Menée aux Etats-Unis auprès de 7 620 patients ayant survécu à un cancer et ayant reçu une greffe de cellules souches hématopoïétiques, cette étude rétrospective analyse le risque de fractures

Increased Incidence of Fractures in Recipients of Hematopoietic Stem-Cell Transplantation

Pundole, Xerxes N. ; Barbo, Andrea G. ; Lin, Heather ; Champlin, Richard E. ; Lu, Huifang

Purpose : The number of long-term survivors after hematopoietic stem-cell transplantation (HSCT) for malignant and nonmalignant disorders is increasing, and late effects are gaining importance. Osteoporosis and fractures can worsen the quality of life of HSCT survivors, but the burden of the disease is unknown. Patients and Methods : We conducted a retrospective study of patients older than age 18 years who underwent an HSCT at The University of Texas MD Anderson Cancer Center from January 1, [...]

Cette étude présente des recommandations américaines et canadiennes pour la détection, l'évaluation et la prise en charge de la fatigue chez des patients atteints de cancer

Screening, evaluation, and management of cancer-related fatigue: Ready for implementation to practice?

Berger, Ann M. ; Mitchell, Sandra A. ; Jacobsen, Paul B. ; Pirl, William F.

Evidence regarding cancer-related fatigue (fatigue) has accumulated sufficiently such that recommendations for screening, evaluation, and/or management have been released recently by 4 leading cancer organizations. These evidence-based fatigue recommendations are available for clinicians, and some have patient versions; but barriers at the patient, clinician, and system levels hinder dissemination and implementation into practice. The underlying biologic mechanisms for this debilitating symptom [...]

Mené au Royaume-Uni auprès de 73 patients atteints d'un mésothéliome pleural malin, cet essai analyse l'impact d'une chimiothérapie par pemetrexed ou par cisplatine/carboplatine sur leur qualité de vie

The effect of chemotherapy on health-related quality of life in mesothelioma: results from the SWAMP trial

Arnold, D. T. ; Hooper, C. E. ; Morley, A. ; White, P. ; Lyburn, I. D. ; Searle, J. ; Darby, M. ; Hall, T. ; Hall, D. ; Rahman, N. M. ; De Winton, E. ; Clive, A. ; Masani, V. ; Dangoor, A. ; Guglani, S. ; Jankowska, P. ; Lowndes, S. A. ; Harvey, J. E. ; Braybrooke, J. P. ; Maskell, N. A.

Background: The effect of chemotherapy on health-related quality of life (HRQoL) in malignant pleural mesothelioma (MPM) is poorly understood. Patient-individualised prognostication and prediction of treatment response from chemotherapy is useful but little evidence exists to guide practice. Method: Consecutive patients with MPM who were fit for first-line chemotherapy with pemetrexed and cisplatin\carboplatin were recruited and followed up for a minimum of 12 months. This study focussed on the [...]

Menée aux Etats-Unis auprès de 243 patientes ayant survécu à un cancer du sein et 109 témoins, cette étude quantitative et qualitative analyse l'association entre leurs expériences de lymphœdème lié au cancer et la qualité de leur vie sexuelle

Breast cancer-related lymphedema and sexual experiences: a mixed-method comparison study

Radina, M. Elise ; Fu, Mei R. ; Horstman, Lori ; Kang, Yang

Objective Up to 40% of breast cancer survivors develop lymphedema, a chronic and sometimes disabling condition that manifests as abnormal swelling of the effected arm or hand or upper chest areas. Although the effects of lymphedema on quality of life have been well established, less well documented are the sexual experiences of breast cancer survivors with lymphedema. This study is the first to compare the sexual experiences of women with (n = 243) and without breast cancer-related lymphedema [...]

