlo ; Serraino, Diego ; Polesel, Jerry

The synergistic effect of tobacco smoking and alcohol consumption on the risk of head and neck cancers has been mainly investigated as a cross-product of categorical exposure, thus leading to loss of information. We propose a bi-dimensional logistic spline model to investigate the interacting dose–response relationship of two continuous exposures (i.e., ethanol intake and tobacco smoking) on the risk of head and neck cancers, representing results through three-dimensional graphs. This model was [...]

Cette étude fait le point sur l'association entre des maladies inflammatoires chroniques de l'intestin, des facteurs liés au mode de vie tels que le tabagisme, l'utilisation de médicaments immunosuppresseurs pour traiter ces inflammations et le risque de cancers

Cancers Complicating Inflammatory Bowel Disease

Beaugerie, Laurent ; Itzkowitz, Steven H.

Crohn’s disease and ulcerative colitis are lifelong inflammatory bowel diseases of unknown origin that generally begin in young adulthood. It is estimated that at least 0.4% of Europeans and North Americans live with inflammatory bowel disease. Life expectancy is reduced in patients with Crohn’s disease and in patients with ulcerative colitis that is diagnosed when colitis is extensive or that is diagnosed in childhood. There are excess deaths from infection, cardiovascular diseases, and [...]

A partir de données de quatre études menées aux Etats-Unis, cette étude analyse les disparités ethniques dans l'association entre des facteurs reproductifs, une endométriose, des antécédents familiaux, une utilisation de talc et le risque de cancer épithélial invasif de l'ovaire

African Americans and Hispanics remain at lower risk of ovarian cancer than non-Hispanic Whites after considering non-genetic risk factors and oophorectomy rates

Wu, Anna H. ; Pearce, Celeste Leigh ; Tseng, Chiu-Chen ; Pike, Malcolm C.

Background: Risk factors for invasive epithelial ovarian cancer (IEOC) among Hispanics and African Americans are under-studied despite notable differences in incidence relative to non-Hispanic Whites. Methods: We used multivariate logistic regression to examine parity, oral contraceptive use, tubal ligation, endometriosis, family history of ovarian cancer, and talc use and risk of IEOC among Hispanics (308 cases, 380 controls), African Americans (128 cases, 143 controls) and non-Hispanic Whites [...]

Menée en Chine auprès de 98 patients et de 2 016 témoins, cette étude évalue l'association entre des polymorphismes du gène MTHFR et le risque de leucémie myéloïde aiguë chez l'adulte

Polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) are associated with susceptibility to adult acute myeloid leukemia in a Chinese population

Huang, Lulu ; Deng, Donghong ; Peng, Zhigang ; Ye, Fanghui ; Xiao, Qiang ; Zhang, Bing ; Ye, Bingbing ; Mo, Zengnan ; Yang, Xiaobo ; Liu, Zhenfang

Background : Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. Since acute myeloid leukemia (AML) is characterized by rapidly proliferating tissues that have a high requirement for DNA synthesis, it is possible that the presence of MTHFR polymorphisms could be linked to the multifactorial process of AML development. Methods : We evaluated the role of MTHFR C677T and A1298C polymorphisms in a case–control study comprising 98 AML patients and 2016 [...]

Menée aux Etats-Unis à partir de 417 cas et 417 témoins, cette étude évalue l'association entre 266 polymorphismes à simple nucléotide de 23 gènes liés à la famille des métalloprotéases matricielles, le risque de cancer de l'ovaire, ainsi que la survie des patientes

Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome

Wang, Yan ; Ye, Yuanqing ; Lin, Jie ; Meyer, Larissa ; Wu, Xifeng ; Lu, Karen ; Liang, Dong

Ovarian cancer is one of the leading female cancers in the United States. Challenges remain in early diagnosis of this deadly disease. Matrix metalloproteinases (MMPs) family genes are paradoxically involved in cancer promotion and suppression. We hypothesize that genetic variants in MMP genes are associated with ovarian cancer development, so they could be potential markers for ovarian cancer diagnosis and prognosis. In this study of 417 ovarian cancer cases and 417 healthy controls, we [...]