Menée aux Etats-Unis par enquête auprès de 861 patientes ayant survécu à un cancer du sein, cette étude évalue l'association entre l'indice de masse corporelle et des troubles du sommeil

Association of obesity and sleep problems among breast cancer survivors: results from a registry-based survey study

Klyushnenkova, ElenaN ; Sorkin, JohnD ; Gallicchio, Lisa

Purpose : Sleep-related complaints are common among breast cancer survivors. However, the risk factors underlying sleep disturbances in this population are not completely understood. Some studies have shown that maintaining normal weight can result in a reduced risk of cancer-related symptoms, including sleep problems; however, data from published studies are not consistent. This study examined the associations between body mass index (BMI) and sleep-related complaints in breast cancer [...]

A partir des données du registre australien des cancers pédiatriques, cette étude analyse les facteurs associés à la survie à long terme de patients âgés de moins de 14 ans et atteints d'un cancer diagnostiqué entre 1983 et 2010, notamment l'âge et le stade de la maladie au diagnostic

Conditional survival estimates for childhood cancer in Australia, 2002–2011: A population-based study

Youlden, Danny R. ; Baade, Peter D. ; Hallahan, Andrew R. ; Valery, Patricia C. ; Green, Adèle C. ; Aitken, Joanne F.

Background : Conditional survival estimates take into account the time that a patient has remained alive following diagnosis to provide a realistic perspective on the probability of longer term survival. Such estimates are scarce for childhood cancer, particularly by age at diagnosis or stage of cancer. Methods : De-identified population-based data were obtained from the Australian Paediatric Cancer Registry for children aged 0–14 years diagnosed with cancer between 1983 and 2010. Mortality [...]

Menée dans cinq pays scandinaves à partir de données portant sur 32 308 patients ayant survécu un an à un cancer diagnostiqué avant l'âge de 20 ans et de données portant sur 211 489 témoins, cette étude de cohorte rétrospective analyse le risque de maladies cardiovasculaires chez des survivants d'un cancer pédiatrique

Cardiovascular disease in Adult Life after Childhood Cancer in Scandinavia: A population-based cohort study of 32,308 one-year survivors

Gudmundsdottir, Thorgerdur ; F. Winther, Jeanette ; de Fine Licht, Sofie ; G. Bonnesen, Trine ; H. Asdahl, Peter ; Tryggvadottir, Laufey ; Anderson, Harald ; Wesenberg, Finn ; Malila, Nea ; Hasle, Henrik ; H. Olsen, Jørgen ; on behalf of the, ALiCCS study group

The lifetime risk for cardiovascular disease in a large cohort of childhood cancer survivors has not been fully assessed. In a retrospective population-based cohort study predicated on comprehensive national health registers, we identified a cohort of 32,308 one-year survivors of cancer diagnosed before the age of 20 in the five Nordic countries between the start of cancer registration in the 1940s and 1950s to 2008; 211,489 population comparison subjects were selected from national population [...]

A partir des données des registres américains des cancers, cette étude analyse l'association entre une maladie de Waldenström (4 676 cas) et le risque de second cancer, sur la période 1992-2011

Incidence of secondary malignancies among patients with Waldenström macroglobulinemia: An analysis of the SEER database

Castillo, Jorge J. ; Olszewski, Adam J. ; Hunter, Zachary R. ; Kanan, Sandra ; Meid, Kirsten ; Treon, Steven P.

BACKGROUND Waldenström macroglobulinemia (WM) is an indolent malignancy that predominantly affects older individuals who are at risk for secondary malignancies (SMs). The objective of this study was to characterize the incidence of SMs after a diagnosis of WM with the Surveillance, Epidemiology, and End Results (SEER) database. METHODS With SEER-13 data (1992-2011), standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated for the rates of solid and hematologic SMs [...]

Menée aux Etats-Unis auprès de 610 patients atteints d'un cancer de la prostate traité par prostatectomie radicale entre 2005 et 2012, cette étude de cohorte évalue l'association entre l'obésité et le risque de récidive de cancer, en fonction des antécédents d'un diabète de type 2

The impact of obesity on prostate cancer recurrence observed after exclusion of diabetics

Agalliu, Ilir ; Williams, Steve ; Adler, Brandon ; Androga, Lagu ; Siev, Michael ; Lin, Juan ; Xue, Xiaonan ; Huang, Gloria ; Strickler, HowardD ; Ghavamian, Reza

Purpose : Although overall there is a positive association between obesity and risk of prostate cancer (PrCa) recurrence, results of individual studies are somewhat inconsistent. We investigated whether the failure to exclude diabetics in prior studies could have increased the likelihood of conflicting results. Methods : A total of 610 PrCa patients who underwent radical prostatectomy between 2005 and 2012 were followed for recurrence, defined as a rise in serum PSA ≥ 0.2 ng/ml following [...]

A partir des données du registre du cancer familial du côlon portant sur 510 individus vivant aux Etats-Unis, au Canada, en Australie et en Nouvele-Zélande, cette étude de cohorte transversale et multicentrique évalue la prévalence de mutations du gène TP53 chez des patients atteints d'un cancer colorectal avant l'âge de 40 ans

Germline TP53 mutations in patients with early-onset colorectal cancer in the colon cancer family registry

Yurgelun, M. B. ; Masciari, S. ; Joshi, V. A. ; et al.,

Importance : Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer. Objective : To examine the frequency of germline TP53 alterations in patients with early-onset colorectal cancer. Design, Setting, and Participants : This was a multicenter cross-sectional cohort study of individuals recruited to the Colon Cancer Family Registry [...]

Menée au Danemark auprès de patientes ayant survécu à un cancer du sein diagnostiqué entre 1994 et 2007, cette étude de cohorte analyse le risque de décès lié à des maladies chroniques

Relative mortality rates from incident chronic diseases among breast cancer survivors – A 14 year follow-up of five-year survivors diagnosed in Denmark between 1994 and 2007

Ording, Anne Gulbech ; Boffetta, Paolo ; Garne, Jens Peter ; Nyström, Petra Mariann Witt ; Cronin-Fenton, Deirdre ; Frøslev, Trine ; Silliman, Rebecca ; Sørensen, Henrik Toft ; Lash, Timothy L.

Background : It remains unknown whether incident chronic diseases are more often fatal among breast cancer survivors than among women free of breast cancer. Methods : We conducted a nationwide matched cohort study of all Danish breast cancer patients diagnosed between 1994 and 2007, who survived for five years. We compared their long-term mortality with five times as many women from the general population without breast cancer, matched on age. We used time-varying methods to compute mortality [...]

Menée en Italie auprès de 801 patients atteints d'un cancer de la tête et du cou, cette étude multicentrique analyse les caractéristiques démographiques ou liées au mode de vie (consommation d'alcool, tabagisme) associées à la survie globale, au risque de récidive et au risque de second cancer primitif

Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study

Leoncini, Emanuele ; Vukovic, Vladimir ; Cadoni, Gabriella ; Pastorino, Roberta ; Arzani, Dario ; Bosetti, Cristina ; Canova, Cristina ; Garavello, Werner ; La Vecchia, Carlo ; Maule, Milena ; Petrelli, Livia ; Pira, Enrico ; Polesel, Jerry ; Richiardi, Lorenzo ; Serraino, Diego ; Simonato, Lorenzo ; Ricciardi, Walter ; Boccia, Stefania

Background : The purpose of this study is to evaluate whether demographics, lifestyle habits, clinical data and alcohol dehydrogenase polymorphisms rs1229984 and rs1573496 associated with first primary head and neck (HNC) are associated with overall survival, recurrence, and second primary cancer (SPC). Methods : We conducted a follow-up study in five centres including 801 cases. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for overall survival, recurrence and SPC. [...]

Menée aux Etats-Unis auprès de 325 patients ayant survécu à un cancer (âge moyen : 31, 8 ans), cette étude analyse l'efficacité d'un outil permettant d'évaluer leurs difficultés psychologiques et leur qualité de vie en fonction de la prise en compte de la sévérité ou de la fréquence des symptômes de détresse liée au cancer

The impact of events scale: a comparison of frequency versus severity approaches to measuring cancer-specific distress

Salsman, John M. ; Schalet, Benjamin D. ; Andrykowski, Michael A. ; Cella, David

Objective : The Impact of Events Scale (IES) is one of the most widely used measures of event-specific distress. The IES assesses the frequency with which respondents experience intrusive thoughts and avoidant behaviors over the past week. Our aim is to demonstrate the benefit of a severity-based measurement approach of the IES compared with a frequency-based measurement approach. Methods : A mixed group of post-treatment cancer survivors (N = 325; M = 31.8 years old) completed measures [...]

Menée aux Etats-Unis auprès de 143 époux de patientes atteintes d'un cancer du sein récemment diagnostiqué, cette étude analyse l'association entre la sévérité du cancer de leur épouse, des caractéristiques sociodémographiques, leurs symptômes de détresse liées à la maladie et diverses caractéristiques de leur vie professionnelle (absentéisme, baisse de productivité et de performance, etc)

Psychological distress as a mediator of the association between disease severity and occupational functioning among employed spouses of women recently diagnosed with breast cancer

Manne, Sharon L. ; Siegel, Scott ; Heckman, Carolyn J. ; Kashy, Deborah A.

Objective : The purpose was to evaluate whether patient and spouse cancer-specific distress mediated the association between cancer severity and occupational functioning among employed spouses of women diagnosed with breast cancer. We examined whether sociodemographic characteristics, lower spouse-reported marital quality, and lower spouse self-rated health were associated with poorer spouse occupational functioning. Methods : One hundred forty-three currently employed spouses of women [...]

Mené aux Etats-Unis auprès de 48 patientes ayant survécu à un cancer du sein de stade I, II ou III, cet essai randomisé analyse l'efficacité d'une intervention de réadapation cognitive menée en groupe pour améliorer leur fonctionnement neuropsychologique

Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial

Ercoli, L. M. ; Petersen, L. ; Hunter, A. M. ; Castellon, S. A. ; Kwan, L. ; Kahn-Mills, B. A. ; Embree, L. M. ; Cernin, P. A. ; Leuchter, A. F. ; Ganz, P. A.

Purpose : We conducted a randomized clinical trial evaluating the efficacy of a cognitive rehabilitation (CR) intervention compared with a wait list (WL) control condition on cognitive complaints, neuropsychological and brain functioning in breast cancer survivors (BCS). Methods : The small group intervention of five sessions included psychoeducation and cognitive exercises. Eligibility Disease-free BCS with cognitive complaints, diagnosed with stage I, II or III breast cancer, completed [...]

Menée aux Etats-Unis par questionnaire auprès de 675 patientes atteintes d'un cancer du sein de stade I à III et âgées de moins de 40 ans (âge médian au diagnostic : 35, 4 ans), cette étude de cohorte prospective évalue l'association entre leur anxiété et le soutien du partenaire de vie

Partner support and anxiety in young women with breast cancer

Borstelmann, Nancy A. ; Rosenberg, Shoshana M. ; Ruddy, Kathryn J. ; Tamimi, Rulla M. ; Gelber, Shari ; Schapira, Lidia ; Come, Steven ; Borges, Virginia ; Morgan, Evan ; Partridge, Ann H.

Objective : Using a large prospective cohort of women age 40 or younger diagnosed with breast cancer, we examined the relationship between perceived partner support and anxiety. Methods : Six hundred seventy-five young women with breast cancer Stages I–III, median age 36, completed a self-report baseline questionnaire. Perceived partner support was assessed using items extracted from the marital subscale of the Cancer Rehabilitation Evaluation System; generalized social support was assessed [...]

Menée en Italie à partir de données portant sur 73 patients atteints d'un gliome de haut grade, cette étude analyse leur santé psychique, leur qualité de vie et leurs stratégies cognitives mises en place pour faire face à la maladie

Cognitive strategies and quality of life of patients with high-grade glioma

Lucchiari, C. ; Botturi, A. ; Silvani, A. ; Lamperti, E. ; Gaviani, P. ; Innocenti, A. ; Finocchiaro, C. Y. ; Masiero, M. ; Pravettoni, G.

The purpose of this study was to analyze the psychological well-being, quality of life, and cognitive strategies activated by patients with high-grade glioma. We hypothesized that the self-perceived quality of life is modulated by physical and psychological factors and that in order to understand this modulation more psychometric approaches are necessary. Data were collected from a sample of 73 consecutive patients with a histological diagnosis of primary malignant brain cancer (grade IV [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2013 (27 études), cette étude fait le point sur l'efficacité d'interventions visant à promouvoir une activité physique et une alimentation saine chez des patients ayant survécu à un cancer, en fonction du support de communication (par support écrit, par téléphone, par internet, etc)

Telephone, print, and Web-based interventions for physical activity, diet, and weight control among cancer survivors: a systematic review

Goode, AnaD ; Lawler, SheleighP ; Brakenridge, CharlotteL ; Reeves, MarinaM ; Eakin, ElizabethG

Purpose : Broad-reach (non-face-to-face) modalities offer an accessible and cost-effective means to provide behavior change programs in diverse and growing cancer survivor populations. The purpose of this systematic review is to evaluate the efficacy of physical activity, dietary, and/or weight control interventions for cancer survivors in which telephone, short-message service, print, and/or Web is the primary method of delivery. Methods : A structured search of PubMed, Embase, Web of Science, [...]

A partir d'une revue systématique d'essais randomisés (14 essais, 3 377 participants), cette méta-analyse fait le point sur l'utilisation des outils d'aide à la décision permettant le choix éclairé des patients atteints d'un cancer localisé de la prostate et relatifs à leurs traitements

Decision aids for localized prostate cancer treatment choice: Systematic review and meta-analysis

Violette, Philippe D. ; Agoritsas, Thomas ; Alexander, Paul ; Riikonen, Jarno ; Santti, Henrikki ; Agarwal, Arnav ; Bhatnagar, Neera ; Dahm, Philipp ; Montori, Victor ; Guyatt, Gordon H. ; Tikkinen, Kari A. O.

Patients who are diagnosed with localized prostate cancer need to make critical treatment decisions that are sensitive to their values and preferences. The role of decision aids in facilitating these decisions is unknown. The authors conducted a systematic review of randomized trials of decision aids for localized prostate cancer. Teams of 2 reviewers independently identified, selected, and abstracted data from 14 eligible trials (n = 3377 men), of which 10 were conducted in North America. Of [...]

Cet article présente des recommandations relatives à l'utilisation d'outils d'évaluation gériatrique en oncologie

Expert consensus panel guidelines on geriatric assessment in oncology

O'Donovan, A. ; Mohile, S. G. ; Leech, M.

Despite consensus guidelines on best practice in the care of older patients with cancer, geriatric assessment (GA) has yet to be optimally integrated into the field of oncology in most countries. There is a relative lack of consensus in the published literature as to the best approach to take, and there is a degree of uncertainty as to how integration of geriatric medicine principles might optimally predict patient outcomes. The aim of the current study was to obtain consensus on GA in oncology [...]

Menée aux Etats-Unis par enquête auprès de 1 422 médecins spécialistes (711 oncologues radiothérapeutes, 711 urologues), cette étude analyse leurs perceptions vis-à-vis d'outils d'aide à la décision et de leur intérêt pour partager la décision thérapeutique avec leurs patients atteints d'un cancer localisé de la prostate

Shared decision making and use of decision aids for localized prostate cancer : Perceptions from radiation oncologists and urologists

Wang, E. H. ; Gross, C. P. ; Tilburt, J. C. ; et al.,

Importance : The current attitudes of prostate cancer specialists toward decision aids and their use in clinical practice to facilitate shared decision making are poorly understood. Objective : To assess attitudes toward decision aids and their dissemination in clinical practice. Design, Setting, and Participants : A survey was mailed to a national random sample of 1422 specialists (711 radiation oncologists and 711 urologists) in the United States from November 1, 2011, through April 30, 2012. [...]